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All Journal Medula Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Biomedicine and Translational Research Biology, Medicine, & Natural Product Chemistry JPSriwijaya Sari Pediatri Biomedical Journal of Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics & Gynecology Science Pharmacology and Clinical Pharmacy Research Indonesian Journal for Health Sciences (IJHS) Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Plastik Rekonstruksi Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientia Psychiatrica Indonesian Journal of Anesthesiology and Reanimation (IJAR) Sriwijaya Journal of Surgery Jurnal Integrasi Kesehatan dan Sains JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai Jurnal Pengabdian Masyarakat: Humanity and Medicine Natural Sciences Engineering and Technology Journal Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Wal'afiat Hospital Journal International Journal of Islamic and Complementary Medicine Journal of Anesthesiology and Clinical Research Jurnal Riset Kedokteran Conferences of Medical Sciences Dies Natalis WAL'AFIAT HOSPITAL JOURNAL
Ziske Maritska
Department Of Biology Medicine, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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Pattern of Menarche Age in Two Generations Among Female Medical Students in Faculty of Medicine Sriwijaya University Nabila Rizki Sakinah; Ziske Maritska; Lusia` Hayati
Sriwijaya Journal of Medicine Vol. 4 No. 3 (2021): Vol 4, No 3, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v4i3.135

Abstract

In life, women go through many significant events in their growth and body development, one of which is experiencing their first menstruation that commonly occurs during adolescence. In sexual development, the first episode of the first bloodstream is called menarche. The age of menarche is different for each individual, and on average happens in the age range of 11-15 years old. Like many other complex traits, menarcheal age is influenced by many factors, such as genetic and environmental. This study is done to know more about the age distribution of mothers and their daughters to observe the inheriting trend of menarcheal age. This is a descriptive study using 154 samples collected from Faculty of Medicine Universitas Sriwijaya University students batch 2017 that meet the inclusion criteria. Based on the results of research conducted on female students of the Doctor Program Faculty of Medicine Universitas Sriwijaya batch 2017, there is a similarity of distribution in the age of menarche experienced by mothers and their children. Among respondents, the highest age of distribution for female students are between 12 to 14 years old which is 66,9%. For mothers, the age of menarche is the highest between the age of 12 to 14 years old, namely 77,3%. Female students' BMI has the highest distribution of data in normal scores, which is 70,8%. The distribution of menarcheal age on female students Doctor Program Faculty of Medicine Sriwijaya University and mothers have the biggest number in between the age of 12 and 14.
Effect of Extract Omega-3 Fatty Acids Consumption from Mackerel as Adjuvant of Antidepressant Fluoxetine (Rastrelliger kanagurta) on Decreasing Cortisol Hormone Levels Aisyah Izzatinisa; Novita Angkirani; Zabrina Zerlinda; Jessica William; Azizah Hanun Yasmin; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 5 No. 2 (2022): Vol 5, No. 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i2.143

Abstract

Depression, one of the common mental disorders; generally identified by feelings of sadness or disappointment when experiencing a change, loss, or failure and becomes pathological when unable to adapt. According to WHO, Indonesians have a suicide ratio of 3,7 per 100.000 population. People with depression have some dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis, which takes a part in the organism's reaction to depression. As a hormonal response to stress signals, thus the cortisol hormone will be released. The cortisol hormone mainly modulates emotions, especially fear and anxiety. Hence, patients with depression tend to have higher cortisol hormone levels. The most commonly used psychopharmacological medication is antidepressants. However, only about 40-60 out of 100 individuals are helped by taking antidepressants. Thereupon, as support for antidepressants, an adjuvant, i.e., omega-3 fatty acids in mackerel (Rastrelliger kanagurta) is needed. Therefore, the author uses Google Scholar, WHO, PubMed, and HealthLine as references for this literature review. After reviewing the literature, omega-3 fatty acids in mackerel can act as an adjuvant to antidepressants in lowering cortisol hormone levels. The dosage of omega-3 fatty acids needs to be analyzed to optimize the potential of adjuvant therapy for fluoxetine.
Potential of Anti-Secretory and Cytoprotective Effect from Azadiradione as GERD Prevention Corinna Faustina; Villicia Angellika; Alya Rahmadani; Rosalie Dorothea; Ricky Fajar Adiputra; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 5 No. 2 (2022): Vol 5, No. 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i2.144

