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All Journal Jurnal Kedokteran Syiah Kuala Jurnal EduBio Tropika Majalah Kesehatan FKUB Klasikal: Journal of Education, Language Teaching and Science Heart Science Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Narra J Abdimas Langkanae Al-Khidmah Jurnal Pengabdian Masyarakat INOVASI: Jurnal Hasil Pengabdian Masyarakat DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Room of Civil Society Development Seminar Nasional Hasil Penelitian LP2M UNM Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) JIPI (Jurnal IPA dan Pembelajaran IPA) Trends in Infection and Global Health Media Penelitian dan Pengembangan Kesehatan Jurnal Pengabdian Dian Mandala International Journal of Economic Entrepreneurship and Business Management Peternakan Abdi Masyarakat (PETAMAS) Room of Civil Social Development
Mudatsir Mudatsir
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Journal : Heart Science Journal

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Ascorbic acid and calcitriol as alternative preventive strategies for myocardial damage in type 2 diabetes mellitus: an in vivo study using diabetic and atherosclerotic rat models Saputra, Jefri Dwi; Heriansyah, Teuku; Sofyan, Hamny; Dimiati, Herlina; Mudatsir, Mudatsir
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.14

Abstract

BACKGROUND: Type 2 diabetes mellitus can increase the production of reactive oxygen species (ROS) and genetic transcription factors, such as nuclear factor kappa beta (NF-κB). These phenomena may enhance the progression of atherosclerosis. Additionally, NF-κB can induce apoptosis of pancreatic beta cells and accelerate disease progression. OBJECTIVE: To investigate the role of calcitriol and ascorbic acid on NF-κβ expression in vivo in aortic and myocardial tissues of Wistar rats. METHODS: This randomized experimental study involved 24 male Wistar rats of the Rattus norvegicus strain, divided into four groups: NC (negative control), PC (positive control), AG (ascorbic acid group), and CG (calcitriol group). The study spanned 90 days, including a 30-day intervention period. Aortic and myocardial samples were processed into histological preparations and stained using immunohistochemical techniques. NF-κB expression was assessed using an intensity scoring method. RESULTS: The CG group demonstrated the lowest NF-κB immunoexpression in myocardial tissue (0.27 ± 0.08), followed by the AG (0.37 ± 0.05), NC (0.68 ± 0.08), and PC (1.13 ± 0.34) groups, with statistically significant 3sbetween the groups (p < 0.05). In aortic tissue, the CG group also exhibited the lowest NF-κB expression (0.30 ± 0.18), followed by the AG (0.50 ± 0.09), NC (0.97 ± 0.05), and PC (1.23 ± 0.38) groups, with statistically significant differences between the groups (p < 0.05).  Similar trends were observed in the immunohistochemical staining of the NF-κB antigen in myocardial and aortic tissue samples. Calcitriol administration was more effective than ascorbic acid in reducing NF-κB expression in both myocardial (p < 0.05) and aortic tissues (p < 0.05). CONCLUSION: Both ascorbic acid and calcitriol reduce NF-κB expression in the aorta and myocardium, with calcitriol showing greater effectiveness than ascorbic acid.
Ascorbic acid and calcitriol as alternative preventive strategies for myocardial damage in type 2 diabetes mellitus: an in vivo study using diabetic and atherosclerotic rat models Saputra, Jefri Dwi; Heriansyah, Teuku; Sofyan, Hamny; Dimiati, Herlina; Mudatsir, Mudatsir
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.14

