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All Journal Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia JCRS (Journal of Community Research and Service) Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Indonesian Journal of Biological Pharmacy Proceeding of Mulawarman Pharmaceuticals Conferences Sevanam: Jurnal Pengabdian Masyarakat AMMA : Jurnal Pengabdian Masyarakat ANDIL Mulawarman Journal of Community Engagement Journal of Pharmaceuticals and Natural Sciences al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm Jurnal Riseta Soshum
Baso Didik Hikmawan
Universitas Mulawarman
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Green Extraction of Kleinhovia hospita Saponins: Superiority of Microwave Irradiation over Maceration and the Critical Role of Solvent Polarity Hikmawan, Baso Didik; Khotimah, Khusnul; Permana, Mutia Ramadhani Rose; Ahmad, Islamudin; Febrina, Lizma; Arifuddin, Muhammad; Ibrahim, Arsyik; Salam, Supriatno
Indonesian Journal of Biological Pharmacy Vol 5, No 3 (2025): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v5i3.69627

Abstract

Kleinhovia hospita is a hepatoprotective plant rich in bioactive saponins, yet conventional extraction methods remain inefficient. This study aimed to optimize saponin recovery by comparing Microwave-Assisted Extraction (MAE) against conventional maceration and assessing the effect of solvent polarity. Saponins were extracted using MAE (15 minutes) and maceration (72 h) with various ethanol concentrations ranging from 0 to 96%. Total Saponin Content (TSC) was quantified colorimetrically using the vanillin-sulfuric acid method. MAE significantly outperformed maceration, attaining a two-fold increase in saponin purity (106.67 and 52.92 mg Diosgenin Equivalent (DE)/g extract, respectively) in a fraction of the time. Solvent analysis revealed a trade-off: whereas 96% ethanol yielded the highest specific purity (133.89 mg DE/g), it resulted in low mass recovery. In contrast, 50% ethanol extracted the highest Total Saponin Yield (TSY) (18.84 mg/g powder), effectively balancing matrix swelling with solubility. MAE utilizing 50% ethanol is identified as the optimal, rapid, and green strategy for the industrial production of standardized K. hospita extracts.
Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes Arifuddin, M.; Amanda, Rezti; Arifin, Arfiani; Arifin, Arfina Sukmawati; Iswahyudi, Iswahyudi; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Ibrahim, Arsyik; Rijai, Laode
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Co-Authors Adyma, M. Diva Afpriana, Mia Agus Setiawaty Akhmad Jaizzur Rijai Almaida, Maria Almeida, Maria Amanda, Rezti Andika, Arya Bhima Arief Wicaksono Nur Qowiyyu Arifian, Hanggara Arifin, Arfiani Arifin, Arfina Sukmawati Arifuddin, M Arifuddin, Muhammad Azizah, Wilda Azmi, Fatur Rahman Bone, Mahfuzun Chairani Sintya Damayanti, Nina Emilia, Rina Ervina Irmaya Sagita Erwin Samsul Farah, Harra Ismi Farrah, Harra Ismi Febrina, Lizma Gama, Noviyanty Indjar Hairunnisa Hajrah Hajrah Hajrah, Hajrah Hamdani Hamdani Herman Herman Herman Ibrahim, Arsyik Ilmi, Muhammad Fachrul Irawan, Adithya Rizky Islamudin Ahmad Islamudin Ahmad ISWAHYUDI ISWAHYUDI Junaidin, Junaidin khusnul khotimah Kintoko, Kintoko Laksono, Ailsa Purwabhagawanta Saskirana Laode Rijai Lizma Febrina M. Arifuddin M. Arifuddin, M. Malindo, Andi Muhammad Alfian Maulana, Abdul Razak Mohd Azlan Nafiah, Mohd Azlan Muhammad Faisal Muhammad Nuzul Azhim Ash Siddiq Mus, Nurul Muhlisa Nabila, Nur Qurratul Nayaputri, Devina Yasintha Novarossi, Gusti Dimas Noviyanty Indjar Gama Nur Masyitah Zamruddin Nur, Tajuddin Pangesti, Rizka Dhilla Dwi Pasaribu, Handayani Permana, Mutia Ramadhani Rose Rabbani, Najwa Jembar Aulya Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rolan Rusli Rusli, Rolan Rusman, Arman Sabila, Arina Hasya Salam, Supriatno Sari, Indah Dewi Siddiq, Muhammad Nuzul Azhim Ash Simatupang, Devona Valerie Supriatno Supriatno Salam Swastika Praharyawan Syamsiar, Syamsiar Wijaya, Viriyanata WISNU PRABOWO Yanti, Resti Safitri Zamruddin, Nur Masyithah