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All Journal Seminar Nasional Aplikasi Teknologi Informasi (SNATI) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences COPING (Community of Publishing in Nursing) Jurnal Sendratasik JURNAL MATEMATIKA STATISTIKA DAN KOMPUTASI Berkala Ilmiah Pendidikan Biologi (BioEdu) Jurnal Bahan Alam Terbarukan JSI: Jurnal Sistem Informasi (E-Journal) Jurnal Online Mahasiswa (JOM) Bidang Ilmu Keperawatan Jurnal Online Mahasiswa (JOM) Bidang Pertanian Jurnal Online Mahasiswa (JOM) Bidang Perikanan dan Ilmu Kelautan Jurnal Pseudocode SITEKIN: Jurnal Sains, Teknologi dan Industri J-Simbol: Jurnal Magister Pendidikan Bahasa dan Sastra Indonesia Jurnal Studi Sosial Program Pascasarjana P-IPS Jurnal Minds: Manajemen Ide dan Inspirasi Seminar Nasional Teknik Kimia Kejuangan Indonesian Journal of Pharmaceutical Science and Technology Biocelebes Jurnal Ilmiah Rekayasa dan Manajemen Sistem Informasi Jurnal Ilmiah Mahasiswa Ekonomi Manajemen Akuisisi : Jurnal Akuntansi Sistemasi: Jurnal Sistem Informasi RABIT: Jurnal Teknologi dan Sistem Informasi Univrab HIGIENE: Jurnal Kesehatan Lingkungan Jurnal CoreIT Journal of Livestock Science and Production Jurnal Ilmiah Pena: Sains dan Ilmu Pendidikan Seminar Nasional Teknologi Informasi Komunikasi dan Industri Jurnal Eksplora Informatika Jurnal Kimia Terapan Indonesia JURNAL SERAMBI ILMU Media Gizi Pangan Etika Demokrasi AGRINESIA: Jurnal Ilmiah Agribisnis Jurnal Keperawatan Suaka Insan Jurnal Ilmu Kefarmasian Indonesia AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Prosiding Konfererensi Nasional Bahasa Arab Bawi Ayah: Jurnal Pendidikan Agama dan Budaya Hindu Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Majalah Ilmiah Warta Dharmawangsa Jurnal Syntax Transformation Akrab Juara : Jurnal Ilmu-ilmu Sosial INDONESIAN JOURNAL OF BASIC EDUCATION Jurnal Pendidikan Hayati NUSANTARA: Jurnal Pengabdian Kepada Masyarakat JURNAL MUARA PENDIDIKAN Jurnal Marital: Kajian Hukum Keluarga Islam Jurnal Ilmiah Research Student Jurnal Akademik Pengabdian Masyarakat JURNAL ILMIAH PENELITIAN MAHASISWA MAPAN: Jurnal Manajemen Akuntansi Palapa Nusantara Inovasi Kesehatan Global Jurnal Intelek Insan Cendikia Zoologi: Jurnal Ilmu Peternakan, Ilmu Perikanan, Ilmu Kedokteran Hewan Jurnal Manajemen Kewirausahaan dan Teknologi Jurnal Ekonomi Bisnis dan Kewirausahaan Manfish: Jurnal Ilmiah Perikanan dan Peternakan Jurnal Manajemen Bisnis Digital Terkini Jurnal Perikanan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Megawati Megawati
Research Center for Chemistry-LIPI, Region PUSPIPTEK Serpong, Banten 15314, Indonesia
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Antidiabetic Activity of Cocor Bebek Leaves (Kalanchoe pinnata Lam.Pers.) Ethanolic Extract from Various Areas Indah Dwiatmi Dewiyanti; Euis Filailla; Megawati Megawati; Tri Yuliani
Journal of Tropical Life Science Vol. 2 No. 2 (2012)
Publisher : Journal of Tropical Life Science

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Antidiabetic activity of Cocor Bebek leaves (Kalanchoe pinnata Lam.Pers.) ethanolic extract from Bogor city, Kabupaten Bogor and south of Tangerang city has been studied. The study was conducted in vitro using glucosidase inhibitor method. The results of the study showed that IC50 of the extract from Bogor city, Kabupaten Bogor, and Tangerang Selatan city is 40.94 ppm, 33.58 ppm and 16.12 ppm respectively. Meanwhile, IC50 of quersetin which has antidiabetic activity is 10.22 ppm. The results showed that Cocor Bebek leaves (Kalanchoe pinnata Lam.Pers.) ethanolic extract had antidiabetic activity with IC50 less than 100 ppm. However, the activity is lesser than quercetin.Keywords:Kalanchoe pinnata Lam.Pers, antidiabetic activity, glucosidase inhibitor
Acute Toxicity Studies of Brucea javanica Merril Leaves Extract on Mice Marissa Angelina; Indah D Dewijanti; Banjarnahor S D S; Megawati megawati; Tri Yuliani
Journal of Tropical Life Science Vol. 2 No. 2 (2012)
Publisher : Journal of Tropical Life Science

