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All Journal JURNAL GIZI INDONESIA Majalah Kedokteran Bandung Jurnal Arbitrer The Indonesian Biomedical Journal Public Health of Indonesia Media Ilmu Kesehatan Jurnal Kesehatan Jurnal Analis Medika Biosains (JAMBS) Abdi Dosen : Jurnal Pengabdian Pada Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Jurnal Aisyah : Jurnal Ilmu Kesehatan AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Kesehatan Tambusai International Journal of Islamic Education, Research and Multiculturalism (IJIERM) JUMANTIK (Scientific Journal of Health research) Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP) Vitamedica: Jurnal Rumpun Kesehatan Umum
Widya Yanti Sihotang
Universitas Prima Indonesia
Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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The association between smoking behaviour and degenerative diseases Simarmata, Gracia Imanuela; Hartono, Hartono; Sihotang, Widya Yanti; Tobing, Andrico Napolin Lumban; Dharma, Surya; Mylano, Tri Adi; Setiawan, Deni; Willano, Almira; Novianti, Desi; Suwanto, Denny; Haryadi, Haryadi; Mukhtar, Zulfikri; Kunardi, Sidharta; Reza, Faisal
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7756

Abstract

Degenerative diseases represent a leading global cause of death, imposing a substantial health burden, wherein behavioural factors such as smoking are posited to play a significant role. This study aimed to analyse the association between smoking behaviour and the incidence of various degenerative diseases through a systematic literature review. The methodology employed was a systematic literature review, with article searches conducted across Google Scholar, PubMed, and Scopus databases from May to June 2025. Inclusion criteria encompassed full-text articles in Indonesian or English, published between 2020 and 2025, focusing on the association between smoking and degenerative diseases (hypertension, diabetes, stroke, kidney failure, cancer). From 230 identified articles, 15 met the criteria and were analysed. The synthesis of results demonstrated a significant association between smoking behaviour and an increased risk of degenerative diseases. Active smokers exhibited a three-fold higher risk of hypertension (OR=3.445), a twelve-fold higher risk of type 2 diabetes mellitus (OR=12.747), and a greater risk of developing cancer (lung, breast, laryngeal), stroke, and chronic kidney disease (CKD). Exposure to secondhand smoke among passive smokers also increased the risk of breast cancer nearly fourfold (OR=3.778). Underlying mechanisms include oxidative damage, chronic inflammation, endothelial dysfunction, and metabolic dysregulation. It is concluded that smoking is a major modifiable risk factor for degenerative diseases. Strengthening tobacco control policies, intensive health education, and smoking cessation programmes are required as primary prevention strategies.
Risk factors associated with dengue hemorrhagic fever incidence in the Belawan II Community Health Center Sari, Juwita Purnama; Ginting, Rapael; Sihotang, Widya Yanti; Fioni, Fioni; Tarigan, Antje Irmella; Malau, Reghita Claudia; Angkasa, Alexander; Lizar, Budi Septhian
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7813

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern in tropical regions such as Indonesia, where environmental and behavioural factors play crucial roles in its transmission. This study aimed to analyse the factors associated with the incidence of DHF in the working area of the Belawan II Community Health Centre in Medan. A quantitative approach with a cross-sectional design was employed. A sample of 110 housewives was selected via purposive sampling from a population of 150 housewives in the area. Data were collected through questionnaires and observation, then analysed using univariate, bivariate (Chi-Square test), and multivariate (logistic regression) methods. Bivariate analysis revealed significant associations between DHF incidence and the following factors: education level (p=0.001), housewives' knowledge (p=0.000), 3M Plus behaviour (p=0.000), health promotion services (p=0.000), and the presence of mosquito larvae (p=0.000). In contrast, variables for age (p=0.161) and occupation (p=0.898) showed no significant association. Multivariate analysis identified health promotion services as the dominant factor associated with DHF incidence (OR=0.029; 95% CI=0.010-0.084; p=0.000), with housewives' knowledge serving as a supporting factor. In conclusion, DHF prevention efforts in the Belawan II area should prioritise enhancing the quality and coverage of effective health promotion services, complemented by improving household-level knowledge and preventive practices, alongside sustainable control of mosquito breeding sites.
Granule Nanoparticle Citrus sinensis (L.) Osbeck Peel Lowers Blood Glucose Levels and HbA1C in Alloxan-induced Diabetes Rats Maya Sari Mutia; Yelvreza Rastiani Sipayung; Dwi Elmiam; Widya Yanti Sihotang; Juliana Lina
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3334

