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All Journal Jurnal Entropi Sainstek AKADEMIKA Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Sains JURNAL PENDIDIKAN GLASSER Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Chemistry Indonesian Journal of Chemical Research Dalton : Jurnal Pendidikan Kimia dan Ilmu Kimia Jambura FIsh Processing Journal Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Jurnal Riset Pendidikan Kimia (JRPK) Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Stannum : Jurnal Sains dan Terapan Kimia SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Kolaboratif Sains CHEDS: Journal of Chemistry, Education, and Science NUSRA: Jurnal Penelitian dan Ilmu Pendidikan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Redoks : Jurnal Pendidikan Kimia dan Ilmu Kimia Pentagon: Jurnal Matematika dan Ilmu Pengetahuan Alam Jurnal Akademika Kimia Damhil: Jurnal Pengabdian kepada Masyarakat Journal of Community Services on Multidisciplinary Sciences Jurnal Pendidikan Kimia, Fisika dan Biologi Konstanta : Jurnal Matematika dan Ilmu Pengelatuan Alam
Nurhayati Bialangi
Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Other

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Antioxidant Activity of Tilapia (Oreochromis niloticus) Bone Protein Hydrolysate Using the ABTS Method Nurain Dano; Deasy N. Botutihe; Nita Suleman; Nurhayati Bialangi; Najmah Najmah
Jurnal Akademika Kimia Vol. 15 No. 2 (2026)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2026.v15.i2.pp121-128

Abstract

Tilapia (Oreochromis niloticus) bones are a fishery by-product whose use remains limited, despite containing proteins that can be processed into bioactive peptides with antioxidant activity. This study aims to evaluate the characteristics of protein hydrolysate and antioxidant activity from raw and cooked tilapia bones using the ABTS method. Enzymatic hydrolysis was performed using papain at concentrations of 4%, 6%, and 8% (b/v) at pH 7 and 55°C for 4 hours. The parameters analyzed included qualitative amino acid tests, dissolved protein levels determined by the Kjeldahl method, degree of hydrolysis based on dissolved proteins in 10% TCA, and antioxidant activity expressed as IC₅₀ values. The results showed that all samples tested positively for amino acids, including aromatic amino acids. The lowest IC₅₀ value was observed in the treatment of a ripe sample with an enzyme concentration of 8% (6.89 mg/mL), indicating the highest antioxidant activity among the treatments. This is in line with an increase in the degree of hydrolysis to 84.53% under the same conditions, as well as an increase in dissolved protein levels to up to 32.78%. These findings indicate that tilapia bone protein hydrolysate has the potential to serve as a natural source of antioxidants, particularly under optimal hydrolysis conditions.
PERBANDINGAN AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL KULIT BATANG GANDARIA DENGAN METODE DPPH DAN ABTS Boima Situmeang; Nurhayati Bialangi; Weny JA Musa; Ahmad Kadir Kilo; Holisha Widiyanto; Dian Susvira; Nani Yulianti
JURNAL REDOKS : JURNAL PENDIDIKAN KIMIA DAN ILMU KIMIA Vol 8 No 2 (2025): Jurnal Redoks : Jurnal Pendidikan Kimia dan Ilmu Kimia
Publisher : Program Studi Pendidikan Kimia STKIP Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33627/re.v8i2.3323

Abstract

Penelitian ini bertujuan untuk membandingkan aktivitas antioksidan ekstrak metanol kulit batang gandaria (Bouea macrophylla Griff.) menggunakan dua metode pengujian, yaitu DPPH (2,2-diphenyl-1-picrylhydrazyl) dan ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)). Ekstraksi dilakukan secara maserasi menggunakan pelarut metanol. Aktivitas antioksidan ditentukan berdasarkan nilai IC50, yaitu konsentrasi yang diperlukan untuk meredam 50% radikal bebas. Hasil uji menunjukkan bahwa ekstrak memiliki aktivitas antioksidan sangat kuat dengan nilai IC50 sebesar 12,259 ± 0,232 ppm untuk metode DPPH dan 15,831 ± 1,550 ppm untuk metode ABTS. Nilai IC50 yang lebih rendah pada metode DPPH menunjukkan bahwa ekstrak memiliki kemampuan yang lebih tinggi dalam menangkap radikal bebas pada metode tersebut. Hasil ini menunjukkan bahwa kulit batang gandaria berpotensi sebagai sumber antioksidan alami yang efektif dengan kemampuan merangkal radikal bebas DPPH dan ABTS sangat kuat.
The Effect of STEM Integrated Project Based Learning Model on Students' Collaboration Skills in Atomic Structure Padria Haleda; Ishak Isa; Haris Munandar; Nurhayati Bialangi; Julhim S Tangio; Thayban Thayban; Erga Kurniawati
Jambura Journal of Educational Chemistry Vol 7, No 2 (2025): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjec.v7i2.33896

