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All Journal Journal of Marine Research INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Adi Widya : Jurnal Pengabdian Masyarakat Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Cendekia Journal of Pharmacy Science Midwifery Budimas : Jurnal Pengabdian Masyarakat Avicenna : Journal of Health Research Jurnal Farmasi Journal of Fundamental and Applied Pharmaceutical Science Jurnal Pengabdian kepada Masyarakat Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan East Asian Journal of Multidisciplinary Research (EAJMR) Medical Sains : Jurnal Ilmiah Kefarmasian Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Journal of Halal Science and Research Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Ilham Kuncahyo, Ilham
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Formulasi dan Aktivitas Tablet Kunyah Carica papaya L. dan Morinda citrifolia L sebagai Hepatoprotektor selama pengobatan Tuberculosis (TBC) Sunarni, Titik; Prastiwi, Rini; Kuncahyo, Ilham; Mardiyono, .; Rinanto, Yudi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 4 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.28 KB)

Abstract

Formulation of chewable tablets of ethanolic extracts of Carica papaya L leaves and Morinda citrifolia L fruits and investigation of the activity towards liver damage induced by tuberculosis drugs has been performed. The rats were devide into six groups. The normal control without any treatment, negatif control were given INH 10 mg/200g-RIF 10 mg/200g, positif control were given INH-RIF and methicol, and the treatment group were given INH-RIF with chewable tablets of papaya extracts 120mg/200g and morinda extracts 20mg/200g of three tablets formula with PVP 1%, 3% and 5%. Each group were treated every day for 27 days. The measuring to monitor bilirubin serum, ALT and AST levels on 0,14th, 21st and 28th day. The study showed that the group that given chewable tablets of combination of papaya extract 120mg/200g and morinda extract 20mg/200g can prevent the occurrence of liver necrosis with necrosis value of 19,92% (PVP 3%) and 19,90 (PVP1%), compared to the negative control of 41.78% as well as reducing the value of ALT, AST and bilirubin. The tablet formula that can be received on the best of taste and most effective as hepatoprotektor is the chewable tablet with PVP 3%.Keywords : Hepatoprotector, Carica papaya L., Morinda citrifolia L., Isoniazid, Rifampicin
Formulasi dan Aktivitas Tablet Kunyah Carica papaya L. dan Morinda citrifolia L sebagai Hepatoprotektor selama pengobatan Tuberculosis (TBC) Sunarni, Titik; Prastiwi, Rini; Kuncahyo, Ilham; Mardiyono, .; Rinanto, Yudi
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.28 KB) | DOI: 10.35617/jfi.v6i4.144

Abstract

Formulation of chewable tablets of ethanolic extracts of Carica papaya L leaves and Morinda citrifolia L fruits and investigation of the activity towards liver damage induced by tuberculosis drugs has been performed. The rats were devide into six groups. The normal control without any treatment, negatif control were given INH 10 mg/200g-RIF 10 mg/200g, positif control were given INH-RIF and methicol, and the treatment group were given INH-RIF with chewable tablets of papaya extracts 120mg/200g and morinda extracts 20mg/200g of three tablets formula with PVP 1%, 3% and 5%. Each group were treated every day for 27 days. The measuring to monitor bilirubin serum, ALT and AST levels on 0,14th, 21st and 28th day. The study showed that the group that given chewable tablets of combination of papaya extract 120mg/200g and morinda extract 20mg/200g can prevent the occurrence of liver necrosis with necrosis value of 19,92% (PVP 3%) and 19,90 (PVP1%), compared to the negative control of 41.78% as well as reducing the value of ALT, AST and bilirubin. The tablet formula that can be received on the best of taste and most effective as hepatoprotektor is the chewable tablet with PVP 3%.Keywords : Hepatoprotector, Carica papaya L., Morinda citrifolia L., Isoniazid, Rifampicin
Komposisi dan Tutupan Kanopi Vegetasi Mangrove di Perairan Bakauheni, Kabupaten Lampung Selatan Kuncahyo, Ilham; Pribadi, Rudhi; Pratikto, Ibnu
977-2407769
Publisher : Departemen Ilmu Kelautan, Fakultas PerikanJurusan Ilmu Kelautan, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmr.v9i4.27915

