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PENGARUH PEMBERIAN INFORMASI OBAT TERHADAP TINGKAT KEPATUHAN PENGGUNAAN ANTIBIOTIKA PADA PASIEN PNEUMONIA DI RS PKU MUHAMMADIYAH GUBUG Triana Aprilyya; Zaenal Fanani; Galih Kurniawan
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1644

Abstract

Pneumonia is a lower respiratory tract infection that remains a major cause of morbidity and mortality, especially in developing countries like Indonesia. The success of pneumonia therapy depends heavily on patient compliance in using antibiotics appropriately. However, patient compliance with antibiotic treatment remains low, which risks relapse and antibiotic resistance. One important factor that can improve understanding is presenting drug information accurately and clearly. This study aims to determine the effect of providing drug information on the level of antibiotic compliance in pneumonia patients at PKU Muhammadiyah Gubug Hospital. This study used a quasi-experimental method with a non-equivalent control group design, involving two groups of pneumonia patients: those before and after receiving drug information intervention using leaflets. Compliance levels were measured using the MARS (Medication Adherence Rating Scale) questionnaire before and after the intervention. The results of the study will compare the significance of antibiotic compliance levels in the pre- and post-intervention groups (p < 0.05) using the Wilcoxon Signed Rank Test. Patients who were provided with information showed a better understanding of the importance of completing antibiotic therapy as recommended. In conclusion, providing effective drug information can improve patient adherence to antibiotic use, contributing to successful therapy and preventing resistance. These results can serve as a basis for developing drug information intervention programs in hospitals
FORMULASI DAN UJI STABILITAS FISIK DEODORAN SPRAY KOMBINASI EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L) SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus Anisa Nurjanah; Zaenal Fanani; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 4 (2025): Nusantara Hasana Journal, September 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i4.1688

Abstract

Body odor problems triggered by the activity of bacteria such as Staphylococcus aureus are a concern in tropical regions such as Indonesia, which have high temperatures and humidity. Long-term use of synthetic chemical deodorants carries the risk of side effects, so safe and effective natural alternatives are needed. This study aims to formulate and evaluate the physical stability and antibacterial effectiveness of a spray deodorant preparation made from a combination of red betel leaf extract (Piper crocatum Ruiz and Pav.) and starfruit leaf extract (Averrhoa bilimbi L.). The extract was obtained through a maceration method with 70% ethanol as a solvent. This study used a laboratory experimental design with a quantitative approach. The study population was a spray deodorant preparation formulated in four variations: F0 (Negative control), F1 (7.5% red betel leaf + 2.5% starfruit leaf), F2 (5% + 5%), and F3 (2.5% + 7.5%). Physical stability tests included organoleptic tests, pH, displaced volume, and homogeneity. Antibacterial activity test was carried out using the well diffusion method against Staphylococcus aureus ATCC 25923. Data analysis was performed using normality test, homogeneity test, and one-way ANOVA test, and Tukey HSD post-hoc test. The results showed significant differences between treatment groups, but no significant differences between test formulas. All formulas met physical stability standards and showed strong antibacterial activity (inhibition zone 12.1 -14.37 mm). Formula F2 showed the highest inhibition, indicating a synergistic effect of a balanced extract ratio. This study contributes to the development of natural spray deodorant products that are safe, effective, and have the potential to replace synthetic ingredients in pharmaceutical formulations.
ANALISIS FITOKIMIA DAN PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL DAUN KETAPANG KENCANA (Terminalia mantaly) SECARA SPEKTROFOTOMETRI UV-VIS Veronika Puspita Kumalasari; Zaenal Fanani; Emma Jayanti Besan
Nusantara Hasana Journal Vol. 5 No. 5 (2025): Nusantara Hasana Journal, October 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i5.1714