Abstract

The objective of this research is to investigate the influence of the Project-Based Learning (PjBL) model, when integrated with the STEM approach, on students’ collaborative abilities in the topic of atomic structure. The study is motivated by the persistent issue of low collaboration levels among chemistry learners, particularly when dealing with abstract subject matter. Employing a quantitative methodology with a quasi-experimental design—specifically the Non-Equivalent Control Group Design—the research was conducted with two tenth-grade classes at SMA Negeri 1 Suwawa, designating one as the experimental group and the other as the control group. Data were gathered through observation sheets that measured five aspects of collaboration: cooperation, responsibility, communication, adaptability, and compromise. The findings revealed a notable enhancement in collaborative skills within the experimental class following the application of the STEM-integrated PjBL model. The average final observation score for this group reached 76%, surpassing the control group’s 61%. The N-Gain score for the experimental group fell within the medium category (0.48), whereas the control group’s score was classified as low (0.17). Improvements were recorded across all collaboration indicators. Overall, the results suggest that the STEM-integrated PjBL model is effective in fostering collaboration skills and can be recommended as an alternative instructional approach for other chemistry topics to advance 21st-century skill development.
Analysis of Students' Level of Understanding of Hydrocarbon Concepts Using a Three-Level Diagnostic Multiple-Choice Approach Marsya Divya Olii; Nurhayati Bialangi; Julhim S Tangio; Mangara Sihaloho; Erga Kurniawati
Jambura Journal of Educational Chemistry Vol 7, No 2 (2025): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jjec.v7i2.33603

Abstract

This research aims to determine students' conceptual understanding ability of hydrocarbon material using a three-tier multiple-choice diagnostic test instrument. The research was conducted at SMA Negeri 2 Wonosari using a descriptive qualitative approach. The research was carried out in the even semester of the 2024/2025 academic year. The research subjects were the students of class XI B at SMA Negeri 2 Wonosari, with a sample size of 28 students. The instrument used consisted of 15 three-tier multiple-choice questions covering answers, reasoning, and the student's confidence levels. The validity and reliability of the instrument were tested through expert analysis and empirical testing using the Rasch model. Data collection was carried out using the three-tier multiple-choice test. After obtaining the students' responses, the answers were analyzed and categorized based on conceptual understanding levels: Understanding the Concept (UC), Negative Misconception (NM), Positive Misconception (PM), and Not Understanding the Concept (NUC). The results indicate that the average percentage of conceptual understanding was 29.05%, categorized as low; negative misconceptions were 23.10%, also categorized as low; postitive misconceptions were 10.24% categorized as very low; and not understanding the conceptions 37.62%, categorized as low. In conclusion, students of class XI B at SMA Negeri 2 Wonosari showed the lowest average level of conceptual understanding compared to those experiencing misconceptions or lacking scientific understanding of the concept.
IDENTIFIKASI TURUNAN ASAM KARBOKSILAT AKAR Acalypha indica SEBAGAI KANDIDAT INHIBITOR GFAT MELALUI LC-HRMS DAN STUDI IN SILICO Arviani; Yuszda K. Salimi; Nurhayati Bialangi; Ahmad Chandra Lakasan; Zifran Nur Rahman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2828

Abstract

Diabetes mellitus remains a major global health challenge, prompting the exploration of natural products as sources of safer antidiabetic agents. This study aimed to identify bioactive compounds from the roots of Acalypha indica and evaluate their potential as inhibitors of glutamine–fructose-6-phosphate amidotransferase (GFAT), an enzyme involved in glucose metabolism. Compound profiling was conducted using liquid chromatography–high resolution mass spectrometry (LC-HRMS), while the inhibitory potential against GFAT was assessed through in silico docking. This integrated approach has not been previously reported. Metabolite profiling using LC-HRMS tentatively identified thirteen carboxylic acid derivatives, including hydroxycinnamic acid, gluconic acid, trans-aconitic acid, and glucoheptonic acid. molecular docking analysis revealed strong binding affinities of several compounds toward GFAT.  Glucoheptonic acid exhibited the lowest binding energy (−8.0 kcal/mol), followed by xylaric acid A (−7.9 kcal/mol) and trans-aconitic acid (−7.5 kcal/mol). These compounds interacted with key active-site residues Gln421, Ser420, Ser422, and Lys675, suggesting a potential enzyme inhibition mechanism. In silico pharmacokinetic analysis indicated that 2-hexylpentanedioic acid exhibited favorable ADME properties, with high gastrointestinal absorption, no major inhibition of CYP450, and low predicted acute toxicity risk. These findings highlight Acalypha indica roots as a promising source of bioactive carboxylic acid derivatives, with glucoheptonic acid emerging as the most promising candidate for further in vitro evaluation as a GFAT inhibitor
Pemanfaatan Lingkungan Sebagai Laboratorium Alam dalam Pembelajaran Sains Julhim S. Tangio; Lukman A.R Laliyo; Erni - Mohamad; Wiwin Rewini Kunusa; Nurhayati - Bialangi; Deasy N Botutihe; Rustam I Husain
Damhil: Jurnal Pengabdian kepada Masyarakat Vol 5, No 1: June 2026
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/damhil.v5i1.40560

