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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Degraded and Mining Lands Management Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Majalah Kedokteran Sriwijaya Sari Pediatri Biomedical Journal of Indonesia Paediatrica Indonesiana Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Alami Journal (Alauddin Islamic Medical) Journal Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat SRIWIJAYA JOURNAL OF MEDICINE Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL MEDIA KESEHATAN Best Journal (Biology Education, Sains and Technology) MDJ (Makassar Dental Journal) Sriwijaya Journal of Surgery Indonesian Journal of Global Health research Jurnal Menara Medika Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Islamic and Complementary Medicine Indonesian Community Journal Journal of Anesthesiology and Clinical Research Sanitasi: Jurnal Kesehatan Lingkungan AKSONA Conferences of Medical Sciences Dies Natalis Jurnal Sehat Indonesia (JUSINDO) Indonesian Journal of Biomedicine and Clinical Sciences
Irfannuddin Irfannuddin
Faculty Of Medicine, Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Epigenetik pada Alergi Susu Sapi Vera, Risa; Irfannuddin, Irfannuddin; Salim, Eddy Mart; Karmila, Ariesti
Sari Pediatri Vol 26, No 6 (2025)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.6.2025.399-404

Abstract

Alergi susu sapi dipengaruhi oleh dua faktor utama, yaitu predisposisi genetik dan faktor lingkungan. Interaksi antara faktor genetik dan faktor lingkungan mencetuskan terjadinya alergi susu sapi diperantarai oleh mekanisme epigenetik. Faktor lingkungan selama masa prenatal  maupun postnatal dapat memengaruhi program epigenetik pada masa awal perkembangan sistem imun. Faktor lingkungan, seperti paparan terhadap mikroba, faktor diet pada  ibu dan anak serta  mikrobiota pada saluran cerna memengaruhi  proses imunitas di masa yang akan datang dan berperan penting dalam perkembangan penyakit alergi.
The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review Erlyn, Putri; Irfannuddin, Irfannuddin; Murti, Krisna; Lesbani, Aldes
Jurnal Kedokteran Brawijaya Vol. 33 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2023.033.01.6

Abstract

Hemostasis is an emergency medical treatment to reduce pain and patient mortality, therefore research is being developed to find effective hemostasis. The utilization of natural materials for hemostasis and wound healing is rapidly expanding, including chitosan found in shell extracts. Chitosan is obtained from chitin found in the soft shells of marine animals such as squid, shrimp, and crabs, or from hard shells such as clams, crabs, and lobsters. Chitosan offers advantages such as good biodegradability, biocompatibility, and non-toxicity, and has been widely used in biomedical, chemical, food, and cosmetic industries. This literature review aims to investigate the potential of shell extracts, particularly the characteristics of chitosan, in wound healing across hemostasis, inflammation, proliferation, and remodeling stages. The study results indicate that extracts from shells containing chitosan exhibit varying characteristics in terms of molecular weight and degree of deacetylation. Chitosan with higher molecular weight and degree of deacetylation tends to yield better outcomes in hemostasis and wound healing. The material is effective in reducing antithrombin, enhancing blood clotting processes, and aiding clot formation. Increased molecular weight contributes to stimulating various cytokines, such as TNF-α, TGF-ß1, and FGF2, which play a key role in the wound healing process. Additionally, higher degree of deacetylation chitosan is effective in stimulating fibroblast proliferation. Chitosan also influences VEGF in inducing angiogenesis and enhancing neovascularization in bone healing. Chitosan from shell extracts with certain molecular weight characteristics and degree of deacetylation has the potential to be the material of choice for accelerating hemostasis and wound healing.
Novel Insights into the Pathophysiology of Coronary Slow Flow Phenomenon: The Role of Triglycerides-Glucose Index and Electrocardiogram Risk Score in Subclinical Atherosclerosis Kusuma, Singgih; Erwin Sukandi; Taufik Indrajaya; Ferry Usnizar; Irfannuddin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1228

