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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Veteriner BIOTROPIA - The Southeast Asian Journal of Tropical Biology Gadjah Mada International Journal of Business Journal of Tropical Biodiversity and Biotechnology Science and Technology Indonesia Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Jurnal Riset Akuakultur JSFK (Jurnal Sains Farmasi & Klinis) Jambura Journal of Chemistry Majalah Farmasetika Narra J Makara Journal of Science Gunung Djati Conference Series Jurnal Kedokteran Hewan Current Biomedicine Policy Brief Pertanian, Kelautan, dan Biosains Tropika Borneo Journal of Pharmacy
Huda Shalahudin Darusman
IPB University
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Effects of patin fish-based nutritional intervention on biochemical and physiological recovery in malnourished rats: An in vivo study and its implications for clinical nutrition Hidayaturrahmah, Hidayaturrahmah; Suprayogi, Agik; Darusman, Huda S.; Roosita, Katrin; Hanif, Novriyandi
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1811

Abstract

Malnutrition is a major global health concern, especially in developing countries. Although patin fish oil and protein offer benefits, their individual and combined effects on maternal physiology remain unclear, particularly during early pregnancy. The aim of this study was to assess the effect of patin-based nutritional intervention on total serum protein, albumin, hemoglobin levels, body weight during pregnancy, body weight during lactation, heart rate, respiratory rate, body temperature, external appearance, behavioral activity, and milk production in malnourished rats. An in vivo study was conducted using Rattus norvegicus rats. The rats were divided into six groups: (1) healthy control, receiving standard feed; (2) malnourished control, receiving an 8% low-protein diet; (3) malnourished group, receiving standard feed; (4) malnourished treated with patin oil; (5) malnourished treated with patin meat; and (6) malnourished treated with a combination of patin oil and meat. The treatment consisted of 21 days during pregnancy and 23 days during lactation, for a total of 44 days. Our data indicated that patin-based intervention significantly increased total protein (p=0.044), albumin (p=0.001), and hemoglobin levels (p=0.034) compared to malnourished control group. The malnourished animals treated with patin oil showed the highest increases in total protein (1.67%), albumin (17.75%), and hemoglobin (24.26%). Body weight gain improved significantly in patin-treated group in both pregnancy (p=0.032) and lactation (p<0.001) compared to the malnourished control, with the highest gains observed in the patin oil group. Milk production also increased significantly (p<0.05), reaching its peak in the patin oil and meat combination group (6.97 g). Physiological parameters, including heart rate (p=0.021), respiratory rate (p=0.025), and body temperature (p=0.023), were significantly different among groups, of which patin oil and meat groups had the most optimal parameters compared to malnourished control group. In conclusion, patin-based nutritional intervention effectively enhances protein metabolism, hematological parameters, and physiological health in malnourished maternal rats, with patin oil demonstrating the most pronounced effects.
Analisis Kemiripan Obat, Prediksi Toksisitas dan Studi Molecular Docking Metabolit Sekunder Dari Streptomyces carpaticus Terhadap Protein Caspase-3 Sebagai Antikanker Leukemia Suduri, Adam; Darusman, Huda Shalahudin; Mariya, Silmi
Jambura Journal of Chemistry Vol 6, No 2 (2024): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i2.26802