Abstract

BACKGROUND: The peel of Citrus sinensis (L.) Osbeck (sunkist orange) peels, which are often seen as waste, actually contains valuable properties such as antioxidants, hypoglycemic, nephroprotective, and anti-inflammatories. The potential effects of C. sinensis peel on diabetes have been discussed but not clear yet. Therefore, this study was performed to evaluate the effects of Granule Nanoparticle Sunkist Peel (GNSP) extracts as an antidiabetic agent in alloxan-induced diabetic rats.METHODS: The nanoparticle suspension was prepared by mixing a formulation of 0.2% chitosan and 0.1% sodium tripolyphosphate. The characteristics of nanoparticles were measured by flow time, tap index and angle of repose. Rats were induced with alloxan injection to create diabetes rat models. Rats were divided into five groups; normal control group, diabetic controls, and diabetic rats receiving either 50, 100, or 200 mg/kg/day GNSP. After 28 days of diabetes induction, rats were euthanized, and blood as well as tissue samples were collected. Blood glucose levels, HbA1c, and histopathology of the liver, kidneys, and pancreas were then assessed.RESULTS: The particle size of the synthesized material was 92.3 nm, which confirmed the nature of nanoparticle. The characteristics of the granule nanoparticle were also in accordance with the standards for drugs suitable for consumption. The administration of GNSP in dose dependent manner significantly decrease blood glucose levels and HbA1C to normal levels compared to control group (p<0.05). Histopathological analysis indicated recovery in pancreas, liver, and kidney tissues following GNSP administration.CONCLUSION: GNSP administration lowers blood glucose levels and HbA1C, as well as improved histopathological condition of pancreas, liver, and kidney in diabetic rats. These findings suggest the potential of utilizing GNSP as a potent antidiabetic agent.KEYWORDS: Citrus Sinensis (L.) Osbeck, histopathology, hyperglycemia, nano medicine, and type 2 diabetes mellitus
Aqueous and n-Hexane Fractions of Eruca sativa Differentially Target Glycemic Control and Pancreatic Islet Protection in Diabetic Rats Nasution, Sri Lestari Ramadhani; Tamarin, Tamarin; Purba, Amelia Salsabila; Suhartina, Suhartina; Sihotang, Widya Yanti
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3994

