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All Journal Jurnal Penelitian Saintek Jurnal Ilmu Dasar Jurnal Matematika & Sains WIDYATAMA Pharmacon Journal of Community Services and Engagement Journal of Nutraceuticals and Herbal Medicine Jurnal Kreativitas PKM Jurnal Penyuluhan Perikanan dan Kelautan INTEGRITAS : Jurnal Pengabdian Jurnal Ners Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Farmasi dan Sains Indonesia (JFSI) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Journal of Pharmaceutical and Sciences. Jurnal Ilmiah Kesehatan Usadha Journal of Pharmacy Borneo Journal of Pharmacy Journal of Community Services and Engagement: Voice of Community (VOC) Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Journal of Nutraceuticals and Herbal Medicine Jurnal Sains dan Kesehatan
Haryoto Haryoto
Universitas Muhammadiyah Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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EFEK ANTIINFLAMASI EKSTRAK ETANOL KULIT KACANG TANAH (Arachis hypogaea L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI KARAGENIN Haryoto Haryoto
Pharmacon: Jurnal Farmasi Indonesia Vol 11, No 1 (2010)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v11i1.63

Abstract

Kulit kacang tanah mengandung luteolin yang berpotensi sebagai antiinflamasi secara in vitro dan in vivo. Penelitian ini bertujuan untuk mengetahui efek antiinflamasi ekstrak etanol kulit kacang tanah (Arachis hypogaea L.) pada tikus jantan galur Wistar yang diinduksi karagenin Penelitian menggunakan rancangan acak lengkap pola searah. Dua puluh lima ekor tikus putih jantan galur Wistar dibagi menjadi 5 kelompok. Kontrol negatif menggunakan CMC-Na 0,5% 2,5 mL/200 gBB, kontrol positif menggunakan Na-diklofenak 6,75 mg/kgBB. Ekstrak etanol kulit kacang tanah yang diujikan yaitu dosis 50, 100 dan 200 mg/kgBB. Larutan uji diberikan secara peroral dengan volume pemberian 2,5 mL/200 gBB 1 jam sebelum kaki hewan uji diradangkan dengan karagenin 1% secara subplantar. Pengukuran volume kaki tikus dilakukan tiap 0,5 jam selama 6 jam. Data volume udem dihitung nilai AUC (Area Under the Curve) rata-rata volume udem terhadap waktu dan persen daya antiinflamasi. Data dianalisis dengan anava satu jalan dan dilanjutkan uji LSD (Least Significant Difference) dengan taraf kepercayaan 95%.  Hasil penelitian menunjukkan bahwa ekstrak etanol etanol kulit kacang tanah (Arachis hypogae L.) dengan dosis 50, 100 dan 200 mg/kgBB mempunyai persen daya antiinflamasi berturut-turut sebesar 16,33%; 26,39% dan 31,70%, sedangkan Na-diklofenak 6,75 mg/kgBB sebesar 32,24%.Kata kunci: kulit kacang tanah (Arachis hypogaea L.), ekstrak etanol, antiinflamasi
Cytotoxic Assay of Semipolar Fraction Of Ethanolic Extract From Sugar Apple (Annona Squamosa L.) Stem Bark on T47D Cells Cita Hanif Muflihah; Haryoto Haryoto; Peni Indrayudha
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.12268

Abstract

Previous research has shown that some compounds in leaves and seeds of sugar apple have a cytotoxic activity. The aim of this research was to determine the cytotoxicity of semipolar fraction of ethanolic extract from sugar apple stem bark (Annona squamosa L.) on T47D cancer cells. The semipolar fraction of ethanolic extract from sugar apple stem bark was collected by fractionation using Vacuum Liquid Chromatography (VLC) with hexane:ethyl acetic (9:1, 8:2, 7:3, and  6:4)  as  mobile  phase.  Cytotoxicity from the fractions of five different concentration namely; 25, 50, 100, 150, and 250, µg/mL was measured by MTT assay. The potency of the cytotoxicity was defined by the ability of the fraction to inhibit the growth of T47D cells indicated by the value of IC50. Qualitative analysis of contained compounds in the fraction was done by Thin Layer Chromatography (TLC) method using silica gel F 254 as a stationary phase and hexane:ethyl acetic (7:3) as a mobile phase. UV 254 and 366 nm lamp also Dragendorff, citroboric, and FeCl3 spray reagents were used to visualize the spots of the secondary metabolites. The result proved that the semipolar fraction of ethanolic extract from sugar apple stem bark showed potential cytotoxicity on T47D cancer cells with IC50value of 70,77 µg/mL. Qualitative analysis showed that the fraction contained flavonoids and alkaloids which is presumably responsible for its cytotoxic activity. 
Antioxidant Activity of Polar Fraction of Methanol Extract from Tree Bark Of Shorea acuminatissima with DPPH Method Haryoto Haryoto; Broto Santoso; Hafid Nugroho
Jurnal ILMU DASAR Vol 8 No 2 (2007)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.742 KB)

