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All Journal Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Jurnal Mandala Pharmacon Indonesia Bivalen: Chemical Studies Journal Jurnal Pengabdian Masyarakat (ABDIRA) ANDIL Mulawarman Journal of Community Engagement Journal of Pharmaceuticals and Natural Sciences al Kimiya : Jurnal Ilmu Kimia dan Terapan Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm
Samsul, Erwin
Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Impact of Dietary Lead (Pb) on the Human Gastrointestinal Tract: A Review Samsul, Erwin; Muzaqi, Muhammad Choirul; Yotam, Yotam; Putra, Mitosie Gunarsa Caesar; Mutiara, Nur Adinda; Gunawan, Jevon Ecclesia; Rahman, Muhammad Alif; Salsabila, Syifa Kamila
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 2 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i2.4753

Abstract

Lead (Pb), a toxic heavy metal, frequently contaminates food and beverages due to environmental pollution and industrial processes. This study reviews lead's toxic effects on the human gastrointestinal tract through a narrative literature review from credible databases such as PubMed, Elsevier, and Google Scholar. Findings reveal that lead concentrations vary by food type, processing methods, and storage duration. For instance, lead levels in preserved eggs range from 334-1782 mg/kg, exceeding the safe limit (0.25 mg/kg), causing nausea, vomiting, and abdominal pain. Unwashed pears reached 18.5 mg/kg after 12 days, triggering similar symptoms. In contrast, grapes and vegetables showed low lead levels (<0.04 mg/kg) with no significant clinical effects. Food poisoning cases like contaminated candy in schools highlight the urgent need for strict monitoring. This review emphasizes strengthening food safety regulations, raising public awareness, and promoting further research to reduce exposure in the global food supply chain
Aktivitas antioksidan ekstrak etanol daging buah rambutan hitam (Nephelium ramboutan-ake) dengan metode DPPH, ABTS dan FRAP: Antioxidant activity of rambutan hitam (Nephelium ramboutan-ake) flesh ethanol extract utilizing DPPH, ABTS, and FRAP methods Febrina, Lizma; Rusli, Rolan; Samsul, Erwin; Rusman, Arman; Setyowati, Widiastuti Agustina Eko
Bivalen: Chemical Studies Journal Vol. 8 No. 1 (2025)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v8i1.4839

Abstract

Rambutan hitam atau maritam (Nephelium ramboutan-ake) merupakan tumbuhan tropis khas Kalimantan Timur. Tumbuhan ini tumbuh liar dihutan-hutan Kalimantan. Secara empiris, masyarakat setempat menggunakan buah rambutan hitam untuk pengobatan kanker. Namun demikian, penelitian ilmiah mengenai rambutan hitam masih sangat terbatas. Oleh karenanya, penelitian ini bertujuan untuk menganalisis aktivitas antioksidan dari buah rambutan hitam dengan menggunakan metode DPPH, ABTS, dan FRAP. Analisis aktivitas antioksidan dilakukan secara kolorimetri menggunakan spektrofotometer UV-Vis pada panjang gelombang tertentu. Hasil penelitian ini mengungkapkan bahwa ekstrak etanol daging buah rambutan hitam memiliki aktivitas antioksidan dengan kategori kuat baik dianalisis menggunakan metode DPPH (IC50 = 32,51 ± 0,21 mg/L), ABTS (IC50 = 30,04 ± 0,31 mg/L), dan FRAP (EC50 = 34,22 ± 0,17 mg/L). Aktivitas antioksidan yang kuat dari rambutan hitam menggambarkan potensi yang besar dari rambutan hitam dalam mengurangi dampak negatif radikal bebas. Adapun aktivitas antioksidan buah rambutan hitam dilaporkan pertama kali pada tulisan ini.
Workshop Pembuatan Gummy Candy Madu Kelulut Di Desa Bangun Rejo Kabupaten Kutai Kartanegara Samsul, Erwin; Junaidin, Junaidin; Rijai, Laode; Ibrahim, Arsyik; Herman, Herman; Rusli, Rolan; Ahmad, Islamudin; Febrina, Lizma; Farah, Harra Ismi; Hikmawan, Baso Didik; Rija’i, Hifdzur Rashif; Supriatno, Supriatno; Rusman, Arman; Almeida, Maria; Riki, Riki; Arifuddin, M; Bone, Mahfuzun; Arifian, Hanggara; Setiawaty, Agus
Journal of Community Research and Service Vol. 9 No. 2: July (2025)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jcrs.v9i2.69839