Abstract

Kegiatan pengabdian kepada masyarakat merupakan bagian integral dari Tri Dharma Perguruan Tinggi, yang melibatkan lembaga, dosen, dan mahasiswa dalam berkontribusi kepada masyarakat. Dalam konteks ini, dilakukan pengabdian melalui pengenalan lingkungan sebagai laboratorium alam yang bertujuan untuk meningkatkan pengetahuan dan minat siswa dalam mempelajari IPA. Tujuan dari kegiatan pengabdian ini adalah memberikan pengetahuan, pemahaman, kepedulian, dan minat siswa dalam mempelajari ilmu pengetahuan alam. Proses pelaksanaan kegiatan meliputi perencanaan, pelaksanaan, dan evaluasi kegiatan. Hasil yang diperoleh dari kegiatan ini antara lain adalah peningkatan minat siswa dalam belajar IPA sains dan memahami lingkungan dapat dijadikan sebagai laboratorium alam. Respon siswa menunjukkan rata-rata persentase mencapai 88,67%, Indikator dengan persentase tertinggi adalah keinginan siswa untuk mengikuti kegiatan serupa, yaitu sebesar 93,33%, diikuti oleh ketertarikan siswa terhadap pembelajaran sains sebesar 92,50%. Dengan demikian, dapat disimpulkan bahwa kegiatan pengabdian ini berhasil meningkatkan pengetahuan, sikap, dan minat siswa dalam memanfaatkan lingkungan sebagai sumber belajar
Karakterisasi Kitosan dari Cangkang Sotong (Sepia officinalis) dari Pantai Tanjung Kramat Kota Gorontalo: Characterization of Chitosan from Cuttlefish Shells (Sepia officinalis) from Tanjung Kramat Beach, Gorontalo City Stasya Anggriani Talib; Nurhayati Bialangi; Arviani; Yuszda K. Salimi; Deasy Natalia Botutihe
Jurnal Kolaboratif Sains (Special Issue) - Jurnal Kolaboratif Sains (JKS) - Oktober 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i10.8866

Abstract

Kitosan, biopolymer kationik alami dari deasetilasi kitin eksoskeleton hewan laut, memiliki sifat biokompatibilitas, biodegradabilitas, dan non-toksisitas yang menarik untuk berbagai aplikasi. Penelitian ini bertujuan untuk mengkarakterisasi kitosan yang diisolasi dari limbah cangkang sotong yang diperoleh dari Pantai Tanjung Kramat, Kota Gorontalo dengan focus rendemen, kadar air, dan analisis Fourier Transform Infrared (FITR). Proses isolasi melibatkan tahap demineralisasi, deproteinasi, dan deasetilasi. Hasil penelitian menunjukkan rendemen kitosan tertinggi 28% pada perlakuan HCl 5%, sedangkan kadar air seluruh sampel berkisar antara 2,00-2,21% dan memenuhi standar SNI 7949:2013 (?12%). Analisis FTIR mengidentifikasi gugus fungsi utama dan derajat deasetilasi (DD) tertinggi mencapai 80,17% pada perlakuan HCl 7%, memenuhi standar mutu (?75%). Penelitian ini memberikan wawasan penting mengenai potensi cangkang sotong sebagai sumber kitosan berkualitas.
Analisis Kualitas Soal Tes Formatif untuk Mengukur High Order Thinking Skills pada Materi Kesetimbangan Kimia Nabila Nur Indah Dunggio; Mangara Sihaloho; Netty Ino Ischak; Nurhayati Bialangi; Lukman A. R. Laliyo
NUSRA : Jurnal Penelitian dan Ilmu Pendidikan Vol. 7 No. 3 (2026): NUSRA: Jurnal Penelitian dan Ilmu Pendidikan, Agustus 2026
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/nusra.v7i3.6525

