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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Degraded and Mining Lands Management Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Majalah Kedokteran Sriwijaya Sari Pediatri Biomedical Journal of Indonesia Paediatrica Indonesiana Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Alami Journal (Alauddin Islamic Medical) Journal Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas JURNAL MEDIA KESEHATAN Best Journal (Biology Education, Sains and Technology) MDJ (Makassar Dental Journal) Sriwijaya Journal of Surgery Indonesian Journal of Global Health research Jurnal Menara Medika Bioscientist : Jurnal Ilmiah Biologi MAHESA : Malahayati Health Student Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Islamic and Complementary Medicine Indonesian Community Journal Journal of Anesthesiology and Clinical Research Sanitasi: Jurnal Kesehatan Lingkungan Conferences of Medical Sciences Dies Natalis Jurnal Sehat Indonesia (JUSINDO) Jurnal Penyakit Dalam Indonesia Indonesian Journal of Biomedicine and Clinical Sciences Indonesian Journal of Global Health Research
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PRODUKSI TEH DAUN SUNGKAI SEBAGAI MINUMAN IMUNOSTIMULATOR Subandrate Subandrate; Sadakata Sinulingga; Fatmawati Fatmawati; Irfannuddin Irfannuddin; Susilawati Susilawati; Rini Yana; Medina Athiah; Safyudin Safyudin
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 1 (2022)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/logista.6.1.10-14.2022

Abstract

Pada pertengahan tahun 2021 kasus Covid19 di Indonesia melonjak lagi termasuk di Kota Palembang. Lonjakan kasus tersebut tidak hanya memberikan dampak bagi masyarakat luas tetapi juga bagi lingkungan kampus Universitas Sriwijaya. Oleh karena itu, perlu dilakukan upaya meningkatkan imunitas tubuh menggunakan herbal tradisional Indonesia. Salah satu tanaman yang memiliki manfaat sebagai imunostimulator adalah tanaman sungkai. Kegiatan pengabdian kepada masyarakat ini berupa pembuatan teh dari daun sungkai. Proses pembuatan teh dilakukan di Laboratorium Kimia Dasar Kedokteran Fakultas Kedokteran Universitas Sriwijaya. Sekitar 27 kg daun sungkai segar dicuci dan dipotong kecil lalu dikeringkan. Daun sungkai kering digiling menjadi serbuk kasar (simplisia). Jumlah simplisia daun sungkai yang didapatkan sekitar 5,1 kg. Takaran sekali minum daun sungkai adalah sekitar 25 g untuk daun segar dan 3 g untuk simplisia. Simplisia daun sungkai dimasukkan ke dalam kantong teh dengan berat bersih 3 g per kantong. Satu kantong teh dapat diseduh dengan 240 mL air panas dan diminum 1-2 kali sehari selama 5 hari. Pada pengabdian ini dihasilkan 1700 kantong teh yang dikemas dalam 340 kemasan (5 kantong teh/kemasan). Produksi teh daun sungkai telah dilakukan dengan baik lalu dibagikan ke civitas akedemika melalui Dekan Fakultas Kedokteran dan Rektor Universitas Sriwijaya. Kata kunci: Covid19, Daun sungkai, Imunostimulator, Simplisia, Teh ABSTRACT In mid-2021, Covid-19 cases in Indonesia began to increase, including in Palembang. This condition not only has an impact on society but also for Sriwijaya University. To reduce the impact of Covid19, it is possible to increase the body's immunity with traditional Indonesian herbs, Sungkai. Sungkai has benefit as an immunostimulator. This community service is in the form of tea production from sungkai leaves. The process of making tea is carried out at Laboratorium Kimia Dasar Kedokteran, Faculty of Medicine, Universita Sriwijaya. About 27 kg of fresh sungkai leaves are washed, cut, and then dried to obtain about 5.1 kg of simplicia. The daily dose of sungkai leaves is about 25 g for fresh leaves and 3 g for simplicia. About 3 g simplicia was put into tea bags. One tea bag can be brewed with 240 mL of hot water and drunk 1-2 times a day for 5 days. A total of 1700 tea bags were produced and packaged in 340 packages (5 tea bags/package). Sungkai leaf tea production has been carried out well and then distributed to the academic community through the Dean of the Faculty of Medicine and the Chancellor of Universitas Sriwijaya. Keywords: Covid19, Sungkai leaf, Immunostimulator, Simplicia, Tea
COVID-19 Prevention: Healthy and Clean-Living Behavior Program on Toilet Access in Tiban New Village, Batam City, Indonesia Hengky Oktarizal; Yuanita Windusari; Irfannuddin Irfannuddin; R. Kintoko Rochadi; Ahmadi Ahmadi; Roni Saputra; Mega Gemala
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 10 No. 2 (2022): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educatio
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V10.I2.2022.138-143

