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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Degraded and Mining Lands Management Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Majalah Kedokteran Sriwijaya Sari Pediatri Biomedical Journal of Indonesia Paediatrica Indonesiana Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Alami Journal (Alauddin Islamic Medical) Journal Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL MEDIA KESEHATAN Best Journal (Biology Education, Sains and Technology) MDJ (Makassar Dental Journal) Sriwijaya Journal of Surgery Indonesian Journal of Global Health research Jurnal Menara Medika Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Islamic and Complementary Medicine Indonesian Community Journal Journal of Anesthesiology and Clinical Research Sanitasi: Jurnal Kesehatan Lingkungan AKSONA Conferences of Medical Sciences Dies Natalis Jurnal Sehat Indonesia (JUSINDO) Indonesian Journal of Biomedicine and Clinical Sciences
Irfannuddin Irfannuddin
Faculty Of Medicine, Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Dampak Paparan Gas Hidrogen Sulfida (H2S) Terhadap Kadar Gula Darah Pada Pekerja Pabrik Crumb Rubber Di Kota Palembang Sumatera Selatan Ferly Oktriyedi; Irfannuddin Irfannuddin; Ngudiantoro Ngudiantoro; M. Hatta Dahlan
Sanitasi: Jurnal Kesehatan Lingkungan Vol. 14 No. 2 (2021): Agustus
Publisher : Poltekkes Kemenkes Yogyakarta

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Abstract

Hydrogen sulfide (H2S) is one of the pollutants in the air. One of the industries that cause H2S odor is the natural rubber industry. Exposure to H2S has an impact on increasing blood sugar levels. High blood sugar levels can lead to diabetes. Diabetes mellitus can increase risks such as myocardial infarction, stroke, kidney failure, lower extremity amputation and vision loss. Based on this, the authors are interested in studying the impact of exposure to H2S gas on blood glucose levels in crumb rubber factory workers in the city of Palembang. This study is a cross-sectional analysis. The study was conducted at the crumb rubber factory in Palembang City in March 2020. The sampel this study with a total of 215 workers. Data analysis using chi square with p <0.05. The results of the analysis concluded that there was no relationship between age (pV=0.758), gender (pV=0.532), smoking (pV=1,000), body mass index (pV=0.571), exposure to H2S gas (pV=0.772) with blood glucose levels. This is probably because the main role of H2S in the pancreas is to protect pancreatic B cells and regulate insulin secretion. H2S can protect pancreatic b cells in the following three ways: (1) reducing ROS production; (2) inhibits the expression of thioredoxin binding protein-2-a redox protein associated with diabetes that promotes apoptosis; and (3) increased GSH content, all of which reduce oxidative stress damage.
THE EFFECT OF INTERMITENT FASTING DIET ON KIDNEY FUNCTION Esa Indah Ayudia; Huntari Harahap; Irfannuddin Irfannuddin
International Journal of Islamic and Complementary Medicine Vol. 1 No. 2 (2020): International Journal Islamic Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.664 KB) | DOI: 10.55116/IJIM.V1I1.9

Abstract

Obesity is a condition in which the ratio of body weight and height exceeds the specified standards. Obesity is an increase in total body fat, that is, if you are found to be overweight> 20% in men and 25% in women because of fat. The intermittent fasting diet is a calorie restriction method that is widely used for health or weight loss reasons. Overall kidney function is based on nephron function and impaired function is caused by decreased nephron action. Several laboratory tests have been developed to evaluate kidney function and identify the disorder early on. This can help clinicians to take early prevention and management in order to prevent the progression of kidney disorders to kidney failure. Renal function tests are carried out by examining the levels of urea and cretinin.
THE BIOMOLECULAR CHARACTERISTICS OF ANGIOTENSIN II TYPE 1 RECEPTORS AS PARAMETERS IN KIDNEY FIBROSIS: A BIOINFORMATICS ANALYSIS Evi Lusiana; Irfannuddin Irfannuddin
Majalah Kedokteran Sriwijaya Vol 54, No 2 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i2.17535