Abstract

Gastroesophageal Reflux Disease (GERD) is a pathological state due to stomach reflux within the esophagus, which causes necrosis of esophageal mucosa, resulting in erosions, ulcers, and other complications. GERD is still a growing global issue with 783.95 million cases worldwide in 2019. Although PPIs were used as medications to treat GERD, there were refractions and adverse effects to the patients. Azadiradione, terpenoids that can be found in A. indica and various plants, has potential as alternative H+/K+ ATPase inhibitor sources with its anti-secretory and cytoprotective activity. Some studies explain that there is also adverse effects of azadiradione. Further research are needed to determine alternative sources, safety dosage, usage duration, side effects, also drug-food or drug-drug interaction of azadiradione.
Genetic Factors Affecting Neuroplasticity Ziske Maritska; Muhammad Fakhri Altyan; Ardy Oktaviandi; Muhammad Barkah; Amirah Dhia Nabila Sinum; Emelda Emelda; Hawari Martanusa; Rini Nindela; Nita Parisa; Bintang Arroyantri Prananjaya; Puji Rizki Suryani; Eka Febri Zulissetiana
Sriwijaya Journal of Medicine Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i2.152

Abstract

Neuroplasticity pertains to the brain's ability to adjust functions or structure in response to events and is an important factor for skill-learning development as well as functional recovery from a neurological disorder. Numerous factors could influence neuroplasticity processes. This literature review aims to discuss the roles of genetic factors in neuroplasticity. The literature search was conducted using the keywords “neuroplasticity”, genetics”, “genes”, and polymorphism” in search engines like google scholar and PubMed, covering original articles, reviews, and text book both in Bahasa Indonesia and English for the last ten years. Genetic variation including gene polymorphism was responsible for the impact of BDNF, ApoE, and dopamine on the functional neural repair of the brain. Certain processes might directly influence neuroplasticity; others might interfere indirectly through the process. A deeper insight into genetic influence regarding neuroplasticity could lead to a better understanding and potential improvement of treatment.
GLUT4 as A Protein Target for Type 2-Diabetes Mellitus Therapy With Natural Compounds Vivi Hendra Sutandar; Mgs. Irsan Saleh; Ziske Maritska
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.154

Abstract

WHO reported 1.9 million death cases of diabetes patients in 2019. Diabetes is caused by damage in the pancreas which resulted in a lack of insulin or insulin resistance.  Medication for Type 2-Diabetes Mellitus (T2DM) mainly focuses on lowering blood glucose and treating affected organs. Current medications are still lacking; thus research is needed in finding novel medications to accommodate T2DM. This paper aims to present the current research on potential plant extract in increasing GLUT4 translocation in diabetes conditions. insulin resistance state affecting GLUT4 translocation which is important in affecting glucose uptake. Some research shows that plant extract proved to be potential in increasing the translocation of GLUT4 and helping lowering blood glucose levels.
Risk Factor Analysis of the Incidence of Placenta Previa at RSUP Dr. Mohammad Hoesin Palembang in 2020–2021 Dian Widia Lestari; Firmansyah Basir; Ziske Maritska; Hartati Hartati; Rara Inggarsih
Sriwijaya Journal of Medicine Vol. 5 No. 3 (2022): Vol 5, No. 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v5i3.156

