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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Berkala Perikanan Terubuk Alchemy : Journal of Chemistry The Journal of Pure and Applied Chemistry Research Jurnal Agroekoteknologi Pharmacon CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Teknologi Laboratorium Chimica et Natura Acta Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jambura Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Gema Wiralodra Canrea Journal: Food Technology, Nutritions, and Culinary Journal Bubungan Tinggi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Indonesia Jurnal IPTEK Bagi Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Hydrological and Environmental for Sustainability Makara Journal of Science Jurnal Farmasi Sains dan Praktis JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR) Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry Jurnal Sains dan Kesehatan JURNAL REKAYASA KIMIA & LINGKUNGAN DIVERSITAS HAYATI: Journal of Conservation and Biological Resources
Madyawati Latief
Prodi Kimia Fakultas Sains Dan Teknologi Universitas Jambi
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Journal : Alchemy : Journal of Chemistry

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Studi In Silico Senyawa Bioaktif Kopi Arabika (Coffea Arabica) Sebagai Kandidat Antikanker terhadap Reseptor PI3K p110-delta subunit Melani, Fitria; Putri, Silvi Ayudiah; Zulnita, Anis; Latief, Madyawati; Sutrisno, Sustrisno; Tarigan, Indra Lasmana
ALCHEMY:Journal of Chemistry Vol 13, No 1 (2025): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v13i1.28636

Abstract

Each year, 9.6 million people lose their lives to cancer, making it the world's second worst killer. Cancer is a disorder that results from genetic changes and has abnormal growth and spreads to other parts of the body. Cancer treatment is currently done with chemotherapy which has unfavorable side effects, so research needs to be done to determine safer alternatives to cancer treatment. This study aims to determine the activity of bioactive compounds in Arabica coffee beans that have potential as anticancer through identification of target receptors and interaction studies using molecular docking methods against PI3K p110-delta subunit receptors. The results showed that of the 21 compounds, five compounds gave good results, namely compounds 4-O-feruloylqunic acid, 4-O-caffeoylqunic acid, gluconic acid, 3-O-feruloylqunic acid and 3-O-caffeoylqunic acid with bond energy (ΔG) and inhibition constant values of -5.47; -5.33; -4.73; -4.69; -4.40 kcal/mol and 98.02; 123.62; 340.97; 363.82; 591.97 μM, respectively. So that these test ligands/compounds can have potential as PI3K receptor inhibitors in cancer treatment
Co-Authors -, Maison Addion Nizori Ahmad Fadhil Alfi Khatib, Alfi Alrizal, Alrizal Amanda, Dwi Rahma Amanda, Hilda Anggi Ayunda Triani Anggun Tri Fisesa Ardhica, Jammes Arum, Dewi Azizah, Regina Wan Batubara, Ummi Mardhiah Bela, Anisa Betharia Juli Mas Tambunan Br Sembiring, Vera Lorensya Budiyanto Budiyanto Budiyati Ichwan Bulan, Catherine Putri Delviani, Delviani Dewi, Tribuana Tungga Dwi Wahyu Ramadhan Dyah Puspitasari, Ratih Elis Kartika Ermadani Ermadani Faizar Farid Farah, Farah Fauzan Azima Fikriansyah, Muhammad Fiolita Etsa Aurora Fisesa, Anggun Tri Fitrianingsih Fitrianingsih FITRY TAFZI Havizur Rahman Helmina Mandalahi Helmina Mandalahi, Helmina Hengky Irawan, Hengky Heriyanti Heriyanti Heriyanti Heriyanti, Heriyanti Humaryanto, Humaryanto Husna, Naimul Ihsan, Mahya Ilmavia Wilantika Indra Lasmana Tarigan Jamaludin Al-Anshori Kharisma, Tiara Kurnia Nastira Ningsih Lenny Marlinda Lince Muis Lince Muis Lizawati Lizawati Lucky Zaehir Maulana Maharani, Rizky Maharani, Viola Giary Rizkillah Masruri Masruri Melani, Fitria Muhaimin Muhaimin Muhaimin Muhaimin Mursyid Djawas Nabila, Annisa Candra Nadia Rahmasari Natasya, Dian Nelson Nelson Nelson Nindita Clourisa Amaris Susanto Nurjannah, Sofia Nurul Huda Oktavioni, Marsella Pebralia, Jesi Prabawa, Satria Prahandika, Graha Puspitasari, Ratih Dyah Putri Maya Sari Putri Maya Sari Putri Maya Sari Putri, Silvi Ayudiah Putri, Yunika Eka qurrota aini Rahayu Sindy Ramadhan, Ilham Ifandi Ratih Dyah Puspitasari Razai, Tengku Said Resta, Ichy Lucya Restina Bemis Restina Bemis, Restina Riany, Hesti Rizki Ananda Rosi Rahayu Saharin, Siti Munirah Samsidar Samsidar Saputra, Muhammad Furqon Novryan Sarah Aknesia Marbun Sari, Tika Seow, Eng Keng Shadrina, Putri Nur Shindi Amanda Rizki Sholeha Annisa Martines Silaban, Desy Vania Silvi Leila Rahmi Sinurat, Julius Alvin Novensius Suci, Ulan Susanto, Nindita Clourisa Amaris Sutrisno Sutrisno, Sustrisno Sutrisno, Sutrisno Tarigan, Indra L. Uce Lestari Vitadella, Veronika Warni, Tri Wazzan, Huda Winda Dwi Setiawati Wulan Safitri, Wulan Yana Cahyana Yoza Fendriani Yulianti, Nike Desvi Yusnaidar Yusnaidar Yusnaidar, Yusnaidar Yusof, Yus Aniza Zulnita, Anis