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All Journal Jurnal Entropi Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jambura Journal of Chemistry Jambura Nursing Journal Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Ilmiah Farmako Bahari JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Indonesian Journal of Pharmaceutical Education Sciences of Pharmacy Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products
Nur Ain Thomas
Universitas Negeri Gorontalo
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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PENGARUH KONSENTRASI HYDROXYPROPYL METHYLCELLULOSE SEBAGAI BAHAN PENGIKAT PADA SEDIAAN TABLET EKSTRAK RIMPANG JAHE MERAH (zingiber officinale Var. Rubrum.) Nur AIn Thomas; Widy Susanti Abdulkadir; Muhammad Taupik; Nur Oktaviana
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11667

Abstract

Lozenges are solid preparations made from aromatic and sweet taste that can dissolve slowly in the mouth, which are intended to treat infections in the mouth and throat. Hydroxypropyl Methylcellulose (HPMC) is a binder that can be used in lozenges.This study attempted to examine the effect of the concentration of HPMC as a binder in the tablet preparation of red ginger rhizome extract (Zingiber officinale Var Rubrum) by wet granulation method. This study was a laboratory experimental study by comparing the three concentrations of HPMC binder used in each formula i.e., FI (4%), FII (5%), FIII (6%).The resulting tablets were tested for physical properties including organoleptic tests, weight uniformity, tablet hardness, tablet friability and hedonic tests. Based on the results of the study, it was shown that with an increase in the concentration of the HPMC binder, the physical quality of the resulting tablet also increased. The higher the concentration of HPMC used, the better the uniformity of weight and the high level of tablet hardness. However, tablet friability will decrease. The results showed that the concentrations of 4%, 5%, and 6% had an effect on the tablet physical properties whichwas fragility. Further, formula II with a concentration of 5% had better tablet physical quality and was preferred by respondentsbased on hedonic tests.
Skrining Fitokimia dan Uji Aktivitas Antioksidan Kulit Batang Matoa (Pometia pinnata) Dengan Metode 1,1-Diphenyl-2 picrylhidrazyl (DPPH) Hamsidar Hasan; Nur Ain Thomas; Faramita Hiola; Fika Nuzul Ramadhani; Anggun Sasmita Ibrahim
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.10995

Abstract

Pometia pinnata is a plant belonging to the Sapindaceae family that spread in the tropics, including Indonesia, which can be used as antioxidants. It is known to contain flavonoid compounds. Flavonoid is a substance that has antioxidants in capturing free radicals because it contains a hydroxyl group which is a reducer and can be beneficial for hydrogen donors to free radicals. This study aims to determine the chemical content and antioxidant activity of Pometia pinnata skin using 1,1-Diphenyl-2-Picrylhidrazyl (DPPH). Sample extraction was conducted using a multilevel extraction method with n-hexane, chloroform, ethyl acetate, and ethanol as solvents. The results showed that Pometia pinnata skin extract contains Alkaloids, Flavonoids, Saponins, Tannins, Steroids, and Terpenoids. While the value of antioxidant activity showed the IC50 value of n-hexane, chloroform, ethyl acetate, and ethanol extracts are 25, 5, 9, 4 µg/mL. The IC50 value indicates that the antioxidant activity is in an extremely strong category.
BIOSINTESIS NANOPARTIKEL PERAK EKSTRAK ETANOL 96% DAUN KELOR (Moringa oleifera) DAN UJI AKTIVITASNYA SEBAGAI ANTIOKSIDAN Fujiana Abd Karim; Robert Tungadi; Nur Ain Thomas
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11725