Abstract

BACKGROUND: Type 2 diabetes mellitus can increase the production of reactive oxygen species (ROS) and genetic transcription factors, such as nuclear factor kappa beta (NF-κB). These phenomena may enhance the progression of atherosclerosis. Additionally, NF-κB can induce apoptosis of pancreatic beta cells and accelerate disease progression. OBJECTIVE: To investigate the role of calcitriol and ascorbic acid on NF-κβ expression in vivo in aortic and myocardial tissues of Wistar rats. METHODS: This randomized experimental study involved 24 male Wistar rats of the Rattus norvegicus strain, divided into four groups: NC (negative control), PC (positive control), AG (ascorbic acid group), and CG (calcitriol group). The study spanned 90 days, including a 30-day intervention period. Aortic and myocardial samples were processed into histological preparations and stained using immunohistochemical techniques. NF-κB expression was assessed using an intensity scoring method. RESULTS: The CG group demonstrated the lowest NF-κB immunoexpression in myocardial tissue (0.27 ± 0.08), followed by the AG (0.37 ± 0.05), NC (0.68 ± 0.08), and PC (1.13 ± 0.34) groups, with statistically significant 3sbetween the groups (p < 0.05). In aortic tissue, the CG group also exhibited the lowest NF-κB expression (0.30 ± 0.18), followed by the AG (0.50 ± 0.09), NC (0.97 ± 0.05), and PC (1.23 ± 0.38) groups, with statistically significant differences between the groups (p < 0.05).  Similar trends were observed in the immunohistochemical staining of the NF-κB antigen in myocardial and aortic tissue samples. Calcitriol administration was more effective than ascorbic acid in reducing NF-κB expression in both myocardial (p < 0.05) and aortic tissues (p < 0.05). CONCLUSION: Both ascorbic acid and calcitriol reduce NF-κB expression in the aorta and myocardium, with calcitriol showing greater effectiveness than ascorbic acid.
Co-Authors . Zulfan Abdul Malik Setiawan Abidin, Taufik F. Abram L. Wagner Adlim Adlim Agung Pranata Agus Hendra Al Rahmad Agussabti Agussabti Ainal Mardhiah Aksa, Rahmad Al-kautsar Al-kautsar Alfingsih, Dede Alfonso J. Rodriguez-Morales Ali A. Rabaan AlKautsar, AlKautsar Allaily Allaily Amalia Sutriana Amanda Yufika Amir-Behghadami, Mehrdad Anak Agung Dewi Megawati, Anak Agung Dewi Armayanti, Feby Asrudi, Asrudi Ayulinda, Arianisah P. Bakhtiar Bakhtiar Binti Firdaus, Shausan Bouchra, Assarag Damayanti Damayanti Damayanti Damayanti Dedhi Yustendi Dedy Syahrizal Dewi Puji Rahayu Diah, Muhammad Elfrida Ratnawati Endah Widyastuti1 Enitan, Seyi Samson Evendi Evendi Fajar, Jonny Karunia Farhan, M. Farrah Fahdhienie Fathima, Raisha Ferdi Riansyah Firzan Nainu Firzan, Firzan Gani, Azhari Garjito , Triwibowo Ambar Habeahan, Nova Lina Sari Hafnati Rahmatan Hamny Sofyan Hanipah, Sri Harapan Harapan Harapan Harapan Hasan, Denny I. Herlina Dimiati, Herlina Hibran, Syukron Hilman Syarif Hizir Sofyan Ibnu Khaldun Ichsan Ichsan Ikram Ikram Ikram, Aamer Ima Maria Iqbal, Qanita Irwan Saputra Ismail Ismail Ismail, M. Nasir Iswahyudi Iswahyudi Jayawarsa, A.A. Ketut Kamil, Qatrunnada Khader, Yousef S. Koyanagi, Ai Kuldeep Dhama Kurnia F. Jamil Latief, Kamaluddin Lemu, Yohannes K. Linguissi, Laure SG. M. Aman Yaman M.Aman Yaman Maelani, Imelda Maimun Syukri, Maimun Makmur, Ali Mamun, Mohammed A. Maulana, Teuku Maulina Maulina Mellinia, Sania A. Monica, Santy Muhammad Daud Müller, Ruth Mulyadi Mulyadi Mutiara, Suci Nalapraya, Widhy Y. Nanda, Cut M. Nirwana, Aura Nur Wahyuniati, Nur Nurjannah Nurjannah Nurjannah Nurjannah Oktariani, Mutiyah Pandji Wibawa Dhewantara Parera, Aser parman parman Parperis, Konstantinos Puspita, Laurensia Elya Putri, Widia Rademaker, Marius Rahly, Fawwa Ramadana, Rizki R. Ramadhana, Ika F. Ramli, Ratu Bulkis Ratu Bulkis Ramli Rayhan, Muhammad A. Reza Maulana Rina Purnama Sari Roy Nusa Rudi Kurniawan Sah, Ranjit Said Usman Saktianggi, Panji Probo Sallam, Dina E. Samingan Samingan Samsul Anwar Saputra, Irwan Saputra, Jefri Dwi Sarifuddin Sarifuddin Sasmono, R. Tedjo Selvina, Selvina Shylvana Adella* Siagian, Afwandy Taga Siregar, Tongku N. Sirinam, Salin Sofyan, Sarwo E. Sri Hanifah Sri Jeksi Sriyanti, Cut Susanna Susanna Syahraini, Aigia Synat Keam Te, Haypheng Teuku Heriansyah, Teuku Tiara Mustika Wardani* Usman, Said Utomo, Prattama S. Vento, Sandro Viveiros-Rosa, Sandro G. Wahyuniar Wahyuniar Wartha, Eva Wira Winardi Wollina, Uwe Yesi Astri Yossadania, Asyriva Yufika, Amanda Yuliana Yuliana Yusmanidar Yusmanidar Zahrul Fuadi Zinatul Hayati Zinatul Hayati Zulfan Zulfan Zulfikar Zulfikar