Abstract

BACKGROUND: The search for novel antidiabetic agents that simultaneously lower blood glucose and protect pancreatic β-cells is crucial. While Eruca sativa is known for its antidiabetic properties, the specific contribution of its solvent fractions to different therapeutic targets remains poorly understood. Therefore, this study was conducted to identify how different fractions selectively target glycemic control or pancreatic islet integrity.METHODS: Twenty-five male Wistar rats were rendered diabetic by a single intraperitoneal injection of 45 mg/kg streptozotocin. Diabetic animals were divided into five groups (n=5): diabetic control, positive control (0.45 mg/kg glibenclamide), and three treatment groups receiving n-hexane, ethyl acetate, or aqueous fractions of 400 mg/kgBW E. sativa for 14 days. Phytochemical screening was performed to identify bioactive profiles. Blood glucose was monitored periodically, and pancreatic tissues were assessed using a histopathological scoring system (0–4) and islet area measurement.RESULTS: Aqueous fraction showed the most potent antihyperglycemic activity, significantly reducing blood glucose (208.8±36.02 mg/dL) compared to the diabetic control (419.6± 117.11 mg/dL). Conversely, the n-hexane fraction provided superior pancreatic protection, maintaining the highest islet area (19,109.81±7,549.98 µm²) and the best histopathological score (2.8±0.8) among all treatment groups. Phytochemical screening revealed a distinct distribution of compounds, with flavonoids concentrated in the aqueous fraction and terpenoids in the n-hexane fraction.CONCLUSION: This study demonstrates that therapeutic efficacy of E. sativa is fraction-specific, driven by its distinct phytochemical profiles. The aqueous fraction is the most effective for rapid glycemic control, significantly reducing blood glucose levels. Conversely, the n-hexane fraction provides superior pancreatic protection, as evidenced by the highest islet area and improved histopathological scores. These findings suggest that E. sativa possesses a dual-target potential; while the aqueous fraction excels in antihyperglycemic action, the n-hexane fraction is more potent for pancreatic islet preservation. KEYWORDS: Eruca sativa, diabetes mellitus, histopathology, pancreatoprotective, solvent fractions, antihyperglycemic
Non-Verbal Elements as Primary Attentional Anchors Across Generational Cohorts: Eye-Tracking Evidence from Multimodal Communication Context Rizki Edmi Edison; Deni Adha Akbari; Pratiwi Cristin Harnita; Widya Yanti Sihotang
Jurnal Arbitrer Vol. 13 No. 2 (2026)
Publisher : Masyarakat Linguistik Indonesia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/ar.13.2.161-174.2026

Abstract

Contemporary multimodal communication environments integrate verbal with non-verbal elements within unified communicative artefacts spanning health, commercial, digital, and persuasive discourse. Despite theoretical consensus in multimodality and semiotics that non-verbal and verbal modes carry distinct processing affordances, objective neurophysiological evidence for the attentional priority of non-verbal elements, and its consistency across generational cohorts, remains limited in the literature. This study aims to investigate whether non-verbal visual elements consistently capture first visual fixation before verbal elements across multiple multimodal communication contexts, and to examine whether this attentional pattern is consistent across two generational cohorts, Generation Z and Millennials. A cross-contextual multi-study synthesis design was employed, integrating eye-tracking data from four previously published empirical studies conducted at Universitas Prima Indonesia and Universitas Muhammadiyah Prof. Dr. HAMKA. Across all four studies, non-verbal elements captured first fixation in almost all of participants, although no statistically significant inter-cohort difference was observed within one of studies. These findings provide neurophysiological evidence that non-verbal visual elements constitute universal primary attentional anchors in multimodal discourse, functionally independent of communicative context and generational cohort. The results carry direct implications for language-sensitive communication design, plurilingual health messaging, multimodal pedagogy, and the theoretical understanding of verbal–non-verbal semiotic hierarchies in multilingual and multicultural communication environments.
Drug Management On Availability Of Drugs In Pharmaceutical Installations Pabatu General Hospital Pt Pmn Using Fifo & Fefo Methods Fitri Aidani Ulfa Harahap; Ratih Nur Indah Siregar; Widya Yanti Sihotang; Ali Napiah Nasution
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i1.137

