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All Journal Journal of Marine Research INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Adi Widya : Jurnal Pengabdian Masyarakat Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Cendekia Journal of Pharmacy Science Midwifery Budimas : Jurnal Pengabdian Masyarakat Avicenna : Journal of Health Research Jurnal Farmasi Journal of Fundamental and Applied Pharmaceutical Science Jurnal Pengabdian kepada Masyarakat Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan East Asian Journal of Multidisciplinary Research (EAJMR) Medical Sains : Jurnal Ilmiah Kefarmasian Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Journal of Halal Science and Research Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Ilham Kuncahyo, Ilham
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PEMBERDAYAAN SISWA SMK MELALUI TECHNOPRENEUR KAPSUL NANOKALSIUM DARI CANGKANG TELUR AYAM Sunardi, Sunardi; Mahayana, Argoto; Hafizah, Dila Auli; Sumardiyono, Sumardiyono; Prasasti, Anin; Alfiana, Ina; Iswandi, Iswandi; Putri, Hana Maylinda; Kuncahyo, Ilham; Sugiyarmasto, Sugiyarmasto; Hidayati, Nur; Soebiyanto, Soebiyanto; Gunawan, Lucia Sincu
BUDIMAS : JURNAL PENGABDIAN MASYARAKAT Vol 6, No 3 (2024): BUDIMAS : Jurnal Pengabdian Masyarakat
Publisher : LPPM ITB AAS Indonesia Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/budimas.v6i3.14837

Abstract

The partner in this Community Service Program is SMK TUNAS NUSANTARA, Industrial Chemistry Department in Jaten, Karanganyar. Students in this department do not yet have knowledge about waste-based technopreneur. One of the opportunities that can be taken is to produce nanocalcium herbs from chicken eggshells. Partners face several obstacles, namely: 1) Lack of knowledge of Industrial Chemistry SMK students about calcium; 2) Limited knowledge and skills in making nanocalcium herbal capsules; and 3) Lack of knowledge and skills related to food safety, packaging, and marketing. To overcome these problems, the Community Service program is carried out through: 1) Making herbal nanocalcium from eggshell; 2) Training on making nanocalcium herbal capsules; 3) Marketing management training. As a result, the partners succeeded in producing nanocalcium herbal capsules that are beneficial for bone health and now have the provision to become technopreneurs.
PENGARUH TRANSCUTOL P DAN PEG 400 DALAM PEMBUATAN TABLET LIQUISOLID NIFEDIPIN TERHADAP MUTU FISIK DAN DISOLUSI Kuncahyo, Ilham; Hutami, Shabrina Nindya; Wulandari, RR Sri
Cendekia Journal of Pharmacy Vol 9, No 1 (2025): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v9i1.330