Abstract

A workshop on making gummy candy based on stingless bee honey was held in Bangun Rejo Village, Kutai Kartanegara Regency, as an effort to empower the community through innovation in locally processed food products. The aim of this activity was to improve the skills of MSME actors and village residents in producing stingless honey gummy candy, and to elevate the added value of local honey. The methods used included a short theoretical session about the composition of stingless bee honey and the technical process of gummy candy production, a live demonstration, group practice among participants, as well as evaluation via pre-test and post-test on understanding and skills. The workshop was attended by 50 participants from various MSMEs and community groups. Results showed that after training there was an increase in participant understanding by approximately 75% compared to before the training. Furthermore, participants succeeded in making gummy candy with a chewy texture, the natural sweetness of stingless bee honey, and a distinctive aroma that was well accepted in organoleptic tests. This workshop made a tangible contribution to local product diversification, increasing production capacity, and the potential enhancement of village income through signature products based on stingless bee.
Efektivitas Ekstrak Kratom (Mitragyna speciose) pada Inhibisi Withdrawal Syndrome Model Adiksi Morfin Indriyanti, Niken; Hajrah, Hajrah; Priastomo, Mukti; Samsul, Erwin; Prabowo, Wisnu Cahyo; Prasetya, Fajar
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.535

Abstract

Kratom (Mitragyna speciose) secara empiris banyak digunakan di area Kalimantan untuk berbagai keluhan yang berkaitan dengan nyeri. Banyak hasil penelitian bahwa tanaman ini mampu mengatasi kecanduan narkotik, dan sebaliknya. Maka, penelitian ini mengukur potensi kratom pada penanganan gejala withdrawal syndrome adiksi morfin. Pengujian dilakukan secara in vivo pada model mencit yang diinduksi adiksi morfin. Hasil yang didapatkan berupa aktivitas penekanan gejala adiksi pada parameter perilaku psikomotorik, sensitivitas saraf pendengaran, dan sensitivitas saraf mata terhadap cahaya. Pemberian bahan uji aman pada parameter bilirubin dan urobilinogen, serta parameter ginjal. Penelitian lebih lanjut diperlukan untuk menelusuri efek terhadap organ otak dan limpa. Ekstrak kratom memiliki multiple compounds yang memungkinkan adanya penekanan aktivitas adiksi. Maka disimpulkan bahwa pemberian ekstrak etanol kratom dengan dosis 4 mg/kgBB mencit mampu menekan gejala withdrawal syndrome pada model adiksi morfin.
Remaja Berdaya: Edukasi untuk Memahami dan Menghindari Kenakalan Remaja pada Siswa SMP Negeri 1 Dempar Febrianur, Hana Giska; Maharani, Putri; Meysi, Amelia; Payuk, Seprianto; Al Dzaky, Audric; Ramlin; Kurniawan, Ridho Setya; Samsul, Erwin
ANDIL Mulawarman Journal of Community Engagement Vol. 1 No. 3 (2024): ANDIL Mulawarman J Comm Engag
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LP2M), Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/andil.v1i3.1621

Abstract

Juvenile delinquency has become a serious problem that requires special attention and handling, including in the environment of SMP Negeri 1 Dempar. Thus, education is determined as an effort to provide students with a deep understanding of various aspects of juvenile delinquency, its impact on themselves and the environment, and effective strategies to avoid delinquent behavior. This education is carried out using the lecture method and reaction evaluation and cognitive evaluation are carried out. The results of this activity indicate significant success in increasing understanding of adolescence, avoiding juvenile delinquency, and encouraging the development of positive life skills. This is evidenced by the results of the Wilcoxon Signed Rank Test which produces a value of p = 0.000 (p <0.05), meaning that there is a difference in student knowledge between before and after being given intervention in the form of juvenile delinquency education. KEYWORDS: Education, Juvenile Delinquency, Adolescent, Dempar
The Potential of Carbon Monoxide (CO) as a Therapeutic Agent in Cancer Treatment: A Literature Review: Potensi Karbon Monoksida Sebagai Agen Terapeutik Dalam Pengobatan Kanker: Tinjauan Literatur Samsul, Erwin; Dewi, Jingga Apriani Jevita; Agustina, Inayah Yuli; Atmadja, Meilda Keysia Angelica; Rombe, Irene Aliet; Nabilah, Cindy; Sari, Mila Kansia; Putri, Nur Arinda
Jurnal Riseta Naturafarm Vol. 2 No. 2 (2025): Jurnal Riseta Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrn.v2i2.5664

