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All Journal JURNAL GIZI INDONESIA Majalah Kedokteran Bandung The Indonesian Biomedical Journal Public Health of Indonesia Media Ilmu Kesehatan Jurnal Kesehatan Jurnal Analis Medika Biosains (JAMBS) Abdi Dosen : Jurnal Pengabdian Pada Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Jurnal Aisyah : Jurnal Ilmu Kesehatan AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Kesehatan Tambusai International Journal of Islamic Education, Research and Multiculturalism (IJIERM) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Buletin Kedokteran dan Kesehatan Prima
Widya Yanti Sihotang
Universitas Prima Indonesia
Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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HUBUNGAN PERILAKU DENGAN KEJADIAN DERMATITIS KONTAK IRITASI PADA KARYAWAN PENCUCIAN MOBIL DI FIT & GO MEDAN Simanullang, Andry; Siagian, Masryna; Sihotang, Widya Yanti; Panjaitan, Andrean Kristianto; Ginting, Anandestra
Jurnal Kesehatan Tambusai Vol. 5 No. 2 (2024): JUNI 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i2.28235

Abstract

Dermatitis sering ditemukan pada pekerjaan industri terutama penyedia jasa cuci mobil, Dermatitis kontak iritasi adalah reaksi inflamasi pada kulit atau imun tubuh yang ditandai dengan eritema (kemerahan), edemis ringan (pembengkakan), dan pecah-pecah setelah kontak langsung pada agent atau kontak eksternal. Kulit adalah bagian terluar oleh tubuh yang berfungsi sebagai pelindung awal tubuh jika terkena sesuatu atau terinfeksi oleh bahan kimia, jika kulit terkena atau terinfeksi bahan kimia sesuatu yang membuat fungsinya tidak akan berjalan dengan baik maka akan memudahkan masuknya virus atau bakteri kedalam tubuh. Penelitian ini dilakukan dengan jenis penelitian kuantitatif dengan desain penelitian menggunakan cross sectional yaitu di mana peneliti mengukur data variabel dependen dan independen hanya sekali pada saat bersamaan. Penelitian ini menggunakan metode analisis univariat dan analisis bivariat. Penelitian ini bertujuan untuk mengetahui ada tidaknya hubungan perilaku dengan kejadian dermatitis kontak iritasi pada karyawan pencucian mobil di Fit & Go Medan. Populasi dan sampel dalam penelitian ini seluruh pekerja yang ada di Fit & Go sebanyak 40 karyawan. Berdasarkan hasil uji statistik yang dilakukan dengan chi-square didapatkan bahwa nilai p-value pengetahuan, sikap, dan tindakan > 0,05 (di atas 0,05) dengan kata lain nilai tersebut tidak diterima. Sehingga kesimpulan yang didapatkan bahwa tidak adanya hubungan yang signifikan antara pengetahuan, sikap, dan tindakan di pencucian mobil Fit & Go Medan.
The association between smoking behaviour and degenerative diseases Simarmata, Gracia Imanuela; Hartono, Hartono; Sihotang, Widya Yanti; Tobing, Andrico Napolin Lumban; Dharma, Surya; Mylano, Tri Adi; Setiawan, Deni; Willano, Almira; Novianti, Desi; Suwanto, Denny; Haryadi, Haryadi; Mukhtar, Zulfikri; Kunardi, Sidharta; Reza, Faisal
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7756

Abstract

Degenerative diseases represent a leading global cause of death, imposing a substantial health burden, wherein behavioural factors such as smoking are posited to play a significant role. This study aimed to analyse the association between smoking behaviour and the incidence of various degenerative diseases through a systematic literature review. The methodology employed was a systematic literature review, with article searches conducted across Google Scholar, PubMed, and Scopus databases from May to June 2025. Inclusion criteria encompassed full-text articles in Indonesian or English, published between 2020 and 2025, focusing on the association between smoking and degenerative diseases (hypertension, diabetes, stroke, kidney failure, cancer). From 230 identified articles, 15 met the criteria and were analysed. The synthesis of results demonstrated a significant association between smoking behaviour and an increased risk of degenerative diseases. Active smokers exhibited a three-fold higher risk of hypertension (OR=3.445), a twelve-fold higher risk of type 2 diabetes mellitus (OR=12.747), and a greater risk of developing cancer (lung, breast, laryngeal), stroke, and chronic kidney disease (CKD). Exposure to secondhand smoke among passive smokers also increased the risk of breast cancer nearly fourfold (OR=3.778). Underlying mechanisms include oxidative damage, chronic inflammation, endothelial dysfunction, and metabolic dysregulation. It is concluded that smoking is a major modifiable risk factor for degenerative diseases. Strengthening tobacco control policies, intensive health education, and smoking cessation programmes are required as primary prevention strategies.
Risk factors associated with dengue hemorrhagic fever incidence in the Belawan II Community Health Center Sari, Juwita Purnama; Ginting, Rapael; Sihotang, Widya Yanti; Fioni, Fioni; Tarigan, Antje Irmella; Malau, Reghita Claudia; Angkasa, Alexander; Lizar, Budi Septhian
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7813

