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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Alchemy : Journal of Chemistry The Journal of Pure and Applied Chemistry Research Jurnal Agroekoteknologi CHEMPUBLISH JOURNAL JOURNAL ONLINE OF PHYSICS Jurnal Teknologi Laboratorium Chimica et Natura Acta Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jambura Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Canrea Journal: Food Technology, Nutritions, and Culinary Journal Jurnal Pengabdian Masyarakat Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal of Hydrological and Environmental for Sustainability Makara Journal of Science JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR) Jurnal Pengabdian Pada Masyarakat Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry Jurnal Sains dan Kesehatan JURNAL REKAYASA KIMIA & LINGKUNGAN
Madyawati Latief
Prodi Kimia Fakultas Sains dan Teknologi Universitas Jambi
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Journal : CHEMPUBLISH JOURNAL

 1 
KARAKTERISASI SENYAWA DARI FRAKSI AKTIF ANTIBAKTERI DAUN Garcinia celebica linn (Kandis) Latief, Madyawati
CHEMPUBLISH JOURNAL Vol 1, No 1 (2015)
Publisher : Program Studi Kimia FST Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.759 KB)

Abstract

Telah diisolasi 3-oxofridelin dari fraksi etil asetat yang merupakan fraksi aktif antibakteri dari daun Garcinia celebica (Guttiferae).  Struktur molekul senyawa ditetapkan berdasarkan data spektroskopi IR, 1H dan 13C NMR serta perbandingan data tersebut dengan data sejenis yang telah dilaporkan.  Aktivitas antibakteri dari senyawa isolasi juga diuji dengan menggunakan bakteri  Escherichia coli, Shigella dysentriae, Bacillus subtilis dan Staphylococcus aureus. Kata Kunci : Garcinia celebica, Guttiferae, fridelin, antibakteri
ADSORPSI MERKURI (II) MENGGUNAKAN ZEOLIT DARI FLY ASH BATUBARA Mandalahi, Helmina; Muis, Lince; Latief, Madyawati
CHEMPUBLISH JOURNAL Vol 1, No 1 (2015)
Publisher : Program Studi Kimia FST Universitas Jambi

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Abstract

Pembuatan zeolit dari abu terbang batubara dan diaplikasikan sebagai adsorben untuk penyerapan merkuri (II) telah dilakukan. Zeolit dibuat dari abu terbang batubara dengan menggunakan metode solid state dan dikarakterisasi dengan menggunakan XRD dan FTIR. Adsorpsi merkuri (II) menggunakan zeolit dilakukan dengan variasi suhu furnace dan waktu kontak. Hasil karakterisasi dengan XRD memperlihatkan bahwa tipe zeolit adalah Faujasit dengan puncak pada 6,0688°; 15,3959°; dan 23,2781°. Karakterisasi dengan FTIR menunjukkan bahwa abu terbang dapat digunakan untuk pembuatan zeolit pada 462,92 cm-1. Adsorpsi merkuri (II) menggunakan zeolit menunjukkan bahwa suhu optimum furnace adalah 7500C dan waktu kontak optimum pada 150 menit. Data isoterm digambarkan dengan Persamaan Langmuir dan kinetika adsorpsi mengikuti model kinetika orde dua pseudo dengan konstanta laju adsorpsi adalah 0,818 (g/mg min). Kata kunci: abu terbang, batubara, zeolit, adsorpsi, merkuri (II)  
Flavonoid Compounds from Ethanol Extract of Sungkai Leaves (Peronema canescens. Jack) and Antibacterial Activity Test Against Staphylococcus epidermidis and Escherchia coli Susanto, Nindita Clourisa Amaris; Ardhica, Jammes; Nelson; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41653