Abstract

Placenta previa is a placenta that lies at the bottom of the uterus, above or very close to the internal cervical ostium. The exact cause of placenta previa is still unknown, but several factors have been associated with an increased risk of placenta previa. This study aims to determine the relationship between maternal age, parity, distance between pregnancies, history of placenta previa, history of cesarean delivery, history of curettage, assisted reproductive technology, multiple pregnancies, and fetal gender on the incidence of placenta previa at RSUP Dr. Mohammad Hoesin Palembang in 2020-2021. This study is an observational analytic study with a case control design. This study used secondary data from medical records of obstetric patients at RSUP Dr. Mohammad Hoesin Palembang in 2020-2021 that met the inclusion criteria and exclusion criteria. The study sample amounted to 100 people consisting of 50 cases and 50 controls. The results of bivariate analysis using the chi-square test and the fisher exact alternative test showed that maternal age (p=0.010), parity (p=0.038), history of cesarean delivery (p=0.000), and history of curettage (p=0.001) had a significant relationship with the incidence of placenta previa. Distance between pregnancies (p=0.204), history of placenta previa (p=0.242), and fetal sex (p=0.162) did not have a significant relationship with the incidence of placenta previa. The results of multivariate analysis using binary logistic regression test showed that the most influential risk factors for the incidence of placenta previa were history of cesarean delivery (OR=54.751) and history of curettage (OR=20.204). It can be concluded that a history of cesarean delivery and a history of curettage are the most influential risk factors for the incidence of placenta previa.
Genetic Conditions Associated with Intellectual Disability in Indonesian Population: A Review Ziske Maritska; Atikah M. Ihsan; Ina Rahmawati; Perawati Perawati; Mohammad Hilal Atthariq Ramadhan; Bintang Arroyantri Prananjaya; Nita Parisa
Sriwijaya Journal of Medicine Vol. 7 No. 1 (2024): Vol 7, No 1, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i1.220

Abstract

Intellectual disability (ID) brings challenges to the affected individuals, their families, and the community at large. It is a multifactorial condition with many contributing factors, namely genetics. This review aims to briefly provide several related genetic conditions for ID in the Indonesian population. Literature studies search relevant articles using PubMed and Google Scholar using the terms ‘intellectual disability’, ‘genetics', ‘Indonesian population’. In Indonesia, the prevalence of children with ID is 1–3%, with 62,011 school-aged children affected with Intellectual Disability. Genetics plays a role in around 25–50% of cases. ID in the Indonesian population is associated with several genetic disorders, namely Duchenne muscular dystrophy (DMD), autism spectrum disorder (ASD), fragile X syndrome (FXS), Down syndrome (DS), Apert syndrome, and subtelomeric chromosomal rearrangements. There is limited research on genetics related to intellectual disability in Indonesia, implying further research is needed.
The Role of Multimodalities Approach in Diagnosing Disorders of Sex Development (DSD): Brief Review Ziske Maritska; Masagus Irsan Saleh Hasani; Fachmi Idris; Zen Hafy; Didit Pramudhito; Kemas Yusuf Effendi
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.238

Abstract

Disorders of Sex Development (DSD) encompass rare congenital conditions involving atypical development of chromosomes, gonads, or sex anatomy. The 2006 global consensus led to a shift in the approach to handling DSD cases, emphasizing integrated treatment involving various scientific disciplines. DSD diagnosis involves a structured and multimodality approach, including history, pedigree analysis, physical examination, imaging, hormone and chromosome analysis, and genetic testing. An in-depth anamnesis and detailed pedigree analysis help trace family history and inheritance patterns of Mendelian traits in DSD cases. Thorough physical examination, including general and specific assessments, helps screen for abnormalities in sexual development. Karyotyping, hormone level investigation, and imaging examinations are crucial for supporting the diagnosis of DSD. However, genetic or molecular examination remains the modality for definitively confirming the genetic disorder underlying DSD, subsequently leading to a better understanding and management of the condition. Considering the limited resources available in the field in efforts to establish a molecular diagnosis of DSD, it is recommended to explore the role of anamnesis, pedigree analysis, physical examination, imaging examination, hormonal laboratory examination, and chromosome analysis in efforts to approach the diagnosis of DSD.
Analysis of Morphometric Variations in the Thickness of the Mandibular Symphysis in Patients at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia Muzakkie, Mufida; Muhammad Fikri Aulia; S.N.A. Ratna Sari Devi; Ziske Maritska
Sriwijaya Journal of Surgery Vol. 7 No. 1 (2024): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v7i1.96

