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All Journal Universa Medicina Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Biomedika dan Kesehatan SULTANIST: Jurnal Manajemen dan Keuangan Maker: Jurnal Manajemen Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Pengabdian kepada Masyarakat Nusantara International Journal Of Science, Technology & Management (IJSTM) Journal of Management and Entrepreneurship Research International Journal of Community Service JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA Jurnal Indonesia Sosial Sains Room of Civil Society Development AMMA : Jurnal Pengabdian Masyarakat Room of Civil Social Development
Sisca Sisca, Sisca
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Journal : Universa Medicina

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Progesterone decrease plasma membrane in human sperm with subnormal hypoosmotic swelling test scores Sisca, Sisca; Yunaini, Luluk; Pujianto, Dwi Ari
Universa Medicina Vol 38, No 1 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (607.791 KB) | DOI: 10.18051/UnivMed.2019.v38.56-62

Abstract

BackgroundProgesterone (P4) is known as a female hormone affecting oocyte maturation and developing uterine wall. A proteomic study identified several receptors including P4 receptors on human sperm. The role of P4 in human sperm cells remains unknown as to whether P4 has non-genomic effects on human sperm. The present study aims to determine the effect of progesterone (P4) on the hyperactivated motility and membrane integrity of human sperm cells.MethodsSemen from normal individuals was obtained from donors. The semen was washed by gradient density centrifugation. P4 was added to each semen sample to final concentrations of 0 (control), 250, 500, 750 and 1000 ng/mL. After the sample treatment was completed, the sperm membrane integrity was assessed with the hypoosmotic swelling test (sodium citrate dihydrate and D-fructose) and the hyperactivated sperm motility parameter was determined with the Computer Assisted Sperm Analyzer [CASA] (Hamilton Thorne, IVOS II, USA). The percentage was then compared between the treatment groups and the control group. The percentage differences were analyzed with the Sigmastat version 2.0 statistical program.ResultsAdministration of P4 increased sperm hyperactivated motility when compared with the control group at a concentration of 500 ng/mL, but the increase was statistically not signicant (p>0.05). In contrast, P4 decreased sperm membrane integrity significantly (p=0.042). And the mean of plasma membrane integrity in all groups was subnormal hypoosmotic swelling test score. ConclusionProgesterone administration tends to increase sperm hyperactivated motility. The integrity of plasma sperm membrane was affected by progesterone.
Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

Abstract

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.
Co-Authors Acai Sudirman Alfred Pakpahan, Alfred Ambarita, Gita Theresia Andy Wijaya Arshandy, Eliza Arsita, Mita Bela, Isa Bella, Isa Butarbutar, Marisi Chendrasari, Julian Christina Yanita Setyawati, Christina Yanita Darwin Lie Daulay, Dina Agustin David David David Tjahyadi Debi Eka Putri Debora Nainggolan Devita, Arleen Dharma, Edy Dwi Ari Pujianto Efendi Efendi Effendi, Ida Eka Daryanto, Eka Erbin Chandra Ervina Ervina Fahri, Muhammad Imam Fitria Halim Gabrielle, Laurentia Ganeca Widyatama, Haryo Halim, Catherine Hendrick Sasimtan Putra Hengki Mangiring Parulian Simarmata Hutabarat, Defi Mariani Ilona, Florinda Jaya Edy, Hosea Khariri Khariri Kiki, Erina Kisno Kogoya, Alvionita Krishna Murthi, Aditya Lestari, Indah Widya Listyarini, Winny Lora Ekana Nainggolan Luluk Yunaini Mahardieni, Karlina Mailoli, Jesica Marto Silalahi Marudut Mulia Siregar, Victor ML Edy Parwanto Monica Dwi Hartanti, Monica Dwi Musa Fernando Silaen Oladimeji, Ashaolu Victoria Orliando Roeslan, Muhamad Parwanto, Edy Prasetyaningsih, Noviani Retno Widianti Reza Aditya Digambiro Robert Tua Siregar Robertus, Thomas Samira, Jihan Setyaningrum, Dyah Ayu Woro sherly sherly Simanjuntak, Delima Asyanti Simarmata, Hengki Mangiring Parulian Simatupang, Febriyanti Sinaga, Fitri Yanti Sugara, Heru Syarif Hidayat THABIT, JIHAN SAMIRA Tjahyadi, Joey Joshua Vidova Widyatama, Haryo Ganeca Xavierees, Endrico Yani Kurniawan, Yani Yunitra, Imelda