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All Journal Majalah Kedokteran Bandung Medula Juke Jurnal Ilmu Kedokteran dan Kesehatan Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran Jurnal Riset Ilmu Kesehatan Umum dan Farmasi JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Intanri Kurniati
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Korelasi Aminotransferase Platelet Ratio Index (APRI) Dengan Kadar Bilirubin Serum Pada Penderita Sirosis Hepatis Akibat Infeksi Virus Hepatitis C Di RSUD Dr. H. Abdul Moeloek Lampung Vira Katya Aurelia; Intanri Kurniati
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.518

Abstract

Hepatitis C is an Inflammation in Liver because of Hepatitis C Virus (HCV). When HCV turning into the bloodstream and enter the liver, HCV will attached to liver cells and starting proliferate. Liver cells becomes broken and causing fibrosis. When in the fibrosis phase, Trombopoietin will in the lower phase and thrombocytopenia will happen. An enzyme that most associated with the destruction of the liver cells is AST and ALT. APRI is apredictor of the cirrhosis progressivity with 81% sensitivity to assess the severity of cirrhosis that APRI is the patients AST value and the platelet. In liver cirrhosis will turns into hyperbillirubine. Intrahepatic phase involves inflammation or abnormalities in the liver that interfere with the removal of bilirubin. This study aims to determine the correlation between APRI and serum bilirubin levels and the mean correlation between AST, ALT, platelets and serum bilirubin levels in patients with hepatic cirrhosis due to hepatitis C virus infection at RSUD Dr . H. Abdul Moeloek Lampung. This study used a consecutive sampling research design and was conducted in June-July 2020. The study sample was 51 subjects. The data used in this study are secondary data, namely medical records. The case group consisted of 27 male patients and 24 female patients. Data were analyzed using Pearson test. : The results of bivariate analysis between APRI and serum bilirubin levels showed a p value of 0.000 which indicates a positive and very strong correlation between APRI and serum bilirubin levels, positive and strong correlation between AST and ALT with serum bilirubin levels, and negative and sufficient correlation between platelets and Serum Bilirubin levels in patients with hepatic cirrhosis due to hepatitis C virus infection at Dr. H. Abdul Moeloek Lampung
Efektivitas Ekstrak Buah Adas (Foeniculum vulgare) Terhadap Penurunan Kadar Glukosa Darah Siti Maharani; Intanri Kurniati; Agustya Tjiptaningrum
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.574

Abstract

Diabetes mellitus is a condition that occurs when blood glucose levels exceed normal limits. This is caused by the pancreas not producing enough insulin or because the insulin produced is not effective in helping the absorption of glucose into the body's cells. The prevalence of diabetes in 2019 in the world is estimated to reach 463 million people aged 20-79 years. Diabetes mellitus affects more men in the world, namely 9.65% of the world's population, while the prevalence of sufferers is female as much as 9%. Indonesia is ranked 7th with the most diabetes mellitus sufferers in the world. Indonesia has as many as 10.7 million people with diabetes mellitus recorded. DKI Jakarta ranks first with the most diabetes mellitus sufferers in Indonesia, namely 3.4% of the population. Diabetes mellitus treatment does not aim to cure the disease completely, but only to control blood sugar levels so that they are within normal limits. One of the causes of diabetes mellitus is due to oxidative stress. One of the herbal plants known to have antioxidant content is fennel fruit (Foeniculum vulgare). occurrence of oxidative stress. Fennel contains flavonoids, saponins, cardiac glycosides, terpenoids, and tannins. These compounds have an antihyperglycemic effect by inhibiting alpha glucosidase. Flavonoids are antioxidant compounds that can play a role in preventing oxidative stress associated with diabetes mellitus.
Hubungan Konsumsi Kafein dengan Kejadian Depresi Indah Salsabila; Putu Ristyaning Ayu Sangging; Intanri Kurniati; Ratna Dewi Puspitasari
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.488