Abstract

The Ketapang Kencana plant (Terminalia mantaly) is one of the plants with potential as a source of bioactive compounds. Traditionally, various parts of this plant, such as the leaves, stems, and root bark, have been used in several countries to treat diseases such as diabetes, dysentery, and malaria. This study aims to identify the active compounds present in the ethanol extract of Ketapang Kencana leaves and to determine the total flavonoid content of the ethanol extract of Ketapang Kencana leaves. The extraction was carried out using the maceration method with 70% ethanol as the solvent. Phytochemical screening of the ethanol extract of Ketapang Kencana leaves was conducted using specific chemical reagents. The results of the phytochemical screening showed that the ethanol extract of Ketapang Kencana leaves contains alkaloids, flavonoids, saponins, tannins, and triterpenoids. The total flavonoid content of the ethanol extract of Ketapang Kencana leaves, determined using the colorimetric method with UV-Vis spectrophotometry and quercetin as the standard, was found to be 26.847 mgQE/g extract on average.
Larvicides Activity of Krokot Extract into Aedes aegypti Mortality Fanani, Zaenal; Hidayah, Noor; Yulianti, Nur Fajria
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1857

Abstract

Dengue Hemorrhagic Fever (DHF) is transmitted by Aedes aegypti, one of controlling vectors which is larvicides. Synthetic larvicides cause several problems so that alternative natural larvicides are used. One of which is the krokot (Portulaca oleracea, L.), the content such as flavonoids, tannins, alkaloids, and saponins can be used as larvicides. This study aims to determine the larvicides activity of krokot extract on mortality of Aedes aegypti. The study was conducted using experimental quantitative research. The study was conducted by pouring the ethanol extract on 25 larvae and repeated 3 times, for 24 hours. The result of larvae mortality test at concentrations of 4%, 5% and 6%, namely 39%, 57% dan 72%. LC50 value from krokot extract on the larvae mortality, that is equal to 9.294%. Based on the study, it can be concluded that the krokot ethanol extract is able to kill 50% of the Aedes aegypti larvae population.   Keywords:          krokot, ethanol extract, Aedes aegypti, mortality
APLIKASI INFORMATION MOTIVATION BEHAVIORAL SKILLS OF ANTIRETROVIRAL THERAPY UNTUK MEMPERBAIKI KEPATUHAN PASIEN AIDS Fanani, Zaenal; Rahmawati, Riana Putri; Arif, Fahrudin; Simbara, Ari; Mafitri, Hanifah Miftah
IJF (Indonesia Jurnal Farmasi) Vol 8, No 1 (2023): Indonesia Jurnal Farmasi
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijf.v8i1.2218

Abstract

Human Immunodeficiency Virus (HIV) merupakan sejenis virus yang menginfeksi sel darah putih yang menyebabkan menurunnya kekebalan daya tahan tubuh manusia, sedangkan Acquired Immune Deficiency Syndrome (AIDS) adalah sekumpulan gejala yang timbul karena menurunnya daya tahan tubuh yang disebabkan oleh infeksi HIV. Kepatuhan dalam pengobatan (medication compliance) adalah mengkonsumsi obat terapi ARV yang telah diresepkan oleh dokter dan dosis yang tepat dalam pengobatan hanya efektif apabila memenuhi ketentuan dalam meminum obat ARV tersebut. Pengukuran kepatuhan minum obat ARV dalam penelitian ini dilakukan dengan menggunakan pendekatan Information Motivation Behavioral Skills (IMB) Model of Antiretroviral Therapy (ARV) Adherence. Mengetahui dan menganalisa hubungan Information Motivation Behavioral skills (IMB) Model of Antiretroviral Therapy (ART) terhadap Kepatuhan Minum Obat pasien HIV/AIDS di Klinik CST RSUD Sunan Kalijaga Demak. Jenis penelitian ini adalah penelitian eksperimental dengan pendekatan metode deksriptif korelasi. Pendekatan waktu pengumpulan data dalam penelitian ini dilakukan dengan menggunakan metode cross sectional design. Sampel yang diambil dalam penelitian ini yaitu sebanyak 62 sampel responden. Hasil karakteristik informasi (information) tentang obat ARV dengan kategori informasi tinggi sebanyak 51 responden (82,3%), motivasi (motivation) minum obat ARV dengan kategori tinggi sebanyak 44 responden (71,0%) dan keterampilan berperilaku (behavioral skills) dengan kategori tinggi sebanyak 53 responden (85,5%). Ada hubungan antara informasi dan keterampilan berperilaku terhadap tingkat kepatuhan terhadap kepatuhan minum obat pasien HIV/AIDS.
Development of Wonosoco Village as a Fair, Healthy, and Productive Tourism Village in Kudus Regency Jauhar, Muhamad; Fanani, Zaenal; Etikasari, Ria; Maulana, Bonnix Hedy; Novitasari, Arina; Putra, M. Adib Jaharii Dwi; Pusparatri, Edita; Sukoharjanti, Bintari Tri; Nasriyah, Nasriyah; Ariyanto, Andhika; Muslim, Ahmad Suriyadi
DIKDIMAS : Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 1 (2024): DIKDIMAS : JURNAL PENGABDIAN KEPADA MASYARAKAT  VOL 3 NO 1 APRIL 2024
Publisher : Asosiasi Profesi Multimedia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/dikdimas.v3i1.257