Abstract

AGTR1 is a modulator of angiotensin II-induced signal transduction. This article aims to examine the biomolecular characteristics of AGTR1 and the role of AGTR1 in the renal fibrosis pathway in Rattus norvegicus rats. The gene ID NC 051352.1 and protein ID NP 112271.2 for AGTR1 were retrieved from the National Center for Biotechnology Information's website. The 'NCBI' website has details on AGTR1's structure, location, and expression. Protease prediction using 'PEPTIDE CUTTER'; glycosylation index prediction using NETNGLYC; and target protein location evaluated on the 'TARGETP' homepage. AGTR1 in Rattus norvegicus is located on chromosome 17p12, This protein has a stability score of 34.48. The aliphatic index was 114.62. AGTR1 is found inside, outside, and on the transmembrane, as determined by the THMM. Only 21 enzymes were predicted to be capable of cleaving the AGTR1 protein, out of a total of 37 protease. AGTR1 protein has four glycosylated amino acid sequences. AGTR1 protein is primarily at other location 0.850, secretory pathway (0.590), and a little amount in mitochondria (0.018AGTR1/AT1R is a marker for renal fibrosis in the renin angiotensin system, which can lead in vasoconstriction, inflammation, fibrosis, sodium retention, and water retention. The AGTR1 protein's molecular feature is a determinant in the progression of renal fibrosis, revealed to a bioinformatics study.
Memanusiakan Pasien: Aplikasi Klinis Berdasarkan Prinsip Fisiologi (Fungsi Tubuh) Irfannuddin
Conferences of Medical Sciences Dies Natalis Vol. 1 No. 1 (2019): Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sr
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Anggapan lemahnya kompetensi pelaku profesi kesehatan di Indonesia oleh masyarakat merujuk pada keluhan kurangnya komuniasi, empati, tindakan medis yang kurang komprehensif. Saat melakukan terapi kepada pasien, dokter dituntut memiliki dasar keilmuan yang kuat, berupa pemahaman konsep dasar untuk memperbaiki struktur dan fungsi tubuh manusia. Konsep dasar ini dapat dipelajari melalui prinsip fisiologi, untuk diaplikasikan di ranah klinis.
Efek Indeks Massa Tubuh dan Lingkar Pinggang terhadap Arus Puncak Ekspirasi Huntari Harahap; Esa Indah Ayudia; Citra Maharani; Irfannuddin
Conferences of Medical Sciences Dies Natalis Vol. 1 No. 1 (2019): Conferences of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sr
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Penilaian terhadap fungsi paru, pemantauan obstruksi paru maupun respon pengobatan paru yang diberikan dapat dilakukan dengan memeriksa arus puncak ekspirasi. Arus puncak ekspirasi seseorang dipengaruhi oleh antropometri dan kondisi lingkungan. Laki-laki memiliki arus puncak ekspirasi lebih besar dari wanita. Obesitas yang dinilai dengan pengukuran indeks massa tubuh juga dapat menurunkan arus puncak ekspirasi dan gangguan mobilitas pada diafragma. Pengukuran lingkar pinggang dapat menilai obesitas sentral yang merupakan salah satu faktor risiko penyakit kardiovaskuler dan sindrom metabolik. Lemak perut yang tinggi juga mempengaruhi fungsi paru karena menyebabkan berkurangnya FEV1 dan FVC.
Comfortable Menopouse with Ex ercise irfannuddin
Conferences of Medical Sciences Dies Natalis Vol. 2 No. 1 (2020): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Menopouse is a health problem related to aging that is sure to be experienced by every woman when she reaches middle age. Menopouse is caused by the decreases of estrogen in ovaries due to the failure of negative feedback mechanism in hormonal reproductive system. The decline of estrogen synthesis will affect on various disorder of multi system organs. An appropriate and regular physical exercise is a form of natural intervention that can be done to improve menopause symptoms and decrease risk of degenerative diseases. It is recommended that resistance training is supervised by a professional, or following proper guidelines to prevent the adverse effects.
DOMINO CLINICAL CARDS TRAINING TO IMPROVE LECTURERS' ABILITIES IN CLINICAL REASONING LEARNING MEDIA Irfannuddin Irfannuddin; Eka Febri Zulissetiana; Susilawati Susilawati; Mailan Alexander
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Medical practitioners sometimes perform inappropriate decisions and procedures. In making decisions, doctors may take a poor thinking called cognitive and representative bias.One matrix approach that can be developed to build learners' clinical reasoning is the domino game method. Domino card games (DCC) are a form of visual learning that can increase student learning motivation. DCC media is carried out in the form of competitive games. However, DCC is part of collaborative and peer learning methods. Collaborative learning is a method in which learners collaborate with each other. This method is considered to increase learning motivation. Collaboration makes them understand their learning process. The process of collaboration makes them internalize knowledge with critical thinking skills. Peer learning is the learning activity of a group of students from a similar social group. Peer learning activities can be in peer tutoring, peer assessment, or game and simulation forms. Peer learning tutoring can improve the quality of learning efficiently.DCC is an alternative instrument that can be developed to improve clinical reasoning skills. Through this training, some lecturers have been able to compile and develop DCC prototypes. Furthermore, they can apply according to their respective fields of knowledge.
PRODUKSI TEH DAUN SUNGKAI SEBAGAI MINUMAN IMUNOSTIMULATOR Subandrate Subandrate; Sadakata Sinulingga; Fatmawati Fatmawati; Irfannuddin Irfannuddin; Susilawati Susilawati; Rini Yana; Medina Athiah; Safyudin Safyudin
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 1 (2022)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/logista.6.1.10-14.2022