Abstract

Moringa leaf potentially has a high antioxidant becouse it contains secondary metabolite, one of which is quercetin. Therefore, to avoid harmful chemicals in the synthesis of silver nanoparticles, it is made by using a bio reductant of Moringa leaf extract. This study aims to know the optimal temperature in the formation of silver nanoparticles, to characterize the nanoparticle, and to rest the antioxidant AgNPs of Moringa leaf by using the DPPH method. This is a laboratory experimental study. The synthesis of nanoparticles uses a concentration of 0,4% Moringa leaf extract, which is reacted to AgNO3 with a concentration of 1 mM in a ratio of 1:9 at various temperatures of 60oC, 70oC, and 80oC for 30 minutes. The formed nanoparticles are characterized by using UV-VIS spectrophotometry and showing the optimum temperature for nanoparticles formation, which is 80oC. It is then continued to characterize using PSA and showing the average size of nanoparticles at a temperature of 80oC, which is 82,9 nm with a PDI value of 0,225. The result of the calculation of IC50 AgNPs shows that Moringa leaf obtains a value of 61.78 ppm, which is included in the strong category, meanwhile the thick extract of Moringa leaf without the addition of silver nanoparticles obtain a value of 124.41 ppm, which is included in the weak category.
Efek Antelmintik Ekstrak Metanol Kulit Batang Nangka (Artocarpus heterophyllus) terhadap Cacing Ascaris lumbricoides Hamsidar Hasan; Nur Ain Thomas; Muhammad Taupik; Gita Potabuga
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.14217

Abstract

Jackfruit (Artocarpus heterophyllus) is a type of plant that grows in Indonesia which functions as a food ingredient and as traditional medicine. Generally, this genus contains prenylated flavonoid compounds. This study aimed to determine the anthelmintic effect of jackfruit bark extract against Ascaris lumbricoides worms by utilizing total maceration with methanol solvent as the extraction method, which yielded 6.61%. Roundworm Ascaris lumbricoides are found in pig intestines. The samples were divided into 5 groups, including positive control of 250 mg combantrin solution, negative control of NaCMC and a treatment group of jackfruit bark extract with a concentration of 1%, 3%, and 5%. Each group consisted of three worms, incubated at 37oC for 24 hours with a 6 hours interval. The results showed that at a concentration of 5%, a jackfruit bark extract was efficient as an anthelmintic caused two worms to lyse at 6 hours and  one at 12 hours.
Uji Efektivitas Mukolitik Ekstrak Umbi Bawang Dayak (Eleutherine bulbosa (Mill) Urb) Robiatun Rambe; Zulmai Rani; Nur Ain Thomas
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.7041

Abstract

Dayak Onions are a typical Borneo plant that have been used by generations of Dayaks as herbal medicine. Empirically, tubers can be used as cough medicines. The purpose of this study was to determine the mucolytic effect of Dayak onion tuber extract by in vitro and the concentration range which gaves an equivalent effect with the effect of 0.1% acetylcysteine. This study conducted extraction using maceration. The test solution was made with a concentration of 0.5%, 1%, and 1.5% mixed with a mucus-phosphate buffer pH 7 20:80. The test solution was incubated for 30 minutes at 37oC. Further, positive control used was 0.1% acetylcysteine drug and the negative control was mucus solution without extract. Viscosity values obtained were analyzed using the One-way Anova statistical test with a confidence level of 99% (α 0.01). Based on the results, it was revealed that the extract of Dayak tuber with a concentration of 0.5%, 1%, and 1.5% showed a significant difference and a concentration of 0.5%.  Mucolytic effectiveness was better than positive controls (acetylcysteine).
Pengembangan Tanaman Jahe Menjadi Produk Olahan Sehat Sebagai Alternatif Pencegahan Covid 19 di Desa Ilotunggula Kecamatan Tolinggula Kabupaten Gorontalo Utara Hamsidar Hamsidar; Widysusanti A.K; Nur Ain Thomas
Jurnal Sibermas (Sinergi Pemberdayaan Masyarakat) Vol 10, No 1 (2021): Jurnal Sibermas (Sinergi Bersama Masyarakat)
Publisher : Univeristas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/sibermas.v10i1.10399

