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Irfannuddin Irfannuddin
Faculty Of Medicine, Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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THE QUALITY OF SLEEP IN BRAIN TUMOR PATIENTS Diansari, Yunni; Handayani, Sri; Mukhlisa; Marisdina, Selly; Syahputri, Rizka Aprillia; Susanty, Tri; Irfannuddin
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.553

Abstract

The Quality of Sleep in Brain Tumors Patients. Sleep quality is often compromised in patients with brain tumors. The underlying factors contributing to sleep quality disturbances in this patient population are multifaceted, and investigating these factors remains scarce. Sixty-eight patients with brain tumors, aged ≥ 18 years, were selected consecutively, and data was recorded in the form of sociodemographic characteristics (gender and age), clinical characteristics (clinical manifestations, tumor type, location, comorbid diseases) and therapy characteristics (management and types of drugs). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data were analyzed bivariate with chi-square and multivariate with logistic regression. Around 45.6% experienced poor sleep quality. Age, gender, systemic malignancies, pain, type of primary brain tumor, tumor location, operation, radiotherapy, and steroid have a significant relationship with sleep quality in patients with brain tumors (p-value <0.05). Multivariate analysis shows that age is the factor that most strongly influences the sleep quality of patients with brain tumors. Age, gender, systemic malignancies, pain, type of primary brain tumor, tumor location, operative treatment, radiotherapy, and steroids influence the quality of sleep in patients with brain tumors, but age has the most decisive influence.
Association of Vitamin D Deficiency and Diabetic Foot Ulcer Patients in Dr Mohammad Hoesin General Hospital Palembang Dahlan, Kemas; Yususf, Fahmi Jaka; Irfannuddin, Irfannuddin; Murti, Krisna; Muradi, Akhmadu; Liberty, Iche Andriyani
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 1 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i01.149

Abstract

Vitamin D plays a role in the healing process of diabetic foot ulcers (DFU); it can improve the immune system, regulate inflammation function, and regulate growth factors in diabetes mellitus (DM). The immunomodulatory effects of vitamin D include reduced production of IL-2, IL-6, and TNF-alpha and increased production of IL-10. It also increases the activity of antimicrobial peptides (AMP) such as cathelicidin, and it promotes the differentiation of monocytes into macrophages, phagocytosis, and the production of lysosomal enzymes. Furthermore, vitamin D stimulates growth factors including vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-β). In this study, the incidence of DM and DFU in DM patients at RSUP Dr. Mohammad Hoesin Palembang will be compared to serum vitamin D levels. This research uses quantitative methods with an analytical observational design. The Mean vitamin D serum level was 11,727 ng/mL, and there was a significant association between serum vitamin D deficiency and DFU (p-value; 0.036 < 0.05). There was a significant association between serum vitamin D deficiency and DFU occurrence (p-value; 0.036 < 0.05) in Mohammad Hoesin General Hospital Palembang. Based on the results of this study, we proposed that patients with diabetic foot ulcers should have their serum vitamin D levels checked, and that vitamin D should be given to them as part of their therapy.
Walking as a Modality for Enhancing Physical Fitness : A Review Maya, Rachel; Irfannuddin, Irfannuddin; Putri, Siti Sarahdeaz Fazzaura
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 1 (2025): Juni 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i1.10979