Abstract

Background: Carbon monoxide (CO) has shown potential as an anti-cancer therapy, rather than simply functioning as a toxin. Recent research indicates that carbon monoxide (CO), which is a carbon-based nanoparticle, can target cancer cells and induce apoptosis. CO shows promising cytotoxic activity against cancer cell lines as one of the therapies in cancer treatment. The purpose of this article is to present a concise look at the physiological and biochemical traits of CO and the mechanism of its therapeutic potential in the treatment of cancer Methods: This study is a literature review. The database used in the search for this article using google scholar, pubmed, and elsevier. the data collection process uses the keywords “Carbon Monoxide, cancer, anti- cancer therapy” which are taken from the results of research that has been done previously both from within and outside the country. The results of this research article review are Carbon Monoxide (CO) not only has a toxic effect but also has a cytotoxic effect on cancer cells. In cancer cells treated with CO, there was a significant reduction in Akt (protein kinase B) phosphorylation, a key factor in cancer neovascularization, by 30-50%.
Pharmacognosic Study and Determination of Marker Compounds Soursop Leaves (Annona muricata) M. Arifuddin; Faisal, Muhammad; Samsul, Erwin; Hikmawan, Baso Didik; Prabowo, Wisnu; Ahmad, Islamudin; Ibrahim, Arsyik
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 1 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/zjthbv92

Abstract

Soursop (Annona muricata) is reported to have great efficacy in traditional medicine in Indonesia so it is very vulnerable to being faked or sold as low quality. Apart from having a delicious fruit taste, Soursop leaves have also been used as an effective cancer medicine by the public and have been scientifically proven so that Soursop can be used as a phytopharmaceutical product. Therefore, it is necessary to carry out research to determine pharmacognosy parameters and marker compounds as ingredients needed to obtain the authenticity of simplicia and plant extracts. This research includes macroscopic and microscopic examination of leaves, macroscopic and microscopic examination of simplicia, fluorescence characteristics of simplicia, determining the solubility of methanol extract in various non-polar and polar solvents as well as the characteristics of marker compounds that can be used as alternatives to existing marker compounds from Soursop (Annona muricata). The research results obtained are important information as a stage for the identification and standardization of soursop leaves (Annona muricata) as a raw material for herbal medicine.
Potential and Activities of the Sunscreen Lotion Preparation of Bawang Dayak (Eleutherine americana (Aubl.) Merr. by Ethanol Extract Fraction from East Boneo Ibrahim, Arsyik; Badawi, Satriani; Rusman, Arman; Riki; Samsul, Erwin; Sulistyarini, Riski; Arifuddin, M.; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/yrb89026

Abstract

Has conducted research Potential and Activities of the Sunscreen Lotion of Bawang Dayak (Eleutherine americana (Aubl.) Merr. by ethanol extract fraction from East Borneo. The purpose of the study was to determine the potency ann activity of the sunscreen ethanol extracts fraction of Bawang Dayak in the preparation of a lotion with the parameter measuring the percent transmission erythema (% Te) and pigmentation (% Tp) in vitro in the room temperature 27oC storage and accelerated temperature 40oC. Lotion dosage formulations using ethanol extracts fraction bawang Dayak with a concentration of 0.1% and 0.2%, and positive control is a trademark preparation Bless Sunscreen Lotion SPF 15®. Stages of research include the formulation and measurement of absorbance and value %Te) and %Tp at various storage temperatures with UV-Vis spectrophotometry at λ 292.5 to 372.5 nm. The analysis of research data using a program SPSS. The results showed that ethanol extract fraction concentration in lotion preparations of bawang Dayak 0.1% and 0.2% active as a sunscreen included in the category of sunblock. The extract fraction is active as a sunscreen and in the Sunbloc category, with the best concentration as a sunscreen being 0.2%, with its sunscreen potential not being significantly different from the control Sunscreen SPF 15® at the 5% level.
Toxicity Analysis: A Collection of Case Studies and Drug Management Strategies Samsul, Erwin; Khotimah, Ika; Harludi, Theodora Jane; Purba, Gmelina Adelia Putri; Wahyuda, Aji Arda Nur; Sudarma, Mahatma Setya; Rajo, Nur Wulan Mas; Rahma, Saina Cintami Abdila; Ardhito, Willy
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i1.0114