Abstract

Drug management on drug availability at the Pharmacy Installation of Pabatu General Hospital PT PMN Serdang Bedagai is still not good. Drug management includes drug selection, drug planning, and procurement as well as drug storage and distribution. This study aims to determine the management of drug availability at the Pharmacy Installation of Pabatu General Hospital PT PMN Serdang Bedagai. This type of research is a descriptive approach with NLP (Neuro-Linguistic Programming) techniques. The population in this study were all staff or employees at the pharmaceutical installation of Pabatu General Hospital PT PMN Serdang Bedagai and a sample of 9 people. The collection of data with primary and secondary data and the data were analyzed by data reduction, data display (data display), and drawing conclusions or levers. The results showed that the drug management at the Pharmacy Installation of Pabatu RSU PT PMN was effective and efficient which includedinput, process, and output. It is suggested that every human resource in the pharmaceutical installation of Pabatu General Hospital PT PMN should be given the opportunity to improve their knowledge and skills regarding drugmanagement in the installation, so that in the future drug management can be better and the pharmacy installation plays a role in staff development and educational programs such as developing new staff orientation programs, education, and training based on the need for competency development of human resources and head of evaluation to conduct independent research or contribute to research on the development of pharmaceutical service practices in hospitals.
Analisis Pelaksanaan Clinical Pathway Berdasarkan Perspektif Pasien dan Tenaga Kesehatan Widya Yanti Sihotang; Enda Menaisa Sitepu; Ermi Girsang
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 9, No 2 (2024)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/jumantik.v9i2.16079

Abstract

Penerapan clinical pathway di rumah sakit memberikan pelayanan yang aman, berkualitas, dan efektif kepada pasien dengan menjaga kepentingan mereka sesuai dengan standar pelayanan. Tujuan dari penelitian ini adalah untuk menganalisis pelaksanaan Clinical Pathway dari perspektif pasien dan tenaga kesehatan dengan metode mix-methods. Dalam metode kuantitatif, 361 pasien menjadi sampel penelitian yang dianalisis secara univariat, sedangkan metode kualitatif menggunakan teknik wawancara mendalam terhadap informan komite medik, manajemen, komite mutu, case manager, dokter, perawat, farmasi dan nutrisionis. Analisis data kualitatif dilakukan dengan teknik triangulasi. Hasil penelitian menggambarkan pelaksanaan Clinical Pathway menurut perspektif pasien secara umum berjalan dengan baik dengan persentase sebesar 66,5% akan tetapi masih banyak pasien yang menjawab pelaksanaan Clinical Pathway kurang baik dengan persentase sebesar 33,5%. Pelaksanaan Clinical Pathway berdasarkan perspektif tenaga kesehatan sudah berjalan dengan baik namun sering ditemukan beberapa kendala dalam pelaksanaaan terkhususnya dalam komunikasi, pelatihan, komitmen, serta monitoring dan evaluasi yang berkelanjutan terhadap pelaksanaan Clinical Pathway masih kurang.
Prevalensi Dan Faktor Risiko Hipertensi Pada Sopir Truk Di Wilayah Pesisir Belawan Tahun 2026 Kartika Sari Rizki; Tasya Eka Putri Tarigan; Riwana Br Manalu; Widya Yanti Sihotang
VitaMedica : Jurnal Rumpun Kesehatan Umum Vol. 4 No. 3 (2026): Juli : VitaMedica : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/vitamedica.v4i3.901