Abstract

Background: The current low level of prevention of COVID-19 is one of the severe problems in Indonesia. Healthy and Clean-Living Behavior or PHBS (Perilaku Hidup Bersih dan Sehat) program and sanitation access are some things that can be done in terms of prevention during a pandemic. New Tiban Village ranks 3rd with the highest number of COVID-19 cases in Batam City. Objective: This study aims to determine whether there was a relationship between implementing the Healthy and Clean-Living Behavior program and toilet access on the incidence of COVID-19 in New Tiban Village, Batam City, Indonesia. Methods: A quantitative analytic observational study with a total sample of 115 families. The instrument used in this study was a questionnaire. The acquired data were analyzed with chi-square analysis using SPSS as the tool. Results: The results showed a significant relationship between the application of the Healthy and Clean-Living Behavior program towards COVID-19 cases p = 0.006. There was an effective relationship between toilet access towards COVID-19 cases p = 0.000. Conclusion: In this study, there was a significant relationship between applying the Healthy and Clean-Living Behavior program and toilet access toward COVID-19 with a value of α < 0.05. Recommendations for the community include always carrying out health protocols by maintaining distances and always washing hands using running water and soap after activities outside the home.
PENGARUH DIET KETOGENIK TERHADAP EKSPRESI Ki-67, CASPASE-3, DAN MDA PADA JARINGAN HATI Harahap, Huntari; Irfannuddin, Irfannuddin; Murti, Krisna
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.339 KB) | DOI: 10.22437/jmj.v6i2.5973

Abstract

Obesity is a problem of global epidemics and arise a health threat to people. The prevalence of obesity in the United States in 2016 was around 39.8% in adults aged 40-59 years and 18.5% in young adults aged 20-39 years. One of the dietary patterns used to overcome obesity is the ketogenic diet. The main metabolic reaction due to the ketogenic diet occurs in the liver which make lesion. The ketogenic diet is a high-fat diet, quite protein, low in carbohydrates (usually less than 50 g / day). The effect of the ketogenic diet on the liver is help maintain TCA cycle homeostasis, prevents the accumulation of intermediate fatty acids that are not oxidized, maintains the redox balance of the liver, and supplies energy to extrahepatic organs in the glucose deficiency stage. The ketogenic diet can reduce cell proliferation which is characterized by a decrease in the percentage of cells in ki-67 positive staining and increase cell apoptosis which is characterized by an increase in caspase-3 positive staining and reduce oxidative stress as assessed by MDA reduction. Key Words : Obesity, Ketogenic Diet, Ki-67, Liver, Caspase-3, MDA
DIFFERENCES OF SHORT-TERM CONSUMPTION OF SEMENDO ROBUSTA AND ARABICA COFFEE TOWARDS SWEET TASTE SENSITIVITY Pudi Handayani; Irfannuddin Irfannuddin; Alifia Salsabila; Shanty Chairani; Nursiah Nasution
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I2.20924

Abstract

The most consumed and cultivated coffee in Indonesia is robusta and arabica coffee. Robusta and arabica coffee have different characteristics such as morphology, contents, and taste. Coffee consumption could cause alteration in taste sensitivity, especially sweet taste. Those could affect daily sugar consumption. The present study aimed to determine the differences of short-term consumption of semendo robusta and arabica coffee towards sweet taste sensitivity. This study used experimental study with a cross-over design approach that involved 21 students from the Faculty of Medicine Sriwijaya University. Semendo robusta and arabica coffee are used in this study. Sweet taste sensitivity was tested using the whole mouth test method by rinsed with sucrose solution at a concentration of 0,16, 0,32, 0,64, and 1,28 mol/l, which was given from the lowest concentration. Sweet taste sensitivity scores were rated at baseline and after the consumption of semendo robusta and arabica coffee which took place on different days. The lowest sucrose concentration that was correctly interpreted by the subject was noted as a taste sensitivity score. Data were analyzed using the Chi-square test. The chi-square test showed that the decrease in sweet taste sensitivity was more frequently happening after semendo arabica coffee consumption than semendo robusta coffee consumption (p<0,05). Short-term consumption of semendo arabica coffee has significantly increased the risk of sweet taste sensitivity reduction 4 times greater than semendo robusta coffee. There were differences in sweet taste sensitivity between short-term consumption of semendo robusta and arabica coffee.
Sensitivity and Specificity of Ultrasonographic Compared with CT Angiography in Detecting Femoropopliteal and Infrapopliteal Arterial Lesions in Lower Extremity Arterial Disease in Dr. Mohammad Hoesin General Hospital Palembang Radi Noorsyawal; Kemas Dahlan; Hanna Marsinta; Irfannuddin
Sriwijaya Journal of Surgery Vol. 4 No. 1 (2021): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v4i1.55

