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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Pangan ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Hemera Zoa Jurnal Sain Veteriner Buletin Peternakan Medical Journal of Indonesia Current Biochemistry Jurnal Ilmu Ternak Veteriner Warta IHP (Warta Industri Hasil Pertanian) Historika Jurnal Medik Veteriner ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Patologi Indonesia KIDDO: Jurnal pendidikan Islam Anak Usia Dini Indonesian Journal of Applied Research (IJAR) International Journal of Multidisciplinary: Applied Business and Education Research Journal of Education Research Jurnal Pusat Inovasi Masyarakat Jurnal Kedokteran Hewan Journal of Research and Publication Innovation VALUTA Jurnal Administrasi Bisnis, Manajemen dan Ekonomi Policy Brief Pertanian, Kelautan, dan Biosains Tropika Health Gate Jurnal Agripet Civitas: Jurnal Pengabdian Masyarakat Neraca: Jurnal Ekonomi, Manajemen dan Akuntansi
Agus Setiyono
Departemen Klinik, Reproduksi Dan Patologi Fakultas Kedokteran Hewan, Institut Pertanian Bogor. Jl. Agatis Kampus IPB Dramaga 16680
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Effects of Physalis angulata extracts on bleomycin-induced rat: analysis on lung inflammation and fibrosis Wibowo, Suryo Anggoro Kusumo; Rumende, Cleopas Martin; Isbagio, Harry; Setiyono, Agus; Setiabudy, Rianto; Rachmadi, Lisnawati; Kertia, Nyoman
Medical Journal of Indonesia Vol. 34 No. 4 (2025): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257875

Abstract

BACKGROUND Scleroderma is an immune-mediated connective tissue disease, with interstitial lung disease as one of its manifestations. Physalis angulata (P. angulata) or ciplukan has shown potential in treating fibrosis, but its role in preventing lung inflammation and fibrosis remains unknown. This study aimed to evaluate the effect of P. angulata extract in a bleomycin (BLM)-induced scleroderma rat. METHODS Sprague-Dawley rats were divided into 6 groups. For lung inflammation prevention, 3 groups received: (1) BLM only, (2) BLM+50 mg/kgBW P. angulata, and (3) BLM+100 mg/kgBW P. angulata. After 14 days, rats were sacrificed and bronchoalveolar lavage (BAL) leukocyte count, interleukin-6 (IL-6) levels, and lung injury score were assessed. For fibrosis prevention, another 3 groups received the same interventions and were sacrificed after 51 days. Fibrosis score, fibrosis area, hydroxyproline, transforming growth factor-beta (TGF-β), and matrix metalloproteinase-13 (MMP-13) levels were analyzed. BLM was administered subcutaneously, while P. angulata was given orally for 14 days. IL-6, TGF-β, and MMP-13 were measured by ELISA and hydroxyproline by colorimetric method. Mean differences and p-values were calculated using appropriate statistical tests. RESULTS P. angulata extract did not prevent lung inflammation, as there were no differences in BAL leukocyte count (p = 0.126), IL-6 levels (p = 0.173), or lung injury scores (p = 0.397) between the BLM-only group and those receiving P. angulata. The extract also did not prevent lung fibrosis, with no differences in fibrosis scores (p = 0.173), fibrosis area (p = 0.359), hydroxyproline (p = 0.295), TGF-β (p = 0.374), or MMP-13 (p = 0.088) levels among groups. CONCLUSIONS P. angulata extract did not prevent the development of lung inflammation or fibrosis.
Ekstrak Teh Hijau Mengurangi Luas Area Fibrosis Paru Tikus Desdiani; Iris Rengganis; Samsuridjal Djauzi; Agus Setiyono; Mohammad Sadikin; Sri Widia A. Jusman; Nurjati Chairani Siregar; Suradi; Putri C. Eyanoer
Majalah Patologi Indonesia Vol. 29 No. 1, Januari 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.403

Abstract

BackgroundPulmonary fibrosis is often found in infectious diseases and chemical exposure in the work environment. Antifibrotic effects can befibropreventive and fibrolysis. Bleomycin can cause inflammation and pulmonary fibrosis. Catechin is proven can repair liverdamages due to alcohol induction. The aim of this study is to examine the effect of antifibrotic green tea catechin on reducing thearea of rat lung fibrotic.MethodsThis research was carried out in vivo experimentally in the Laboratory Animal Management Unit at Faculty of Veterinary MedicineIPB in 4 groups of rat experiments, consisting of 3 rats in the negative control group, 3 rats in the positive control group, 3 rats in thegroup of rats given bleomycin on the 8th day and 28thwith green tea extract every day from day 0 to 49 days (fibropreventive), 3groups of rats given bleomycin days 0 and 21 with green tea extract every day from day 15 to 49 (fibrolysis). Histopathologicalexamination was performe for all groups of rats.ResultsThis study showed that administration of green tea extract in fibropreventive groups and fibrolysis groups could reduce the fibrosisarea in rat lungs based on Aschroft's modified scale.ConclusionBased on the results of this study it was found that the anti-fibrotic activity of green tea extract was proven to be able to suppressthe development of pulmonary fibrosis both by fibropreventive and fibrolysis
Effect of subacute administration of orange juice (Citrus sinensis) on duodenal structure in paediatric Sprague-Dawley rats (Rattus novergicus) Teo Qin Yan; Altaff Hendry; Daniel Latief Andre; Muhammad Luthfi Rahman; Win Satya Rudramurti; Nadine Hanifa Permana; Dian Maulia Utami; Diah Nugrahani Pristihadi; Agus Setiyono
ARSHI Veterinary Letters Vol. 8 No. 3 (2024): ARSHI Veterinary Letters - August 2024
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.8.3.69-70

