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All Journal Jurnal Penelitian Saintek EKSAKTA: Journal of Sciences and Data Analysis POSITRON Jurnal Kimia Khatulistiwa Sainstek BERKALA SAINSTEK Jurnal Sains dan Teknologi Biomedika Pharmacon Jurnal Kimia Mulawarman Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) ALCHEMY Jurnal Penelitian Kimia Buletin Farmatera Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Dinamisia: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Jambura Journal of Chemistry Jurnal Ilmu dan Teknologi Kayu Tropis ISM (Intisari Sains Medis) : Jurnal Kedokteran Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Cahaya Mandalika Jurnal Teknologi Kimia Unimal Jurnal Akademika Kimia Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Journal of Comprehensive Science Gema Lingkungan Kesehatan Jurnal Laboratorium Khatulistiwa Journal of The Indonesian Society of Integrated Chemistry al Kimiya : Jurnal Ilmu Kimia dan Terapan

Ari Widiyantoro

Program Studi Kimia, Fakultas MIPA, Universitas Tanjungpura, Pontianak 78124

Author-ID : 415800

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Senyawa Aktif Antiinflamasi dari Kulit Batang Pasak Bumi (Eurycoma longifolia Jack) Ari Widiyantoro; Indri Kusharyanti; Lia Destiarti; Elvi Rusmiyanto Pancaning Wardoyo
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 12, ISSUE 2, August 2011
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pasak bumi (Eurycoma longifolia Jack) merupakan salah satu famili Simaroubaceae yang mengandung senyawa kimia dengan aktivitas biologik yang potensial.Penggunaannya di masyarakat selama ini hanya terbatas sebagai aprodisiaka, namun beberapa penelitian menunjukkan ditemukannya senyawa kimia dengan aktivitas sebagai antimalaria, antikanker dan antioksidan. Penelitian ini mengungkapkan adanya senyawa kimia yang bersifat antiinflamasi dengan tinjauan reduksi radang pada kaki tikus yang terinduksi karagenan. Hasil penelitian diperoleh suatu senyawa quassinoid yang bersifat antiinflamasi yaitu eurycomaosida, namun aktivitasnya lebih rendah dibanding indometasin sebagai kontrol positif. Kata Kunci : Eurycoma longifolia Jack, antiinflamasi, udema, karagenan, quassinoid

Senyawa Sitotoksik dari Fraksi Diklorometana Kulit Terong Ungu (Solanum melongena L.) Terhadap Sel Kanker Payudara T47D Ari Widiyantoro; Harlia Harlia; Banu Prasetya
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 11, No 2 (2021): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v11i2.3110

Eggplant (Solanum melongena L.) is a plant that contains antioxidants and potentially as a cancer drug. This study was conducted to identify the cytotoxic activity of secondary metabolite compound against T47D breast cancer cells based on the IC50 value. Isolation Eggplant peel was carried out in several steps, such as maceration, partition, and chromatography.The result 1H-NMR (DMSO, 500 MHz) analysis optained a chemical shift of δ 0.86 ppm (1H,m), δ 1.44 ppm (1H,s), δ 1.34 ppm (2H, brs), δ 1.62 ppm (1H, m), δ 3.31 ppm (4H, brs), δ 3.73 ppm (1H, t), dan δ 7.69 ppm (1H,m). Based on the chemical shift 3 ' isolate tends to have similarities to the aglycon pregnan compound steroids. The results showed that the dichloromethane fraction obtained IC50 values of 160.79 µg / mL and the isolate obtained IC50 values of 124.44 µg / mL. The IC50 value obtained by the dichloromethane fraction and isolate was classified as moderate cytotoxic so that it could be used to prevent and inhibit the growth of cancer cells.

