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All Journal Journal of Food and Pharmaceutical Science JURNAL ILMIAH KESEHATAN KEPERAWATAN Disease Prevention and Public Health Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Majalah Farmaseutik Indonesian Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Jurnal Ilmiah Pharmacy PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Pharmacology and Therapy
Laela Hayu Nurani
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Pharmascience

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Efek Imunomodulator Ekstrak Etanol Akar Pasak Bumi (Eurycoma Longifolia, Jack) terhadap Ekspresi CD57 pada Hepar Tikus yang Diberi Doksorubisin Wahyuningtyas, Nurma; Amukti, Danang Prasetyaning; Nurani, Laela Hayu; Salamah, Nina
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.18499

Abstract

Agen kemoterapi yang terbukti dapat menurunkan imunitas tubuh adalah doksorubisin. Akar pasak bumi (Eurycoma longifolia, Jack) telah digunakan untuk meningkatkan imunitas serta antikanker. CD57 merupakan suatu penanda diferensiasi terminal dan  disfungsi limfosit pada sel T CD8+, CD4+, dan NK sel. Studi ini menyelidiki efek EEAPB pada ekspresi CD57 hati mencit SD (Sprague Dawley) yang diberi doksorubisin. Dalam penelitian ini, 49 tikus dibagi menjadi 7 kelompok. Kelompok I sebagai kontrol doksorubisin, kelompok II sebagai kontrol EEAPB 200 mg/kgBB, dan kelompok III, IV, dan V sebagai kelompok perlakuan doksorubisin + EEAPB 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Kelompok VI sebagai kontrol pelarut (CMC Na 1%), dan kelompok VII sebagai kontrol sehat. Penelitian dilanjutkan dengan pewarnaan hati tikus dengan imunohistokimia untuk mengidentifikasi ekspresi CD57, dan pengujian statistik dilakukan dengan SPSS. Seluruh kelompok perlakuan mempunyai efek penurunan % ekspresi CD57 secara signifikan dibandingkan dengan kelompok kontrol doksorubisin. Oleh karena itu, EEAPB dapat meningkatkan imunitas dengan menurunkan persentase ekspresi CD57 pada hati tikus strain SD yang telah diberikan doksorubisin secara signifikan dan dosis yang dapat menurunkan persentase ekspresi CD57 maksimal, yaitu 50 mg/Kg BB. Kata Kunci: Doksorubisin, Kemoterapi, Pasak Bumi, Anti kanker, Hepatoprotektor A chemotherapy agent that has been shown to lower immunity is doxorubicin. The root of pasak bumi (Eurycoma longifolia, Jack) has been used to boost immunity and as an anticancer. CD57 is a marker of terminal differentiation and lymphocyte dysfunction in CD8+, CD4+, and NK T cells. This study investigated the effect of EEAPB on liver CD57 expression of SD (Sprague Dawley) mice treated with doxorubicin. In this study, 49 mice were divided into seven groups. Group I as doxorubicin control, group II as EEAPB 200 mg/kgBB control, and groups III, IV, and V as doxorubicin + EEAPB 50 mg/kgBB, 100 mg/kgBB, and 200 mg/kgBB treatment groups. Group VI was used as solvent control (CMC Na 1%), and group VII was used as healthy control. The study was followed by staining the liver of mice with immunohistochemistry to identify CD57 expression, and statistical testing was performed with SPSS. All treatment groups had the effect of decreasing the % expression of CD57 compared to the doxorubicin control group. Therefore, EEAPB can improve immunity by reducing the percentage of CD57 expression in the liver of SD strain rats that have been given doxorubicin at a dose that reduces the maximum rate of CD57 expression, which is 50 mg/Kg BW.
Co-Authors Abdul Rohman Abdul Rohman Abdul Rohman Abdul Rohman Achmad Mursyidi Achmad Mursyidi Afiana Rohmani Agitohutomo, Muhammad Ainiyah, Nadia Putri Aisyah, Vani Aisyah, Vani Akrom Akrom, Akrom Aldri Frinaldi ANDI WIJAYA Anggita Rosiana Putri Anjar Windarsih Annisa Fatmawati Any Guntarti Any Guntarti Any Guntarti Any Guntarti Any Guntarti Arif Santoso Aris Asahi Aristiani, Windi Aristiani, Windy Astuti, Ratih Arum Azzahra, Fara Bachri, Mochammad Saiful Citra Ariani Edityaningrum, Citra Citra Dhea Cantika Danang Prasetyaning Amukti Daru Estiningsih Daud, Intan Devi Kumala Dewi Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Dewi, Devi Kemala Dian Prasasti Djannah, Sitti Nur Djannah, Sitti Nur Dwi Utami Edityaningrum, Citra Ariyani Eka Kumalasari Eka Kumalasari Eka Kumalasari Eka Sakti Wahyuningtyas Eka Wahyuning Tyas Elya Zulfa, Elya Endang Darmawan Eti Nurwening Sholikhah Eti Nurwening Sholikhah Fara Azzahra Fara Azzahra Fauziyya, Riri Feri Anggita Hastanto Feri Anggita Hastanto Fikri Achmad Arif Fitriyati, Laeli Galih Dwi Mulyati Gela Setya Ayu Putri Hari Susanti Heni Lutfiyati, Heni Heni Setyowati Esti Rahayu Hidayati, Sholihatil Husnun Khairunnisa Pratiwi Ibnu Gholib Gandjar Ibnu Gholib Gandjar Ibnu Gholib Gandjar Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ichwan Ridwan Rais Iin Narwanti Iin Narwanti Iis Wahyuningsih Intan Rahayu Irfan, Nawwar Irnawati Irnawati Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Jumina Jumina Jumina Jumina Kartikadewi, Arum Khairurrizki, Amanda Khayatulisma, Dika Kurnianto, Erwan Lalu Muhammad Irham Mahardika Agus Wijayanti Meta Safitri Milanie, Rida Dwi Miratun Syarifah Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Fikri Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mustofa Mustofa Nanik Sulistyani Nasruddin Nasruddin Nasruddin Nasruddin Nasruddin, N Nina Salamah Nining Sugihartini Nining Sugihartini Nugrahini, Febrina Nur Azizah Nur Ismiyati Nurkhasa Nurkhasa, Nurkhasa Nurkhasanah Nurkhasanah Mahfudh Nurkhasanah Nurkhasanah Putri Kurniasiwi Putri Lestari Rahma Dona Ramadhan, Muhammad Marwan Rini Sulistyawati Rizki Amelia Rohman, Abdul Salsabila, Nia Sapto Yuliani SATRIYAS ILYAS Sikumbang, Isabella Meliawati Sitarina Widyarini Sitarina Widyarini Siti Fatmawati Fatimah, Siti Fatmawati Siti Rofida Siti Salma Yusuf Siti Setianingsih Sitti Nur Djannah Sudjadi . Sugiyanto - Sulistyorini, Dwi Agustin Suwidjiyo Pramono Syarif, Yaumi Musfirah Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tri Ani Marwati Tri Yanuarto Tria Zakinah Utari, Dina Vani Aisyah Vivi Sofia Wahyu Widyaningsih Wahyuningtyas, Nurma Widea Rossi Desvita Widyarini, Sitarina Wihasty Nur Istyqomah Wiwara Awisarita Yaumi Musfirah Syarif Yeni Dianita Yeni Yeni, Yeni Dianita Yeni, Yeni Dianita Yoga Yuniadi Yusuf, Siti Salma Zainab Zainab Zainab Zainab