Abstract

Shorea accuminatissima, which is known locally as Meranti kuning, is one species of Dipterocarpaceae family. This plant contains compounds that are expected to have antioxidant activity. This research was carried out to examine the radical scavenger activity of polar fraction of methanolic extract from the tree bark of S. accuminatissima by using DPPH (2,2-difenil- 1-pikrilhidrazil) method with vitamin C as comparator. Powder of tree bark of S. accuminatissima was macerated in methanol. The methanolic extract was then evaporated to obtained dry extract. Extract with concentration of 200, 100, 50, 25 and 10 µg/mL were used to test its radical scavenger activity. The result showed that polar fraction of methanolic extract and vitamin has IC value of 319.83 and 3.72 µg/mL, respectively.
PETERNAK KAMBING DESA SINDON KECAMATAN NGEMPLAK BOYOLALI Haryoto Haryoto; Muhtadi Muhtadi; Rusdin Rauf
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 4 No. 1 (2020): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v4i1.2020.36-42

Abstract

The issue of animal feed and the efficiency of the goat breeding production process, is still a big problem for conventional goat breeders. Therefore, the use of fermented feed technology to save time providing feed, as well as the use of a communal cage system for efficiency and effectiveness in the management of goat farms, needs to be trained and mastered by goat breeders. The purpose of this IbM is to develop the capability of the goat business and increase the yields of goat farmers in the village of Sindon, kec. Ngemplak kab. Boyolali Some solutions offered to help partner problems are (1) introduction and training to goat breeders in Sindon village, Ngemplak district, Boyolali Regency regarding the use of fermented feed technology for integrated management of goat livestock, (2) training and providing technology of leaf counting machines for the production process of fermented feed goat livestock, (3) training and assistance for themanagement of goats by utilizing a communal cage system to increase the efficiency andeffectiveness of the production process. The expected outcome of this IbM activity is to increase the ability of the goat business, increase income and the effectiveness of the goat farming process in Sindon village, Ngemplak district, Boyolali district.AbstrakPermasalahan pakan ternak dan efisiensi proses produksi peternakan kambing, masih menjadi persoalan besar bagi para peternak kambing konvensional. Oleh karenanya, pemanfaatan teknologi pakan fermentasi untuk menghemat waktu penyediaan pakan, serta pemanfaatan sistem kandang komunal untuk efisiensi dan efektifitas dalam pengelolaan peternakan kambing sangat perlu dilatihkan dan dikuasai oleh peternak kambing. Tujuan IbM ini adalah pengembangan kemampuan usaha ternak kambing dan peningkatan hasil budidaya pada peternak kambing di desa Sindon, kec. Ngemplak kab. Boyolali. Beberapa solusi yang ditawarkan untuk membantu permasalahan mitra adalah (1) pengenalan dan pelatihan pada peternak kambing desa Sindon kecamatan Ngemplak Kabupaten Boyolali tentang pemanfaatan teknologi pakan fermentasi untuk pengelolaan ternak kambing terpadu, (2) pelatihan dan pemberian teknologi mesin pencacah dedaunan untuk proses produksi pakan fermentasi ternak kambing, (3) pelatihan dan pendampingan untuk pengelolaan ternak kambing dengan pemanfaatan sistem kandang komunal untuk peningkatan efisiensi dan efektifitas proses produksi. Luaran yang diharapkan dari kegiatan IbM ini adalah peningkatan kemampuan usaha ternak kambing, peningkatan pendapatan serta efektifitas proses budidaya ternak kambing di desa Sindon kecamatan Ngemplak kabupaten Boyolali.
Tests of Ash Content, Moisture Content and Dry Shrinkage of Ethanol Extracts of Capidada Leaves (Sonneratia alba) and Ketapang (Terminilia cattapa) Annisa Meyndra Komala; Haryoto Haryoto
Journal of Nutraceuticals and Herbal Medicine Vol 3, No 1 (2020): JNHM 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v3i1.10549