Abstract

The development of Wonosoco Village as a fair, healthy, and productive tourist village in Kudus Regency has the potential to provide benefits for the community and enrich the tourism industry in the area. This activity aims to understand policies, clean and healthy living behavior, and marketing strategies, and empowerment of community businesses in tourist villages. This activity was carried out in November 2023 in Wonosoco Village, Undaan District, Kudus Regency. This activity was attended by 16 people consisting of village government, health cadres, youth groups, tourism awareness groups, and religious leaders. Delivery of material uses interactive lecture and focus group discussions in 3 sessions of 30 minutes/session. The material provided includes tourism village development policies, clean and healthy living behavior in public places, marketing strategies, and empowerment of community businesses in tourist villages. Service providers carry out assessments and evaluations using questionnaires on knowledge of clean and healthy living behavior in public places and perceptions of community participation in developing tourist villages. Data analysis is interpreted descriptively. The majority of the community has good knowledge about clean and healthy living behavior in public places (87%) and a perception of community participation in developing Wonosoco Village as a Tourism Village (50%). This activity is the first step in developing a just, healthy, and productive tourist village so it requires follow-up from local stakeholders. This follow-up takes the form of assisting in the development of tourist villages, monitoring and evaluating the success of developing tourist villages that are just, healthy, and productive.
HEALTH COUNSELING TO INCREASING KNOWLEDGE AND COMPLIANCE IN HYPERTENSION PATIENTS Zaenal Fanani; Yunita Rusidah; Shinta Dwi Kurnia; Lailatul Farikhah; Munandiyah Munandiyah
(IJP) Indonesia Jurnal Perawat Vol 10, No 2 (2025): INDONESIA JURNAL PERAWAT
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijp.v10i2.2674

Abstract

Hypertension is a silent killer because it often occurs without complaints, symptoms can vary among individuals, and are almost the same as the symptoms of other diseases and can cause several complications including coronary heart disease, stroke and kidney failure. To support appropriate hypertension therapy, health counseling is needed given that knowledge and adherence to the expected therapeutic effect can be achieved. The purpose of this study was to determine the influence of health counseling on increasing patient knowledge and compliance. Primary data collection was carried out from February to March 2023, using the one-group pre and post-test experimental quasi-methods, for 55 respondents. The research instrument used two questionnaires, namely patient knowledge and compliance. Blood pressure was 140/90 in 34 (61,82%) patients and the duration of hypertension was 5 years in as many as 43 (78,2%) patients. The percentage of patients who completed the post-test patient knowledge was as high as 100%, and the percentage of patients who completed the post-test compliance was as high as 63,64%. A significant difference was found between the two data sets (p= 0.000). Patient knowledge and compliance increased significantly from before health counseling to after health counseling.
PENGARUH PEMBERIAN AIR REBUSAN DAUN SELEDRI TERHADAP PENURUNAN TEKANAN DARAH PADA LANSIA Zaenal Fanani; Irawati Indrianingrum; Ari Simbara; Lailatul Farikhah; Dhanty Ayunita Mahadhany
(IJP) Indonesia Jurnal Perawat Vol 9, No 1 (2024): INDONESIA JURNAL PERAWAT
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijp.v9i1.2499