Abstract

Virus corona diketahui menyerang sistem kekebalan tubuh manusia yang dapat ditularkan dari orang ke orang. Oleh sebab itu kondisi ini menimbulkan kecemasan dan kekhawatiran dalam diri akibat virus corona, sehingga perlu mempertahankan kondisi tubuh dengan imun yang kuat agar dapat mencegah covid 19. Salah satu yang menjadi pilihan adalah rempah herbal. Rempah herbal yang paling populer adalah jahe. Jahe adalah tanaman dari suku Zingiberaceae yang berupa rimpang yang sangat populer sebagai rempah-rempah dan bahan obat. Rimpangnya berbentuk Jemari yang menggembung diruas-ruas tengah. Rasa dominan pedas disebabkan senyawa keton bernama gingerol. Senyawa ini dapat menjaga sistem imun tubuh dan juga berfungsi sebagai antiinflamasi dan antioksidan yang tinggi karena kandungan vitamin C nya yang mampu mencegah terjadinya peradangan paru-paru. Kegiatan dilaksanakan di Desa Ilotunggula Kecamatan Tolinggula Kabupaten Gorontalo Utara, yang merupakan salah satu kabupaten yang mempunyai potensi bahan baku jahe yang sangat melimpah. Pengembangan jahe menjadi produk minuman dan makanan olahan sehat dapat meningkatkan penjualan bahan baku petani jahe, meningkatkan pendapatannya, membantu warga dalam mencegah covid 19. Produk ini dapat dikonsumsi guna peningkatan gizi masyarakat dan dapat dipasarkan langsung ke masyarakat. Sehingga dapat menjadi alternatif sumber pendapatan ekonomi bagi masyarakat dan secara tidak langsung ikut mendukung program pemerintah dalam hal mengurangi dampak covid 19.
Formulasi Dan Evaluasi Fisik Sediaan Mouthwash Ekstrak Etanol Kulit Buah Matoa (Pometia Pinnata) Nur Ain Thomas; Mahdalena Sy. Pakaya; Ariani H. Hutuba; Yayah Rachmatiyah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15538

Abstract

Matoa peels contained phenolic, saponin, tannin, flavonoid and terpenoid which functions as anti-bacterias to Streptococcus mutans that can cause dental caries and active ingridients for mouthwash preparations. Mouthwash is a solution to be used as a cleansing agent that can improve mouth hygiene, esthetics and breath freshness. This study aimed to identify the etanol extract of Matoa peels to be formulated mouthwash preprations and its physical evalutions. This study employed methods that includes peels extraction, extract phytochemical screening, mouthwash preparation productions and mouthwash preparations evluations consisting of organoleptic, pH and viscosity test. The testing was conducted in day 0, 7, 14, 21 and 28. The findings revealed formula 2 as the best formula with 10% of glycerin concentration.
Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Stabilitas Fisik Sediaan Krim Nur Ain Thomas; Robert Tungadi; Dizky Ramadani Putri Papeo; Andi Makkulawu; Yuni Sarah Manoppo
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13532

Abstract

God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations.
Effect of HEC (Hydroxyethyl Cellulose) Polymer on Nanoemulsion-Based Curcumin Transdermal Patch Release Rahmatia Is. Kaluku; Robert Tungadi; Nur Ain Thomas
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.12025

Abstract

Curcumin a hydrophobic polyphenolic compound and water-insoluble that creates low systemic bioavailability inside the body, has broad pharmacological activity, including anti-inflammation. This study aims to formulate, characterize and evaluate the nanoemulsion based on curcumin through an in vitro transdermal patch preparation. This study starts from formulating a curcumin nanoemulsion solution and characterizing the particle size of curcumin through PSA (Particle Size Analyzer). Further, it formulates the transdermal patch preparation with the smallest curcumin particles within three concentrations (HEC 0,625%, 1,25%, and 2,5%) combined with HPMC 2,5% as polymer. Those formulations are evaluated through organoleptic, thickness, weight uniformity, humidity, and folding resistance tests. In the next step, this study examines the penetration through an in vitro by using a franz diffusion cell within 72 hours. The result shows increasing penetration on each formula where the best penetrations occur in the 15th and 24th hours. It also discovers that the formula containing HEC 2,5% (2c) creates the highest cumulative drug penetration (15,83%). Therefore, it deduces that curcumin nanoemulsion in the transdermal patch has good characteristics and is compatible between drug and polymer.
Studi Kasus : Pengetahuan dan Persepsi Masyarakat Tentang Vaksin Covid-19 Teti Sutriati Tuloli; Nur Rasdianah; Nur Ain Thomas; Madania Madania; Devie Ariany Daud
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15930