Abstract

Introduction. Accurate knowledge of mandibular thickness is necessary for performing surgical treatments on the mandible. The Champy procedure has become the predominant approach for treating fractures of the mandible. Placing plates along these lines is believed to offer the best possible fixing and stability. The objective of this study is to analyze and compare the thickness of the mandible in patients, specifically depending on their gender. The purpose is to gain a more comprehensive understanding of the differences in mandibular architecture across various populations in South Sumatra, Indonesia. Methods. This study is a cross-sectional analytical-observational study. The Department of Radiology of Dr. Mohammad Hoesin Central General Hospital, located in Palembang, conducted the study. We included a total of 103 research participants in this study, all of whom met the specified inclusion criteria. Results. There is a notable difference in the thickness of the lower jawbone in the front part (A and B) that runs parallel to Champy's line, depending on the person's gender. Males have a greater morphometric thickness of the mandibular symphysis in comparison to females. The thickness of the mandibular symphysis closely links to gender disparities. Conclusion. The thickness of symphysis A in men was substantially greater than in females, while the thickness of symphysis B in males was also significantly greater than in females, with a P value less than 0.001.
Maxillary Intercanine Width in a South Sumatran Population: Implications for Maxillofacial Reconstruction Mufida Muzakkie; Lawrencia Toline; SNA Ratna Sari Devi; Ziske Maritska
Sriwijaya Journal of Surgery Vol. 7 No. 2 (2024): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v7i2.113