Abstract

The rise of antibiotic-resistant bacteria has intensified the global search for alternative antimicrobial agents, particularly from natural sources. Traditional medicinal plants have been widely recognized for their therapeutic potential, and Peronema canescens Jack is well-known to contain bioactive compounds. Among its pharmacological properties, its antibacterial potential has drawn scientific interest. Secondary metabolites such as flavonoids, tannins, and phenolics are believed to contribute to its antimicrobial activity. However, the specific antibacterial compounds in P. canescens remain largely unidentified. This study seeks to isolate and characterize antibacterial compounds from the ethanol extract of Sungkai leaves, aiming to discover new natural antibacterial agents. The research objectives include isolating antibacterial compounds using maceration extraction and fractionation, conducting phytochemical screening to identify metabolite classes, assessing antibacterial activity using the paper disc diffusion method, and characterizing bioactive isolates through UV-Vis spectrophotometry and FTIR analysis. The results indicate that the ethyl acetate fraction of the ethanol extract of P. canescens leaves exhibits significant antibacterial activity, particularly at concentrations of 500 and 1000 ppm. UV-Vis spectrophotometric analysis identified flavonoid compounds, including apigenin, flavones, and flavonols, based on characteristic absorption peaks. FTIR analysis confirmed the presence of functional groups associated with flavonoids, supporting their antibacterial potential. These findings highlight P. canescens as a promising source of natural antibacterial agents. Further studies focusing on compound purification and in vivo antibacterial testing are recommended to explore its pharmaceutical applications.
Formulation and Characterization of Microencapsules Containing Ethanol Extract of Sungkai Leaves (Peronema canescens Jack) Tarigan, Indra Lasmana; Farah, Farah; Puspitasari, Ratih Dyah; Saharin, Siti Munirah; Latief, Madyawati
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.43042

Abstract

The Sungkai plant (Peronema canescens Jack) is a widely recognized medicinal plant in Indonesia, with its leaves recently gaining attention for their potential health benefits. This study explores the microencapsulation of ethanol extract from Sungkai leaves using three different coating materials—maltodextrin, inulin, and Arabic gum—at varying concentrations. The aim of this study was to identify the optimal microencapsulation formulation using these materials. Microencapsulation was performed using the extrusion method, and the best formulation was characterized by evaluating its physicochemical properties, morphology, and infrared (IR) spectrum. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The results showed that microencapsulant formulation A1 exhibited superior physicochemical properties compared to other formulations. Scanning electron microscopy (SEM) analysis of sample A1 revealed a smooth surface with a slightly rounded shape and minimal wall folds or cracks, suggesting good stability. Fourier-transform infrared (FTIR) analysis confirmed effective encapsulation of the ethanol extract. While the crude extract demonstrated the highest antioxidant activity, microencapsulation slightly reduced this activity. Among the microencapsulated samples, formulation A1 (using Arabic gum) retained the most antioxidant potential. In conclusion, formulation A1, utilizing Arabic gum as the coating material, was found to be the optimal microencapsulation formulation for the ethanol extract of Sungkai leaves.
Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies Fikriansyah, Muhammad; Nelson, Nelson; Latief, Madyawati; Tarigan, Indra Lasmana
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.23726

Abstract

Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values ​​of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.
Antioxidant Activity of Bioactive Compounds in the Ethyl Acetate Extract of Putat Leaves (Planchonia valida) Nelson; Silaban, Desy Vania; Farid, Faizar; Puspitasari, Ratih Dyah; Tarigan, Indra Lasmana; Ramadhan, Ilham Ifandi; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41632

Abstract

The Putat leaf (Planchonia valida) is a plant traditionally used by the community in the Tanjung Lanjut area, Jambi, both as a salad ingredient and as a traditional medicine to treat skin diseases and promote health. This identifies that the putat plant contains chemical compounds that potentially have antioxidant activity. In this study, putat leaf samples (Planchonia valida) that potentially have antioxidant activity. In this study, Planchonia valida (P. valida) leaf samples using n-hexane and ethyl acetate solvents through a multistep maceration process. Subsequently, phytochemical screening and antioxidant activity tests were conducted to obtain information about fractions that have the potential to be further isolated. The extraction percentage with a yield value of 1,28% was obtained in the maceration process. Further isolation was carried out using isolate liquid chromatography and FT-IR instruments. The obtained isolate was in the form of a wet solid, and through characterization, it was classified as a steroid compound suspected to be ergosterol. Free radicals or oxidants have reactive effects on the human body and can trigger various types of diseases. Antioxidants are known to have the ability to inhibit or neutralize free radicals in the human body. This study tested antioxidant activity using the DPPH (1,1-diphenyl-1,1-picrylhydrazyl) method on isolating F1. Isolate F1 was found to have antioxidant activity with a value of 714.637 ppm, falling into the range of weak antioxidant activity
Isolasi Proses Bioaktif Ekstrak Metanol Daun Putat (Planchonia valida) sebagai Antioksidan Farid, Faizar; Br Sembiring, Vera Lorensya; Nelson, Nelson; Saputra, Muhammad Furqon Novryan; Putri, Silvi Ayudiah; Tarigan, Indra Lasmana; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41634