Abstract

This research investigates the impact of orange juice consumption on the histological structure of the duodenum, a critical site for nutrient absorption and digestion. Focusing on pediatric animals, orange juice (with a pH of 3) was administered to post-weaning rats aged 4 weeks to 6 weeks at dosages ranging from 0g/kg BW to 20g/kg BW over two weeks. Duodenal histopathology was assessed, focusing on parameters such as the quantity of crypts of Lieberkuhn, as well as the length, height, width, and depth of villi (measured in μm). Anatomical pathology examination included measurements of the length and width of the duodenum (also in μm), as well as the color mean (OD). The research findings indicate no significant changes in histo-pathology or anatomy pathology of the duodenum. This suggests that young individuals can adapt to acidic challenges without compromising gastrointestinal health. These findings offer reassurance regarding the short-term consumption of acidic orange juice (with a pH of 3) with minimal risks to intestinal integrity, both during growth and development.
Co-Authors Aditya Dharmawan, Aditya Aditya Wahyu Nugraha Afifah, Amalia Aisjah Girinda Akhmad Endang Zainal Hasan Akterono D. Budiyati Allaily Allaily Altaff Hendry Alvin Jefry Amrozi Andriyanto . Anggraini , Ninik Anita Esfandiari Annasit Arif Yahya Arifianto, Dinar Ario Damar Astrie Kusuma Dewi Aulia Dina Kristina Bayu Sandi Chintia Ayu Puspita Cleopas Martin Rumende Daniel Latief Andre Darsono Darsono Desdiani Diah Nugrahani Pristihadi Dian Maulia Utami Dian Pratiwi DIMAS ANDRIANTO Dwi Astuti E. Mulyati Effend Effend, E. Mulyati Eko Prasetyo Nugroho Eko Suryanto Ekowati Handharyani Elok Puspita Rini Elpita Tarigan Eny Nur Aisyah Evy Damayanthi Fachriyan Hasmi Pasaribu Feri Kusnandar Gani, Ainal Gatut Ashadi Hamid, Farid Alfalaki Handayu Untari Handayu Untari Handoko, Susilo Hanif Alamudin Manshur Hapsari Mahatmi Hardika Hardika, Hardika Harry Isbagio Hasim Hasim Hasim Hasim Hasim Hasim Hasim Hasim, . Husnawati, . I Ketut Suada I Komang Gede Wiryawan I wayan Teguh Wibawan Idqan Fahmi Iftitah, Selfi Lailiyatul Ike Agustiani Imron Arifin Indriani, Erdila IPB, DGB Iris Rengganis Ismah Atika Salmah Japanis Permatasari, Retno Jusman, Sri Widia Azraki Kustiariyah Tarman Lala M Kolopaking Liesbetini Haditjaroko Lily Natalia Lisnawati Rachmadi M Agus Setiadi M. Aman Yaman M. Misbah, M. Ma'mun Sarma Maharani Maharani, Maharani Maningtyas, Rosyidamyani Twinsari Masdiana C. Padaga Mega Safithri Miko Afrian Mochamad Alfinanda Santriagung Mohammad Irham Bagus Santoso Mohammad Sadikin Muhammad Daud Muhammad Ihsan Muhammad Luthfi Rahman Muhammad Ridla Muhammad Zuhdi Badruzzaman Muhammad Zulkifli Muharam Saepulloh Mutholaah Nadine Hanifa Permana Nahrowi Nahrowi Nahrowi Nathasia, Novena Neni Nuryani Nina Herlina Nugroho, Budi Sulistiyo Nurjati Chairani Siregar Nurliani Bermawie Nurliani Bermawie Nurliani Bermawie Nurrahman, Arif Nyoman Kertia Oktariza, Wawan Olive Wisepti Pratama Ono Suparno Pramono Prastyo, Danang Pribadi, Yohanes Kusuma Purnamiharja, Tsulatsy Puspitasari Purwiyatno Hariyadi Putri C. Eyanoer Rachmat Nabib Rahminiwati, Min Rayendra, Raendi Restu Librani Retno Damayanti Soejoedono Rianto Setiabudy Risa Tiuria Samsuridjal Djauzi Sandi, Bayu Sangko Sayuti Nasution Sangko Sayuti Nasution, Sangko Santi Noviasari Sekar Winahyu Ariadini Setiadi, Hirawan Shila Rahmafia Putri SILMI MARIYA Siti Zulaikhah Slamet Budijanto Sri Purwaningsih, Sri Sri Wahyuni Salam Sudradjat Sumiati Suradi Suria Darma Tarigan Syahruddin Said Syifa Khaerani Teo Qin Yan Tomas Iriyanto Tri Isyani Tungga Dewi Trioso Purnawarman Ulfah Juniarti Siregar Unang Patriana Upik Kesumawati Hadi Utamimah, Sri Vetnizah Juniantito Wibowo, Suryo Anggoro Kusumo Widiyanto, Totok Win Satya Rudramurti Winahyu Ariadini, Sekar Wiranda G Piliang Wiwin Winarsih Wiyono, W. WoroWiranti, Rahayu Yeni Kartika Sari, Yeni Kartika