Abstract

Pada pertengahan tahun 2021 kasus Covid19 di Indonesia melonjak lagi termasuk di Kota Palembang. Lonjakan kasus tersebut tidak hanya memberikan dampak bagi masyarakat luas tetapi juga bagi lingkungan kampus Universitas Sriwijaya. Oleh karena itu, perlu dilakukan upaya meningkatkan imunitas tubuh menggunakan herbal tradisional Indonesia. Salah satu tanaman yang memiliki manfaat sebagai imunostimulator adalah tanaman sungkai. Kegiatan pengabdian kepada masyarakat ini berupa pembuatan teh dari daun sungkai. Proses pembuatan teh dilakukan di Laboratorium Kimia Dasar Kedokteran Fakultas Kedokteran Universitas Sriwijaya. Sekitar 27 kg daun sungkai segar dicuci dan dipotong kecil lalu dikeringkan. Daun sungkai kering digiling menjadi serbuk kasar (simplisia). Jumlah simplisia daun sungkai yang didapatkan sekitar 5,1 kg. Takaran sekali minum daun sungkai adalah sekitar 25 g untuk daun segar dan 3 g untuk simplisia. Simplisia daun sungkai dimasukkan ke dalam kantong teh dengan berat bersih 3 g per kantong. Satu kantong teh dapat diseduh dengan 240 mL air panas dan diminum 1-2 kali sehari selama 5 hari. Pada pengabdian ini dihasilkan 1700 kantong teh yang dikemas dalam 340 kemasan (5 kantong teh/kemasan). Produksi teh daun sungkai telah dilakukan dengan baik lalu dibagikan ke civitas akedemika melalui Dekan Fakultas Kedokteran dan Rektor Universitas Sriwijaya. Kata kunci: Covid19, Daun sungkai, Imunostimulator, Simplisia, Teh ABSTRACT In mid-2021, Covid-19 cases in Indonesia began to increase, including in Palembang. This condition not only has an impact on society but also for Sriwijaya University. To reduce the impact of Covid19, it is possible to increase the body's immunity with traditional Indonesian herbs, Sungkai. Sungkai has benefit as an immunostimulator. This community service is in the form of tea production from sungkai leaves. The process of making tea is carried out at Laboratorium Kimia Dasar Kedokteran, Faculty of Medicine, Universita Sriwijaya. About 27 kg of fresh sungkai leaves are washed, cut, and then dried to obtain about 5.1 kg of simplicia. The daily dose of sungkai leaves is about 25 g for fresh leaves and 3 g for simplicia. About 3 g simplicia was put into tea bags. One tea bag can be brewed with 240 mL of hot water and drunk 1-2 times a day for 5 days. A total of 1700 tea bags were produced and packaged in 340 packages (5 tea bags/package). Sungkai leaf tea production has been carried out well and then distributed to the academic community through the Dean of the Faculty of Medicine and the Chancellor of Universitas Sriwijaya. Keywords: Covid19, Sungkai leaf, Immunostimulator, Simplicia, Tea
COVID-19 Prevention: Healthy and Clean-Living Behavior Program on Toilet Access in Tiban New Village, Batam City, Indonesia Hengky Oktarizal; Yuanita Windusari; Irfannuddin Irfannuddin; R. Kintoko Rochadi; Ahmadi Ahmadi; Roni Saputra; Mega Gemala
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 10 No. 2 (2022): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educatio
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V10.I2.2022.138-143