Abstract

Hipertensi sering terjadi pada lansia yang dikaitkan dengan proses penuaan. Seiring dengan bertambahnya usia, risiko seseorang untuk mengalami hipertensi semakin meningkat. Pengobatan hipertensi secara non farmakologi juga dapat diberikan melalui konsumsi seledri. Senyawa apiin dari daun seledri bersifat diuretik dan diduga mampu melebarkan pembuluh darah dan menurunkan tekanan darah. Tujuan penelitian ini untuk mengetahui pengaruh pemberian air rebusan daun seledri terhadap penurunan tekanan darah pada lansia. Jenis penelitian ini kuantitatif menggunakan metode quasi experimental design, dengan rancangan non equivalent control group design. Teknik sampling menggunakan stratified random sampling sampel, dengan jumlah responden 46 orang. Hasil penelitian menunjukkan ada pengaruh pemberian rebusan daun seledri terhadap tekanan darah pada lansia kelompok intervensi, dengan nilai p-value kelompok intervensi 0,000. Dan tidak ada pengaruh pemberian rebusan daun seledri terhadap tekanan darah pada lansia kelompok kontrol, dengan nilai p-value 0,01. Kesimpulan penelitian ini yaitu, adanya pengaruh pemberian rebusan daun seledri terhadap penurunan tekanan darah pada lansia.
KETERKAITAN PENGETAHUAN SANTRIWATI DENGAN PERILAKU PENCEGAHAN KUDIS PADA LINGKUP PONDOK PESANTREN Zaenal Fanani; Bintari Tri Sukoharjanti; Yayuk Mundriyastutik; Lailatul Farikhah; Ari Simbara
(IJP) Indonesia Jurnal Perawat Vol 8, No 2 (2023): INDONESIA JURNAL PERAWAT
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijp.v8i2.2168

Abstract

Kudis atau skabies merupakan gangguan kulit yang dikarenakan oleh parasitisme dan ekspresi Sarcoptes scabiei, sejenis tungau subspesies hominis. Kudis di Indonesia merupakan gangguan kulit peringkat ke-3 terbanyak. Santriwan maupun Santriwati termasuk dalam populasi risiko tinggi serta rentan terkena serangan kudis. Meskipun penyakit ini dapat diobati, namun sering kali terlambat didiagnosis dan menunda pengobatan, sehingga membuatnya lebih mungkin untuk menyebar ke seluruh pondok pesantren. Jenis penelitian analitik ini memakai cross-sectional design, untuk dimaksudkan agar mengetahui keterkaitan antara variabel independen dengan dependen yang dianalisa pada suatu titik masa tertentu. Dilakukan penelitian menggunakan metode deskriptif yang bertujuan untuk mewujudkan gambaran yang sistematis, berdasarkan fakta dan akurat. Pengumpulan data dilakukan hanya satu kali menggunakan instrumen penelitian berupa kuesioner. Penelitian menggunakan jumlah responden sebanyak 70 individu. Data kuesioner responden menunjukkan usia 15-17 tahun sebanyak 34 santriwati (49%), responden dengan tingkat pendidikan MTS sebanyak 38 santriwati (54%), responden dengan riwayat kelas 7-9 sebanyak 42 santriwati (60%), responden memiliki pengetahuan cukup sejumlah 48 santriwati (69%), responden memiliki pengetahuan baik sejumlah 38 santriwati (54%). Hasil uji bivariat perilaku menggunakan chi square diperoleh nilai 0,035 untuk P (Asymptotic significance). Dengan melihat nilai asymp. Sig Pearson Chi Square 0,05 atau lebih besar, dapat ditunjukkan adanya keterkaitan antara tingkat pengetahuan dengan perilaku pencegahan kudis yang signifikan.
STUDI FARMAKOEPIDEMIOLOGI VITAMIN PENAMBAH DARAH PADA IBU HAMIL DI WILAYAH KERJA PUSKESMA BANYUDONO I BOYOLALI Yayuk Mundriyastutik; Zaenal Fanani; Ana Zumrotun Nisak; Muhammad Al Anshori Nasrullah
Indonesia Jurnal Kebidanan Vol 4, No 2 (2020): INDONESIA JURNAL KEBIDANAN
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/ijb.v4i2.1363

