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Journal : Indonesian Journal of Medicine

Comparison of The Effectiveness of Remifentanyl versus Fentanyl in Pediatric Undergoing Methotrexate Therapy Purwoko, Purwoko; Putro, Bambang Novianto; Pamungkas, Ferdy; Siswanto, Febby Gunawan
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Anesthesia procedure is routinely performed for some painful pediatric oncologic procedures such as lumbar puncture (LP) and bone marrow examination (BME).  Several studies mentioned that fentanyl and remifentanyl are often used as anesthetic agent of this procedure, but none of them compare the recovery time of both agent. This study aims to compare the recovery time of fentanyl and remifentanyl in pediatric patients undergoing methoterexate therapy.Subjects and Method: This was a double-blind randomized controlled trial on 36 patients who underwent intratechal methotrexate chemoterapy under general anesthesia anesthesia in pediatric intervention room of Moewardi General Hospital Surakarta that met inclusion criteria. The dependent variable was recovery time and the independent variable were fentanyl and remifentanyl. The samples were divided into 2, Fentanyl (F) and Remifentanyl (R) group. Recovery time was recorded after the procedure until the subject reached Pediatric Glasgow Comma Scale (PGCS) of 15. Statistical analysis was Mann Whitney U Test using SPSS 25 for Windows.Results: The mean recovery time of F group was 373.39 ± 29.48 seconds, while R group was 124.67±11.55 seconds. There was a significant difference in recovery time between patients in the Fentanyl group and the Remifentanyl group (p= 0.000).Conclusion: Remifentanyl recovery time was significantly faster than with fentanyl in pediatric patients undergoing intrathecal methotrexate chemotherapy.Keywords: Fentanyl, Methotrexate, Outpatient anesthesia, Recovery time, RemifentanylCorrespondence: Ferdy Pamungkas. Anesthesiology Department, Moewardi General Hospital, Surakarta. Jalan Kolonel Sutarto 132 Jebres, Kecamatan Jebres, Surakarta City 57126. Central Java, Indonesia. dr.ferdypamungkas@gmail.com. +6281230269501.Indonesian Journal of Medicine (2022), 07(01): 115-121https://doi.org/10.26911/theijmed.2022.07.01.12
Effect of Preoperating Maltodextrin 12.5% Carbohydrate Drink on High Sensitive C Reactive Protein Levels Post-Brachytherapy Purwoko, Purwoko; Arianto, Ardana Tri; Putra, Eka Satrio; Purnomo, Frederick Johan
Indonesian Journal of Medicine Vol. 10 No. 3 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.3.853