Abstract

Nifedipine as a hypertension drug has the problem of low solubility (BCS class II), leading to decreased dissolution and bioavailability. Formulation of nifedipine liquisolid using non-volatile solvents can overcome this problem. This study aimed to evaluate the effect of Transcutol P and PEG 400 as non-volatile liquisolid ingredients on the physical quality and dissolution of nifedipine liquisolid tablets. This study used seven nifedipine liquisolid formulations, each with varying concentrations of Transcutol P or PEG 400 as non-volatile solvents and lactose as carrier material. Formula 1 (20% Transcutol: 80% lactose), Formula 2 (25% Transcutol: 75% lactose), Formula 3 (30% Transcutol: 70% lactose), Formula 4 (20% PEG 400: 80% lactose), Formula 5 (25% PEG 400: 75% lactose), Formula 6 (30% PEG 400: 70% lactose), and one control formula. The nifedipine liquid produced from each formula was forged into tablets using the direct felting method with a weight of approximately 200 mg. The tablets were tested for physical quality and dissolution, and the results were statistically analyzed using SPSS version 12.0. The results showed that Transcutol P and PEG 400 as liquisolid ingredients for nifedipine tablets provided good physical quality and improved the quantity and rate of drug release. The effect of PEG 400 as a liquisolid material for nifedipine tablets slowed down the disintegration time and accelerated the dissolution rate compared with Transcutol P. The dissolution profile showed that the release of nifedipine tablets with PEG 400 liquisolid material reached 30% at the fifth minute, meeting the requirements according to Indonesian Pharmacopoeia VI, which stipulates that more than 75% should be released at the sixtieth minute
PEMBERDAYAAN SISWA SMK MELALUI TECHNOPRENEUR KAPSUL NANOKALSIUM DARI CANGKANG TELUR AYAM Sunardi, Sunardi; Mahayana, Argoto; Hafizah, Dila Auli; Sumardiyono, Sumardiyono; Prasasti, Anin; Alfiana, Ina; Iswandi, Iswandi; Putri, Hana Maylinda; Kuncahyo, Ilham; Sugiyarmasto, Sugiyarmasto; Hidayati, Nur; Soebiyanto, Soebiyanto; Gunawan, Lucia Sincu
BUDIMAS : JURNAL PENGABDIAN MASYARAKAT Vol. 6 No. 3 (2024): BUDIMAS : Jurnal Pengabdian Masyarakat
Publisher : LPPM ITB AAS Indonesia Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The partner in this Community Service Program is SMK TUNAS NUSANTARA, Industrial Chemistry Department in Jaten, Karanganyar. Students in this department do not yet have knowledge about waste-based technopreneur. One of the opportunities that can be taken is to produce nanocalcium herbs from chicken eggshells. Partners face several obstacles, namely: 1) Lack of knowledge of Industrial Chemistry SMK students about calcium; 2) Limited knowledge and skills in making nanocalcium herbal capsules; and 3) Lack of knowledge and skills related to food safety, packaging, and marketing. To overcome these problems, the Community Service program is carried out through: 1) Making herbal nanocalcium from eggshell; 2) Training on making nanocalcium herbal capsules; 3) Marketing management training. As a result, the partners succeeded in producing nanocalcium herbal capsules that are beneficial for bone health and now have the provision to become technopreneurs.
Optimization of chitosan and sodium tripolyphosphate as a carrier system for nanoparticles of ethanol extract of aloe vera (Aloe vera l.) as an antioxidant Efrilia, Erin; Sunarni, Titik; Kuncahyo, Ilham
Journal of Health Management and Pharmacy Exploration Vol. 3 No. 1 (2025): February 2025
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v3i1.532

Abstract

Aloe Vera has phenolic active compounds that are proven to have potential antioxidant activity but are sensitive to light, easily oxidized and unstable at high temperatures. To overcome this, aloe vera is formulated into a chitosan and sodium tripolyphosphate carrier system. The interaction between chitosan and sodium tripolyphosphate for nanoparticle formation is strongly influenced by the ratio of both. The purpose of this study was to obtain the optimal formula of aloe vera extract nanoparticle preparation with chitosan and sodium tripolyphosphate carrier system with critical parameters including particle size, polydispersity index, zeta potential, sorption efficiency and antioxidant activity. Aloe vera was extracted with 96% ethanol using maceration method. Determination of chitosan and sodium tripolyphosphate concentration variation using simplex lattice design method. The results of the tests that have been carried out, the characteristics of aloe vera nanoparticle preparations with variations in the concentration of chitosan: sodium tripolyphosphate in runs 2 & 6 have the most optimal formula with the ratio of chitosan: sodium tripolyphosphate = (0.3: 0.1).
Pengaruh Komponen Self Nanoemulsifying Drug Delivey System (SNEDDS) Fenofibrat Terhadap Karakteristik Dan Uji Disolusi Kuncahyo, Ilham
Parapemikir : Jurnal Ilmiah Farmasi Vol 14, No 2 (2025): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v14i2.8620

Abstract

Fenofibrat sebagai obat antikolesterol masuk dalam BCS (Biopharmaceutics Classification System) kelas II, yaitu obat yang memiliki kelarutan rendah sehingga proses disolusi lambat yang berakibat menurunkan bioavailabilitas. Permasalahan tersebut dapat dihindari salah satunya dengan memperbaiki sistem penghantaran obat. Penelitian ini bertujuan untuk mengeksplorasi sistem penghantaran obat Self Nanoemulsifying Drug Delivey System (SNEDDS) fenofibrat dengan memvariasi komponen SNEDDS yaitu : minyak miglyol 812, surfaktan tween 80 dan kosurfaktan PEG 400. Penelitian ini menggunakan enam formula dengan perbandingan konsentrasi 10%-20% miglyol 812, 50%-60% tween 80 dan 20%-30% PEG 400. Masing-masing formula dibuat SNEDDS fenofibrat kemudian dilakukan karakterisasi meliputi ukuran partikel, drug loading, % transmitan, waktu emulsifikasi dan disolusi. Data hasil penelitian dianalisis dan dibandingkan dengan pustaka. Hasil penelitian SNEDDS fenofibrat memberikan hasil karakterisasi dan profil disolusi yang berbeda signifikan. F4 dengan jumlah komponen surfaktan (twenn 80) dan kosurfaktan (PEG 400) dalam proporsi yang besar dan minyak (miglyol 812) dalam proporsi yang kecil memberikan ukuran partikel yang kecil, waktu emulsifikasi yang cepat serta drug loading yang besar dibandingkan F1, F2, F3, F5 dan F6. Untuk hasil disolusi menunjukkan semua formula SNEDDS fenofibrat mampu mempercepat disolusi dibandingkan formula kontrol yang berisi serbuk obat fenofibrate. F3 dan F4 memberikan % disolusi obat yang lebih baik dibandingkan F1, F2, F5 dan F6
Optimization and Characterization of Naringenin Transfersomes with Simplex Lattice Design and Anti-Aging In Vivo Study Yuliana, Sinta; Kuncahyo, Ilham; Harmastuti, Nuraini
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.782