Abstract

Kondisi kesehatan vegetasi mangrove yang berada di daratan dan pulau – pulau kecil sangat penting dalam menjaga keseimbangan ekosistem pesisir dan laut. Perbedaan kondisi tumbuh mangrove dapat mempengaruhi dinamika perubahan vegetasi dan tutupan kanopi mangrove. Penelitian ini bertujuan untuk menganalisis struktur, komposisi dan tutupan kanopi mangrove di Perairan Bakauheni, Kabupaten Lampung Selatan. Metode yang digunakan dalam penelitian ini yaitu metode deskriptif. Penentuan titik atau stasiun sampling dengan menggunakan metode purposive sampling. Metode pengambilan data vegetasi mangrove dengan metode plot sampling dan pengambilan data tutupan kanopi mangrove dengan metode hemispherical photography. Penelitian ini dilakukan di 4 lokasi yaitu Desa Kramat (DK), Desa Muara Bakau (DMB), Pulau Rimau Balak (PRB), dan Pulau Kandang Balak (PKB) yang terdiri dari 4 stasiun penelitian. Hasil penelitian menunjukkan bahwa kawasan Perairan Bakauheni yang terdiri dari 4 lokasi peneltiian ditemukan 14 spesies mangrove di dalam plot dan di luar plot penelitian. Nilai Kerapatan mangrove berkisar 966–1634 ind/ha. Nilai Indeks Keanekaragaman (H’) dan Keseragaman (J’) di lokasi penelitian termasuk dalam kategori rendah. Hasil persentase tutupan kanopi mangrove termasuk kategori padat berkisar 72,04±13,18% – 86,41±1,08%. The health condition of mangrove vegetation on land and small islands is very important in maintaining the balance of coastal and marine ecosystems. Differences in mangrove area conditions can affect the dynamics of changes in vegetation and mangrove canopy cover. This study aims to analyze the structure, composition and cover of mangrove canopies in Bakauheni Waters, South Lampung Regency. The method used in this research is descriptive method. Determination of the point or sampling station using purposive sampling method. The method of collecting mangrove vegetation data using plot sampling method and mangrove canopy cover data collection using hemispherical photography method. This research was conducted in 4 locations, namely Kramat Village (DK), Muara Bakau Village (DMB), Rimau Balak Island (PRB), and Kandang Balak Island (PKB) consisting of 4 research stations. The results showed that the Bakauheni Waters area which consisted of 4 research sites found 14 mangrove species inside the plot and outside the research plot. Mangrove density values range from 966-1634 ind/ha. The value of Diversity Index (H') and Uniformity (J') in the study location is included in the low category. The percentage yield of mangrove canopy cover including the dense category ranges 72.04±13.18% - 86.41±1.08%.
Formulasi Sediaan Tablet Effervescent dari Ekstrak Etanol Tanaman Bundung (Actionoscirpus grossus) sebagai Antioksidan Noval Noval; Ilham Kuncahyo; Adam Ferdian Sigit Pratama; Syafira Nabillah; Roosma Hatmayana
Jurnal Surya Medika (JSM) Vol 7 No 1 (2021): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v7i1.2649

Abstract

Bundung (Actinoscirpus grossus) is a plant that contains an antioxidant compound proven in previous studies, which has a moderate antioxidant or IC50 by 128 ppm. Antioxidant compounds can reduce the negative impact of oxidants, including metal binding enzymes and proteins. Antioxidant compounds act by donating one electron to the oxidant compound to inhibit oxidants activity. The purpose of this study was to formulate the Bundung plant extract into effervescent tablets, obtain effervescent samples that are physically stable, and can be used as antioxidants to inhibit free radicals in the body. The research method was experimental by using scoring parameters to determine the most optimal formulation. Physical evaluation includes organoleptic, weight uniformity, friability, hardness, and dissolving time. The results showed that the optimum formula was the formula I with a concentration of 68 mg of citric acid and sodium bicarbonate. Tablet effervescent is a brown color and characteristic odor of Bundung plant extract. Effervescent tablets have an weight uniformity (0.314 grams), friability (0.05%), hardness (7.75 ± 0.43 kg). Variations in citric acid and sodium bicarbonate concentration can affect uniformity, friability, hardness, and dissolving time. Room conditions cause this during the production process of effervescent tablets.
PENGARUH MATRIKS PEKTIN DAN HPMC K15M TERHADAP DAYA MENGAPUNG DAN MENGEMBANG SERTA DISOLUSI PADA TABLET FLOATING VERAPAMIL HCl DENGAN METODE FACTORIAL DESIGN Valentina Ayuk Armadani; Siti Aisiyah; Ilham Kuncahyo
Jurnal Farmasi (Journal of Pharmacy) Vol 9, No 1 (2020): Maret
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v9i1.100