Abstract

Abstrak: Berjalan kaki berperan penting dalam menjaga kebugaran jasmani yang krusial bagi kesehatan. Kebugaran jasmani terdiri atas dua komponen utama, yaitu kesehatan dan keterampilan. Kebugaran umumnya diukur melalui penilaian daya tahan kardiorespirasi, kekuatan otot, kelenturan, dan komposisi tubuh. Tinjauan ini melakukan penelusuran literatur komprehensif menggunakan publikasi terkemuka seperti Elsevier, PubMed, dan sumber relevan lainnya. Penelusuran ini berfokus pada penelitian yang telah melalui telaah sejawat mengenai dampak berjalan kaki terhadap kebugaran. Banyak penelitian menunjukkan bahwa berjalan kaki adalah olahraga sederhana dan mudah diakses, serta memberikan manfaat signifikan, seperti peningkatan daya tahan kardiorespirasi, kekuatan otot, dan kelenturan. Disarankan berjalan kaki 150 menit per minggu guna memperoleh manfaat optimal. Untuk memaksimalkan manfaatnya, diperlukan postur tubuh yang benar dan teknik pernapasan baik. Selain manfaat fisik, berjalan kaki juga meningkatkan kesejahteraan mental dan sosial. Aktivitas ini fleksibel dan sesuai untuk berbagai kelompok usia, termasuk individu dengan kondisi kesehatan tertentu. Memahami hubungan antara berjalan kaki dan kebugaran membantu masyarakat mengintegrasikan aktivitas ini guna meningkatkan kesehatan. Penelitian di masa depan dapat berfokus pada aspek kebugaran tertentu untuk mengembangkan pedoman yang lebih tepat bagi berbagai kelompok masyarakat.
Pengaruh Puasa Ramadhan terhadap Kadar Neuropeptida Y pada Remaja Obesitas dan Overweight Tanzila, Raden Ayu; Irfannuddin, Irfannuddin; Kesuma, Yudianita; Liberty, Iche Andriyani
Syifa'Medika Vol 15, No 2 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v15i2.9609

Abstract

Obesitas pada remaja merupakan masalah kesehatan yang semakin meningkat, dengan dampak serius terhadap metabolisme dan risiko penyakit kronis. Puasa Ramadan diketahui dapat mempengaruhi pola makan dan metabolisme energi, tetapi pengaruhnya terhadap kadar Neuropeptida Y (NPY) sebagai regulator nafsu makan masih belum banyak diteliti, terutama pada remaja obesitas dan overweight di Kota Palembang. Penelitian ini merupakan studi observasional kohort yang melibatkan 80 remaja laki-laki obesitas dan overweight yang melakukan puasa dan kelompok kontrol yang tidak puasa. Pengukuran kadar NPY dilakukan sebelum dan setelah puasa Ramadan menggunakan metode ELISA, sementara nafsu makan subjektif diukur dengan kuesioner Adult Eating Behaviour Questionnaire (AEBQ). Analisis data dilakukan menggunakan uji statistik univariat dan bivariat. Hasil penelitian menunjukkan bahwa puasa Ramadan secara signifikan meningkatkan food avoidance dan menurunkan food approach pada kelompok obesitas dan overweight (p<0,05). Namun, tidak ditemukan perubahan bermakna pada kadar NPY sebelum dan setelah puasa Ramadan (p>0,05). Simpulan yang didapat adalah puasa ramadan memiliki efek signifikan terhadap pola nafsu makan subjektif pada remaja obesitas dan overweight, tetapi tidak secara signifikan mempengaruhi kadar NPY. Temuan ini menunjukkan bahwa puasa Ramadan dapat menjadi intervensi awal yang baik dalam mengubah kebiasaan makan, meskipun mekanisme molekuler yang mendasari efek ini memerlukan penelitian lebih lanjut.
Secondhand smoke exposure and its role in the pathogenesis of preeclampsia: a narrative review of molecular and epidemiological perspectives Yenny Febriany; Irfannuddin; Mohammad Zulkarnain; Yusuf Effendi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.19209

Abstract

Preeclampsia (PE) is a pregnancy complication characterized by hypertension after 20 wk of gestation, often accompanied by proteinuria or organ dysfunction. This condition is linked to genetic, environmental factors, and exposure to secondhand smoke (SHS). This study explores the relationship between SHS exposure and PE risk through a narrative literature review. Epidemiological and molecular studies data demonstrate that SHS exposure increases PE risk via oxidative stress, inflammation, and angiogenic disruptions. The analysis reveals that SHS exposure enhances reactive oxygen species (ROS) production, triggers systemic inflammation through the NF-κB pathway, and impairs angiogenic function by lowering the PlGF/sFlt-1 ratio. The risk significantly increases with exposures ≥2 hr/d or weekly frequencies ≥4 d, particularly in poorly ventilated domestic and occupational settings. Biomarkers such as cotinine and carbon monoxide (CO) are employed to assess exposure levels, providing robust evidence that duration and intensity of exposure are pivotal in PE pathogenesis. These findings highlight the importance of preventive strategies, including smoking bans, public health education, and integration of biomarker-based assessments into prenatal care. Future research should aim to clarify the molecular and epigenetic mechanisms involved and explore therapeutic interventions to mitigate SHS-induced damage.
THE EFFECT OF TAHAJUD PRAYER ON STRESS Pranata, Lilik; Irfannuddin, Irfannuddin; Ali, Zulkhair; Andraini, Trinovita
Menara Medika Vol 7, No 2 (2025): VOL 7 NO 2 MARET 2025
Publisher : Fakultas Kesehatan Universitas Muhammadiyah Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/mm.v7i2.6951