Isolasi dan Karakterisasi Senyawa Kimia dari Kulit Batang Manggis (Garcinia mangostana Linn) Isolation and Characterization of Chemical Compound from Bark of Mangosteen (Garcinia mangostana Linn) Lia Destiarti; Ari Widiyantoro; Elvi Rusmiyanto; Maryati Maryati; Harlia Harlia; Ratu Safitri; Unang Supratman
Jurnal Ilmu dan Teknologi Kayu Tropis Vol 7, No 2 (2009): Jurnal Ilmu dan Teknologi Kayu Tropis
Publisher : Masyarakat Peneliti Kayu Indonesia

The purpose of this research is to isolate and characterize chemical compound from bark of mangosteen. Bark of mangosteen was macerated with methanol. The extract from that process was fractionated with n-hexane, methylen chloride, and ethyl acetate. Ethyl acetate fraction was separated and purified by vacuum column chromatography, gravitation column chromatography, and preparative thin layer chromatography. The relative pure compound was afforded from ethyl acetate fraction of mangosteen bark (8.5 mg) resulting from 1.5 kg of mangosteen bark. The yellow amorphous powder of compound melts at 114 ~ 116ºC (uncorrected). The purity of compounds was tested by 1 and 2 dimension thin layer chromatography which gave one spot on TLC plate. The ultraviolet-visible (in CH3OH solvent) spectrum showed absorption maximum at 318 nm (sinamoyl group/band I), 258 (shoulder), and 243 nm (benzoyl group/band II). Addition of NaOH caused batochromic shift of band I and band II predicted as two hydroxyl at C-4’ and C-7, respectively. The infrared spectrum displayed absorption bands of OH stretching at 3436 cm-1, C-H stretching at 2920 cm-1, C=O stretching at 1631 cm-1, C-O-C stretching at 1094 cm-1, and C-H aromatics bending at 970-800 cm-1. A molecular ion in the FABMS at m/z 271.36 [M+H] + was consistent for the molecular formula C15H10O5. The 1H NMR spectrum showed characteristic resonances of a flavone. Based on the result of phytochemical test and analysis of the spectrum, it is predicted that the compound belongs to flavone, a kind of flavonoids which has hydroxyl at C-5, C-7, and C-4.

Cytotoxic Compound from Ethyl Acetate Fraction of Brucea javanica (L.) Merr Fruit Against HeLa Cell Line Nurlina Nurlina; Ari Widiyantoro
ALCHEMY Jurnal Penelitian Kimia Vol 11, No 1 (2015): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.11.1.108.58-71

The pure compound relatively (85 mg) was isolated from 4.5 kg Brucea javanica (L.) Merr. fruits sample. It was obtained from ethyl acetate fraction as a red-brownish amorphous solid of melting point 202-206 oC. Phytochemical screening of isolate showed positive result of terpenoid group. Based on analysis by UV, IR,1H-NMR and 13C-NMR spectroscopy and by comparison with known related compounds, indicated that isolate is quassinoid compound named Picras 3- en- 21- oat acid, 15-(acetyloxy)-13,20- epoxy-3-(ß-D- glucopyranosyloxy)-11, 12- dihydroxy -2, 16- dioxo -, methyl ester. Cytotoxic test using MTT assay method showed that compound have IC50 9,7 µg/mL.

Efektivitas Ekstrak Etanol Kulit Buah Terung Ungu (Solanum melongena L.) sebagai Antimalaria terhadap Jumlah Eosinofil pada Mencit (Mus musculus) yang Diinduksi Plasmodium berghei Muhammad Faisal Haris; Muhammad Ibnu Kahtan; Ari Widiyantoro
Jurnal Sains Farmasi & Klinis Vol 7, No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Malaria is a disease caused by Plasmodium that is transmitted to humans through female Anopheles mosquito bite. Many cases of antimalarial drug resistance such as chloroquine led to the need for new antimalarial discoveries. Eggplant contains many secondary metabolites that are potential as antimalarial. This study aimed to determine the effectivity of ethanol extract of eggplant peels as antimalarial towards eosinophil in mice induced by Plasmodium berghei. Eggplant peels were extracted by maceration method using 70% ethanol. The analysis of secondary metabolites from the ethanol extract of eggplant peels was conducted using tube test and thin layer chromatography. The percentage of parasitemia and eosinophil were calculated from peripheral blood smear of mice which were treated with extracts at the doses of 0.075, 0.15, and 0.30 mg/20 g of body weight. Dihydroartemisinin-piperaquin (3.744 mg/20 g of body weight) was used as positive control, while distilled water was used as negative control. The study showed that ethanolic extract of the eggplant peels contained alkaloids, flavonoids, terpenoids, steroids, phenolic, and saponins. The extract effectively reduced parasitemia at a dose of 0.075 mg/20 g, but it was not effective in increasing the number of eosinophil in mice. There was no correlation between the number of parasitemia and eosinophil. The study concludes that ethanolic extract of the eggplant peels exhibits antimalarial activity, but does not show immunomodulatory activity in increasing eosinophil.