Abstract

 AbstrakPenularan HIV kepada anak yang secara teori di kontribusikan dari proses penularan dari ibu ke anak. Penggunaan zidovudin dalam terapi HIV/AIDS cukup banyak digunakan. Menurut WHO, lini pertama penatalaksanaan HIV/AIDS adalah kombinasi satu macam Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) dan dua macam Nucleoside Reverse Transcriptase Inhibitor (NRTI), satu diantaranya haruslah zidovudin.Desain penelitian yang digunakan adalah analitik korelasi, menggunakan pendekatan cross sectional, pada penelitian ini populasinya adalah bayi dengan ibu HIV pada tahun 2020 di Rumah Sakit Genteng sebanyak 28 pasien, dengan menggunakan teknik Accidental sampling, untuk mengetahui hubungan antara kedua variabel dilakukan uji statistik Chi Square dengan tingkat signifikansi 0,05.Hasil penelitian yang diperoleh hasil hubungan antara umur lahir bayi mendapatkan hasil nilai Chi Square hitung 11.667 3.841 Chi Square tabel. berat badan lahir bayi mendapatkan hasil nilai Chi Square hitung 2.263 3.841 Chi Square tabel. Kepatuhan minum obat Zidovudine mendapatkan hasil nilai Chi Square hitung 18.200 5.991 Chi Square tabel dengan keberhasilan terapi Zidovudine pada bayi ibu HIV di RSUD Genteng. Sehingga dapat disimpulkan terdapat hubungan antara umur bayi dan kepatuhan minum obat Zidovudine dengan keberhasilan terapi Zidovudine, dan tidak terdapat hubungan berat badan lahir bayi dengan keberhasilan terapi Zidovudine. Sedangkan faktor yang peling berpengaruh adalah faktor kepatuhan dalam minum obat Zidovudine dengan hasil Chi Square hitung paling besar.Pada dasarnya penularan HIV dari ibu dapat dicegah dengan obat Zidovudine. Namun keberhasilan juga dipengaruhi oleh faktor lain diantaranya umur lahir bayi dengan kepatuhan minum obat Zidovudine.
Co-Authors Abida Ardelia Ahmad Suriyadi Muslim Ana Nurul Fitriyani Ana Nurul Fitriyani Ana Zumrotun Nisak Anisa Nurjanah Anny Rosiana Masithoh Ari Simbara Ari Simbara, Ari Arina Novitasari Ariyanto, Andhika Bintari Tri Sukoharjanti Bonita Anzila Desi Dhanty Ayunita Mahadhany Dwi ASTUTI Dwi Rizqi Roniawati Emma Jayanti Besan Endang Setyowati Etikasari, Ria Fahrudin Arif Galih Kurniawan Ilun Fadillah Intan Adevia R Intan Adevia Rosnarita Iqbal Amaluddin Pambudi Irawati Indrianingrum Julia Megawati Djamal Julia Winda Sari Kharisma Aprilita Rosyidah Kinanti Putri Amalia Laila Septania Rafi Lailatul Farikhah Lailatul Farikhah Mafitri, Hanifah Miftah Mariza Kusuma Wariana Maulana, Bonnix Hedy Muhamad Jauhar Muhamad Khudzaifi Muhammad Al Anshori Nasrullah Muhammad Bayu Nirwana Muhammad Khudzaifi Muhammad Syariful Imam Munandiyah Munandiyah Nasriyah Nasriyah Noor Cholifah Noor Hidayah Noor Hidayah Noor Hidayah Novam Danu Pamungkas Nur Aisah Nur Aisah Nur Aisah Nur Fajria Yulianti Pusparatri, Edita Putra, M. Adib Jaharii Dwi Rahmawati, Riana Putri Ria Etikasari Ridwan Ridwan Ridwan Ridwan Ridwanto, Muhammad Rika Murharyanti Rusnoto Rusnoto Sabiq Ismil Adhom Safira Dinnul Qayyimah Sakila Jauza Adiba Sari, Dwi Maya Ratna Shinta Dwi Kurnia shinta dwi kurnia Siti Mumfaridatul Mukarromah Sukoharjanti, Bintari Tri Tities Kusuma Pratama Tiyas Putri N Tiyas Putri Nugraheni Triana Aprilyya Tyas Putri Nugraheni Ulviani Yulia Husna Ulviani Yulia Husna Umi Farida Veronika Puspita Kumalasari Vivin Rosvita Vivin Rosvita Vivin Rosvita Windy Aulina Yayuk Mundriyastutik Yulianti, Nur Fajria Yulis Trinovita Yunita Febrianti Yunita Rusidah Yunus Mustaqim, Yunus