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All Journal Journal of Marine Research INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Adi Widya : Jurnal Pengabdian Masyarakat Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Cendekia Journal of Pharmacy Science Midwifery Budimas : Jurnal Pengabdian Masyarakat Avicenna : Journal of Health Research Jurnal Farmasi Journal of Fundamental and Applied Pharmaceutical Science Jurnal Pengabdian kepada Masyarakat Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan East Asian Journal of Multidisciplinary Research (EAJMR) Medical Sains : Jurnal Ilmiah Kefarmasian Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Journal of Halal Science and Research Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Ilham Kuncahyo, Ilham
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Optimisation and Characterisation of Curcumin Nanoparticles with Chitosan-TPP Combination Using Ionic Gelation Method as a Cut Wound Healer setyawan, Ferdinta D; Kuncahyo, Ilham; Herdwiani, Wiwin
East Asian Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i9.10865

Abstract

Curcumin has low oral bioavailability, low solubility, and is easily degraded, making its clinical application difficult. This study aims to determine the effect of optimum concentration and formula of chitosan and TPP in the preparation of curcumin nanoparticles on particle size, zeta potential, adsorption efficiency, and incision wound healing. The optimisation method used simplex lattice design method. There were 8 draft formulas consisting of a combination of chitosan and TPP. Each formula was tested for zeta potential value, adsorption efficiency, particle morphology, and wound healing ability. The optimum formula was then determined and analysed using the simplex lattice design method. The combination of chitosan and TPP with simplex lattice design gives an influence on curcumin nanoparticles which reduces particle size, gives a negative zeta potential value, increases the sorption efficiency of the active substance (curcumin) and accelerates the healing effect of cut wounds in mice. The proportion of chitosan and TPP that can produce the optimum formula using simplex lattice design on the critical parameters of particle size, zeta potential value, sorption efficiency and wound healing ability is chitosan.
Optimization of Antibacterial Gel Preparation Formula of Aloe Vera Leaf Flesh Fraction (Aloe Vera L.) Against Staphylococcus Epidermidis Using Simplex Lattice Design Method Setyaningrum, Dewi Anggraheni; Kuncahyo, Ilham; Rahmawati, Ismi
East Asian Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i9.10945

Abstract

Acne is experienced by 90% of teenagers due to infection with the bacteria Staphylococcus epidermidis. Bacterial infections are treated with antibiotics, but excessive use causes resistance, so medicinal plants are used that do not have side effects. (Aloe vera L.) have antibacterial activity because contain anthraquinone compounds. The aim of research is update the optimization of aloe vera leaf gel to increase the effectiveness of use. The research method uses Simplex Laticce Design with HPMC, Karbopol and TEA. The optimum formula concentration of 1.3379% HPMC, 2.540% Carbopol and 0.481% TEA produced predicted and experimental values for adhesion power (7.977 and 7.5 seconds), spreadability (7 and 6.87 cm), pH (6.128 and 6 ), viscosity (246.775 and 265.3 dPa.S) and inhibition zone (23.772 and 22.66mm). The results of the Paired Sample Test for verification data show a p value of 0.430 > 0.05, is not significant difference between the predicted and the experimental.
Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) of Curcumin with D-Optimal Mixture Design Method Kusumawati, Mulyaningtyas Ayu; Iswandi, Iswandi; Kuncahyo, Ilham
East Asian Journal of Multidisciplinary Research Vol. 3 No. 11 (2024): November 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/eajmr.v3i11.12051

Abstract

Curcumin, known for its anti-inflammatory, antibacterial, anticarcinogenic, and antioxidant properties, faces challenges due to poor water solubility and low bioavailability as a BCS class II compound. The study investigates using a self-nanoemulsifying drug delivery system (SNEDDS) to enhance these properties, optimizing the formulation with the D-Optimal Mixture Design method. Sixteen formulas were prepared using oleic acid, Tween 80, and PEG 400. Each formula was characterized by particle size, % transmittance, emulsification time, and drug loading. The optimized formula, containing 10% oleic acid, 70% Tween 80, and 20% PEG 400, achieved a particle size of 80.167 nm, an emulsification time of 39.36 seconds, near 100% transmittance, and high drug loading.
Development and optimization of curcumin transfersomes in gel formulations as an antioxidant Mointi, Sella Septiyani; Kuncahyo, Ilham; Harmastuti, Nuraini
Science Midwifery Vol 13 No 4 (2025): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i4.2139