Abstract

Naringenin acts as an antioxidant, neutralizing free radicals that are present in the atmosphere and which are responsible for a number of adverse effects on the skin, including photoaging, the formation of wrinkles, and a loss of radiance. The objective of this study is to determine the effect of varying phospatidilcholine, cholesterole, and tween 80 on the characteristics of naringenin transfersome and their efficacy as anti-aging agents. A total of 14 naringenin transfersome formulas were subjected to testing using the Design-Expert application, using simplex lattice design method. The particle size, polidispersity index, zeta potential, and % Entrapment efficiency were evaluated. Subsequently, the optimal formula was subjected to in vivo anti-aging testing. The characterization results obtained for the PSA test indicate a range of values between 70 and 90 nm for the naringenin transfersomes. The % Efficiency of Absorption test yielded results between 80 and 92%, while the PDI test exhibited a range close to. The value of zero is obtained for the zeta potential, and the results are distant from this value. The optimum formula, as predicted by the Simplex lattice design method, provides results for the characterization test that are in close alignment with the actual outcomes.
Optimization and Formulation of Fenofibrate Transfersome Using The Thin Layer Hydration Method Putri, Sukma Oktafiani; Iswandi, Iswandi; Kuncahyo, Ilham
Riset Informasi Kesehatan Vol 12 No 2 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i2.773