Abstract

Background: Peripheral artery disease (PAD) is a chronic occlusive arterial disease of the extremities caused by atherosclerosis.1 It is estimated that 20-30% of the population worldwide suffered PAD.2 PAD is associated with a 1-year mortality and limb loss rate of 20%.7 Critical limb ischemia (CLI) is a late stage clinical presentation of PAD. Imaging of the entire artery is possible using CT angiography. However, CT angiography has its drawbacks because the contrast used can be nephrotoxic, the risk of allergies, expensive, and not all health services have it. Ultrasonographic’s (USG) sensitivity, specificity and accuracy were 96.55%, 61.53%, and 78.84% for detecting lower limb distal artery lesions.11 Ultrasonographic does not require the use of contrast, radiation, low cost and almost all health services have them.12 However, the Ultrasonographic examination has its limitations depending on the operator's capabilities. It is therefore necessary to conduct research that have never been previously studied in South Sumatra. Methods: This study is a diagnostic test study that examines the sensitivity and specificity of ultrasound in detecting LEAD artery lesions. The samples were 29 patients. Results: At the femoropopliteal level, the results obtained were 91% sensitivity and 86% specificity. At the infrapopliteal level, the results obtained were 95% sensitivity and 87% specificity. Conclusion: Ultrasonographic has high sensitivity and specificity in detecting LEAD’s lesions
Efek Puasa Terhadap Biomarker Hepar : Sebuah Tinjauan Pustaka Sistematis Anggraini, Wieke; Irfannuddin, Irfannuddin; santoso, budi; Sinulingga, Sadakata; Zulissetiana, Eka Febri; Nurwany, Raissa
Syifa'Medika Vol 15, No 1 (2024): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v15i1.8773

Abstract

Terdapat berbagai penelitian yang melihat dampak puasa sebagai intervensi diet yang untuk menurunkan berat badan, menurnkan hemoglobin terglikosilasi, menurunkan risiko aterogenik, meningkatkan sirkulasi sitokin dan proliferasi sel imun. Tinjauan ini bertujuan untuk melihat penelitian terkait puasa dalam menurunkan inflamasi. Tinjauan ini disusun sesuai dengan algoritma PRISMA yang melibatkan 31 kepustakaan yang dikumpulkan dari Pubmed maupun EuropePMC. Tinjauan ini menemukan bahwa puasa dapat mengurangi inflamasi yang ditandai dengan berbagai biomarker. Oleh karena itu puasa dapat menjadi salah satu intervensi diet yang dapat bermanfaat bagi kesehatan jika dilakukan dalam jangka waktu yang lama dan secara konsisten
The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review Erlyn, Putri; Irfannuddin, Irfannuddin; Murti, Krisna; Lesbani, Aldes
Jurnal Kedokteran Brawijaya Vol. 33 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2023.033.01.6