Abstract

Verapamil HCl merupakan penghambat kanal Ca2+ untuk terapi hipertensi dan angina pectoris. Verapamil HCl memiliki bioavabilitas 10-20% dan waktu paruh 4 jam sehingga dapat dibuat sediaan gastroretentive untuk mempertahankan kadar terapi obat. Penelitian ini bertujuan mengetahui pengaruh matriks pektin dan HPMC K15M terhadap kemampuan mengapung, mengembang dan pelepasan obat pada tablet floating verapamil HCl.Penelitian ini menggunakan empat formula variasi konsentrasi matriks pektin dan HPMC K15M dengan metode kempa langsung kemudian dilakukan pengujian terhadap sifat fisik serbuk dan tablet. Pengaruh dan interaksi antara pektin dan HPMC K15M ditentukan dengan metode factorial design menggunakan software Design Expert.Matriks pektin dan HPMC K15M memberikan pengaruh terhadap kemampuan mengapung, mengembang dan pelepasan obat dari tablet floating verapamil HCl. HPMC K15M berpengaruh dominan terhadap floating lag time yang lebih cepat dan floating time yang lebih lama. Peningkatan HPMC K15M dan pektin menurunkan jumlah pelepasan di awal   dan   kecepatan   pelepasan   obat,   serta   meningkatkan   kemampuan   mengembang. Kombinasi pektin dan HPMC K15 M (1,5:1) mempunyai floating lag time cepat, floating time lama, dan kemampuan mengembang paling besar serta mengikuti orde nol.
OPTIMIZATION AND ACESSING THE INFLUENCE OF XANTHAN GUM, EFFERVESCENT COMPONENTS AND HARDNESS ON FLOATATION BEHAVIOR AND DRUG RELEASE OF GASTRO-FLOATING CAPTOPRIL TABLET Syaiful Choiri; T.N. Saifullah Sulaiman; Ilham Kuncahyo
Indonesian Journal of Pharmacy Vol 25 No 4, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1016.536 KB) | DOI: 10.14499/indonesianjpharm25iss4pp255

Abstract

This research purposed to optimize, investigate and evaluate the influence of xanthan gum, sodium bicarbonate-citric acid as effervescent components and hardness on floatation behavior and drug release of gastro-floating captopril tablet with floating system. A 23 full factorial design (8 runs) was applied to optimize the floating captopril tablet using xanthan gum (X1), ratio of effervescent components (X2) and hardness (X3) as independent variables. Optimum area was determined by superimposed contour plot of floating lag time (Y1), cumulative drug release at 60min (Q60) (Y2) and drug release constant rate (Y3) using Design Expert® software. Xanthan gum, effervescent components and hardness were affected the floatation behavior and drug release. Hardness was the most dominant factor affected the floatation behavior and drug release. Based on superimposed contour plot, the optimum area was in range of xanthan gum 58–100mg, sodium bicarbonate 45–63mg, citric acid 7–25mg and hardness at 70–98N.
Pengaruh Magnesium Stearat, Talk atau Kombinasinya Terhadap Waktu Hancur dan Disolusi Tablet Prednison Pada Campuran Interaktifnya Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.098 KB) | DOI: 10.31001/jfi.v6i1.9