Abstract

Background: Hypertension is a global health problem often referred to as the "silent killer" because it generally does not cause symptoms until serious complications occur. Truck drivers in the coastal area of Belawan are exposed to significant occupational risk factors, including prolonged sitting, long working hours, and low physical activity. Objective: To analyze the prevalence of hypertension and factors associated with hypertension among truck drivers in the Belawan coastal area in 2026. Methods: A quantitative study with observational analytic cross-sectional design involving 150 active truck drivers at Jl. Baru Logistic, Bagan Deli, Medan Belawan. Data were collected through structured interviews and blood pressure measurement using a calibrated Omron digital sphygmomanometer. Data were analyzed by univariate, bivariate (Chi-Square), and multivariate (multiple logistic regression) methods. Results: The prevalence of hypertension was 50% (75 of 150 respondents) and prehypertension was 30% (45 respondents of 150 respondents). Bivariate analysis showed significant associations between hypertension and length of service (p=0.001), working duration (p=0.002), and physical activity (p=0.007). night shift work (p=0.068) Lifestyle (p=0.989), stress level (p=0.337), and JKN ownership (p=0.337) were not significantly associated. Multivariate analysis indicated that length of service (OR=2.207; p=0.008) and working duration (OR=0.2166; p=0.003) were significantly associated with hypertension. Conclusion: Hypertension has a very high prevalence among truck drivers in the Belawan coastal area (50%) prehypertension was 30%, with length of as the main risk factors. Targeted health promotion and preventive interventions for this occupational group are urgently needed.
Co-Authors Adeline Sacharissa Firdaus Adrisya Lubis, Putri Anggie Ali Napiah Nasution Aminuyati Anggraini, Sari Angkasa, Alexander Anita Zahra Aulia, Wan Syarifah Buenita, Buenita Chairul, Muhammad Damanik, Anggi Oktavia Damayanti, Etha Wilda Hasiani Deni Adha Akbari DENI SETIAWAN Dina, Sarah Dwi Elmiam Edy Fachrial Enda Menaisa Sitepu Ermi Girsang Eva Ellya Sibagariang faisal Reza Faridahanum, Faridahanum Felix Leonardi Fioni, Fioni Fitri Aidani Ulfa Harahap Ginting, Anandestra Ginting, Chrismis Novalinda Ginting, Tarianna Girsang, Ermi Hakim, Mia Amara Hamsi, Ulpah Zahara Harahap, Emira Nadiah Haris, Muhammad Akbar Harmileni Hartono Hartono Haryadi - Henny Henny, Henny Irwanda, Desi Danilah Isabela Silalahi, Marlinang Juliana Lina Kartika Sari Rizki Kunardi, Sidharta Kurniawan, Muhammad Aditya Leni Diana Lilis Novitarum Lina, Juliana Lizar, Budi Septhian Mahulae, Wigma Aprinda Elizabeth Br Malau, Reghita Claudia Manihuruk, Gresika Br Saragih Maya Sari Mutia Maya Sari Mutia Mukhtar, Zulfikri Mutia, Maya Sari Mylano, Tri Adi Nabila, Putri Nasution, Ali Napiah NAUFAL, NAUFAL Novianti, Desi Ongko, Nicolas Xavier Pahala Maringan J. Simangunsong Pane, Putri Yunita Panjaitan, Andrean Kristianto Panjaitan, Hajijah I. L. Paska Ramawati Situmorang Pratiwi Cristin Harnita Purba, Amelia Salsabila Purba, Sarah Putri Uli Endrianda Br Putranto Manalu Putri, Indah Juwita Dwi Rafika, Nazla Ghina Ramadhini, Amelya Putri Rapael Ginting Ratih Nur Indah Siregar Riwana Br Manalu Rizki Edmi Edison Samosir, Frans Judea Santy Deasy Siregar Sari, Ajeng Mestika Sari, Juwita Purnama Septiavianti, Nadia Siagian, Masryna Siahaan, Prestony Petra Habinsaran Silitonga, Impola Dinita Felicia Simanullang, Andry Simarmata, Gracia Imanuela Sinaga, Valentino Sinurat, Buenita Siti Rahma Soleh, Ardian Sri Lestari Ramadhani Nasution Stephan, Weldy Stephanie Raibalaki Suandy, Suandy Suhartina Suhartina, Suhartina Suhartomi Surya Dharma Suvina, Vivi Suwanto, Denny Suyono, Tan Syahfitri, Nadia Tamarin, Tamarin Tampubolon, Jenni Tarigan, Antje Irmella Tasya Eka Putri Tarigan Tobing, Andrico Napolin Lumban Trirasetya, Mutiara Ulfa Victor Trismanjaya Hulu Wicaksana, Praja Dwi Widyaningsih Widyaningsih, Widyaningsih Willano, Almira Yelvreza Rastiani Sipayung Yolanda Eliza Putri Lubis Yulizal, Ok Zahran Nst, Mhd Raja Zendrato, Erianto Zendrato, Victorwan Novri Zulfahmi Zulfahmi