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Nanda Nanda
English Department FBS UNP Padang
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Journal : Riset Informasi Kesehatan

 1 
A Test of the effectiveness of the ethyl acetate fraction of dayak onion bulbs (eleutherine bulbosa (mill.) urb) as an antihypertensive Sari, Putri Nilam; Andika, Miming; Hasnita, Evi; Hasanah, Rizqa; Fitriani, Oriza Sativa; Putra, Fajrian Aulia; Rahmadasmi, Nola; Nanda, Nanda; Handayani, Tuti
Riset Informasi Kesehatan Vol 13 No 1 (2024): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v13i1.836

Abstract

Hypertension is a condition where blood pressure exceeds normal limits, where systolic blood pressure is above 140 mmHg and diastolic blood pressure is above 90 mmHg. One plant that can lower blood pressure is Dayak onion bulbs. The aim of this study was to determine the effectiveness of the ethyl acetate fraction of Dayak onion bulbs (Eleutherine bulbosa (Mill) Urb) in reducing blood pressure in hypertensive male white rats. The method was experimental, using 36 male white rats, divided into 6 groups, namely negative control, positive control, dose group (50, 100, 200 mg/kgbb) and comparison group (catopril). The inducer used was 8% NaCl for 14 days. Blood pressure measurements are carried out using a Non-Invasive Blood Pressure (NIBP) device. Data analysis used One Way Anova and continued with the Duncan test. The results showed that administration of Dayak onion bulb ethyl acetate fraction had an effect on reducing systolic, diastolic, mean arterial blood pressure and heart rate significantly (p<0.05). The conclusion shows that the effective dose in reducing blood pressure is administration of the ethyl acetate fraction at a dose of 200 mg/kgbb. There was a histopathological improvement in the thickness of the left ventricular muscle in mice.
Co-Authors Adha, Howardi Visza Adrianto, Fajri Afrida Afrida Ahmad, Shidq Dhiyaurrahman AIDILA, DINA Aini, Latyfa’ Anggraeni, Maya Erliza Angriani, Elda Astari, Silvy Astrid, Astrid Auril, Titania Auzan, Zulfakar Azelia, Cindy Bakry, Mohammad Iqbal Balgis Balgis Bestfy Anitasari Chairunnisa Chairunnisa Chairunnisa, Yusfa Ciseta Yoda, Tilawatil Cumbhadrika, Chitto Damasri, Wulan Darman Darman Desfita, Mediana Din, Muhammad Elita, Anggun Dian Eriene, Eriene Dheanda Absharina Eva Zulisa Evi Hasnita, Evi Fatmawati, Kiki Febriana, Tita Adhaha Firmansyah, Adhitya Fitri Siregar, Irmalia Fitriani, Oriza Sativa Fitriani, Oryza Sativa Fuady, Khairul Hadinata Rambe, Indra Hamid Marpaung, Paisal Hamid, Afriadi Hasibuan, Nikmah Sari Hayat, Mustofa Howardi Visza Adha Hutabarat, Anis Pitria Ikhsan, Syarbini Imani, Rafki Indrawati Indrawati Jumriani, Jumriani Keri, Ismail Khairul, Weni Laia, Yuniati Luky Wahyu Sipahutar Magfirah Indah R Mapparessa, Nurlaela MARKUASA SIAGIAN, MUHAMMAD RAJASYAH Marvin Horale Pasaribu MASYURA, ELVIRA ENDAH Maulana, Irfahany Mawati, Mawati Melvariani Syari Batubara Miming Andika MUFIDAH, Andi Ainil Mukhlis Mukhlis Mya Yuwanita Suhanda Mya Yuwanita Suhanda Nabilla Nabilla Nandiatama, Rio Aditya Nasution, Fery Endang Ningsih, Sri Dewi Gusti Nizar Alfi, Muhamad Nurdin, Jurana Nurliani, Navila Nyoman, I Oktavia, Rahmi Olivia, Sonia Rida Pratiwi, Inggrit Prawiro, Radius Prima Astuti Handayani Pulungan, Husniah Ramadhani Putra, Fajrian Aulia Putri Nilam Sari Putri, Refalina Dwi Sagita Rafiqah Amanda Lubis, Rafiqah Amanda RAHMADANI, SHABRINA Rahmadasmi, Nola Reswita, Yefri Rizqa Hasanah Rosidin Rosidin Sa'dah, Lailatul Safrizal Safrizal Sapriani, Wiwita Saputra, Rahmat Saragi, Esrani Mutiara Br Sari, Kharisma Permata Savitri, Afridha Cita Silvy Astari Simamora, Grace July Arta Siregar, Irmalia Fitri Sufina, Meri Sumiati Sumiati Supriyono Supriyono Suraidah Suraidah, Suraidah Syaiful . Syapudra Hsb, Emdra Tanjung, Angga F. Tanra, Andi Ainil Mufidah Tesa Anggraini, Tesa Anggraini Tiarnida Nababan Try Winda4, Amisha Vina Sumsari, Vina Sumsari Wahyudi, Angga Wati, Laely Septiya Zahira, Rizka