Abstract

Background: Coronary slow flow phenomenon (CSFP) is characterized by delayed distal coronary vessel opacification without significant epicardial coronary stenosis. The underlying mechanisms of CSFP remain unclear, but subclinical atherosclerosis is a likely contributor. This study investigated the relationship between the Triglycerides-Glucose Index (TyG), Electrocardiogram Risk Score (ERS), and carotid intima-media thickness (CIMT) in CSFP patients. Methods: This cross-sectional study involved 31 patients diagnosed with CSFP at Dr. Mohammad Hoesin General Hospital Palembang. CSFP was determined based on coronary blood flow slowdown on angiography. Data collection included anamnesis, physical examination, laboratory tests, echocardiography, and CIMT measurement. Statistical analysis was performed using SPSS 27. Results: The majority of CSFP patients were male (51.6%) with a mean age of 50.87 ± 13.94 years. Dyslipidemia was the most prevalent risk factor (77.4%), followed by hypertension (35.5%), smoking (22.6%), and diabetes mellitus (6.5%). Statistical analysis revealed significant positive correlations between TyG index and CIMT (r = 0.445, p = 0.012), and between ERS and CIMT (r = 0.476, p = 0.007). Conclusion: TyG and ERS indices are positively correlated with CIMT in CSFP patients. These indices may be useful tools for cardiovascular risk evaluation and early identification of high-risk patients for subclinical atherosclerosis and potential CSFP.
Co-Authors Ahmad Junaidi Ahmadi Ahmadi Aini, Lela Aldes Lesbani Aldiar Ali Ghanie Alifia Salsabila Amallia, RA Hoetary Tirta Andi Miarta Andi Saputra Andi Saputra Andika Okparasta Andini Agustina Anggraini, Wieke Ardesy Melizah Kurniati Arwan Bin Laeto Budi Santoso Citra Maharani Dahlan, Kemas Daniel Saputra Dewi Susan Diansari, Yunni Dwi Budi Santoso Eddy Ibrahim Eddy Mart Salim, Eddy Mart Eka Febri Zulissetiana Eka Febri Zulissetiana Elsafani Faddiasya Erni Desmita Erwin Sukandi Erwin Sukandi Esa Indah Ayu, Esa Indah Fachmi Idris Fajarini, Agustina Fatmawati Fatmawati Febian Aji Wicaksono FERLY OKTRIYEDI Ferry Usnizar Fredi Heru Irwanto Geo Vanda Ghina Kartika Handayani, Sri Hanna Marsinta Hestiningsih, Tyas Huntari Harahap Husodo, Reyki Yudho Iche Andriyani Liberty, Iche Andriyani INDRA FRANA JAYA KK Indriyani Indriyani Jayawarsa, A.A. Ketut Karmila, Ariesti Kemas Dahlan Koibuchi, Noriyuki Krisna Murti Kusuma, Singgih Legiran Legiran Lela aini Lestari, Ajeng dwinta Lilik Pranata M. Hatta Dahlan M. Hatta Dahlan Mailan Alexander Mariana Mariana marisdina, selly Masagus Irsan Saleh Masayu Rita Dewi Masayu Rita Dewi Maya, Rachel Medina Athiah Mega Gemala Miftahurrahmah Miftahurrahmah, Miftahurrahmah Minerva Riani Kadir Monica, Ricca Muhammad Hatta Dahlan Muhammad Irsan Saleh Mukhlisa Mukhlisa, Mukhlisa Muradi, Akhmadu Nadia Mutiara Ngudiantoro . Nur Rachmat Lubis Nursiah Nasution Nursiah Nasution Nursiah Nasution, Nursiah Nurwany, Raissa Oktarizal, Hengky Pahrul, Dedi Patiyus Agustiansyah Poedji Loekitowati Hariani Pudi Handayani Putri Erlyn Putri, Sarahdeaz Siti Fazzaura R.Kintoko Rochadi Rachel Maya Raden Muhammad Indra Radi Noorsyawal Radiyati Umi Partan Ramadhoni, Pinto Desti Rini Nindela Rini Yana Risa Vera, Risa Rizal Sanif Roni Saputra Sadakata Sinulingga Safri Dhaini Safyudin Shanty Chairani Sintiya Halisya Pebriani Siti Nurmaini Siti Rusdiana Puspa Dewi Siti Sarahdeaz Fazzaura Putri Subandrate Suheryanto Suprapti Suprapti Susanty, Tri Susilawati Susilawati Susilawati Susilawati Swanny Swanny, Swanny Syahputri, Rizka Aprillia Syarif Darwin Tanzila, R.A Tanzila, Raden Ayu Taufik Indrajaya Taufik Indrajaya Tri Suciati Trijoso Permono Trinovita Andraini Yenny Febriany Yuanita Windusari Yudhie Tanta Yudianita Kesuma, Yudianita Yunita Fediani Yunita Fediani Yunita Panca Putri, Yunita Yusuf Effendi Yususf, Fahmi Jaka Zaky Hasan Zulkarnain, Mohammad Zulkhair Ali Zulkifli