Abstract

Introduction: Stress is a physical and emotional reaction that occurs when a person faces pressure or environmental changes that require them to adapt. If stress is left unchecked, it can lead to many disorders. One thing that can be done is to perform tahajud prayers. The purpose of this study is to determine the benefits of tahajud prayer on stress. Method: The research design uses a literature review method by analysing articles from databases such as PubMed, Science Direct, ProQuest, and Google Scholar, focusing on articles published between 2020 and 2025, using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart approach. After selection, six articles were found to meet the inclusion criteria. Results: Tahajud prayer therapy can reduce stress levels. Discussion: Every individual experiences different levels of stress, so the process of performing tahajud prayer must be adapted to the stress level. The activity of tahajud prayer should be performed regularly without coercion and with sincerity.
Factor Affecting Insomnia in Ischemic Stroke Patients Fajarini, Agustina; Mukhlisa, Mukhlisa; Handayani, Sri; Ramadhoni, Pinto Desti; Irfannuddin, Irfannuddin
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.66533

Abstract

Highlight: Insomnia is prevalent in ischemic stroke patients and can hinder the recovery process. Stroke patients have a higher prevalence of insomnia and related symptoms than the general population.  This study found a complex relationship between physical, psychological, and social risk factors for insomnia following ischemic stroke.   ABSTRACT Introduction: Insomnia is common in ischemic stroke patients and can negatively impact on the post-stroke recovery process by interfering with the body's natural healing process, reducing the effectiveness of rehabilitation therapy, and affecting the recovery of cognitive function. Effective management and early intervention in  insomnia are needed to enhance health services for stroke patients, promote optimal recovery, and improve their quality of life. Objective: This study aimed to identify and analyze the various factors associated with the occurrence of insomnia among patients with ischemic stroke. Methods: This is a cross-sectional study that used secondary data from medical records and primary data gathered through questionnaire-based interviews. The subjects were 105 ischemic stroke patients at the Neurology Clinic of Dr. Mohammad Hoesin Hospital, Palembang, between May to July 2024. The data acquired for further analysis included social and demographic details, comorbid conditions, depression, anxiety, pain, insomnia, medication use, sleep hygiene, and stroke clinical features. The data was then analyzed using IBM SPSS Statistics 24 and assessed through bivariate and multivariate analyses to evaluate the relationships between variables. Results: The prevalence of insomnia in this study was 42.9%, with mild insomnia observed in 26.7%, moderate insomnia in 13.3%, and severe insomnia in 2.9% of the subjects. Obstructive sleep apnea (OSA) (OR: 22.718), sleep hygiene index (OR: 6.490), and education level (OR: 3.453) were identified as determinants related to insomnia in ischemic stroke patients. Indirect factors associated with insomnia in ischemic stroke patients include depression, the number of comorbid diseases, pain, diabetes, a history of insomnia, anxiety, and stroke onset. Conclusion: There is a complex relationship between various physical, psychological, and social factors and the incidence of insomnia after ischemic stroke.  
Association of Vitamin D Deficiency and Diabetic Foot Ulcer Patients in Dr Mohammad Hoesin General Hospital Palembang Dahlan, Kemas; Yususf, Fahmi Jaka; Irfannuddin, Irfannuddin; Murti, Krisna; Muradi, Akhmadu; Liberty, Iche Andriyani
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 1 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i01.149