Abstract

This study aimed to develop a Higher Order Thinking Skills (HOTS)-based formative test instrument on chemical equilibrium material and to analyze the quality of the instrument based on validity, reliability, difficulty level, discrimination power, and distractor effectiveness using the Rasch Model. This study employed a Research and Development method involving 564 students as research subjects. The developed instrument consisted of HOTS multiple-choice questions at cognitive levels C4, C5, and C6. Instrument validity was analyzed through expert validation, while empirical analysis was conducted using Winsteps and Microsoft Excel. The results showed that the instrument obtained a validity percentage of 88.95%, categorized as very valid. Rasch Model analysis indicated that all items met the item fit criteria with a Cronbach Alpha reliability value of 0.78, categorized as good. The item difficulty levels consisted of easy, moderate, and difficult categories, with moderate items being dominant. All items demonstrated good discrimination power as indicated by positive Pt Measure Corr values. In addition, most distractors functioned effectively because they were selected by students. The distribution of HOTS items consisted of 44.44% C4 level, 33.33% C5 level, and 22.22% C6 level. Therefore, the HOTS-based formative test instrument on chemical equilibrium material was considered feasible for measuring students’ higher-order thinking skills.
Co-Authors Agus Malik Ibrahim Agus Malik Ibrahim Ahmad Chandra Lakasan Ahmad Fajar Muzakir Ahmad Kadir Kilo Ahmad, Halid S. Akram La Kilo Anggraini Dj Usman Ari Widiantoro Ari Widiyantoro Arviani Arviani Arviani Arviani Astin Lukum Boima Ramses Situmeang Boima Situmeang Boima Situmeang Boima Situmeang Boima Situmeang Boima Situmeang Deasy N Botutihe Deasy N. Botutihe Deasy N. Botutihe Deasy Natalia Botutihe Dian Susvira Dian Susvira Diky Kurniawan Djalil, Jhodi Pratama Djalil, Moh. Rifaldi Dzulhijar Eka Puspita Sari Erga Kurniawati Erni - Mohamad Erni Mohamad Faradin, Faradin Fauziah, Eka Donna Fitri Hadji giu, fitri ani Halalutu, Hamdan Halalutu, Hamdan Hamid Majelis Haris Munandar Hendri Iyabu Hidayatullah, Ryan Holisha Widiyanto Holisha Widiyanto Holisha Widiyanto Ibrahim, Agus Malik Ibrahim, Agus Malik Ishak Isa Isna Lailatusholihah Jafar La Kilo Jinanti, Nazwa Julhim S Tangio Julhim S Tangio Julhim S. Tangio Juliandoz Julinton Sianturi Jumarni Kamarudin Kupang, Sri Revayana La Alio La Alio La Alio La Ode Aman Lailatusholihah, Isna Lailatussholihah, Isna Laliyo, Lukman Lintang Panji Setyoko Lintong, Kristin Lisdawati N. Umar Lukman A. R. Laliyo Lukman A. R. Laliyo M Amrin Sunardi Mangara Sihaloho Mardjan Paputungan Marsya Divya Olii Marsya Divya Olii Masrid Pikoli Meli A. Rasid Miftahul Nur Moh Adam Mustapa Mohamad Adam Mustapa Muhridja, Melisa Mulyadi, Agus Musa, Weni J.A Musa, Weny J.A. Mustafid, Afif Hidayatul Mutmainah I. Supu Nabila Nur Indah Dunggio Najmah Najmah Najmah Najmah Nani Yulianti Nani Yulianti Nani Yulianti Netty Ino Ischak Ngabito, Putri Amalia Nilda Apriyati Tengo Ninik Triayu Susparini, Ninik Triayu Nita Suleman Nona Wingti Posangi Nur Rafida Akub Nur Riska Apriana Nur, Dian Nurain Dano Nurfadilah M. Kasim Nurkhaliq, Nurkhaliq Nurlaela Abd. Kadir Ode, Nur Mei Yulianty Padria Haleda Pakaya, Agustina H. Paputungan, Fadilah Alawiya Parulian, Boima Ramses Perry Zakaria Putri Amalia Ngabito R Tulie, Wina Zulviana Ramadhan, Muhammad Bagus Reski Rahmatia Idris Rifki Brahmono Idrus Risnayanti R Juramang Rustam I Husain Rustam I. Husain Sahami, Ulin Saiman Saiman Samosir, Andeston Sumandoli Saronom Silaban Setiyandani, Kurnia Indah Setyoko, Lintang Panji Situmeang, Boima Sri Wijayanti Sriwijayanti Sriwijayanti Sriwijayanti Sriwijayanti Stasya Anggriani Talib Suleman Duengo Sumarlin Soleman Susparini, Ninik Triayu Susvira, Dian Thayban, Thayban Vivi D. A. Sangkota Wenny J A Musa Weny J.A Musa Weny J.A Musa Weny JA Musa Weny JA Musa Weny JA Musa Weny Musa Widiyanto, Holisha Widy Susanti Abdulkadir Wiwin Rewini Kunusa Wiwiyani, Wiwiyani Yayurulia Hadju Yuliana Retnowati Yusuf, Risciana Yuszda K Salimi Yuszda K. Salimi Yuzda K Salimi Zifran Nur Rahman