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All Journal Indonesian Journal of Chemistry Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Ilmu Kefarmasian Indonesia JCRS (Journal of Community Research and Service) Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Indonesian Journal of Biological Pharmacy Proceeding of Mulawarman Pharmaceuticals Conferences Sevanam: Jurnal Pengabdian Masyarakat AMMA : Jurnal Pengabdian Masyarakat ANDIL Mulawarman Journal of Community Engagement Journal of Pharmaceuticals and Natural Sciences al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm Jurnal Riseta Soshum
Baso Didik Hikmawan
Universitas Mulawarman
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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AKTIVITAS ANTIHIPERURISEMIA INFUSA DAUN KENIKIR (Cosmos caudatus Kunth.) PADA MODEL MENCIT HIPERURISEMIA TERINDUKSI KALIUM OKSONAT Erwin Samsul; Muhammad Romi Adipasa Pratama; Baso Didik Hikmawan; Herman Herman; Junaidin Junaidin; Lizma Febrina; Arsyik Ibrahim; Rolan Rusli; Hifdzur Rashif Rijai; Islamudin Ahmad; Arman Rusman; M. Arifuddin
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 9 No. 1 (2026): Jurnal Farmasi Medika/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v9i1.66746

Abstract

Hyperuricemia is a metabolic disorder characterized by elevated serum uric acid levels due to excessive production or impaired excretion. Conventional therapy using xanthine oxidase inhibitors such as allopurinol is effective but may cause adverse effects with prolonged use. This study aimed to evaluate the antihyperuricemic activity of kenikir (Cosmos caudatus Kunth.) leaf infusion in a potassium oxonate-induced hyperuricemic mouse model. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, and tannins. Twenty-five male mice were randomly assigned into five groups (n=5): negative control (0.5% NaCMC), positive control (allopurinol 100 mg/kgBW), and three treatment groups receiving 10%, 15%, and 20% infusion. Hyperuricemia was induced using chicken liver juice and potassium oxonate (300 mg/kgBW). Each mouse received 0.5 mL orally. Blood uric acid levels were measured hourly for four hours using EasyTouch GCU. Statistical analysis using the Kruskal–Wallis test showed no significant difference among groups (p=0.220). However, descriptively, the 15% concentration demonstrated the highest percentage reduction (56.77%), followed by 20% (41.28%) and 10% (38.74%), compared with allopurinol (66.01%). These findings suggest that kenikir leaf infusion exhibits potential antihyperuricemic activity and supports further investigation with optimized dosing, larger sample size, and enzymatic validation. Keywords: Cosmos caudatus, hyperuricemia, potassium oxonate, uric acid
Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes M. Arifuddin; Rezti Amanda; Arfiani Arifin; Arfina Sukmawati Arifin; Iswahyudi Iswahyudi; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Arsyik Ibrahim; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis M. Arifuddin; Fatur Rahman Azmi; Iswahyudi Iswahyudi; Mahfuzun Bone; Harra Ismi Farrah; Hanggara Arifian; Maria Almeida; Arman Rusman; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Junaidin Junaidin; Lizma Febrina; Rolan Rusli; Arsyik Ibrahim; Islamudin Ahmad; Herman Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Co-Authors Adyma, M. Diva Afpriana, Mia Agus Setiawaty Akhmad Jaizzur Rijai Almaida, Maria Almeida, Maria Andika, Arya Bhima Arfiani Arifin Arfina Sukmawati Arifin Arief Wicaksono Nur Qowiyyu Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Arman Rusman Arsyik Ibrahim Arsyik Ibrahim Azizah, Wilda Bone, Mahfuzun Chairani Sintya Damayanti, Nina Emilia, Rina Ervina Irmaya Sagita Erwin Samsul Erwin Samsul Erwin Samsul Farah, Harra Ismi Fatur Rahman Azmi Febrina, Lizma Gama, Noviyanty Indjar Hairunnisa Hajrah Hajrah Hajrah, Hajrah Hamdani Hamdani Hanggara Arifian Harra Ismi Farrah Herman Herman Herman Hifdzur Rashif Rija'i Hifdzur Rashif Rijai Ibrahim, Arsyik Ilmi, Muhammad Fachrul Irawan, Adithya Rizky Islamudin Ahmad Islamudin Ahmad Islamudin Ahmad Iswahyudi Iswahyudi Junaidin Junaidin Junaidin, Junaidin khusnul khotimah Kintoko, Kintoko Laksono, Ailsa Purwabhagawanta Saskirana Laode Rijai Lizma Febrina Lizma Febrina Lizma Febrina M. Arifuddin M. Arifuddin M. Arifuddin M. Arifuddin, M. Mahfuzun Bone Malindo, Andi Muhammad Alfian Maulana, Abdul Razak Mohd Azlan Nafiah, Mohd Azlan Muhammad Faisal Muhammad Nuzul Azhim Ash Siddiq Muhammad Romi Adipasa Pratama Mus, Nurul Muhlisa Nabila, Nur Qurratul Nayaputri, Devina Yasintha Novarossi, Gusti Dimas Noviyanty Indjar Gama Nur Masyitah Zamruddin Nur, Tajuddin Pangesti, Rizka Dhilla Dwi Pasaribu, Handayani Permana, Mutia Ramadhani Rose Rabbani, Najwa Jembar Aulya Rezti Amanda Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki Riki Riki RIKI RIKI, RIKI Rolan Rusli Rusman, Arman Sabila, Arina Hasya Salam, Supriatno Sari, Indah Dewi Siddiq, Muhammad Nuzul Azhim Ash Simatupang, Devona Valerie Supriatno Supriatno Salam Swastika Praharyawan Syamsiar, Syamsiar Wijaya, Viriyanata WISNU PRABOWO Yanti, Resti Safitri Zamruddin, Nur Masyithah