Abstract

Narcotics, Psychotropics, and Addictive Substances (NAPZA), are any compound or drug that can alter the central nervous system and behavioural patterns, that can also cause an addiction. Narcotics and psychotropics in itself can be categorized into 3 categories of narcotics, and 4 categories of psychotropics, based on their use as a medication and the possibility of an addiction. Since NAPZA can alter the central nervous system, the possibility of their toxicity needs more attention. This study is done to review the handling and the mechanism of toxicity of NAPZA. We used the narrative review method to gather information from various sources, including 3 websites, 1 book, 7 national articles, and 22 international articles that were published in the time span of 2014 to 2024. From the 11 cases of NAPZA toxicity, 4 were caused by narcotics, 4 by psychotropics, and 3 by addictive substances, with most cases were of drug misuse by the productive population. The main handling of narcotics toxicity were to secure the breathing function, oxygen supplementation, and the use of Naloxone as an antidote. While psychotropics and addictive substances poisoning were handled with the use of benzodiazepines, hemodialysis, or to increase the rate of drug elimination in the plasma.
Review of the Effects of the Abuse of Narcotics, Psychotropics, and Other Addictive Substances Samsul, Erwin; Amiruddin, Widya Salsabila Putri; Hasanah, Fitri; Wulandari, Tiara Sahfitri; Basongan, Oktariani; Syam, Mawar Inrian; Yusuf, Muhammad; Gala, Kretentia Aprilia; Rachmawati, Nova Sri
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 1 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i1.2836

Abstract

The purpose of this study was to identify the forms of drug abuse and evaluate the impact of drug abuse in the community. This research uses a qualitative approach and is a descriptive study. This research uses the narrative literature method. This review process used the narrative review method by collecting literature from various sources, including scientific journals, government reports, and relevant conference articles, with the inclusion criteria being articles published within the last 10 years, in Indonesian or English, and discussing topics related to the impact or intervention of drug abuse. In the initial stage of searching journal articles, 17,083 articles from 2019-2024 with identified keywords such as "Drug Abuse", "Substance Abuse Cases", and "Psychotropic Abuse" were found. Of the collected articles, 25 journal articles met the criteria. The analysis was done descriptively to synthesize information based on certain categories, such as health impact and policy effectiveness. Based on the literature, the most common drug abuse included mephedrone, trihexyphenidil, LSD, and amphetamine. The results of this study indicate that the effects of drug use include agitation (30%), addiction (20%), hallucinations (60%), aggression (50%), euphoria (70%), and disorientation (50%). It is recommended to avoid using drugs because it can harm the body's condition.
Co-Authors Agus Setiawaty Agustina, Inayah Yuli Aji Ayatullah Al Dzaky, Audric Almeida, Maria Amiruddin, Widya Salsabila Putri Andi Tenri Kawareng Andreanus A. Soemardji Ardhito, Willy Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Atmadja, Meilda Keysia Angelica Badawi, Satriani Baso Didik Hikmawan Basongan, Oktariani Bone, Mahfuzun Dandy Zwageri Dewi, Jingga Apriani Jevita Faizatun Maulidha Farah, Harra Ismi Febrianur, Hana Giska Febrina, Lizma Fitri Hasanah Gala, Kretentia Aprilia Gunawan, Jevon Ecclesia Hajrah Hajrah, Hajrah Harludi, Theodora Jane Herlina Argantari Basuki Herman Herman Hikmawan, Baso Didik Ibrahim, Arsyik Indriyanti, Niken Islamudin Ahmad Islamudin Ahmad Junaidin Junaidin Junaidin, Junaidin Karisman Karisman Khotimah, Ika Kurniawan, Ridho Setya Laode Rijai M. Arifuddin M. Arifuddin M. Arifuddin, M. Meysi, Amelia Michael Rendy Yakubus Mohd Azlan Nafiah, Mohd Azlan Muhammad Faisal Muhammad Faisal Muhammad Yusuf Mus, Nurul Muhlisa Mutiara, Nur Adinda Muzaqi, Muhammad Choirul Nabilah, Cindy Niken Indriyanti Payuk, Seprianto Prabowo, Wisnu Cahyo Prasetya, Fajar Priastomo, Mukti Purba, Gmelina Adelia Putri Putra, Mitosie Gunarsa Caesar Putri Maharani Putri, Nur Arinda Rachmawati, Nova Sri Rahma, Saina Cintami Abdila Rahman, Muhammad Alif Rajo, Nur Wulan Mas Ramlin Rezekilah Rezekilah Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rolan Rusli Rombe, Irene Aliet Rusli, Rolan Rusman, Arman Salam, Supriatno Salsabila, Syifa Kamila Salsabila, Unik Hanifah Sari, Mila Kansia Setyowati, Widiastuti Agustina Eko Siti Kusmardiyani Sudarma, Mahatma Setya Sulistyarini, Riski Suparningtyas, Juniza Firdha Supriatno Supriatno Salam Syam, Mawar Inrian Syamsiar, Syamsiar Vita Olivia Siregar Wahyuda, Aji Arda Nur WISNU PRABOWO Wulandari, Tiara Sahfitri Yotam, Yotam