Abstract

Curcumin, a natural compound with potent antioxidant properties, faces challenges in pharmaceutical use due to its poor water solubility and low bioavailability. To overcome these limitations, curcumin was encapsulated in a transfersome drug delivery system and subsequently incorporated into a gel to enhance topical delivery and improve drug release efficiency. This study aimed to evaluate the influence of phospholipid, Tween 80, and cholesterol ratios on the physicochemical properties of curcumin-loaded transfersomes and to assess the antioxidant activity of the optimized transfersome gel. A Simplex Lattice Design (SLD) using Design Expert software generated 14 formulations varying in the three components. Transfersomes were produced via the thin layer hydration method and analyzed for particle size, zeta potential, and entrapment efficiency (%EE). The resulting gel was characterized for pH, viscosity, spreadability, adhesiveness, diffusion behavior using Franz cells, and antioxidant activity through the DPPH assay. Statistical analyses employed ANOVA, Wilcoxon, and T-tests. The optimized formulation containing 700 mg phospholipid, 200 mg Tween 80, and 50 mg cholesterol yielded particles of 134.627 nm, zeta potential –8.924 mV, and 93.656% EE. Antioxidant evaluation showed IC₅₀ values of 24±1.78 ppm (transfersome) and 42±2.5 ppm (gel), both indicating very strong antioxidant activity. The gel released 23.12 µg/cm² curcumin within 150 minutes.
PELATIHAN PEMBUATAN AROMATERAPI ROLL ON PADA KELOMPOK DHARMA WANITA SMAN 1 WONOSARI KLATEN Titik Sunarni; Suhartinah, Suhartinah; Ilham Kuncahyo; Harjanti, Reslely; Siti Aisiyah; Vivin Nopiyanti
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 4 No. 2: Juli 2024
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v4i2.8009

Abstract

Sediaan aromaterapi roll on menjadi salah satu pilihan pada saat kita mengalami gangguan kesehatan misalnya rasa mual dan tidak enak badan karena masuk angin atau rasa pegal karena lelah setelah beraktivitas. Kegiatan ini bertujuan untuk memberikan informasi, pengetahuan dan keterampilan terkait sediaan aromaterapi bentuk roll on serta wacana untuk meningkatkan jiwa kewirausahaan peserta. Kegiatan pengabdian dilakukan dengan metode ceramah, diskusi dan praktek secara langsung tentang pembuatan sediaan roll on aromaterapi. Peserta kegiatan adalah kelompok Dharma Wanita SMAN 1 Wonosari Klaten. Selesai kegiatan dilakukan evaluasi terhadap kegiatan yang sudah dilakukan. Peserta kegiatan pengabdian sangat antusias selama pelaksanaan kegiatan ditunjukkan dengan hasil evaluasi dan diskusi bersama yang sudah dilakukan. Kegiatan dinilai bermanfaat untuk menambah pengetahuan dan kemampuan dalam pembuatan sediaan roll on aromaterapi serta meningkatkan jiwa kewirausahaan peserta.
Formula Development and Characterization Testing of Niacinamide Nano Liposomes as Anti Aging Dewi, Fitri Jaya Santi Utami; Kuncahyo, Ilham; Saifullah, T.N
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11223