Abstract

Interactive mixtures give advantages for the mixtures containing low dose drug such as prednisone as it guarantee homogeneity, stability and increase the dissolution of prednisone. Flowability and compactibility of the interactive mixtures are relatively good, it can be directly compressed to produce tablet. The addition of lubricant / glidant of Mg stearat , talc or their mixture as the cohesive materials to the prednisone-granule interactive mixtures produce prednisone- granule-lubricant/ glidant which affect the tablet properties such as disintegration time and release of the drug. Based on these matter, a study was done to examine effect of Mg stearat, talc or their mixtures to the disintegration time and dissolution of prednisone interactive mixtures tablet. For the investigation of these effects, experiments were done using optimization approach based on simplex lattice design with Mg stearate and talc as the independent variable. The experiments data were implemented into the equation relation to the simplex lattice design : Y= a(A) + b (B) + ab (A) (B). Based on the coefficient value of the disintegration time and drug dissolution equations, profiles are made, lubricant/glidant effects on the disintegration time and drug dissolution can be analyzed. Magnesium stearate cause prednisone interactive mixtures disintegration time tablet are more longer than talc, although the affect interaction is relativity more little. Magnesium stearate compared with talc gives C30 value and DE-60, although the interaction gives affect relativity more little.
OPTIMASI CAMPURAN AVICEL PH 101 DAN PATI JAGUNG DALAM PEMBUATAN TABLET EKSTRAK DAUN MIMBA (Azadirachta indica A. Juss) SECARA Simplex Lattice Design Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 6 No 1 (2009): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.098 KB) | DOI: 10.31001/jfi.v6i1.10

Abstract

Avicel PH 101 is an excipient in tablet making that can be used as diluent, binder, lubricant, and disintegrator. Avicel is not economically an advantage so that it needs to be combined with cheaper materials. Combination of Avicel PH 101 with corn starch is able to accelerate the disintegration time of the tablet. Mimba (Azadirachta indica A. Juss) leave is a traditional medicine that is used as anti-inflammation. The study was to find out the optimum proportion of Avicel PH 101 and corn starch mixture in tablet making of mimba leaves extract by simplex lattice design method. The extract of mimba leaves was obtained by maceration of mimba leaves powder with ethanol 70%. The obtained extract was evaporated until a thick extract was obtained. Tablet formulation was based on SLD method with excipients of Avicel PH 101 (A) and corn starch (B) i.e. F1 (100% A), F2 ( 50% A : 50% B), F3 (100% B). The tablets of mimba leaves extract were made by wet granulation. The equation was used to make tablets with total respond of the most optimum granules physical properties. The data of the physical properties of granules from optimum formula as calculation result based on SLD equation with the experiment result was analyzed using T-test. Tablets from optimum formula were physically tested including weight uniformity, hardness, friability and disintegration time. The result of theexperiment indicated that the mixture of 90% Avicel PH 101 – 10% corn starch produced an optimum result in granules physical properties and the obtained tablets of mimba leaves extract fulfilled tablet physical property test.
Optimasi Campuran Carbopol 941 dan HPMC dalam Formulasi Sediaan Gel Ekstrak Daun Jambu Mete secara Simplex Lattice Design Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6212.826 KB) | DOI: 10.31001/jfi.v8i1.29

Abstract

Cashew leaves can be used as an antibacterial. The use of this cashew leaves in direct application can an unpractical, so it was made in the form of gel. This research was to get the gel optimum formula of the cashew leaves extract using two addition substances they were carbopol 941 and HPMC based on the simplex lattice design. The cashew leaves extract was obtained by maceration using ethanol 70% then it was evaporated to obtain concentrated extract. The optimum gel was based on simplex lattice design method with 2 components i.e. carbopol 941(C) and HPMC (H) used 3 formulations: formula I (100% C: 0% H), formula II (50% C: 50% H) and formula III (0% C: 100% H). Observation of physical properties included viscosity, the time of sticking and spreading ability, than it used to obtain SLD equation. The equation is used to make optimum gel formulation with the highest total respond of gel’s physical properties. The obtained data of simplex lattice design was compared to the result of real test by T-test. The result of the experiment showed that cashew leaves extract can be optimum formula of cashew leaves gel extract was obtained from the mixture of carbopol 941 60% - HPMC 40%. The result of t-Test of viscosity, adhesiveness and distribution showed that there was no significant difference between prediction and the result of real test.
Optimasi Formula Tablet Lepas Lambat Tramadol HCl dengan Kombinasi Matriks Mukoadhesif PVP dan Xanthan Gum secara Simplex Lattice Design Chaesti Setyo Hastuti; Ilham Kuncahyo; Muhammad Dzakwan
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (902.073 KB) | DOI: 10.31001/jfi.v11i1.59