Abstract

Indonesian original medicine requires new development, one of the important stages is by testing which can be used as a parameter to determine standards for certain extracts. Capidada leaves (Sonneratia alba J. Smith) and ketapang leaves (Terminalia cattapa L.) are a type of mangrove that have various activities such as anti-bacterial, anti-inflammatory, antioxidant, as well as the benefits of capidada leaves and ketapang leaves. Therefore, it is necessary to standardize extracts to ensure quality that matches the quality. This research tries to test the water content, ash content, and drying shrinkage levels, which later can be used as a reference for the determination of extract quality standards. The extract was obtained through maceration using 96% ethanol. Test results obtained on capidada leaves are water content (10,38 ±0,52%v/b), total ash content (17,97±1,75%), drying shrinkage levels (10,35±0,35%), and the test results obtained for the ketapang leaves are water content (7,08±0,38%), total ash content (10,51±0,43%) and drying shrinkage levels (13,67±1,58%). To find out all aspects that are not directly related to pharmacological activities but affect the aspects of quality, safety, the stability of extracts and preparations produced, this research studied the ash content, water content, and drying shrinkage levels on ethanol extracts of mangrove capidada leaves (Sonneratia alba) J. Smith.) And ketapang (Terminalia cattapa L.)
Cytotoxicity of Methanol Leaf Extract of Artocarpus Altilis, Artocarpus Heterophyllus, and Artocarpus Camansi Against MCF-7 Breast Cancer Cells H. Haryoto; Pratiwi Widowati
Journal of Nutraceuticals and Herbal Medicine Vol 1, No 1 (2018): JNHM 2018
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v1i1.5737

Abstract

Artocarpus had been used as traditional medicine for cancer, cirrhosis, malaria, hypertension, and diabetes. This research aimed to evaluate the cytotoxic activity of methanol leaf extract of Artocarpus altilis, Artocarpus heterophyllus, and Artocarpus camansi against MCF-7 breast cancer cell. The leaf extracts of Artocarpus altilis, Artocarpus heterophyllus, and Artocarpus camansi were obtained by the method of maceration with methanol. Phytochemical screening wasperformed by Thin Layer Chromatography with the use of silica GF-254 for stationary phase and ethyl acetate: n-hexane (2:8) for mobile phase. The cytotoxic test was conducted by MTT with diverse concentrations of extract, namely 500, 250, 125, 62.5, and 31.25 μg/mL. The results of cytotoxic test were measured by ELISA reader. Based on phytochemical screening, tannin, and alkaloids were found in three extracts. Cytotoxic test demonstrated that those extracts had low cytotoxic activity against MCF-7 breast cancer cells, with IC50 of 120.85; 339.46 and 530.88 μg/mL, respectively, for Artocarpus altilis, Artocarpus heterophyllus, and Artocarpus camansi.
Cytotoxic Activities of Ethanol Extract, Nonpolar Semipolar, and Polar Fractions of Dioscorea esculenta L.) on MCF7 Cancer Cell H Haryoto
Journal of Nutraceuticals and Herbal Medicine Vol 2, No 1 (2019): JNHM 2019
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v2i1.7853

Abstract

One of the disease that have a high contribution to the death of women in the world is breast cancer. It leads to the research and exploration to find its cure. This study is conducted to know the anti-cancer activity onethanol extract, nonpolar, semipolar, and polar fractions of lesser yam (Dioscorea esculenta L.) herbs. It also aims to find out the content of compound on semipolar fraction Dioscorea esculenta L. herbs. The extraction was carried out using maceration technique with 96% ethanol as solvent. Then, the fractination was done using vacuum liquid chromatography method with n-hexane and acetone as mobile phase with the ratio of 9:1, 8:2, 7:3, 6:4, and 5:5. After that, the phytochemical test was undertaken using the thin layer chromatographywith n-hexane and acetone as mobile phase with proportion 7:3. Meanwhile, the cytotoxic test was conducted using MTT assay method with IC50calculation was counted using linear regression between the log concentration and the percentage of living cells. The semipolar fraction of Dioscorea esculenta L. herbs has IC50value of 632,42 µg/mL, whereas the ethanol extract, nonpolar and polar fractions have the IC50 value 1000 µg/mL. Furthermore, the compound of the semipolar fraction of Dioscorea esculenta L. herbs are saponins, terpenoids, alkaloids, and phenolics.
ISOLASI DAN IDENTIFIKASI EKSTRAK ETANOL DAUN MAREME (Glochidion arborescens Blume.): ISOLATION AND IDENTIFY OF ETHANOL EXTRACT OF MAREME LEAVES (Glochidion arborescens Blume.) Niati Ambarsari; Haryoto
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022): Forthcoming Issue
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.407