Abstract

Depression is a mood disorder. Depression is characterized by a feeling of sadness that lasts continuously and for a long time, which can interfere with a person's physical condition and social life. Around 121 million people in the world suffer from depression. It is estimated that only 30% of people with depression get proper treatment. This number does not include people who have clinical symptoms of depression but are not actually diagnosed. Some patients are also considered not to get proper treatment. The number of Indonesian populations aged more than 15 years and diagnosed with depression is 12 million sufferers. Pharmacological therapy in depressed patients is antidepressants such as serotonin and noradrenaline reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs). However, there are side effects that can result from long-term use of these drugs. Therefore, other treatments such as giving herbal medicines are needed to reduce symptoms in people with depression. Giving caffeine with the right dose can reduce the risk of depression, because of its ability to block the adenosine receptor subunit. However, caffeine consumption with doses above 68mg and below 509mg per day is assessed to have the opposite effect that increases the risk of developing depression.
Pola Pengobatan Coronavirus Disease-19 (COVID-19) dengan Komorbiditas Tuberkulosis Paru Pada Pasien Rawat Inap RSUD Al-Ihsan Bandung Tahun 2020 Chanief Hassan Widjaja; Novita Carolia; Intanri Kurniati
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.846

Abstract

Coronavirus disease-19 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and attacks the respiratory tract as its main target. Pulmonary tuberculosis (TB) is a disease with high incidence in Indonesia and transmitted through the respiratory tract and attacks lung organs same as COVID-19, allowing the possibility for co-infection of the two microorganisms simultaneously. The purpose of this study was to determine the pattern of treatment for COVID-19 and pulmonary TB at inpatient care facility Al-Ihsan Hospital Bandung. This study was an observational descriptive study with retrospective approach. The number of samples were 15 who had COVID-19 and pulmonary tuberculosis, taken from March until December 2020 at inpatient care facility Al-Ihsan Hospital Bandung. The sample taken using the total sampling technique, then analyzed using univariate test.There are five types of drugs found in this study, which is antibiotics, anti-tuberculosisdrugs, antivirals, corticosteroids, and vitamins. The types of antibiotics used were azithromycin (80%), levofloxacin (80%), ceftazidime (13.33%), ofloxacin (6.67%), and cefotaxime (6.67%). Anti-tuberculosis drugs with fixed dose combination (FDC) were given to 13 samples (86.67%). The types of antiviral drugs used were isoprinosine (80%), oseltamivir (13.33%), and chloroquine (6.67%). The types of corticosteroid drugs used were dexamethasone (33.33%) and bethametasone (6.67%). Types of vitamins used were vitamin C (100%), vitamin B6 (6.67%), vitamin D (73.33%), and zinc supplements (33.33%).
Gangguan Sekresi dan Sensitivitas Insulin pada Remaja dengan Riwayat Keluarga Diabetes Melitus Tipe 2 Ardika, Okta Besti; Larasati, TA; Suharmanto, Suharmanto; Kurniati, Intanri
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.943

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by impaired insulin secretion or hyperglycemia due to the inability of pancreatic β-cells to compensate for increased glucose levels in the blood. The pathophysiology of T2DM may result from the interaction of environmental and genetic factors. A person who has a family history of T2DM will experience genetic mutations that cause impaired insulin secretion and sensitivity. The genetic inheritance of the child is based on the parent alleles of both parents including some genes that have mutations. There are three types of genetic inheritance mechanisms described by parent of origin effects (POE), namely genomic imprinting, mitochondrial inheritance, and maternal intrauterine effects. The mechanism of impaired insulin secretion and sensitivity in someone with a family history of T2DM during puberty, which is also triggered by stress and hormonal imbalance, results in insulin resistance, especially significant when entering adolescence and supported by a family history of T2DM. In children with a family history of T2DM, it was found that pancreatic β-cell compensation was 30% lower compared to children without a family history of T2DM.
Article Review: Faktor Risiko dan Klasifikasi Retinopati Diabetik pada Pasien Diabetes Melitus Tipe 2 Dalillah, Fathian Nur; Yusran, Muhammad; Kurniati, Intanri; Rengganis Wardani, Dyah Wulan Sumekar
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.958