Abstract

Background: Brachytherapy is radiation therapy that will cause inflammation and tissue damage that leads to inflammation, characterized by the release of pro-inflammatory cytokines, including hs-CRP levels in the plasma. Preoperative administration of glucose solution is known to reduce the increase in cortisol, and is thought to reduce postoperative hs-CRP levels. So far there has been no research that specifically examines the effect of preoperative carbohydrate administration on hs-CRP values after brachytherapy. This study aims to determine the effect of preoperative carbohydrate administration on post-brachytherapy hs-CRP values. Subjects and Method: This study was designed a double-blind randomized controlled trial was conducted at the Radiotherapy Unit of Dr. Moewardi General Hospital, Surakarta, from April to September 2022. Sixty-four cervical cancer patients with ASA physical status I or II undergoing brachytherapy under general anesthesia were recruited using consecutive sampling. Participants were randomly assigned into two groups: an intervention group receiving 12.5% maltodextrin solution and a control group receiving mineral water. The independent variable was preoperative carbohydrate administration, and the dependent variable was hs-CRP level measured 2 hours before and 4 hours after brachytherapy. Data were analyzed using paired t-test Results: Post-brachytherapy hs-CRP levels were significantly lower in the treatment group (mean = 2.565 ± 2.0 mg/dL) compared to the control group (mean = 3.69 ± 2.58 mg/dL; p = 0.019). Both groups showed significant increases in hs-CRP from pre- to postoperative values (p < 0.001). The change in hs-CRP (Δhs-CRP) was also significantly lower in the treatment group (p = 0.025). Conclusion: The administration of maltodextrin was able to significantly reduce post-brachytherapy hs-CRP levels compared to placebo.
Co-Authors Abdul Mutalib Abidin Abidin Adang Hardi Gunawan Agus Mulyono Ahmad Syarif Hidayatullah, Ahmad Syarif Aini, Fica Aida Nadhifatul Anggit Murdani Antesty, Sella Antonius Antonius April, Dian Ardana Tri Arianto Ashri Hidayati Asrofi, Asrofi Azainil Azainil Baehaqi, Sirojul Bambang Irawan Bambang Irawan /E21207042 Cahya Nova Ardianto Chaeruman Chaeruman Chairuman Chairuman Chumairoh, Lutfi Cinkalasari, Bunga Ayu Desyandri Desyandri Djoharly Caniago Elmusyafa’, Muchammad Sabath Eny Lestari Eti Kristanti Fatkhullah, Faiz Karim Fauzan . Fauzi Ahmad Muda Fikri, Muhammad Ali Fitri Yunita Fitroh Adhilla Hadi Susilo, Sugeng Haeruddin Haeruddin Hamilaturroyya, Hamilaturroyya Hanafiah Hanafiah, Hanafiah Hananto, Arif Zuhal Amin Hari Setiabudi Husni, Hari Setiabudi Haris Puspito Buwono Hartono, Rudi Herawati , Anisa Nur Hidayah, Ian Fii Barril IFAH KHADIJAH, IFAH Ihsaniar, Aura Indaryanti Indaryanti Irawan, Noval Jahid, Md. Abu Judijanto, Loso K. Hashimoto Karyadi Karyadi Komariah, Laili Kuntoadi, Danang Kurniawan, Rangga Muhammad Kusworo, Leo Jati Laksmi Andri Astuti Mandasari Saragih, Yasmirah Marhadi Marhadi, Marhadi Maskur Maskur Mudrikah, Mudrikah Muhammad Ramli Muzaki, Mochamad Noor, Laili Savitri Nurdiani, Tanti Widia Pamungkas, Ferdy Pasiri, Rafi Al Poppy Laksita Rini Pramana, Yanuar Sigit Priyatno Harsasto Pujianto Pujianto Purnomo, Frederick Johan Putra, Eka Satrio Putro, Bambang Novianto Rachmawati, Nuzulia Rahmadillah Putra Yuslam, Aviv Rakhmawati Rakhmawati Ramadhani, Tito Ramadhani Ramidi, Ramidi Ratlan Pardede Safari, Apay Sainal, Sainal Saputra, Wahyu Yas Setiawan , Zunan Setiawan, Zunan Setyawan, Rai Rake Sholikah, Mar’atus Siswanto, Febby Gunawan Sri Aguswarini Sri Aguswarini Lestiyowati Sri Bagiawati Sri Setiyowati Sri Setyowati Subagio, Lambang Subaryata, Subaryata Sudarso Kaderi Wiryono Sugalih, Michael Primanda Suherman, Usep Sukardi Sukardi Sulistyo, Beni Agus Suprihatin Suprihatin Suryandari, Retno Suseno, Andi Susilo Utomo Swasono R. Tamat Syamsul Hadi Titi Candra Sunarti Uswatun Chasanah Utik Bidayati, Utik Waeno, Mahamadaree Wahyu Nugroho Waluyo, Cahyo Tri Warman Warman Widiantoro, Akbar Sigit Widyastuti Widjaksana Widyatmike Gede Mulawarman Wildan Saugi Yatmi, Yatmi Yayan Tahyan Yono Sugiarto Yulistika, Efri Zainal Abidin Zainudin bin Hassan, Zainudin bin