Abstract

Niacinamide has a mechanism of action as an anti-aging agent by increasing fibroblast production by stimulating collagen synthesis and can increase elastin which can prevent wrinkles on the skin of the facial area. The most commonly used method is thin layer hydration followed by sonication. Determination of the optimum formula using expert design with the simplex lattice design method. The purpose of the study was to determine the effect of Phosphatidylcholine concentration of 0.5-5% and Cholesterol concentration of 0.3-5% on the physical properties of niacinamide liposomes, obtain the optimal formula for nano liposomes niacinamide and determine the anti-aging activity of Niacinamide liposomes tested on the backs of rabbits. In the simplex lattice design method, the optimal formula of Phosphotidylcholine with a concentration of 4.7% and cholesterol with a concentration of 0.3% was obtained which produced nanoliposome characteristics including particle size of 135.7 zeta potential -77.19, Adsorption Efficiency of 98.01% and has anti -aging activity with parameters increasing collagen 29.98% and elasticity 65.56%. Niacinamide preparations provide a large increase in anti-aging activity and increase permeability so that they can provide a faster effect than niacinamide serum without liposomes.
Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) Naringenin Components with D-Optimal Mixture Design Method and Anti-Aging Test In Vivo Taena, Adriani; Kuncahyo, Ilham; Sunarni, Titik
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11236

Abstract

Naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl) chroman-4-one) is one of the flavanone aglycone compounds that has the main activity as an antioxidant. The purpose of this study was to determine the optimum formula and characterization of naringenin SNEDDS and to see the anti-aging activity of the optimum formula of naringenin SNEDDS. The optimum formula of naringenin SNEDDS was obtained by a combination of oil components, surfactants and cosurfactants (miglyol, tween 80 and transcutol) using the D-optimal mixture design method. The characteristics of naringenin SNEDDS are seen based on parameters such as drug loading, emulsification time, % transmittance, particle size analyzer (PSA) and zeta potential. The results of the optimum formula characterization test of naringenin SNEDDS obtained drug loading of 2.004507 mg/5 ml, emulsification time of 13.07 seconds, percent transmittance of 85.1%, particle size of 78.76 nm and zeta potential of -8.14 mV. Based on the results of the characteristics obtained from the optimum formula, the naringenin SNEDDS preparation meets the characteristics of good SNEDDS and has the potential to be developed into a drug preparation.
Optimization of Naringenin Self-Nano Emulsifying Drug Delivery System (SNEDDS) Formula with D-optimal Mixture Design Method Yudanti, Gendis Purno; Kuncahyo, Ilham; Ikasari, Endang Diyah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004319

Abstract

This study aimed to optimize and formulate the poorly water-soluble naringenin in the Self-Nano Emulsifying Drug Delivery System (SNEDDS) using D-optimal mixture design. D-optimal mixture design was used to optimize SNEDDS loading naringenin by selecting SNEDDS composition as an independent factor and SNEDDS characterization as a response. SNEDDS in the optimal formula were characterized, including transmittance, particle size, emulsification time, and drug loading. Triacetin, Tween 80, and transcutol p were respectively the selected oil, surfactant, and co-surfactant phases for their greatest ability to dissolve naringenin. The optimization results showed that the optimal formula was that using 10% triacetin, 70% of Tween 80, and 20% of transcutol p. SNEDDS loading naringenin produced nanoemulsion with 88.74±2.27 % of transmittance, 14.8 nm of particle size, 51.13 ± 4.53 mg/L of drug loading, and 18.58 ± 0.62 second of emulsification time. This study concludes that the D-optimal mixture design can be used to optimize and prepare the SNEDDS loading poorly-water soluble naringenin.  
Optimization and Characterization of Fenofibrate Self-Nanoemulsifying Drug Delivery System (SNEDDS) Preparations Sukarno; Ilham Kuncahyo; Endang Dyah Ikasari
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i1.451

Abstract

Fenofibrate is a third-generation fibric acid derivative included in BCS (biopharmaceutical classification system) class II, namely high permeability, low solubility. This research aims to obtain the optimum formula for miglyol oil, cremophor RH 40 and PEG 400 according to characterization tests of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research is an experimental study by formulating fenofibrate in the form of SNEDDS, which was made in 16 formulas using the D-optimal method, which was formulated in the form of SNEDDS with the composition miglyol, cremophor RH 40 and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, size. globules, zeta potential to obtain the optimum formula, and then analyzed using the one sample T-Test. The optimization results obtained the optimum formula, namely miglyol at 4%; cremophor RH 40 is 5%, and PEG 400 at 1%. Characterization test: emulsification time was 24 seconds, Transmittance % was 98.7%, Drug loading was 181 mg, globule size was 126 nm, and zeta potential of 12.26 mV. The dissolution test of the fenofibrate capsule dissolved 57.05%, while the fenofibrate SNEDDS capsule was 64.86%. This means that the dissolution of the optimum formula for SNEDDS fenofibrate is better than pure fenofibrate.
Optimization of naringenin sunscreen cream formula using the simplex lattice design method Kartikasari, Ayu Lifia Nur; Wibowo, Anisa Devi Kharisma; Kuncahyo, Ilham
Journal of Halal Science and Research Vol. 4 No. 2 (2023): September
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jhsr.v4i2.7172