THE EFFECTIVITY OF THE ETHANOL EXTRACT OF EGGPLANT (SOLANUM MELONGENA L.) PEELS AS ANTIMALARIAL TO MONOCYTE IN MICE (MUS MUSCULUS) INDUCED BY PLASMODIUM BERGHEI Ari Widiyantoro
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Malaria is a disease caused by Plasmodium that is transmitted to humans by the bite of the female Anopheles mosquito. Malaria can be treated with antimalarial drugs such as chloroquine and artemisinin, but in some endemic areas, it is reported that parasitic resistance to chloroquine was reported so that malaria eradication becomes increasingly difficult. The occurrence of this resistance causes the need for new antimalarial findings. Eggplant (Solanum melongena L.) has many secondary metabolites, one of which is solanidine which is toxic to bacteria, fungi, viruses, and protozoa. Eggplant peel was extracted by maceration method using 70% ethanol. The analysis of secondary metabolites from the ethanol extract of eggplant peels used tube test and thin-layer chromatography. The level of parasitemia and the number of monocytes were calculated from blood smear of mice (Mus musculus) which were treated with extracts at a dose of 0.075 mg/20 g of body weight; 0.15 mg/20 of body weight; and 0.3 mg/20 g of body weight. 3.744 mg/20 g of body weight Dihydroartemisinin-Piperaquine (DHP) was used as positive control and distilled water was used as the negative control. Ethanol extract of the eggplant peels contains groups of alkaloids, flavonoids, terpenoids, steroids, phenolic, and saponins. 0.075 mg/20 g body weight of ethanol extract of the eggplant peels effectively reduces parasitemia and 0.3 mg/20 g body weight of ethanol extract of the eggplant peels effectively increases the number of monocytes in mice. There is no correlation between an increase in the number of monocytes and a decrease in the level of parasitemia. Keywords: antimalarial, eggplant, monocyte, Plasmodium berghei, Solanum melongena L.

ISOLATION OF FLAVONOID FROM ANDONG LEAVES (Cordyline fruticosa (L.) A. Chev.) AND ITS ACTIVITY AS COMPLEXOR OF Fe2+ Herlinda Djohan; Ari Widiyantoro; Anis Shofiyani
Indonesian Journal of Pure and Applied Chemistry Vol 2, No 1 (2019)
Publisher : Tanjungpura University

Flavonoid is one of the phenolic compounds that can complex metals. One of the native plants of Indonesia which has the potential as a metal complexor is the andong plant (Cordyline fruticosa (L.) A.Chev). The isolation process to obtain pure compound are extraction, fractionation, and separation by chromatography. Chromatography method using vacuum liquid chromatography (VLC), gravity column chromatography (GCC) and preparative thin layer chromatography (TLC). This research obtained relatively pure isolate F2.8. The IR (KBr) data on wave numbers of isolate F2.8 were 3430; 2925-2855; 1749; 1609-1512; 1171 and 1100 cm-1.The result of the spectrum 1H-NMR showed flavonoid compound has similar typical spectrum of apigenin compound which showed chemical shift (δH ppm) : 6.85 (1H, s, H-3); 6.29 (1H, s H-6); 6.57 (1H, H-8); 7.03 (2H, d, J = 11.96 Hz, H-3’, H-5’); 8.03 (2H, d, J = 11.72 Hz, H-2’, H-6’). The UV-Vis (CH3OH) spectrum data of isolate F2.8 after the addition of Fe2+ showed a shift at λmax towards a greater direction with a batochromic shift which was caused a decrease in absorbance after the addition of iron (Fe2+) 20 ppm namely: 290 nm; 305 nm with respectively absorbances of 1.62 A; 0.42 A. Based on these data, isolate F2.8 is apigenin which is capable of complexing Fe2+.

AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KENIKIR (Cosmos caudatus Kunth) DENGAN BERBAGAI METODE EKSTRAKSI (ANTIOXIDANT ACTIVITY OF LEAVES EXTRACT OF KENIKIR (Cosmos caudatus Kunth) WITH VARIOUS EXTRACTION METHODS) Ari Widiyantoro; Harlia Harlia
Indonesian Journal of Pure and Applied Chemistry Vol 3, No 1 (2020)
Publisher : Tanjungpura University

Cosmos caudatus Kunth is a vegetable plant that is often used as a food ingredient and traditional medicine. This study aims to determine the antioxidant activity of C. caudatus Kunth leaves extract obtained by a variety of extraction methods. The antioxidant activity test was carried out using the DPPH method. The results showed that the yield of C. caudatus Kunth leaves extract by maceration method (10.98%) was higher than the percolation (7.28%) and soxhletation (8.22%). The antioxidant activity (IC50) of the macerated extract (12.5 ± 0.3 µg/mL) was also higher than the percolated extract (16.8 ± 0.2 µg/mL) and soxhletation (18.8 ± 0.2 µg/mL). The macerated extract showed the highest antioxidant activity because it contained many secondary metabolites such as flavonoids and phenolics.

KARAKTERISASI FLAVONOID DARI DAUN MUNDU (Garcinia dulcis [ROXB.] KURZ) SEBAGAI PENGOMPLEKS Pb (II) Emilda Sari; Ari Widiyantoro; Gusrizal Gusrizal
Indonesian Journal of Pure and Applied Chemistry Vol 2, No 1 (2019)
Publisher : Tanjungpura University

Pb (II) merupakan salah satu zat beracun dan berbahaya. Keberadaannya dalam tubuh manusia dapat mengganggu sistem metabolisme tubuh. Penelitian ini bertujuan untuk mengkarakterisasi flavonoid yang diisolasi dari daun mundu (Garcinia dulcis) sebagai pengompleks logam Pb (II). Tahapan penelitian yang dilakukan meliputi persiapan sampel kemudian ekstraksi, isolasi, dan pemurnian senyawa menggunakan metode kromatografi vakum cair (KVC), kromatografi kolom gravitasi (KKG), dan kromatografi lapis tipis (KLT), sedangkan identifikasi senyawa dilakukan menggunakan spektroskopi ultraungu-tampak (UV-Vis) dan inframerah (IR) serta 1H-NMR. Penelitian ini telah berhasil memperoleh 6 fraksi gabungan dari KVC dan 6 fraksi gabungan dari proses KKG. Pada fraksi F4.1 dari KKG dilakukan pemurnian lebih lanjut dengan metode kromatografi lapis tipis (KLT) preparatif sehingga diperoleh 5 isolat. Pada isolat F4.1.3 dilakukan pengujian keberadaan flavonoid dengan uji fitokimia dan hasilnya positif mengandung fenolik dan flavonoid. Selanjutnya isolat tersebut dilakukan pengujian aktivitas pengompleks terhadap logam Pb (II) 100 ppm, 200 ppm dan 300 ppm. Berdasarkan hasil pengujian UV-Vis, isolat F4.1.3 terdapat dua pita pada 287 nm dan 291 nm yang menunjukkan adanya karakteristik senyawa flavonoid. Pergeseran batokromik dari 287 nm dan 291 menjadi 289 dan 293 nm ini setelah penambahan Pb (II) menunjukkan bahwa isolat memiliki kemampuan mengkompleks Pb (II). Hasil analisis spektra inframerah (IR) dan 1H-NMR diduga isolat F41.3 adalah senyawa 5,8,4’–trihidroksi-flavan.