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern in tropical regions such as Indonesia, where environmental and behavioural factors play crucial roles in its transmission. This study aimed to analyse the factors associated with the incidence of DHF in the working area of the Belawan II Community Health Centre in Medan. A quantitative approach with a cross-sectional design was employed. A sample of 110 housewives was selected via purposive sampling from a population of 150 housewives in the area. Data were collected through questionnaires and observation, then analysed using univariate, bivariate (Chi-Square test), and multivariate (logistic regression) methods. Bivariate analysis revealed significant associations between DHF incidence and the following factors: education level (p=0.001), housewives' knowledge (p=0.000), 3M Plus behaviour (p=0.000), health promotion services (p=0.000), and the presence of mosquito larvae (p=0.000). In contrast, variables for age (p=0.161) and occupation (p=0.898) showed no significant association. Multivariate analysis identified health promotion services as the dominant factor associated with DHF incidence (OR=0.029; 95% CI=0.010-0.084; p=0.000), with housewives' knowledge serving as a supporting factor. In conclusion, DHF prevention efforts in the Belawan II area should prioritise enhancing the quality and coverage of effective health promotion services, complemented by improving household-level knowledge and preventive practices, alongside sustainable control of mosquito breeding sites.
Granule Nanoparticle Citrus sinensis (L.) Osbeck Peel Lowers Blood Glucose Levels and HbA1C in Alloxan-induced Diabetes Rats Maya Sari Mutia; Yelvreza Rastiani Sipayung; Dwi Elmiam; Widya Yanti Sihotang; Juliana Lina
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3334

Abstract

BACKGROUND: The peel of Citrus sinensis (L.) Osbeck (sunkist orange) peels, which are often seen as waste, actually contains valuable properties such as antioxidants, hypoglycemic, nephroprotective, and anti-inflammatories. The potential effects of C. sinensis peel on diabetes have been discussed but not clear yet. Therefore, this study was performed to evaluate the effects of Granule Nanoparticle Sunkist Peel (GNSP) extracts as an antidiabetic agent in alloxan-induced diabetic rats.METHODS: The nanoparticle suspension was prepared by mixing a formulation of 0.2% chitosan and 0.1% sodium tripolyphosphate. The characteristics of nanoparticles were measured by flow time, tap index and angle of repose. Rats were induced with alloxan injection to create diabetes rat models. Rats were divided into five groups; normal control group, diabetic controls, and diabetic rats receiving either 50, 100, or 200 mg/kg/day GNSP. After 28 days of diabetes induction, rats were euthanized, and blood as well as tissue samples were collected. Blood glucose levels, HbA1c, and histopathology of the liver, kidneys, and pancreas were then assessed.RESULTS: The particle size of the synthesized material was 92.3 nm, which confirmed the nature of nanoparticle. The characteristics of the granule nanoparticle were also in accordance with the standards for drugs suitable for consumption. The administration of GNSP in dose dependent manner significantly decrease blood glucose levels and HbA1C to normal levels compared to control group (p<0.05). Histopathological analysis indicated recovery in pancreas, liver, and kidney tissues following GNSP administration.CONCLUSION: GNSP administration lowers blood glucose levels and HbA1C, as well as improved histopathological condition of pancreas, liver, and kidney in diabetic rats. These findings suggest the potential of utilizing GNSP as a potent antidiabetic agent.KEYWORDS: Citrus Sinensis (L.) Osbeck, histopathology, hyperglycemia, nano medicine, and type 2 diabetes mellitus
Aqueous and n-Hexane Fractions of Eruca sativa Differentially Target Glycemic Control and Pancreatic Islet Protection in Diabetic Rats Nasution, Sri Lestari Ramadhani; Tamarin, Tamarin; Purba, Amelia Salsabila; Suhartina, Suhartina; Sihotang, Widya Yanti
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3994