Abstract

Naringenin is a pure isolate belonging to a group of flavonoid compounds with pharmacological effects such as anti-inflammatory, anticancer, antiatherogenic, antifibrogenic, and antioxidant properties. The purpose of this study was to determine the effect of variations in the combination of emulator tween 80 and span 80 on physical quality and stability in naringenin sunscreen preparations, obtain the optimum formula composition from emulsifying agents, and activity of naringenin sunscreen cream preparations in terms of their SPF values. The study used Design Expert 7.1.5 software to design the simplex lattice design method. Each formula was tested for the physical properties of the cream to determine dispersal adhesion for 4 weeks. Naringenin sunscreen cream with a combination of emulsifier tween 80 and span 80 in various concentrations gives a significant difference in the physical quality consisting of the parameters of spreadability, adhesion, and viscosity. The optimum formula for naringenin sunscreen cream obtained the proportion of 9% Tween 80 and 5% span 80. Keywords: Naringenin, Simplex Lattice Design, SPF, Sunscreen.
Co-Authors Adam Ferdian Sigit Pratama Alfiana, Ina Ana Indrayati Anisa Devi Kharisma Wibowo Ayuk Armadani , Valentina Chaesti Setyo Hastuti Chatarina Umbul Wahyuni Dewi, Fitri Jaya Santi Utami Dian Marlina Dian Puspitasari Efrilia, Erin ELISABETH APRILIA Endang Diyah Ikasari Endang Dyah Ikasari Ghani Nurfiana Fadma Sari Gunawan, Lucia Sincu Hafizah, Dila Auli Hutami, Shabrina Nindya Ibnu Pratikto Ismi Rahmawati Iswandi Iswandi Kartikasari, Ayu Lifia Nur Kiki Puspitasary Kusumawati, Mulyaningtyas Ayu M Muchalal M. Andi Chandra M. Andi Chandra M. Henityo Agung As'adi Mahayana, Argoto Mamik Ponco Rahayu Mardiyono Mardiyono, . Mointi, Sella Septiyani Muhammad Dzakwan Noval Noval Nur Hidayati Nuraini Harmastuti Octavia Krisma O Opstaria saptarini Prasasti, Anin Pudiastuti RSP Putri, Hana Maylinda Putri, Sukma Oktafiani Rakhmi Hidayati Reslely Harjanti Resmi, Juniar Kalpika Rini Prastiwi Rizqi Fitria Yanuar Roosma Hatmayana Rudhi Pribadi Saifullah, T.N Septiawan Adi Nugroho Sesilia Putri Nandita Setyaningrum, Dewi Anggraheni setyawan, Ferdinta D Siti Aisiyah Siti Aisiyah Soebiyanto, Soebiyanto Sugiyarmasto Sugiyarmasto, Sugiyarmasto Suhartinah Suhartinah, Suhartinah Sukarno Sumardiyono Sumardiyono Sunardi Sunardi Supriyadi Supriyadi Supriyadi Supriyadi Syafira Nabillah Syaiful Choiri T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman Taena, Adriani Teuku Nanda Saifullah Sulaiman Titik Sunarni Titik Sunarni TN Saifullah Sulaiman, TN Saifullah Turdiyanto, Totok Valentina Ayuk Armadani Vivin Nopiyanti Waluyo Budi Atmoko, Waluyo Budi Wijayanti, Ifa Rizki Wiwin Herdwiani Wulandari, RR Sri Yudanti, Gendis Purno Yudi Rinanto Yuliana, Sinta Zahra, Iklila