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All Journal Journal of Marine Research INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Adi Widya : Jurnal Pengabdian Masyarakat Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Cendekia Journal of Pharmacy Science Midwifery Budimas : Jurnal Pengabdian Masyarakat Avicenna : Journal of Health Research Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Fundamental and Applied Pharmaceutical Science Jurnal Pengabdian kepada Masyarakat Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan East Asian Journal of Multidisciplinary Research (EAJMR) Medical Sains : Jurnal Ilmiah Kefarmasian Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Journal of Halal Science and Research Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Ilham Kuncahyo, Ilham
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Formosa Journal of Multidisciplinary Research (FJMR)

 1 
Formula Development and Characterization Testing of Niacinamide Nano Liposomes as Anti Aging Dewi, Fitri Jaya Santi Utami; Kuncahyo, Ilham; Saifullah, T.N
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11223

Abstract

Niacinamide has a mechanism of action as an anti-aging agent by increasing fibroblast production by stimulating collagen synthesis and can increase elastin which can prevent wrinkles on the skin of the facial area. The most commonly used method is thin layer hydration followed by sonication. Determination of the optimum formula using expert design with the simplex lattice design method. The purpose of the study was to determine the effect of Phosphatidylcholine concentration of 0.5-5% and Cholesterol concentration of 0.3-5% on the physical properties of niacinamide liposomes, obtain the optimal formula for nano liposomes niacinamide and determine the anti-aging activity of Niacinamide liposomes tested on the backs of rabbits. In the simplex lattice design method, the optimal formula of Phosphotidylcholine with a concentration of 4.7% and cholesterol with a concentration of 0.3% was obtained which produced nanoliposome characteristics including particle size of 135.7 zeta potential -77.19, Adsorption Efficiency of 98.01% and has anti -aging activity with parameters increasing collagen 29.98% and elasticity 65.56%. Niacinamide preparations provide a large increase in anti-aging activity and increase permeability so that they can provide a faster effect than niacinamide serum without liposomes.
Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) Naringenin Components with D-Optimal Mixture Design Method and Anti-Aging Test In Vivo Taena, Adriani; Kuncahyo, Ilham; Sunarni, Titik
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11236

Abstract

Naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl) chroman-4-one) is one of the flavanone aglycone compounds that has the main activity as an antioxidant. The purpose of this study was to determine the optimum formula and characterization of naringenin SNEDDS and to see the anti-aging activity of the optimum formula of naringenin SNEDDS. The optimum formula of naringenin SNEDDS was obtained by a combination of oil components, surfactants and cosurfactants (miglyol, tween 80 and transcutol) using the D-optimal mixture design method. The characteristics of naringenin SNEDDS are seen based on parameters such as drug loading, emulsification time, % transmittance, particle size analyzer (PSA) and zeta potential. The results of the optimum formula characterization test of naringenin SNEDDS obtained drug loading of 2.004507 mg/5 ml, emulsification time of 13.07 seconds, percent transmittance of 85.1%, particle size of 78.76 nm and zeta potential of -8.14 mV. Based on the results of the characteristics obtained from the optimum formula, the naringenin SNEDDS preparation meets the characteristics of good SNEDDS and has the potential to be developed into a drug preparation.
Co-Authors Adam Ferdian Sigit Pratama Afif Afghohani, Afif Alfiana, Ina Ana Indrayati Ana Indriyati Anisa Devi Kharisma Wibowo Argoto Mahayana Ayuk Armadani , Valentina Bimo Putranto Candra, Dhimas Tiya Chaesti Setyo Hastuti Chatarina Umbul Wahyuni Dewi, Fitri Jaya Santi Utami Dian Marlina Dian Puspitasari Efrilia, Erin ELISABETH APRILIA Endang Diyah Ikasari Endang Dyah Ikasari Ghani Nurfiana Fadma Sari Gunawan, Lucia Sincu Hafizah, Dila Auli Hutami, Shabrina Nindya Ibnu Pratikto Ismi Rahmawati Iswandi Iswandi Kartikasari, Ayu Lifia Nur Kiki Puspitasary Kusumawati, Mulyaningtyas Ayu M Muchalal M. Andi Chandra M. Andi Chandra M. Henityo Agung As'adi Mahardira Dewantara Mahayana, Argoto Mamik Ponco Rahayu Mardiyono Mardiyono, . Mointi, Sella Septiyani Muhammad Dzakwan Muhammad Dzakwan Nicolay Wening Audrey Noval Noval Nugroho, Muhammad Agung Nur Hidayati Nur Hidayati Nuraini Harmastuti Octavia Krisma O Opstaria saptarini Prasasti, Anin Pudiastuti RSP Putri, Hana Maylinda Putri, Sukma Oktafiani Rakhmi Hidayati Reslely Harjanti Resmi, Juniar Kalpika Rini Prastiwi Rizqi Fitria Yanuar Roosma Hatmayana Rudhi Pribadi Saifullah, T.N Sari, Putri Rovita Septiawan Adi Nugroho Sesilia Putri Nandita Setyaningrum, Dewi Anggraheni setyawan, Ferdinta D Siti Aisiyah Siti Aisiyah Soebiyanto Soebiyanto, Soebiyanto Sugiyarmasto Sugiyarmasto, Sugiyarmasto Suhartinah Suhartinah, Suhartinah Sukarno Sumardiyono Sumardiyono Sumardiyono Sunardi Sunardi Sunardi Supriyadi Supriyadi Supriyadi Supriyadi Syafira Nabillah Syaiful Choiri T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman Taena, Adriani Teuku Nanda Saifullah Sulaiman Titik Sunarni Titik Sunarni TN Saifullah Sulaiman, TN Saifullah Turdiyanto, Totok Valentina Ayuk Armadani Vivin Nopiyanti Waluyo Budi Atmoko, Waluyo Budi Wijayanti, Ifa Rizki Wiwin Herdwiani Wulandari, RR Sri Yudanti, Gendis Purno Yudi Rinanto Yuliana, Sinta Zahra, Iklila