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The objective of the study was to evaluate the oral acute toxicity of Brucea javanica Merril extract on both Male and Female DDY-Mice. Brucea javanica leaves have activity as a cytotoxic, anti-diarhhea, etc. Brucea javanica leaves extract was administered orally for first 24 hours at various dose levels (562.5mg/kg bw, 1125 mg/kg bw, 2250 mg/kg bw, and 4500 mg/kg bw) to determine the toxicity effects. The treatment groups were compared to the normal control. Vital organs (liver, heart, lymph, lungs, etc) and body weight were analyzed to study the toxicity. LD50 determined using Reed and Munich formula. Vital organs average weight showed no difference between control group and treatment groups from the lowest dose until the highest dose. In addition, the body weight data showed no difference between control group and treatment groups. LD50 for Brucea javanica extract using Reed and Munich formula was 1003.65 mg/kg bw. The result of the study showed that extract were categorized as lightly toxic.Keywords: Acute toxicity, Brucea javanica Merril, DDY-Mice, LD50
Toxicological Evaluation of Tetrameles nudiflora Methanolic Extract Sofna Dewita Sari Banjarnahor; Indah D Dewijanti; Marissa Angelina; Megawati Megawati; Sofa Fajriah
Journal of Tropical Life Science Vol. 5 No. 1 (2015)
Publisher : Journal of Tropical Life Science

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Abstract

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animals were divided into 5 groups: Group 1 was given 1 ml solution of 2.5% Tween 80 in a single oral dose; Group 2, 3, 4 and 5 were orally administrated a single dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes on body weight, and behavioural activities were recorded. Mortality was recorded up to 22% of the male group, and 11% within the female group. The T.nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50=46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically non toxic for female (LD50>15 g/kg body weight).Key words : Tetrameles nudiflora, brine shrimp lethality test, acute oral toxicity, LD 50.
Co-Authors A.Adi Al Ma’aridj Naneng Ade Kemala Jaya Agus Muchsin AGUS ROHYADI Agustinus Sahlukh Ahmad, Fairuz Subakir Ahmed Tessario Ekanuramanta Akmal Abdullah Akmal Abdullah Akrom, Akrom Ali Djamhuri Alimuddin Ali Amelia Murtisari Amirullah Amirullah Ana Syntia Andi Galsan Mahie Angraini Angraini Ardiansyah Ahsanul Hayat Arif Marsal Arli Padinu Asril Burhan Astrilia Damayanti Audivia Monica Aulia Riska Ayudita Ayudita Azriful Azriful Banjarnahor S D S Bayu Triwibowo Beny Sukma Negara Budi Leksono Budiman Haruna Christa A. M. Suares Cut Fitri Rostina Dandan Haryono Danes Suhendra Desy Putri Nawangsari Dewi Selvia Fardhyanti Dhoni Hartanto Didik Puji Wahyono Dwi Probonurtjahjo Dwi Santy Damayati Edi Suyanto Edwin Tanuwijaya Eka Rista Harimurti Eki Saputra Erlix Purnama Euis Filailla Fahrul Fahrul Fajar Restuhadi Fathra Annis Nauli Fatmawaty Suaib Fauzan Luthfi Yaumul Adha Firayani Firayani Fuji Asmiati Ningsih Hamzah, Farida Hanum Hani Mulyani Harianingsih, Harianingsih Hasnah Kanji Haspiani Haspiani Hasta Mayas Hendral Aspira Monzeri Henny Hendarti Hidayat, Puput Wahyu Ichsyan Rizky Adi Putra Idawati Syarif Idria Maita Ika Purwanti Imelda Ingir Ladjar Indah D Dewijanti Indah Dwiatmi Dewiyanti Indah Permata Sari Intan Fasya Zahara Ismail Ismail Jeri Lusrian Kelvien Santho Kevin Thomas Khairuddin - Khairunnisa Hadji Ali Krisna Darma Yanti Lumbessy, Salnida Yuniarti Lydia Fanny M Angelina M. Reza Prayogge M.Wahyu Pratama Mahludin H. Baruwadi Maria Ulfa Marissa Angelina Marwati Marwati Mentari Tri Indah Rahmayani Mimi Kazmaini Mirnawati Salampe Mirza Aulia Rahman Mokhtar Sayyid Muhajirin Muhajirin Muhammad David Muhammad Jazman Muhammad Luthfi Hamzah Munnawaroh RR Naning Yuniarti Nasution, Annio Indah Lestari Natasya indriyanti Dg.Maralla Nesdi Evrilyan Rozanda Noer Fauziah Rahman Nova Oktaviani Nur Alam Kasim Nurhalima Nurhalima Nurlaksana Eko Rusminto Nursamsiar Nursamsiar Nurul Huda Nuryoto Nuryoto Nur’aini Maftukhah Oswati Hasanah Pujiati Pujiati Purwoko, Agus Putra, Randi Eka Rabiatul Adawiyah Raharjo Raharjo Rahmawati Rahmawati Ramadhanil pitopang Ratna Dewi Kusumaningtyas Reni Novita Sari Reski Mai Candra Ridha Fitri Ridwan Manda Putra Rijal, Rijal Rimet, Rimet Rini Nuraeni Rizna T D Ruth Samaria Pardede Sinta Melisa Sisca Oktavia Siti Nurwahida Siti Patimah Sofa Fajriah Sofna Dewita Sari Banjarnahor Sri Ernawati Suardi Suardi Suasa Suasa Sudjarwo Sudjarwo Suhartina Suhartina Susmiarti Syaifullah Syaifullah Syaifullah Syaifullah Syariful Anam Tengku Khairil Ahsyar Tengku Khairil Ahsyar Tita Alisya Tri Yuliani Umi Riyani Verawaty Verawaty Vina Dhiean Agustina Vonny Setiaries Johan Wanda Afita Windarti Windarti Wisnu Caraka Adi Wuri Ratu Amnan Yusmarini Yusmarini Yusri Muhammad Yusuf Zarnelly Zarnelly Zarnelly Zarnelly