Abstract

Caspase-3 merupakan enzim protease yang berperan dalam proses apoptosis, dan menjadi target senyawa metabolit dalam menghambat pertumbuhan sel kanker. Tujuan penelitian adalah untuk mengetahui sifat kemiripan obat metabolit sekunder hasil produksi Streptomyces carpaticus yang diperoleh berdasarkan analisis klaster gen biosintesis pada program antiSMASH version 7.1.0, mengetahui hasil prediksi mutagenicity dan toxicity serta mengetahui hasil interaksi metabolit sekunder dengan protein Caspase-3 yang merupakan reseptor terkait sel kanker leukemia menggunakan molecular docking. Hasil analisis kemiripan obat dan prediksi ADME menunjukkan bahwa ketiga metabolit memenuhi aturan Lipinski Rule of Five dan memiliki kemiripan dengan obat. Ketiga metabolit tergolong pada Toxicity Class 5, dan memiliki sifat mutagenic inactive dengan probability Pristinol: 0.93, Raimonol: 0.91 dan Cyslabdan: 0.80 dan toxicity inactive dengan probability Pristinol: 0.75, Raimonol: 0.94 dan Cyslabdan: 0.76. Hasil studi molecular docking, analisis dan validasi situs ikatan dengan protokol penambatan ulang (redocking) ligan standar 5-[4-(1-carboxymethyl-2-OXO-propylcarbamoyl)-benzylsulfamoyl]-2-Hydroxy-Benzoic Acid memiliki nilai RMSD yaitu 0.000. Energi ikatan bebas masing-masing ligan yaitu sebesar -8,9 kkal/mol -9.2 kkal/mol, -7.0 kkal/mol, -7.1 kkal/mol, dan -7.0 kkal/mol. Hasil ini menunjukan bahwa energi ikatan hasil penambatan metabolit sekunder dengan protein Caspase-3 yang paling baik adalah metabolit cyslabdan dengan nilai ikatan bebas -7.4 kkal/mol dan jumlah interaksi 12.
Co-Authors A.S. Satyaningtijas Adi Winarto Adi Winarto Agik Suprayogi Ahmad Kamal Nasution Ahmad Subhan Ai Hertati, Ai Akhiruddin Maddu Andhika Yudha Prawira Andi Hiroyuki Angela Mariana Lusiastuti Apon Zaenal Mustopa Aprilyana, Lia Ardiansyah Nurdin Benvika Damiana Rita Ekastuti Dayana, Hepy Dewi Ratih Agungpriyono Dewi, Fitriya Nur Annisa Dondin Sajuthi DYAH PERWITASARI -FARAJALLAH Ekowati Handharyani Elok Budi Retnani Entang Iskandar Entang Iskandar Entang Iskandar Entang Iskandar Ernes Andhesfa Etih Sudarnika Fadla, Ilma Nadya Fauzi Abdurrahman Munggaran Femke Den Haas Ferdinandez, Mariana Firdaus, Moh Egy Rahman Fitri, Arni Diana Habib Ilham Maulana Al Adhim Hana Intishar Sawitri Hardo Basuki Harrold Halilintar MR Subu Taopan HERA MAHESHWARI Hidayaturrahmah Hidayaturrahmah I wayan Teguh Wibawan Ice Lusia Marta IETJE WIENTARSIH Ikramullah, Muh. Chaeril Indra Bachtiar Indra Bachtiar Indriawati, Iin Iqbal Ngabdusani Irawan, Shasmita Irma Herawati Suparto Jusak Nugraha Kanti Rahmi Fauziyah Karin katina Hasya Katrin Roosita koekoeh santoso Krisnayanti, Ni Putu Eka Lina Elfita Lina Elfita Linda Tjhin Lis Rosmanah Lis Rosmanah Loes (ML) Schure Maria Fatima Palupi Maria Fatima Palupi Maria Fatima Palupi Megawati Iskandar Mia Audina, Mia Muhammad Hamdan Ningrum, Emilna Mega Novi Mayasari Noviana, Rachmitasari Novriyandi Hanif Nugroho, Setyo Widi Pamungkas, Joko Perdhana, Ika Satya Permanawati Permanawati Puji Rianti Putri, Indah Aprianti Rachmitasari Noviana Rahmania Hanim Rahminiwati, Min Randall C. Kyes Rasyida Ulfa Ratna, Lita Tri Ratni Ernita Ratu, Safira Pinaka Pramestika Raymond R. Tjandrawinata Ridzki M.F. Binol Rifqiyah Nur Umami, Rifqiyah Nur Rika Sudranto Rizki Aulia Ansari Rosyid, Bahaudien Savitri Novelina Sela Septima Mariya Setyo Widi Nugroho SILMI MARIYA Silmi Mariya Silmi Mariya Silvy Thiyana Sony Hartono Wijaya Srihadi Agungpriyono Suduri, Adam Sukenda Sukenda Sumitro - Tambunan, Anggitha Tatang Mitra Setia Tatik Mufidah Tommy Langgeng Abimanyu Tri Wibawa UUS SAEPULOH Uus Saepuloh Uus Saepuloh Vinka Aftinata Kusumaputri Wartika Rosa Farida Wasmen Manalu WIDANARNI WIDANARNI Wira, Dwi Wahyuda Yuliana Yuliana Yuliana Zaelani, Bella Fatima Dora