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All Journal Jurnal Penelitian Saintek EKSAKTA: Journal of Sciences and Data Analysis POSITRON Jurnal Kimia Khatulistiwa Sainstek BERKALA SAINSTEK Jurnal Sains dan Teknologi Biomedika Pharmacon Jurnal Kimia Mulawarman Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) ALCHEMY Jurnal Penelitian Kimia Buletin Farmatera Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Dinamisia: Jurnal Pengabdian Kepada Masyarakat JURNAL EDUCATION AND DEVELOPMENT JSFK (Jurnal Sains Farmasi & Klinis) VOX EDUKASI: Jurnal Ilmiah Ilmu Pendidikan FITOFARMAKA: Jurnal Ilmiah Farmasi Jambura Journal of Chemistry Jurnal Ilmu dan Teknologi Kayu Tropis ISM (Intisari Sains Medis) : Jurnal Kedokteran JFM (Jurnal Farmasi Malahayati) Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Cahaya Mandalika Jurnal Math-UMB.EDU Jurnal Teknologi Kimia Unimal Jurnal Akademika Kimia Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Journal of Comprehensive Science Gema Lingkungan Kesehatan Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Laboratorium Khatulistiwa Journal of The Indonesian Society of Integrated Chemistry al Kimiya : Jurnal Ilmu Kimia dan Terapan
Ari Widiyantoro
Program Studi Kimia, Fakultas MIPA, Universitas Tanjungpura, Pontianak 78124
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Cytotoxic Compound from Ethyl Acetate Fraction of Brucea javanica (L.) Merr Fruit Against HeLa Cell Line Nurlina Nurlina; Ari Widiyantoro
ALCHEMY Jurnal Penelitian Kimia Vol 11, No 1 (2015): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.11.1.108.58-71

Abstract

The pure compound relatively (85 mg) was isolated from 4.5 kg Brucea javanica (L.) Merr. fruits sample. It was obtained from ethyl acetate fraction as a red-brownish amorphous solid of melting point 202-206 oC. Phytochemical screening of isolate showed positive result of terpenoid group. Based on analysis by UV, IR,1H-NMR and 13C-NMR spectroscopy and by comparison with known related compounds, indicated that isolate is quassinoid compound named Picras 3- en- 21- oat acid, 15-(acetyloxy)-13,20- epoxy-3-(ß-D- glucopyranosyloxy)-11, 12- dihydroxy -2, 16- dioxo -, methyl ester. Cytotoxic test using MTT assay method showed that compound have IC50 9,7 µg/mL.
Co-Authors Ade Mariadi Aderiya Munika Afandi Afandi Agus Malik Ibrahim Agus Wibowo Ahmad Yani Nelly Wahyuni Lia Destiarti Ajuk Sapar Andi Hairil Alimuddin Andi Hairil Alimuddin Anis Shofiyani Anis Shofiyani Annisa Dyah Astari Putri Annisa Firdaus, Navisa Arif Sulaiman Aritonang, Anthoni B. Bagus Muhammad Ihsan Banu Prasetya Boima Ramses Situmeang Danang Mustofa Dede Suratman Diana Natalia Diana Natalia Dila, Gata Diva Feraldy Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Endah Sayekti Eny Enawaty Gusrizal Gusrizal Haratua Tiur Maria Silitonga Haris, Muhammad Faisal Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Herlinda Djohan Ikhwan, Darul Imelda Hotmarisi Silalahi Indrawati, Ratih Indri Kusharyanti Jayuska, Afghani Julinton Sianturi Kahtan, Muhammad Ibnu Kamarullah Kamarullah Kamarullah Khairiyah, Uun Rabi'atul Kristina Damiyanti Kustiati Kustiati M. Irfani Hendri Mahanani, Annisah Mardhia, Mardhia Maryati Maryati Maulidiyah Salim Millenia, Millenia Mistika Zakiah Mohamad Adam Mustapa Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Basri Muhammad Faisal Haris Muhammad Ibnu Kahtan Muhammad Ibnu Kahtan Nafsiatun Nelly Wahyuni Nur Oktivianti Dewi Nurhayati Bialangi Nurlina, Nurlina Nurul Asikin Puji Ardiningsih Putri, Annisa Dyah Astari Putri, Rinka Carolina Rachmadi, Octavian Rahayu, Warsi Kurnia Ratna Wardani Ratnawaty, Gervacia Jenny Ratu Safitri Risa Nofiani Risa Nofiani Rr. Erni Kusuma Putri Rudiyansyah Rudiyansyah Rudiyansyah Rudiyansyah Rudiyansyah Rudiyansyah Sadenta, Deby Pascalia Samsol Sari Damayanti Sari, Emilda Septian Triadi Syahputra Sharon Angelia Shofiyani, Anis Siti Khotimah Sulistyo, Luthfi Imam suryani, puput eka Susanto, Dhessy Tariz Zharfan ME Thamrin Usman Thamrin Usman Thamrin Usman Titik Lestari Titin Anita Titin Anita Zahara Titin Anita Zahara, Titin Anita Tria Susanti Unang Supratman Uray Ristian Wahyuningsih, Aprilia Tri Warsi Kurnia Rahayu Warsidah, Warsidah Weny Musa Wibowo, M. Agus Wibowo, Muhamad Agus Winda Rahmalia Yoga Pratama Yuswar, Muhammad Akib Yuszda K Salimi Zaharah, Titin Anita