Abstract

Mareme (Glochidion arborescens Blume.) merupakan tumbuhan liar yang banyak tumbuh di pekarangan. Daun Mareme dapat digunakan sebagai obat tradisional dan diduga mengandung senyawa aktif antioksidan golongan flavonoid dan fenol. FT-IR (Fourier Transform Infrared Spectroscopy) merupakan metode yang digunakan untuk identifikasi gugus fungsi pada suatu sampel dan salah satu metode yang sering digunakan untuk identifikasi senyawa metabolit sekunder tanaman obat. Penelitian ini bertujuan untuk identifikasi senyawa metabolit sekunder yang terkandung dalam isolat daun Mareme. Serbuk daun Mareme diekstraksi menggunakan metode maserasi, ekstrak kental diuji skrining fitokimia dan difraksinasi menggunakan Kromatografi Cair Vakum serta diisolasi menggunakan kromatotron. Isolat daun Mareme diidentifikasi menggunakan FT-IR. Ekstrak kental daun Mareme diperoleh sebanyak 95,52 gram dan mengandung senyawa metabolit sekunder flavonoid, saponin, steroid, terpenoid, tannin dan polifenolat. Fraksi non polar diperoleh sebanyak 3,75 gram, fraksi semi polar sebanyak 3,90 gram dan fraksi polar sebanyak 3,25 gram, serta diperoleh isolat sebanyak 850 mg. Isolat daun maeme memiliki gugus fungsi -OH, - CH alifatik, -C=O ester, dan -C-O, dari hasil analisis FT-IR isolat daun Mareme mengandung senyawa flavonoid.
ANTIDIABETES MELITUS EKSTRAK ETANOL BATANG DAN DAUN UBI JALAR KUNING (Ipomoea batatas Linn.) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS JANTAN Haryoto Haryoto; Ahwanti Rukdiatma Nur’aini
Jurnal Farmasi Sains dan Praktis Vol 4 No 2 (2018)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v4i2.2313

Abstract

Diabetes melitus adalah kelainan metabolik yang ditandai dengan keadaan hiperglikemia. Ubijalar merupakan tanaman yang berpotensi dalam pengobatan diabetes melitus. Tujuan penelitianyang dilakukan mengukur efek ekstrak etanol daun dan batang ubi jalar kuning (Ipomoea batatasLinn.) dalam penurunan kadar glukosa darah pada tikus jantan yang diinduksi aloksan 150 mg/kgBB. Penelitian menggunakan tikus jantan sebanyak 15 ekor dibagi menjadi 5 kelompok perlakuan,kelompok kontrol negatif diberi akuadest, kelompok kontrol positif diberi metformin 45 mg/kgBB,dan 3 kelompok perlakuan diberi ekstrak dengan dosis 200, 300, dan 400 mg/kgBB. Perlakuandiberikan selama 12 hari. Aloksan 150 mg/kgBB digunakan agar tikus diabetes dengan kadar glukosadarah ≥ 200 mg/dL. Hasil penurunan kadar glukosa darah berturut-turut pada dosis 200, 300, dan400 mg/kgBB adalah 131,33 mg/dL, 125,33 mg/dL, dan 124,00 mg/dL. Persen penurunan kadarglukosa darah yang efektif dibanding kontrol negatif ditunjukkan dosis 300 mg/kgBB yaitu sebesar66,58%. Hasil uji statistik wilcoxon pada kadar glukosa darah hari ke-3 dibandingkan hari ke-12diperoleh nilai p <0,05 menunjukkan pemberian ekstrak dapat menurunkan kadar glukosa darah.
Pengembangan Usaha Pengolahan Ubi Jalar menjadi Produk Kembang Goyang Bagi Ibu-ibu PKK dan Anggota Karang Taruna di Desa Karangbangun Kabupaten Karanganyar Rusdin Rauf; H Haryoto
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang Sosial Ekonomi dan Psikologi
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (507.391 KB)