Abstract

Putat leaves (Planchonia valida) are a plant that is traditionally used by people in the Tanjung Lanjut areas, Jambi as fresh vegetables, and as a traditional medicine to treat skin diseases and restore health. This identifies that the putat plant contains chemical compounds that have the potential to have antioxidant activity. Extraction was carried out using n-hexane and ethyl acetate solvents using multistage maceration. Next, phytochemical screening and antioxidant activity tests are carried out to obtain information about fractions that can potentially proceed to the isolation stage. In the maceration process, an extract percentage was obtained with a yield value of 1.39%. Next, isolation was carried out using vacuum liquid chromatography. The isolates obtained were then characterized using UV-Vis and FT-IR spectrophotometer instruments. The isolate obtained was in the form of a wet solid, and if seen through characterization, it belonged to the class of steroid compounds; it was suspected to be an ergosterol compound. Antioxidants are known to have the ability to inhibit and reduce the presence of free radicals in the human body. In this study, antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrihidazil) method on F1 isolates. The F1 isolate obtained was proven to have antioxidant activity with a value of 99.2265 ppm, which is classified in the strong antioxidant activity range.
KARAKTERISASI SENYAWA DARI FRAKSI AKTIF ANTIBAKTERI DAUN Garcinia celebica linn (Kandis) Latief, Madyawati
Chempublish Journal Vol. 1 No. 1 (2016): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (139.759 KB)

Abstract

Telah diisolasi 3-oxofridelin dari fraksi etil asetat yang merupakan fraksi aktif antibakteri dari daun Garcinia celebica (Guttiferae).  Struktur molekul senyawa ditetapkan berdasarkan data spektroskopi IR, 1H dan 13C NMR serta perbandingan data tersebut dengan data sejenis yang telah dilaporkan.  Aktivitas antibakteri dari senyawa isolasi juga diuji dengan menggunakan bakteri  Escherichia coli, Shigella dysentriae, Bacillus subtilis dan Staphylococcus aureus. Kata Kunci : Garcinia celebica, Guttiferae, fridelin, antibakteri
Co-Authors -, Maison Addion Nizori Alfi Khatib, Alfi Alrizal, Alrizal Amanda, Dwi Rahma Amanda, Hilda Ardhica, Jammes Arum, Dewi Azizah, Regina Wan Bela, Anisa Br Sembiring, Vera Lorensya Budiyanto Budiyanto Budiyati Ichwan Bulan, Catherine Putri Delviani, Delviani Dewi, Tribuana Tungga Dyah Puspitasari, Ratih Elis Kartika Ermadani Ermadani Faizar Farid Farah, Farah Fauzan Azima Fikriansyah, Muhammad Fisesa, Anggun Tri Helmina Mandalahi, Helmina Hengky Irawan, Hengky Heriyanti Heriyanti, Heriyanti Humaryanto, Humaryanto Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Kharisma, Tiara Lenny Marlinda Lince Muis Lizawati Lizawati Lucky Zaehir Maulana Maharani, Rizky Maharani, Viola Giary Rizkillah Masruri Masruri Melani, Fitria Muhaimin Muhaimin Mursyid Djawas Nabila, Annisa Candra Natasya, Dian Nelson Nelson Nelson Nurjannah, Sofia Nurul Huda Oktavioni, Marsella Pebralia, Jesi Prabawa, Satria Prahandika, Graha Puspitasari, Ratih Dyah Putri Maya Sari Putri, Silvi Ayudiah Putri, Yunika Eka qurrota aini Ramadhan, Ilham Ifandi Razai, Tengku Said Resta, Ichy Lucya Restina Bemis, Restina Riany, Hesti Rizki Ananda Saharin, Siti Munirah Samsidar Samsidar Saputra, Muhammad Furqon Novryan Sari, Tika Seow, Eng Keng Shadrina, Putri Nur Silaban, Desy Vania Silvi Leila Rahmi Sinurat, Julius Alvin Novensius Suci, Ulan Susanto, Nindita Clourisa Amaris Sutrisno, Sustrisno Sutrisno, Sutrisno Tarigan, Indra L. Uce Lestari Vitadella, Veronika Warni, Tri Wazzan, Huda Wulan Safitri, Wulan Yana Cahyana Yoza Fendriani Yulianti, Nike Desvi Yusnaidar, Yusnaidar Yusof, Yus Aniza Zulnita, Anis