Abstract

Diabetik retinopathy (DR) is a major complication of diabetes mellitus and the leading cause of vision loss. This condition can result in vision impairment and even blindness if not promptly and accurately managed. Risk factors that can increase the likelihood of someone experiencing diabetik retinopathy include age, gender, poor glycemic control, hypertension, dyslipidemia, pregnancy, and smoking. Several of these risk factors can lead to diabetik retinopathy through various mechanisms, such as increased oxidative stress, elevated permeability of retinal blood vessels, formation of hard exudates, and other mechanisms. The classification of diabetik retinopathy is divided into two types: nonproliferative diabetes retinopathy (NPDR) and proliferative diabetes retinopathy (PDR). Nonproliferative is further categorized into three severity levels: mild, moderate, and severe, while proliferative is divided into advanced and very advanced stages. The global prevalence of diabetik retinopathy is approximately 34.6%. In Indonesia, the prevalence of diabetes has reached 10.7 million people, making it one of the top 10 countries with the highest diabetes incidence in the world. The province of Lampung also has a significant number of diabetes cases. According to a study, the prevalence of diabetes in Lampung Province is 9.3%. The objective of this article is to enhance comprehension regarding the risk factors impacting the progression of Diabetic Retinopathy (DR). This piece will explore the factors that contribute to an increased severity of DR.
Systematic Review: Hubungan Obesitas dengan Risiko Benign Prostat Hiperplasia Armadani, Melni; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.978

Abstract

Benign prostatic hyperplasia (BPH) is a non-malignant growth of prostate tissue. The incidence of BPH is influenced by various risk factors such as metabolic syndrome, obesity, and genetic predisposition. The prevalence of obesity in Indonesia with a male population over 18 years old was recorded at 26.60%. The research used a systematic review method. The databases used are NCBI and PUBMED with bulletions namely Benign prostate hyperplasia AND obesity, Benign prostate hyperplasia AND cholesterol, or Benign prostate hyperplasia AND body mass index. Obesity can trigger pro-inflammatory conditions, one of which is micro vascular disease which results in inflammation triggering ischemia and oxidative stress. Obesity can involve changes in the expression of genes such as A2M in the stroma and TFFB3 in the prostate gland and induce sIL-1ra levels.Obesity is associated with the risk of BPH through inflammatory response mechanisms from cellular and humoral microvascular inflammation, programmed cell death, gene expression and sIL-1ra levels.
Nutrional Management in Chronic Kidney Disease Patients: Manajemen Gizi pada Pasien Chronic Kidney Disease (CKD) Al Farisi, Ahmad Fathin; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.982

Abstract

Chronic Kidney Disease (CKD) is kidney function disorder for >3 months. CKD is also a concern because of its relatively high prevalence and is one of the most common causes of death in Indonesia. A number of treatments that can be carried out in CKD patients depend on the symptoms, comorbidities, and complications in the patient. Management of CKD patients can be medical, operative, to conservative. Assessment of nutritional status is also a concern in patients with CKD because it is not uncommon for a decrease in nutritional status to occur. CKD patients undergoing dialysis treatment are more prone to experience protein-energy wasting (PEW). There are a number of nutritional therapies that can be performed on CKD patients, namely a low-protein diet, regulation of energy intake, oral supplementation, and IPPN/IPAA
Manajemen Terapi Acute Kidney Injury (AKI) Suherman, Auriva Renasha; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.983

Abstract

Acute Kidney Injury (AKI) is a syndrome characterized by decreased urine production and increased serum creatinine. AKI is a complication in 10 to 15% of patients in hospital and the incidence of AKI in the Intensive Care Unit (ICU) is 20 to 50%. AKI has 3 stages and based on etiology it is divided into 3, namely pre-renal, renal, and post-renal. AKI can be a complication of disease and can cause complications up to end-stage kidney disease. Biomarkers of AKI are not only a guide in diagnosis, but also a guide in the management of AKI. Prevention and management of AKI needs to be carried out in patients. Several AKI treatments that can be carried out include the administration of isotonic crystalloid, Hydroxerthylstarch, vasopressors, diuretics, vasodilators, GF intervention, glycemic control, and nutritional support.
Diagnosis And Treatment of Testicular Torsion Hilmi, Tamadar; Kurniati, Intanri; Hadibrata, Exsa
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.987