Abstract

Desa Karangbangun Kabupaten Karanganyar memiliki potensi hasilpertanian berupa ubi jalar. Upaya peningkatan keterampilanpengolahan produk olahan bagi masyarakat dapat meningkatkanekonomi masyarakat. Tujuan dari kegiatan pengabdian masyarakatini adalah untuk memberikan keterampilan pengolahan ubi jalarmenjadi produk kembang goyang bagi Ibu-ibu PKK dan anggotaKarang Taruna di Desa Karangbangun Kabupaten Karanganyar.Program pengabdian ini dilaksanakan melalui pengenalankarakteristik kimia dan sensorik ubi jalar. Selanjutnya diberikanpelatihan pembuatan tepung ubi jalar ungu menggunakanmesin/teknologi penepungan. Tepung ubi jalar ungu kemudiandijadikan sebagai bahan baku dalam pelatihan pembuatan kembanggoyang. Untuk memperkuat pemasaran produk, diberikan pelatihanpengemasan produk kembang goyang. Hasil evaluasi menunjukkanbahwa mitra dapat mengolah ubi jalar menjadi tepung ubi jalarmenggunakan teknologi penepungan. Mitra juga telah mahirmembuat produk kembang goyang dengan kemasan yang menarik.Melalui kegiatan ini mitra telah memproduksi kembang goyangsecara mandiri dan telah malakukan proses pemasaran produk.
Co-Authors A Anifatussaa'dah abdul, ahwan Abdul, Rasyid Aflit Nuryulia Praswati Ahwanti Rukdiatma Nur’aini Alfa Frista Amalia Suci Medisusyanti Amaliyah Dina Anggraeni Andi Suhendi Annisa Meyndra Komala Ardalia Rinanda Oktaviani Asfy Nurany Atikah Hapsari Aulita Keisya Azzahra, Hanifa Putri Bama, Samsun Ari Broto Santoso Burhanudin Ichsan Cast Torizellia Chairunnisa, Alya Cita Hanif Muflihah Dhiyahul Auliya Diah Siwi Ardiyani Dina Ayu Amalia Dwi Bagus Pambudi Dwi Sarbini Dyah Rahmawatie Ratna Budi Utami Dyera Forestryana Edtano Trinanda Erika Nuur Anisa Putri Erna Herawati Euis Holisotan Hakim Fahriza Mei Trihatmoko Farhand Ahmad Faridita khoirun Nisa' Fida’ Husain Fidhia Nur Rifaini Firstca Aulia Rachma Frida Rosenova Gita Firdaus Hafid Nugroho Hafiz Ramadhan Haliza Arzeti Nurseptiria Haya Nabilah Utama Heng Yen Khong Henggar Prasetyo Wikan Saputro Hidayah Karuniawati Ida Maesaroh Ikhsan, Maulida Nur Jalifah Latip Janies Arly Syahputri Joko Kristianto Khusnul Khotimah Kosworo Kosworo Laila Dzafira Lia Dewi Juliawaty Lina Ayu Kusumastuti Listiana Masyita Dewi Listyana Dewi Prastiwi Lusia, Eka Maemunah Mariska Sri Harlianti Marlupi Dwi Lestari Marsilia Rosa Sinensis HI maryatun maryatun Muhammad Irfan Muhammad Priyadi Muhtadi Muhtadi Munti Sarida Niati Ambarsari Nugroho Adi Suseno Nursalinda Kusumawati Nur’aini, Ahwanti Rukdiatma Peni Indrayudha Pratiwi Widowati Putri Agustina Raafika Studiviani Rahardian Surya Basusena Rizki Ainun Fitriani Rosnah, Rosnah RR. Ella Evrita Hestiandari Rusdin Rauf Sayyidah Nurul Muslihah Sekarsari, Devina Sendy Pradila Putri Siyama, Anis Sjamsul Arifin Achmad Suranto Suranto Suranto, Choirun Nisa Tanti Azizah Sujono Tia Mella Citra Tista Ayu Fortuna Tri Aprilianingtyas Triana Ariska Dewi Utomo, Chandra Wahyu Vitania Marsya Widowati, Pratiwi Wildan Firdaus, Muhammad Yana Maolana Syah Yulia Dwi Nuryanti Yuliana Dwi Jayanti Yurnanda Ambar Mustika