Abstract

Tramadol HCl is a synthetic opioid of cyclohexanol group which acts as an analgesic. To improve the comfort and compliance of patient, therefore tramadol HCl is made in sustained release tablet. In this study, sustained release tablet of tramadol HCl was combined with PVP and xanthan gum mucoadhesive matrix. This study was made in four formulas, they were: control formula (without the matrix), F I (25% PVP : 75% xanthan gum), F II (50% PVP : 50% xanthan gum), and F III (75% PVP : 25% xanthan gum). The tablets were made by dry granulation and compressed to 250 mg weight of tablet. The obtained granules and tablets were tested for the physical properties. The properties determination of the optimum formula used Simplex Lattice Design method (SLD) with Software Design Expert 8.0.6. The parameters used were: flowing time, hardness, friability, and disolution. The experimental results and the theoretical optimum formula were analyzed using t-test. The optimum formula sustained release tablet of tramadol HCl with PVP and xanthan gum mucoadhesive matrix combination by Simplex Lattice Design was obtained in proportion of 55,031% PVP and 44,969% xanthan gum. Pattern of tramadol HCl release on the optimum formula followed diffusion mechanism and zerro orde kinetic. The response of physical properties of optimum formula was obtained from prediction result and examination showed that there was not different significant.
Co-Authors Adam Ferdian Sigit Pratama Alfiana, Ina Ana Indrayati Anisa Devi Kharisma Wibowo Ayuk Armadani , Valentina Chaesti Setyo Hastuti Chatarina Umbul Wahyuni Dewi, Fitri Jaya Santi Utami Dian Marlina Dian Puspitasari Efrilia, Erin ELISABETH APRILIA Endang Diyah Ikasari Endang Dyah Ikasari Ghani Nurfiana Fadma Sari Gunawan, Lucia Sincu Hafizah, Dila Auli Hutami, Shabrina Nindya Ibnu Pratikto Ismi Rahmawati Iswandi Iswandi Kartikasari, Ayu Lifia Nur Kiki Puspitasary Kusumawati, Mulyaningtyas Ayu M Muchalal M. Andi Chandra M. Andi Chandra M. Henityo Agung As'adi Mahayana, Argoto Mamik Ponco Rahayu Mardiyono Mardiyono, . Mointi, Sella Septiyani Muhammad Dzakwan Noval Noval Nur Hidayati Nuraini Harmastuti Octavia Krisma O Opstaria saptarini Prasasti, Anin Pudiastuti RSP Putri, Hana Maylinda Putri, Sukma Oktafiani Rakhmi Hidayati Reslely Harjanti Resmi, Juniar Kalpika Rini Prastiwi Rizqi Fitria Yanuar Roosma Hatmayana Rudhi Pribadi Saifullah, T.N Septiawan Adi Nugroho Sesilia Putri Nandita Setyaningrum, Dewi Anggraheni setyawan, Ferdinta D Siti Aisiyah Siti Aisiyah Soebiyanto, Soebiyanto Sugiyarmasto Sugiyarmasto, Sugiyarmasto Suhartinah Suhartinah, Suhartinah Sukarno Sumardiyono Sumardiyono Sunardi Sunardi Supriyadi Supriyadi Supriyadi Supriyadi Syafira Nabillah Syaiful Choiri T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman Taena, Adriani Teuku Nanda Saifullah Sulaiman Titik Sunarni Titik Sunarni TN Saifullah Sulaiman, TN Saifullah Turdiyanto, Totok Valentina Ayuk Armadani Vivin Nopiyanti Waluyo Budi Atmoko, Waluyo Budi Wijayanti, Ifa Rizki Wiwin Herdwiani Wulandari, RR Sri Yudanti, Gendis Purno Yudi Rinanto Yuliana, Sinta Zahra, Iklila