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All Journal Nurse Media Journal of Nursing Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Andalas obstetrics and gynecology journal Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Kedokteran Hewan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan Cermin Dunia Kedokteran
Daan Khambri
Fakultas Kedokteran, Universitas Andalas
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Jurnal Kedokteran Hewan

 1 
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki Frengki; Deddi Prima Putra; Fatma Sri Wahyuni; Daan Khambri; Henni Vanda; Vivi Sofia
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (855.035 KB) | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method “pharmacokinetics screening and molecular docking”. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki, Frengki; Putra, Deddi Prima; Wahyuni, Fatma Sri; Khambri, Daan; Vanda, Henni; Sofia, Vivi
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method pharmacokinetics screening and molecular docking. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Yanto Wijaya Arifin, Hidayat Arni Amir Asterina Aswiyanti Asri Azamris Azamris Aziza, Zulva Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Dia Rofinda, Zelly Dia Edison Edison Eka Putri Eka Putri Elfira Yusri Erlina Rustam Ermawati Ermawati Ermawati Ermawati Eti Yerizel Fadrian, Fadrian Fatma Sri Wahyuni Frengki Frengki Frengki Frengki, Frengki Hafiz, Muhammad Zaki Abdul Hafni Bachtiar Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda henny Mulyani Henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Hidayat, Nur Latifah Alfaina Husna Yetti Intan, Shinta Ayu Isra Analdo Arza Jamil, Mohd Jamilah Abbas Krisdianto, Boby Febri Leni Merdawati M. Al Farisyi Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Niki Astria Nina Kurniasih Nindita, Priska Audina Nirmala Sari Noni Zakiah Nora, Sondang Noza Hilbertina Noza Hilbertina, Noza Nurhayati Nurhayati Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Prima Astuti Handayani Putra, Fachri Putri, Biomechy Oktomalio Putriyuni, Anandia Ramadanus Ramadanus Ramadanus Rifa, Farras Zahra Rima Semiarty Rini Purnama Sari Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rulli Firmansyah Rustam, Rony Safnita, Dewi Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Sofia Mubarika Sofia Mubarika Haryana Sonar Soni Panigoro Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suchitra, Avit Suyuthie, Heldrian Dwinanda Syamel Muhammad Tofrizal tofrizal - tofrizal Vashti Resti Putri Firdaus Veithzal Rivai Zainal Vivi Sofia Vivi Sofia Vivi Sofia wessi windrasari Wirsma Arif Harahap Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yenita . Yenita Afriyeni Yopiq Triputra Yulia Kurniawati Yusticia Katar Yusticia Katar, Yusticia