Abstract

Testicular torsion is an urgent medical condition that occurs when one or both testicles experience rotation or reversal in the scrotum, thereby disrupting blood flow to the testicles. Testicular torsion usually occurs in young male patients (<25 years). If this occurs it can cause rapid testicular ischemia. Furthermore, if ischemia is not treated immediately, it can threaten the safety of the testicles and affect men's reproduction and quality of life. This disease causes 10% to 15% of acute scrotal disease in children, and causes an orchiectomy rate of 42% in boys undergoing testicular torsion surgery. This article discusses testicular torsion, including definition, symptoms, diagnosis, and management. Testicular torsion is characterized by complaints of pain, swelling and/or tenderness in the scrotum, loss of cremaster reflex, Deming's sign and Angell's sign. Apart from that, we will also discuss early detection techniques for testicular torsion, such as physical examination and ultrasound, which are very important for diagnosing this condition quickly. Testicular viability decreases significantly 6 hours after the onset of symptoms therefore early diagnosis is key. Immediate treatment with manual detorsion or surgery is necessary to restore blood flow to the testicle affected by torsion. Delay in action can cause permanent damage to the testicular tissue. Since testicular torsion is a very time-sensitive diagnosis, it may also be subject to many medicolegal challenges.
Co-Authors Ade Yonata Ade Yonata, Ade Agustya Tjiptaningrum Agustyas Tjiptaningrum Agustyas Tjiptaningrum Al Farisi, Ahmad Fathin Al Ghifari, Ghaza Ahmad Alyssa Fairudz Shiba Andriani, Silvia Angelia, Tisa Anggraeni Janar Wulan Anggraeni Janar Wulan, Anggraeni Janar Aprilia, Sandrina Audy Ardika, Okta Besti Arif Yudho Prabowo Arisqan, Ferdian Syukri Armadani, Melni Audah, Kholis A. Azhar, Hafidz Sirojudhin Bagus Pratama Bayu Anggileo Pramesona Chanief Hassan Widjaja Dalillah, Fathian Nur Deborah Natasha Dewi Nur Fiana Dian Isti Angraini Diana Mayasari Ety Apriliana Evi Kurniawati Evi Kurniawati, Evi Fadhlurrahman, Fadhlurrahman Febilla Naili Alfalah Ferry Mulyadi Fidha Ramayani Giska Tri Putri Hadibrata, Exsa Helmi Ismunandar Hendri Busman Hilmi, Tamadar Indah Purnama Sari Indah Salsabila Indri Windarti Intan Kusumaningtyas Iswandi Darwis Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Jonathan Rivaldo Gultom Kamila Salsabila Karima, Nisa Kenos Stefanus Khairun Nisa Kurniawaty, Evi Muhammad Ricky Ramadhian Muhammad Yusran Muhartono Muhartono Nasution, Salwa Salsabila Ni Made Shanti Novita Carolia Nurrahma, Alya Nabila Nurul Utami Oktadoni Saputra Putri, Morica Angellia Shyama Putri, Najwa Naraniya Putu Ristyaning Ayu Qurani, Istiqomatul rahmawati, selvi Rana Noor Fakhira Siregar Rani Himayani Ratna Dewi Puspita Sari Ratna, Maya Ganda Rengganis Wardani, Dyah Wulan Sumekar Reni Zuraida Risti Graharti Rizki Hanriko Rizky Agung Purnomo Roro Rukmi Windi Perdani, Roro Rukmi Sangging, Putu Ristyaning Ayu Septia Eva Lusina Septiani, Linda Setiawan, Gigih Sinaga, Herman Fransiskus Siti Maharani Suci, Maghfirly Juniarti Eka Suharmanto Suherman, Auriva Renasha Susianti Susianti, Susianti Syazili Mustofa TA Larasati Tibar, Fifi Nurliza Aini Tutik Ernawati Utari Gita Mutiara Vira Katya Aurelia Winda Trijayanthi Utama, Winda Trijayanthi Wulan, Anggraini Janar Yuningrum, Hesti