Abstract

Hemostasis is an emergency medical treatment to reduce pain and patient mortality, therefore research is being developed to find effective hemostasis. The utilization of natural materials for hemostasis and wound healing is rapidly expanding, including chitosan found in shell extracts. Chitosan is obtained from chitin found in the soft shells of marine animals such as squid, shrimp, and crabs, or from hard shells such as clams, crabs, and lobsters. Chitosan offers advantages such as good biodegradability, biocompatibility, and non-toxicity, and has been widely used in biomedical, chemical, food, and cosmetic industries. This literature review aims to investigate the potential of shell extracts, particularly the characteristics of chitosan, in wound healing across hemostasis, inflammation, proliferation, and remodeling stages. The study results indicate that extracts from shells containing chitosan exhibit varying characteristics in terms of molecular weight and degree of deacetylation. Chitosan with higher molecular weight and degree of deacetylation tends to yield better outcomes in hemostasis and wound healing. The material is effective in reducing antithrombin, enhancing blood clotting processes, and aiding clot formation. Increased molecular weight contributes to stimulating various cytokines, such as TNF-α, TGF-ß1, and FGF2, which play a key role in the wound healing process. Additionally, higher degree of deacetylation chitosan is effective in stimulating fibroblast proliferation. Chitosan also influences VEGF in inducing angiogenesis and enhancing neovascularization in bone healing. Chitosan from shell extracts with certain molecular weight characteristics and degree of deacetylation has the potential to be the material of choice for accelerating hemostasis and wound healing.
Determination of mercury in soil and water from a gold mining area in Karang Jaya Sub-district, Musi Rawas Utara, Indonesia Amallia, Ra Hoetary Tirta; Ibrahim, Eddy; Irfannuddin, Irfannuddin; Hariani, Poedji Loekitowati
Journal of Degraded and Mining Lands Management Vol. 11 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15243/jdmlm.2024.112.5375

Abstract

The present study focuses on the assessment of Hg distribution in both soil and water samples from the small-scale gold mining region of Karang Jaya Sub-district, Musi Rawas Utara Regency, South Sumatra Province. For over 30 years, this region has witnessed persistent utilization of mercury as an amalgam for gold extraction. The investigation encompasses an analysis of total mercury levels in soil samples obtained from Sukamenang, Muara Batang Empu, and Terusan Villages. As a comparative reference point devoid of gold mining activities, the neighboring Muara Lakitan Village was selected. The obtained results indicate a moderate to strong contamination level across the 30 sampled locations based on the Geoaccumulation Index (Igeo), with an average Igeo value of 2.6. Furthermore, Pollution Load Index (PLI) and Contamination Factor (CF) values demonstrate high contamination. Conversely, analysis of river water samples from 30 stations along the Rupit River reveals that most of the samples comply with quality standards (<0.0005 mg/L), with an average value at 0.000322 mg/L; only four stations exhibit total Hg concentrations surpassing regulatory thresholds. All soil and river water samples from the control area (10 stations) exhibited no signs of pollution. Appropriate investments in technology, finance, and technical skills are needed to reduce mercury pollution due to small-scale gold mining activities.
Bioinformatics analysis and biomolecular characterization of salivary alpha amylase as risk factor for dental caries: Analisis bioinformatika dan karakterisasi biomolekuler alfa amilase saliva sebagai faktor risiko karies gigi Dewi, Siti Rusdiana Puspa; Irfannuddin
Makassar Dental Journal Vol. 13 No. 2 (2024): Volume 13 Issue 2 Agustus 2024
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v13i2.1035

Abstract

Salivary alpha amylase is a component in human saliva that plays important role in carbohydrate digestion. This article aims to analyze bioinformatics and biomolecular characterization of salivary alpha amylase as risk factor of dental caries. The location of this gene is 1p21.1, with nucleotide is NC_000001.11. This information was taken from National Center for Biotechnology Infor-mation's website. The number of amino acids of salivary alpha amylase is 511, with molecular weight is 577,677.82 amu. The pro-tein is stable with instability index is computed to be 23.58. Only 23 enzymes were predicted to be capable of cleaving the sa-livary alpha amylase out of a total of 37 protease. The aliphatic index is 67.12. From THMM analysis, salivary alpha amylase is found outside of membrane. It is concluded that characteristic of salivary alpha amylase can be considered as indicator for caries.
Studi Meta-Analisis: Hubungan antara Defisiensi Vitamin D dan Penyakit Parkinson Putri, Siti Sarahdeaz Fazzaura; Irfannuddin, Irfannuddin; Murti, Krisna; Kesuma, Yudianita; Koibuchi, Noriyuki
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 9, No 1 (2023): JMK Yayasan RS.Dr.Soetomo, April 2023
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29241/jmk.v9i1.1430