PENINGKATAN PERILAKU PEDULI HUKUM DAN LINGKUNGAN MELALUI PROGRAM KEMITRAAN MASYARAKAT PEDULI HUKUM Kamarullah; Nafsiatun; Muhammad Irfani Hendri; Ari Widiyantoro
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 1 (2019): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v3i1.2056

Law enforcement requires firm assertiveness and public awareness. Law enforcement will guarantee the life of a safe nation and state. Communities need high legal awareness so that they have high legal behavior. The province of West Kalimantan is one of the provinces that experiences land and forest fires every year. Factors of land and forest fires include natural and human factors. Natural factors, especially the dry season is a difficult factor to control, so one of the preventive steps is to control human factors. Control of human factors through increasing the care of law and the environment so that humans do not violate the law, especially the burning of land and forests. The Community Care Law Partnership Program (PKM) is one way to improve legal and environmental care behavior. The method for implementing PKM activities was through socialization and counseling, demonstrations and training, and assistance to partners, namely the people of Rasau Jaya III village, including farmers, PKK women and youth groups. The results of the activity showed that the Rasau Jaya III village officials and the community were enthusiastic in following this activity. The activity was carried out on the sidelines of the busy work of the people of Rasau Jaya III village. Activities are carried out with a persuasive approach so that interaction with the community becomes comfortable. This is done so that the transfer of knowledge and skills goes well. Based on the results of the questionnaire before and after the activity showed that the law and environment care behavior of the community of Rasau Jaya III increased. This condition is very important to create law enforcement and environmental care for a comfortable human life.

Co-Authors Ade Mariadi Agus Malik Ibrahim Ahmad Yani Nelly Wahyuni Lia Destiarti Ajuk Sapar Andi Hairil Alimuddin Anis Shofiyani Anis Shofiyani Annisa Dyah Astari Putri Annisa Firdaus, Navisa Arif Sulaiman Aritonang, Anthoni B. Banu Prasetya Boima Ramses Situmeang Danang Mustofa Diana Natalia Diana Natalia Dila, Gata Diva Feraldy Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Endah Sayekti Gusrizal Gusrizal Haris, Muhammad Faisal Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Herlinda Djohan Ihsan, Bagus Muhammad Ikhwan, Darul Imelda Hotmarisi Silalahi Indrawati, Ratih Indri Kusharyanti Jayuska, Afghani Julinton Sianturi Kahtan, Muhammad Ibnu Kamarullah Kristina Damiyanti Kustiati Kustiati M. Irfani Hendri Mardhia, Mardhia Maryati Maryati Maulidiyah Salim Millenia, Millenia Mistika Zakiah Mohamad Adam Mustapa Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Faisal Haris Muhammad Ibnu Kahtan Muhammad Ibnu Kahtan Nafsiatun Nelly Wahyuni Nurhayati Bialangi Nurlina, Nurlina Nurul Asikin Puji Ardiningsih Putri, Annisa Dyah Astari Putri, Rinka Carolina Rachmadi, Octavian Rahayu, Warsi Kurnia Ratna Wardani Ratnawaty, Gervacia Jenny Ratu Safitri Risa Nofiani Rr. Erni Kusuma Putri Rudiyansyah Rudiyansyah Rudiyansyah Rudiyansyah Sadenta, Deby Pascalia Sari Damayanti Sari, Emilda Septian Triadi Syahputra Sharon Angelia Shofiyani, Anis Siti Khotimah Sulistyo, Luthfi Imam Susanto, Dhessy Thamrin Usman Thamrin Usman Titin Anita Titin Anita Zahara, Titin Anita Unang Supratman Uray Ristian Wahyuningsih, Aprilia Tri Warsidah, Warsidah Weny Musa Wibowo, M. Agus Wibowo, Muhamad Agus Winda Rahmalia Yuswar, Muhammad Akib Yuszda K Salimi Zaharah, Titin Anita

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