Abstract

Vitamin D plays a role in the healing process of diabetic foot ulcers (DFU); it can improve the immune system, regulate inflammation function, and regulate growth factors in diabetes mellitus (DM). The immunomodulatory effects of vitamin D include reduced production of IL-2, IL-6, and TNF-alpha and increased production of IL-10. It also increases the activity of antimicrobial peptides (AMP) such as cathelicidin, and it promotes the differentiation of monocytes into macrophages, phagocytosis, and the production of lysosomal enzymes. Furthermore, vitamin D stimulates growth factors including vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-β). In this study, the incidence of DM and DFU in DM patients at RSUP Dr. Mohammad Hoesin Palembang will be compared to serum vitamin D levels. This research uses quantitative methods with an analytical observational design. The Mean vitamin D serum level was 11,727 ng/mL, and there was a significant association between serum vitamin D deficiency and DFU (p-value; 0.036 < 0.05). There was a significant association between serum vitamin D deficiency and DFU occurrence (p-value; 0.036 < 0.05) in Mohammad Hoesin General Hospital Palembang. Based on the results of this study, we proposed that patients with diabetic foot ulcers should have their serum vitamin D levels checked, and that vitamin D should be given to them as part of their therapy.
Systematic Literature Review: Pengaruh puasa terhadap nafsu makan pada obesitas dan bukan obesitas Tanzila, Raden Ayu; irfannuddin, irfannuddin; Kesuma, Yudianita; Liberty, Iche Andriyani
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p203-216.2024

Abstract

Background: Fasting is the voluntary act of abstaining from food, drink, or both, as well as from anything that breaks the fast for a certain time. In medicine, fasting has an important role in various diseases and health. Several studies have assessed the benefits of fasting in various physiological and pathological conditions, one of which is an appetite in obese and non-obese people. Objective: Writing an article in the form of a systematic literature review aims to analyze the effect of various fasting methods on appetite. Method: Systematic literature review method by taking 19 international journals, according to the specified keyword criteria. Results: From the results of the systematic review analysis, it was found that fasting affects subjective appetite by changing appetite scores and objective appetite by changing appetite regulation parameters such as leptin, ghrelin, PYY, adiponectin, and neuropeptide Y (NPY). Conclusion: It was concluded that fasting had positive benefits on appetite in both obese and healthy individuals. This systematic literature review is expected to be a reference for future researchers and further research can be carried out using a more varied literature search database.
The Effect of Memory Training on Cognitive Function: A Systematic Review Mariana, Mariana; Irfannuddin, Irfannuddin; Idris, Fachmi; Liberty, Iche Andriyani
Indonesian Journal of Global Health Research Vol 6 No S5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS5.4549