Abstract

Beberapa penelitian telah dilakukan untuk mengevaluasi kadar 25(OH)D pada pasien penyakit Parkinson. Namun, hasil penelitian ini tidak konsisten. Penelitian ini melakukan meta-analisis terhadap kadar 25(OH)D pada pasien dengan penyakit Parkinson. Database PubMed digunakan untuk melakukan pencarian literatur secara sistematis. Meta-analisis dilakukan dengan menggunakan model efek acak untuk menghitung perkiraan efek gabungan. Tujuh belas artikel dimasukkan dalam penelitian ini. Meta-analisis mengungkapkan bahwa pasien dengan penyakit Parkinson memiliki kadar 25(OH)D yang lebih rendah dibandingkan dengan kontrol. Temuan dari artikel prospektif dan retrospektif sebagian besar konsisten. Besarnya respon nocebo dalam uji coba terkontrol acak yang dirancang paralel pada penyakit Parkinson sangat penting dan harus dipertimbangkan dalam interpretasi hasil keamanan dan dalam desain dan interpretasi uji klinis masa depan. 
Co-Authors Ahmad Junaidi Ahmadi Ahmadi Aini, Lela Aldes Lesbani Aldiar Ali Ghanie Alifia Salsabila Amallia, RA Hoetary Tirta Andi Miarta Andi Saputra Andi Saputra Andika Okparasta Andini Agustina Anggraeni Janar Wulan Anggraini, Wieke Ardesy Melizah Kurniati Arwan Bin Laeto Athiah, Medina Budi Santoso Chairil Anwar Chalik, Muhammad Novran Citra Maharani Dahlan, Kemas Daniel Saputra Delvy Atriani Dewi Susan Diansari, Yunni Dwi Budi Santoso Eddy Ibrahim Eddy Mart Salim, Eddy Mart Eka Febri Zulissetiana Eka Febri Zulissetiana Elsafani Faddiasya Erni Desmita Erwin Sukandi Erwin Sukandi Esa Indah Ayu, Esa Indah Fachmi Idris Fatmawati Fatmawati Febian Aji Wicaksono FERLY OKTRIYEDI Ferry Usnizar Ferry Usnizar, Ferry Fredi Heru Irwanto Geo Vanda Ghina Kartika Handayani, Sri Hanna Marsinta Harahap, Huntari Hestiningsih, Tyas Husodo, Reyki Yudho Iche Andriyani Liberty, Iche Andriyani INDRA FRANA JAYA KK Indra, Syamsu Indrajaya, Taufik Indriyani Indriyani Jayawarsa, A.A. Ketut Karmila, Ariesti Kemas Dahlan Koibuchi, Noriyuki Krisna Murti Kusuma, Singgih Legiran Legiran Lela aini Lestari, Ajeng dwinta Lilik Pranata M. Hatta Dahlan M. Hatta Dahlan Mailan Alexander Mariana Mariana marisdina, selly Masagus Irsan Saleh Masayu Rita Dewi Masayu Rita Dewi Maya, Rachel Mega Gemala Miftahurrahmah Miftahurrahmah, Miftahurrahmah Minerva Riani Kadir Mohammad Zulkarnain Monica, Ricca Muhammad Hatta Dahlan Muhammad Irsan Saleh Muhammad Prima Cakra Randana Mukhlisa Muradi, Akhmadu Nadia Mutiara Ngudiantoro . Nur Arfian Nur Asini Nurhayati Damiri Nursiah Nasution Nursiah Nasution Nursiah Nasution, Nursiah Nurwany, Raissa Oktarizal, Hengky Pahrul, Dedi Patiyus Agustiansyah Poedji Loekitowati Hariani Pudi Handayani Putri Erlyn R.Kintoko Rochadi Rachel Maya Raden Muhammad Indra Radi Noorsyawal Radiyati Umi Partan Rini Nindela Rini Yana Risa Vera, Risa Rizal Sanif Roni Saputra Rukiah Chodilawati Sadakata Sinulingga Safri Dhaini Safyudin Saleh, Imran Santoso, Budi Shanty Chairani Sintiya Halisya Pebriani Siti Nurmaini Siti Rusdiana Puspa Dewi Siti Sarahdeaz Fazzaura Putri Subandrate Suheryanto Sukandi, Erwin Suprapti Suprapti Susanty, Tri Susilawati Susilawati Swanny Swanny, Swanny Syahputri, Rizka Aprillia Syarif Darwin Tanzila, R.A Tanzila, Raden Ayu Taufik Indrajaya Taufik Indrajaya Tri Suciati Trijoso Permono Trinovita Andraini Yenny Febriany Yuanita Windusari Yudhie Tanta Yudianita Kesuma, Yudianita Yunita Fediani Yunita Fediani Yunita Panca Putri, Yunita Yusuf Effendi Yususf, Fahmi Jaka Zaky Hasan Zulkarnain, Mohammad Zulkhair Ali Zulkifli