Abstract

Background: The current low level of prevention of COVID-19 is one of the severe problems in Indonesia. Healthy and Clean-Living Behavior or PHBS (Perilaku Hidup Bersih dan Sehat) program and sanitation access are some things that can be done in terms of prevention during a pandemic. New Tiban Village ranks 3rd with the highest number of COVID-19 cases in Batam City. Objective: This study aims to determine whether there was a relationship between implementing the Healthy and Clean-Living Behavior program and toilet access on the incidence of COVID-19 in New Tiban Village, Batam City, Indonesia. Methods: A quantitative analytic observational study with a total sample of 115 families. The instrument used in this study was a questionnaire. The acquired data were analyzed with chi-square analysis using SPSS as the tool. Results: The results showed a significant relationship between the application of the Healthy and Clean-Living Behavior program towards COVID-19 cases p = 0.006. There was an effective relationship between toilet access towards COVID-19 cases p = 0.000. Conclusion: In this study, there was a significant relationship between applying the Healthy and Clean-Living Behavior program and toilet access toward COVID-19 with a value of α < 0.05. Recommendations for the community include always carrying out health protocols by maintaining distances and always washing hands using running water and soap after activities outside the home.
PENGARUH DIET KETOGENIK TERHADAP EKSPRESI Ki-67, CASPASE-3, DAN MDA PADA JARINGAN HATI Harahap, Huntari; Irfannuddin, Irfannuddin; Murti, Krisna
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 6 No. 2 (2018): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.339 KB) | DOI: 10.22437/jmj.v6i2.5973