Abstract

Memory is related to the processes that allow us to record, store and then retrieve experiences and information. Memory as an information processor is analogized by psychologists and neurologists as a computer. The recording process, called encoding, is the process of obtaining information conveyed to the system by translating it into neural code which is processed in the brain.The goal of the research titled is to systematically evaluate and synthesize existing studies to determine the impact of memory training interventions on various aspects of cognitive function. This includes assessing how memory training may enhance skills such as attention, processing speed, working memory, and overall cognitive performance. By identifying patterns, strengths, and limitations in the current literature, the study aims to provide insights into the effectiveness of memory training programs and guide future research and practical applications in cognitive enhancement.Method: Articles used in systematic reviews are typically sourced from various academic databases such as PubMed, PsycINFO, Scopus, and Google Scholar. These include studies published in peer-reviewed journals. The keywords used for searching may include phrases like "memory training," "cognitive function," "cognitive enhancement," "working memory," and other related terms. This combination of keywords helps filter relevant articles. For instance, in this review, there might be 150 articles identified through the initial search. After a selection process based on inclusion and exclusion criteria, approximately 30 articles are chosen for further analysis. The articles included in the systematic review are examined systematically, following the PRISMA 2020 guidelines: Study Identification,Study Selection,Data Extraction,Analysis and Synthesis Analyzing the results from the selected studies and compiling conclusions based on the available evidence.Results: The findings from these five literature studies cumulatively imply that activities involving the Al-Quran, such as listening, reading, or memorizing, have a positive impact on various aspects of physical and mental health, cognitive function, and brain responses. The implications of these results may stimulate further research in the field of cognitive interventions, as well as provide a more in-depth look at the role of memorization in the development of cognitive abilities at critical developmental stages.Conclusion: From the five studies reviewed, it can be concluded that memory training interventions, especially in the context of memorizing the Qur'an, contribute positively to the improvement of cognitive function in various age groups, including children, adolescents, adults, and the elderly. The implications of these findings give impetus to further research in the field of cognitive intervention, focusing on memorization strategies, as well as providing deeper insight into the role of memorization in the development of cognitive abilities at critical stages of life.
Co-Authors Ahmad Junaidi Ahmadi Ahmadi Aini, Lela Aldes Lesbani Aldiar Ali Ghanie Alifia Salsabila Amallia, RA Hoetary Tirta Andi Miarta Andi Saputra Andi Saputra Andika Okparasta Andini Agustina Anggraini, Wieke Ardesy Melizah Kurniati Arwan Bin Laeto Budi Santoso Citra Maharani Dahlan, Kemas Daniel Saputra Dewi Susan Diansari, Yunni Dwi Budi Santoso Eddy Ibrahim Eddy Mart Salim, Eddy Mart Eka Febri Zulissetiana Eka Febri Zulissetiana Elsafani Faddiasya Erni Desmita Erwin Sukandi Erwin Sukandi Esa Indah Ayu, Esa Indah Fachmi Idris Fajarini, Agustina Fatmawati Fatmawati Febian Aji Wicaksono FERLY OKTRIYEDI Ferry Usnizar Fredi Heru Irwanto Geo Vanda Ghina Kartika Handayani, Sri Hanna Marsinta Hestiningsih, Tyas Huntari Harahap Husodo, Reyki Yudho Iche Andriyani Liberty, Iche Andriyani INDRA FRANA JAYA KK Indriyani Indriyani Jayawarsa, A.A. Ketut Karmila, Ariesti Kemas Dahlan Koibuchi, Noriyuki Krisna Murti Kusuma, Singgih Legiran Legiran Lela aini Lestari, Ajeng dwinta Lilik Pranata M. Hatta Dahlan M. Hatta Dahlan Mailan Alexander Mariana Mariana marisdina, selly Masagus Irsan Saleh Masayu Rita Dewi Masayu Rita Dewi Maya, Rachel Medina Athiah Mega Gemala Miftahurrahmah Miftahurrahmah, Miftahurrahmah Minerva Riani Kadir Monica, Ricca Muhammad Hatta Dahlan Muhammad Irsan Saleh Mukhlisa Mukhlisa, Mukhlisa Muradi, Akhmadu Nadia Mutiara Ngudiantoro . Nur Rachmat Lubis Nursiah Nasution Nursiah Nasution Nursiah Nasution, Nursiah Nurwany, Raissa Oktarizal, Hengky Pahrul, Dedi Patiyus Agustiansyah Poedji Loekitowati Hariani Pudi Handayani Putri Erlyn Putri, Sarahdeaz Siti Fazzaura R.Kintoko Rochadi Rachel Maya Raden Muhammad Indra Radi Noorsyawal Radiyati Umi Partan Ramadhoni, Pinto Desti Rini Nindela Rini Yana Risa Vera, Risa Rizal Sanif Roni Saputra Sadakata Sinulingga Safri Dhaini Safyudin Shanty Chairani Sintiya Halisya Pebriani Siti Nurmaini Siti Rusdiana Puspa Dewi Siti Sarahdeaz Fazzaura Putri Subandrate Suheryanto Suprapti Suprapti Susanty, Tri Susilawati Susilawati Susilawati Susilawati Swanny Swanny, Swanny Syahputri, Rizka Aprillia Syarif Darwin Tanzila, R.A Tanzila, Raden Ayu Taufik Indrajaya Taufik Indrajaya Tri Suciati Trijoso Permono Trinovita Andraini Yenny Febriany Yuanita Windusari Yudhie Tanta Yudianita Kesuma, Yudianita Yunita Fediani Yunita Fediani Yunita Panca Putri, Yunita Yusuf Effendi Yususf, Fahmi Jaka Zaky Hasan Zulkarnain, Mohammad Zulkhair Ali Zulkifli