Abstract

BACKGROUND: The search for novel antidiabetic agents that simultaneously lower blood glucose and protect pancreatic β-cells is crucial. While Eruca sativa is known for its antidiabetic properties, the specific contribution of its solvent fractions to different therapeutic targets remains poorly understood. Therefore, this study was conducted to identify how different fractions selectively target glycemic control or pancreatic islet integrity.METHODS: Twenty-five male Wistar rats were rendered diabetic by a single intraperitoneal injection of 45 mg/kg streptozotocin. Diabetic animals were divided into five groups (n=5): diabetic control, positive control (0.45 mg/kg glibenclamide), and three treatment groups receiving n-hexane, ethyl acetate, or aqueous fractions of 400 mg/kgBW E. sativa for 14 days. Phytochemical screening was performed to identify bioactive profiles. Blood glucose was monitored periodically, and pancreatic tissues were assessed using a histopathological scoring system (0–4) and islet area measurement.RESULTS: Aqueous fraction showed the most potent antihyperglycemic activity, significantly reducing blood glucose (208.8±36.02 mg/dL) compared to the diabetic control (419.6± 117.11 mg/dL). Conversely, the n-hexane fraction provided superior pancreatic protection, maintaining the highest islet area (19,109.81±7,549.98 µm²) and the best histopathological score (2.8±0.8) among all treatment groups. Phytochemical screening revealed a distinct distribution of compounds, with flavonoids concentrated in the aqueous fraction and terpenoids in the n-hexane fraction.CONCLUSION: This study demonstrates that therapeutic efficacy of E. sativa is fraction-specific, driven by its distinct phytochemical profiles. The aqueous fraction is the most effective for rapid glycemic control, significantly reducing blood glucose levels. Conversely, the n-hexane fraction provides superior pancreatic protection, as evidenced by the highest islet area and improved histopathological scores. These findings suggest that E. sativa possesses a dual-target potential; while the aqueous fraction excels in antihyperglycemic action, the n-hexane fraction is more potent for pancreatic islet preservation. KEYWORDS: Eruca sativa, diabetes mellitus, histopathology, pancreatoprotective, solvent fractions, antihyperglycemic
Co-Authors Adeline Sacharissa Firdaus Adrisya Lubis, Putri Anggie Aminuyati Anggraini, Sari Angkasa, Alexander Anita Zahra Aulia, Wan Syarifah Buenita, Buenita Chairul, Muhammad Damanik, Anggi Oktavia Damayanti, Etha Wilda Hasiani DENI SETIAWAN Dina, Sarah Dwi Elmiam Edison, Rizki Edmi Edy Fachrial faisal Reza Faridahanum, Faridahanum Fioni, Fioni Ginting, Anandestra Ginting, Chrismis Novalinda Ginting, Tarianna Girsang, Ermi Hakim, Mia Amara Hamsi, Ulpah Zahara Harahap, Emira Nadiah Haris, Muhammad Akbar Harmileni Hartono Hartono Haryadi - Henny Henny, Henny Irwanda, Desi Danilah Juliana Lina Kunardi, Sidharta Kurniawan, Muhammad Aditya Leni Diana Leonardi, Felix Lilis Novitarum Lina, Juliana Lizar, Budi Septhian Mahulae, Wigma Aprinda Elizabeth Br Malau, Reghita Claudia Manihuruk, Gresika Br Saragih Maya Sari Mutia Maya Sari Mutia Mukhtar, Zulfikri Mutia, Maya Sari Mylano, Tri Adi Nabila, Putri Nasution, Ali Napiah NAUFAL, NAUFAL Novianti, Desi Ongko, Nicolas Xavier Pane, Putri Yunita Panjaitan, Andrean Kristianto Panjaitan, Hajijah I. L. Paska Ramawati Situmorang Purba, Amelia Salsabila Purba, Sarah Putri Uli Endrianda Br Putranto Manalu Putri, Indah Juwita Dwi Rafika, Nazla Ghina Ramadhini, Amelya Putri Rapael Ginting Samosir, Frans Judea Santy Deasy Siregar Sari, Ajeng Mestika Sari, Juwita Purnama Septiavianti, Nadia Siagian, Masryna Siahaan, Prestony Petra Habinsaran Sibagariang, Eva Ellya Silalahi, Marlinang I. Silitonga, Impola Dinita Felicia Simangunsong, Pahala Maringan J. Simanullang, Andry Simarmata, Gracia Imanuela Sinaga, Valentino Sinurat, Buenita Sitepu, Enda Menaisa Siti Rahma Soleh, Ardian Sri Lestari Ramadhani Nasution Stephan, Weldy Stephanie Raibalaki Suandy, Suandy Suhartina Suhartina, Suhartina Suhartomi Surya Dharma Suvina, Vivi Suwanto, Denny Suyono, Tan Syahfitri, Nadia Tamarin, Tamarin Tampubolon, Jenni Tarigan, Antje Irmella Tobing, Andrico Napolin Lumban Trirasetya, Mutiara Ulfa Victor Trismanjaya Hulu Wicaksana, Praja Dwi Widyaningsih Widyaningsih, Widyaningsih Willano, Almira Yelvreza Rastiani Sipayung Yolanda Eliza Putri Lubis Yulizal, Ok Zahran Nst, Mhd Raja Zendrato, Erianto Zendrato, Victorwan Novri Zulfahmi Zulfahmi