Abstract

The Covid-19 vaccine is still often rejected by the public, especially those who are in places with a lack of information. This affects the public knowledge and perception of the Covid-19 Vaccine. The objective of this study is to determine the level of public knowledge and perception about the Covid-19 Vaccine and to determine the correlation between the characteristics of public and perception of the Covid-19 vaccine and the correlation between the level of public knowledge and perception about the Covid-19 Vaccine. This research is observational research with a quantitative descriptive research design using a cross-sectional approach. The findings indicate that the knowledge level of the people in Tuladenggi Village about the Covid-19 Vaccine in the low category is 22%, medium category is 46%, and high category is 33%. On the other hand, the perception of people in Tuladenggi Village about Covid-19 Vaccine in the negative category is 21%, the neutral category is 25%, and the positive category is 55%. Some of the respondents' characteristics, namely Age, Occupation, Education, Marital Status, Disease History, Vaccination Status, Vaccine Type, and Symptoms, have a significant correlation with perception, with a p-value lower than 0.005. In contrast, Gender and Religion do not have a significant correlation with perception, with a value, higher than 0.005. The correlation between the level of public knowledge about vaccine and perception obtains p-value of 0.000 (p0.05).
Co-Authors A. Mu'thi Andy Suryadi A. Mu’thi Andy Suryadi Abas, Siti Nur Rahmatiya Abto, Nazarudin Adam Mustapa, Mohammad alkatiri, ahmad alkatiri Andi Makkulawu Anggai, Rifka Anggraini Anggun Sasmita Ibrahim Ariani H. Hutuba Arista Idris, Pinkan Bakari, Mohamad Fadly Bioto, Yakob Datu, Novanza L.M.N Defita Zubaidi Devie Ariany Daud Dr. Apt. Hamsidar Hasan S.Si.,M.Si Dwy Jayanto Palay, Rendy Ekaria Revalya Malopo Ekawaty Prasetya Endah Nurrohwinta Djuwarno Faradila Ratu Cindana Faradila Ratu Cindana Mo'o Fika Nuzul Ramadhani Fujiana Abd Karim Gita Potabuga Grasela Mbae Hamsidar Hamsidar Hamsidar Hasan Hamsidar Hasan Hamsidar Hasan Hiola, Faramita Ishak Isa Julianti Akuba Julianty Akuba Juniarista Jessica Pakaya LATIF, MULTIANI S Latif, Multiani S. Lisa Efriani Puluhulawa Lutfiah Pakaya Madania Madania, Madania Madania, Madania Mahdalena Sy Pakaya Mahdalena Sy Pakaya Makkulawu, Andi Maryadi Moh. Rivai Nakoe Mohamad Adam Mustapa Mohamad Aprianto Paneo Mohamad Reski Manno Mohi, Mega Agustiwi Muhamad Alpian Panu Muhammad Taupik Muhammad Taupik Multiani S Latif Multiani S Latif Multiani S. Latif Nabila Novreini Djunaidi Naharil Mumtazah Nakii, Siti Fatmawaty Nur Oktaviana Nur Rasdianah Oktaviani Kahar Pakaya, Nikmasari Papeo, Dizky Ramadani Putri Pido, Nur Huda Puluhulawa, Lisa Efriani Putri Febbiyanti Sabrina Rahmatia Is. Kaluku Rahmulia Thamrin Rakhmadana Fitraeni Basri Rismayani, Nur Robert Tungadi Robert Tungadi Robiatun Rambe Sapiun, Zulfiayu Selvi Marcellia Sidangoli, Adiva Sri Nur'ain E. Ahmad Suleman, Putri Rawe Sulistya Yasin Suryadi, A. Mu'thi Andy Suryadi, A. Mu’thi Andy Suryadi,, A. Mu'thi Andy Susanti Pakaya Teti Sutriyati Tuloli Timo, Nur Kharisma Ekaputri Tomu, Anita Faradiana Pratiwi R. Wanda Gita Van Gobel Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti A.K Windy Riani Suleman Wiwit Zuriati Uno Yayah Rachmatiyah Yelisnawati Harwanto Yuni Sarah Manoppo Zulmai Rani