Abstract

Obesity is a problem of global epidemics and arise a health threat to people. The prevalence of obesity in the United States in 2016 was around 39.8% in adults aged 40-59 years and 18.5% in young adults aged 20-39 years. One of the dietary patterns used to overcome obesity is the ketogenic diet. The main metabolic reaction due to the ketogenic diet occurs in the liver which make lesion. The ketogenic diet is a high-fat diet, quite protein, low in carbohydrates (usually less than 50 g / day). The effect of the ketogenic diet on the liver is help maintain TCA cycle homeostasis, prevents the accumulation of intermediate fatty acids that are not oxidized, maintains the redox balance of the liver, and supplies energy to extrahepatic organs in the glucose deficiency stage. The ketogenic diet can reduce cell proliferation which is characterized by a decrease in the percentage of cells in ki-67 positive staining and increase cell apoptosis which is characterized by an increase in caspase-3 positive staining and reduce oxidative stress as assessed by MDA reduction. Key Words : Obesity, Ketogenic Diet, Ki-67, Liver, Caspase-3, MDA
Co-Authors Ahmad Junaidi Ahmadi Ahmadi Aini, Lela Aldes Lesbani Aldiar Ali Ghanie Alifia Salsabila Amallia, RA Hoetary Tirta Andi Miarta Andi Saputra Andi Saputra Andika Okparasta Andini Agustina Anggraini, Wieke Ardesy Melizah Kurniati Arwan Bin Laeto Budi Santoso Citra Maharani Dahlan, Kemas Daniel Saputra Dewi Susan Diansari, Yunni Dwi Budi Santoso Eddy Ibrahim Eddy Mart Salim, Eddy Mart Eka Febri Zulissetiana Eka Febri Zulissetiana Elsafani Faddiasya Erni Desmita Erwin Sukandi Erwin Sukandi Esa Indah Ayu, Esa Indah Fachmi Idris Fajarini, Agustina Fatmawati Fatmawati Febian Aji Wicaksono FERLY OKTRIYEDI Ferry Usnizar Fredi Heru Irwanto Geo Vanda Ghina Kartika Handayani, Sri Hanna Marsinta Hestiningsih, Tyas Huntari Harahap Husodo, Reyki Yudho Iche Andriyani Liberty, Iche Andriyani INDRA FRANA JAYA KK Indriyani Indriyani Jayawarsa, A.A. Ketut Karmila, Ariesti Kemas Dahlan Koibuchi, Noriyuki Krisna Murti Kusuma, Singgih Legiran Legiran Lela aini Lestari, Ajeng dwinta Lilik Pranata M. Hatta Dahlan M. Hatta Dahlan Mailan Alexander Mariana Mariana marisdina, selly Masagus Irsan Saleh Masayu Rita Dewi Masayu Rita Dewi Maya, Rachel Medina Athiah Mega Gemala Miftahurrahmah Miftahurrahmah, Miftahurrahmah Minerva Riani Kadir Monica, Ricca Muhammad Hatta Dahlan Muhammad Irsan Saleh Mukhlisa Mukhlisa, Mukhlisa Muradi, Akhmadu Nadia Mutiara Ngudiantoro . Nur Rachmat Lubis Nursiah Nasution Nursiah Nasution Nursiah Nasution, Nursiah Nurwany, Raissa Oktarizal, Hengky Pahrul, Dedi Patiyus Agustiansyah Poedji Loekitowati Hariani Pudi Handayani Putri Erlyn Putri, Sarahdeaz Siti Fazzaura R.Kintoko Rochadi Rachel Maya Raden Muhammad Indra Radi Noorsyawal Radiyati Umi Partan Ramadhoni, Pinto Desti Rini Nindela Rini Yana Risa Vera, Risa Rizal Sanif Roni Saputra Sadakata Sinulingga Safri Dhaini Safyudin Shanty Chairani Sintiya Halisya Pebriani Siti Nurmaini Siti Rusdiana Puspa Dewi Siti Sarahdeaz Fazzaura Putri Subandrate Suheryanto Suprapti Suprapti Susanty, Tri Susilawati Susilawati Susilawati Susilawati Swanny Swanny, Swanny Syahputri, Rizka Aprillia Syarif Darwin Tanzila, R.A Tanzila, Raden Ayu Taufik Indrajaya Taufik Indrajaya Tri Suciati Trijoso Permono Trinovita Andraini Yenny Febriany Yuanita Windusari Yudhie Tanta Yudianita Kesuma, Yudianita Yunita Fediani Yunita Fediani Yunita Panca Putri, Yunita Yusuf Effendi Yususf, Fahmi Jaka Zaky Hasan Zulkarnain, Mohammad Zulkhair Ali Zulkifli