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Journal : Universa Medicina

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly Parwanto, Edy; Tjahyadi, David; Amalia, Husnun; Hairunisa, Nany; Edy, Hosea Jaya; Oladimeji, Ashaolu Victoria; Djebli, Noureddine
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.329-345

Abstract

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.
Co-Authors Ab. Razak, Asreene Binti Abikusno, Revalita Adhiwardan, Anggraeni Adianto, Raymond Adlani, Hadianti Agil, Nadifa Ahmed, Dena Ahmed, Dina Al-Sayed, Raghda Alsayed, Raghda Alvin M. Ridwan Amirrudin, Danial Arif Bin Anastasya, Karina Shari Anestessia, Ira Juliet Anggiat, Desi Anggraeni Adiwardhani Angham G Hadi Ariyani, Aziza Asrani, Iffah syahidah Binti Aswar, Andini Atut Cicih Mayasari Briliant, Permaisonya Bufaroosha, Muna Cylla Revata David Tjahyadi dianawati, dianawati Djebli, Noureddine Dwi Lestari, Ade Dyah Ayu Woro Setyaningrum Emad Yousif Emad Yousif Eric Fahed Faza Erlani Kartadinata, Erlani Fadillah, Ibnu Harris Fadlyah, Nur Ashfiya Faradila, Meutia Atika FAUZAN ABDILLAH Florinda Ilona Gerie Amarendra Grace Nerry Legoh Hadi Sumarsono Hameed, Seenar Hari Krismanuel Hosea Jaya Edy Husain, Amani Husnun Amalia Irmiya Rachmiyani Isahak, Marzuki bin Iskandar, Dian Joice Viladelvia Kalumpiu, Joice Viladelvia Julian Chendrasari Kadhom, Mohammed Karina Shari Anastasya Kencana, Gita Khairunisa, Adinda Kudaer, Nuha B Larasari, Andira LEKOK, WIDYAWATI Lestari, Ade Dwi Lie T. Merijanti Lie Tanu Merijanti, Lie Tanu Liman, Patricia Budihartanti Magdalena Wartono Maharani, Ni Putu Radela Maharani, Ronaningtyas Mahdi, Sarah Malika Adira Hasri Mario Mario Marja, Triyoko Septio Mashab, Yasmine Mashabi, Yasmine Meiriani Sari Meiyanti Meiyanti, Meiyanti Mohamad Ridwan, Alvin Mohammed Kadhom Mohammed Kadhom Mohsen Hashim Risan Muhammad Faldy Abdul Aziz Mulia Rahmansyah Natadidjaja, Ronald Irwanto Nor Azlina Khalil Nugroho Abikusno Nugroho, Dwi Agustawan Nuha Kudaer Oladimeji, Ashaolu Victoria Panduwati, Lira Parwanto, Edy Patricia Budihartanti Liman Pertiwi, Iin Indra Pramesti Indri Miranti Prasetyaningsih, Noviani Primandari, Rima Anindita Purnamawati Tjhin Purnamawati Tjhin, Purnamawati Pusparini Pusparini Putri, Fania Sabila Raheem, Rasha Rantung, Alvin Lekonardo Rasha Raheem Redwan, Amamer M Ridwan Harrianto Ridwan, Alvin Mohamad Ridwan, Alvin Muhamad Rima Anindita Risan, Mohsen Hashim Rita Khairani, Rita Rodiah Mohd Radzi Sabrina, Isra Salman, Israa Samira, Jihan Setyaningrum, Dyah Ayu Woro Sri Mulyani Sudarma, Verawati Syafitri, Julia Aina T, Febrina Thamer, Hamsa Tjahjadi, Muljadi Tjam Diana Samara Tubagus Ferdi Fadilah, Tubagus Ferdi Verawati Sudarma Waleed, Reem Wawan Kurniawan Widowati, Henie Witjaksana, Riani YENNY YENNY Yousif, Emad Yudhisman Imran Yuliana Yuliana Yusop, Rahimi M Zaina, Nashita Amira Zainulabdeen, Khalid