Abstract

Introduction: The maxilla is a crucial bone in the facial skeleton, contributing significantly to both aesthetics and function. Understanding the morphometric variations of the maxilla, particularly the intercanine width (ICW), is vital for successful maxillofacial reconstruction procedures. This study aimed to investigate the ICW in a South Sumatran population, considering its implications for reconstructive surgeries. Methods: This retrospective study analyzed computed tomography (CT) scans of 96 adult patients (60 males, 36 females) from South Sumatra. The ICW was measured using 3D reconstruction software, and the data were analyzed for gender-based differences. The findings were compared with existing literature to understand regional variations in maxillary morphology. Results: The mean ICW for males was 3.58 ± 0.27 cm and for females was 3.44 ± 0.18 cm. Males exhibited a significantly larger ICW than females (p < 0.05). These findings are consistent with previous studies indicating sexual dimorphism in maxillary morphology. Conclusion: This study provides valuable data on maxillary intercanine width in a South Sumatran population. The observed gender-based differences highlight the importance of considering patient demographics in maxillofacial reconstruction. This information can aid surgeons in achieving optimal functional and aesthetic outcomes.
Co-Authors Abdullah Sahab Achmad Zulfa Juniarto Adam Triyoga Aditya Rafrenda Agustina Septi Hijir Aisyah Izzatinisa Al Farisi Sutrisno, Muhammad Alya Rahmadani Amalia Salsabilla Amirah Adillah Amirah Dhia Nabila Sinum Andhika Diaz Maulana Anggraini, Friska Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardy Oktaviandi Ardy Santosa Ardy Santosa Arroyantri Prananjaya, Bintang Arroyantri, Bintang Arroyantri, Bintang Atikah M. Ihsan Awang Budi Saksono Ayeshah A Rosdah Azalia Talitha Zahra Azizah Hanun Yasmin Baharudin Baharudin Balqis Wulandari Basir, Salni Beauty Novianty Benny Issakh Benny Issakh Bintang Arroyantri Bintang Arroyantri P Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bunga Anggreini Sari Carissa Delania Cendy Legowo Ching Leng Kee Chris Alberto Amin Citra Wulandari Citra Wulandari Clinton F.M Sitanggang Corinna Faustina Dastamuar, Shalita Defa Pratama Diah Andini Dian Puspita Sari Dian Puspita Sari Dian Widia Lestari Didit Pramudhito Dipta Anggara Diyaz Syauki Ikhsan Diyaz Syauki Ikhsan Eka Febri Zulissetiana Eka Febri Zulissetiana Eka I Fitriana Eka I Fitriana Eka Kurniawan Perangin-Angin Ella Amalia, Ella Emelda Emelda Endah Rahmadani Endi Taris Pasaribu Endi Teris Pasaribu Ernes Putra Gunawan Fachmi Idris Fakhri Abdurrahman Fakhri Abdurrahman Febryana Ramadhani Machyar Ferdy Rahadiyan Fiona Widyasari Firmansyah Basir Fitri Az-Zahrah Fitri Mareta Elzandri Friska Anggraini Ganda Purba Tasti Hartati Hartati Hawari Martanusa Husada, Abdillah Ignatius Aldo Winardi Ina Rahmawati Inggarsih, Rara Irfan Ferdinand Tambunan Irga, Muhammad Irsan Saleh issakh, Benny Jayawarsa, A.A. Ketut Jessica Putri Salim Jessica William Joko Marwoto Joko Marwoto Julius Anzar Karina, Mathius Kemas Yusuf Effendi Khairunnisa, Tyas Citra Khumaisiyah Khumaisiyah Larasati, Veny Lathifah Nudhar Lawrencia Toline Layal, Kamalia Leonardo Satria Lovina Lovina Lusia Hayati Lusia` Hayati M. Khairul Kahfi Pasaribu MA Husnil Farouk Mahayu Dewi Ariani Manurung, Maya Rina Santara Masagus Irsan Saleh Hasani Mayasari Mayasari Mgs Irsan Saleh Mgs. A. Rifqi Murtadho Mgs. Irsan Saleh, Mgs. Irsan Mohammad Hilal Atthariq Ramadhan Mufida Muzakkie Mufida Muzakkie Muhammad Adib Dwitamma Muhammad Adib Dwitamma Putra Muhammad Barkah Muhammad Fakhri Altyan Muhammad Febriandi Djunaidi Muhammad Fikri Aulia Muhammad Hilal Atthariq Ramadhan Muhammad Irsan Saleh Muhammad J. Aldwin Muhammad Rizky Hidayatullah Muhammad Yusuf Wijahaska Muzakkie, Mufida Nabila Rizki Sakinah Nabila, Safa Putri Najla Khairunnisa Nita Parisa Novita Angkirani Novita Sari Noviyanti Eliska, Noviyanti Nudhar, Lathifah Nur Rakhman Pratama Pasaribu, Endi Taris Pasaribu, M. Khairul Kahfi Peby Maulina Lestari, Peby Maulina Perawati Perawati Prananjaya, Bintang Arroyantri Puji Rizki Suryani Puji Rizki Suryani Puji Rizki Suryani Purnamasari, Septi Puspa Zulaika Putra, Marco Manza Quardetta, Rovania Yantinez RACHMAT HIDAYAT Rachmat Taufan Raden Ayu Mulya Liansari rahman, Khaidir Yusuf Rahmat Afif Rahmi Isman Rani Iswara Rara Inggarsih Ratna Sari Devi, Ratna Sari Ricky Fajar Adiputra Rini Nindela Rini Nindela Rini Nindela, Rini Riri Juliantika Rizka Fathia Robby Pardiansyah Rosalie Dorothea Rovania Yantinez Quardetta Rovania Yantinez Quardetta S.N.A Ratna Sari Devi S.N.A. Ratna Sari Devi Safa Nabila Putri Safa Nabila Putri Salim, Jesica Putri Salni Salni Salni Salni Sanely Saphira Nada Khalishah Saputra, Andre Sarah Sari H. S., Maharani Puspita Sarmoko Sarmoko Sativandi Riza Savero Evan Abisha Evan Abisha Sendy Aditya Nugraha Septi Purnamasari Setiadi Winata Shalita Dastamuar Siti Rahma Anissya Kinanti SNA Ratna Sari Devi Sri Nita Sri Nita Stevanny, Bella Sultana MH Faradz Suryani, Puji Rizki Sutandar, Vivi Hendra Syarif Husin Syarifah Aini Syarifah Aini Syarinta Adenina Syauki Ikhsan, Diyaz Syifa Syifa Alkaf Syifa Syifa Syulthoni, Zain Budi Tan Yue Ming Theofilus Aswadi Tiara Fatrin Tinton Ardiyan Tinton Ardiyan Toline, Lawrencia Tri U. Pratiwi Triwani Triwani Triwani Triwani Triwani Triwani Trizky Nataza Putra Try Merdeka Puri Tryvanie R Putra Uswati Uswati Venny Patricia Victor Pulpa Seda Vienna Dwinda Putri Villicia Angellika Yundari, Yundari Yuni Dwi Marantika Yusuf, Khaidir Yusuf Yuwono Zabila Adwie Prilishia Zabrina Zerlinda Zen Hafy Zulkifli