Abstract

Abstract Background: Fenofibrate is a lipophilic drug that is used to treat hypercholesterolemia and hypertriglyceridemia in patients.. The low solubility of fenofibrate can be improved by creating a phenofibrate transfersome delivery system. The objective of this research was to determine the effect of phosphatidylcholine 90G, Tween 80, with sonication on fenofibrate transfersomesand to obtain the optimum composition of phosphatidylcholine 90G, tween 80, with sonication on critical parameters including particle size, zeta potential, absorption efficiency. For formula optimization, the factorial design method was applied. Phosphatidylcholine 90G composition, tween 80, with sonication were used as independent variables, with particle size, zeta potential, and sorption effectiveness as dependent variables. Method: The optimization was carried out with critical parameters of the fenofibrate transfersomes tested including particle size, zeta potential, and adsorption efficiency. The critical parameter test data were analyzed using factorial design. Result: The results showed that there was an effect of phosphatidylcholine 90G, tween 80, and sonication on fenofibrate transfersomes provide effect by including particle size, zeta potential, and sorption efficiency. Conclusion: The optimum proportion of phosphatidylcholine 90G was 95%, tween 80 was 5%, and sonication was 33,39 time. The transfersome ability of fenofibrate was good in the optimum formula in the particle size test was 23,675 nm and zeta potential 52,231 mv and the entrapment efficiency was 96,915 %. Keyword : Fenofibrat, Transfersome, phospatidicoline 90G, thin film layer, Factorial Design.
OPTIMASI PROPORSI CAMPURAN POLIVINIL PIROLIDON DAN AVICEL PH 101 DALAM FORMULASI TABLET ASAM MEFENAMAT SECARA SIMPLEX LATTICE DESIGN Puspitasari, Dian; Kuncahyo, Ilham
Jurnal Farmasi (Journal of Pharmacy) Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mefenamic acid is used as an analgesic and non-steroidal anti-inflammatory drugs. The problem that often occurs in the process of compressing is that mefenamic acid tends to stick on the surface of punch and die-compressing machine, so that it often experiences sticking and within a sustainable manner can cause capping process. The other problems of Mefenamic acid are hydrophobic and having low solubility, so that the dissolution becomes a problem. The combination of Avicel PH101 and PVP is expected to fix the problems, so that well-qualified Mefenamic acid tablets can be obtained. This study was aimed at obtaining the optimum formula of mixed Avicel PH101 and PVP in the manufacture of mefenamic acid tablets by wet granulation, based on the method of simplex lattice design (SLD) with two components, namely: Avicel PH101 (A) and PVP (B). Three formulas of mefenamic acid tablets (F1 (100% A), F2 (50% A: 50% B), F3 (100% B)) are made by wet granulation. The granules are tested for the fluidity, compactibility and dissolution. The result is to obtain SLD equation. The equation is used to determine the optimum formula which is the formula with the total response of the most optimal physical properties of granules. The result of the experiment shows that optimum formula was obtained from Avicel PH 101 30% - PVP 70% mixture at granules’ physical properties, and the obtained tablets of Mefenamic acid fulfills tablet physical property test.
Pengaruh Matriks Pektin dan HPMC K15M Terhadap Daya Mengapung dan Mengembang serta Disolusi pada Tablet Floating Verapamil HCl dengan Metode Factorial Design Ayuk Armadani , Valentina; Aisiyah, Siti; Kuncahyo, Ilham
Jurnal Farmasi (Journal of Pharmacy) Vol. 9 No. 1 (2020): Jurnal Farmasi (Journal of Pharmacy), April 2020
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Verapamil HCl is Calcium Channel blocker (CCB) used to treat hypertension and angina pectoris. Verapamil HCl has a bioavailability of 10-20% and half-life of 4 hours so it can be made gastroretentive preparations for defending drug therapy concentration. This study was purposed to know the effect of pectin and HPMC K15M on floatation behaviour, swelling and drug released of verapamil HCl floating tablet. This study used four varying matrix concentrations of pectin and HPMC K15M with direct compression method then evaluated physical properties of powders and tablets. Effects and interactions between pectin and HPMC K15M were given by factorial design method using software Design Expert®. Matrix of pectin and HPMC K15M gave effects to floatation behaviour, swelling and drud released of verapamil HCl floating tablet. HPMC K15M was dominant influenced about decreased floating lag time and increased floating time. Increased of HPMC K15M and pectin could be decreased initial burst and drug released rate but increased swelling. Pectin and HPMC K15M (1,5:1) combination had the fastest of floating lag time, the longest time of floating time, the greatest of swelling and followed zero order.
Skrining dan Karakterisasi Komponen Self Nano Emulsifying Drug Delivery System (SNEDDS) Atorvastatin Menggunakan Fractional Factorial Design (FFD) Wijayanti, Ifa Rizki; Kuncahyo, Ilham; Herdwiani, Wiwin
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.546

Abstract

Atorvastatin merupakan obat yang memiliki kelarutan rendah dalam air (BCS kelas II) serta memiliki aktivitas farmakologis sebagai terapi hiperkolesterolemia. Self?nanoemulsifying drug delivery systems (SNEDDS) dianggap sebagai pendekatan yang potensial untuk meningkatkan kelarutan atorvastatin karena stabil dan proses pembuatan yang relatif sederhana. Penelitian ini bertujuan untuk memilih komponen dan rasio komponen SNEDDS atorvastatin menggunakan pendekatan desain faktorial terfraksi (DFT) terhadap parameter waktu emulsifikasi, ukuran droplet, indeks polidispersitas (PDI), zeta potensial, persen transmitan, dan loading obat. Variabel yang digunakan dalam pengembangan SNEDDS atorvastatin adalah tipe dan konsentrasi minyak (capryol 90 dan asam oleat), surfaktan (cremophor RH40 dan tween 80), dan ko-surfaktan (transcutol dan PEG 400). Hasil DFT didapatkan 16 run dengan perbedaan proporsi komponen SNEDDS atorvastatin, kemudian dilakukan karakterisasi parameter kritis meliputi waktu emulsifikasi, persen transmitan, ukuran droplet, loading obat, indeks polidispersitas, dan zeta potensial. Komponen dan rasio komponen SNEDDS atorvastatin ditentukan dengan analisa single factor plot menggunakan program design expert 13. Hasil penelitian menunjukkan capryol 90, cremophor RH40, dan transcutol terpilih sebagai komponen minyak, surfaktan, dan ko?surfaktan yang memiliki kontribusi paling besar dalam pembuatan SNEDDS atorvastatin dengan rasio minyak pada 11,1-37,5 %, rasio surfaktan 36,4-77,8 %, rasio ko-surfaktan 11,1-44,4 %.
Co-Authors Adam Ferdian Sigit Pratama Alfiana, Ina Ana Indrayati Anisa Devi Kharisma Wibowo Ayuk Armadani , Valentina Chaesti Setyo Hastuti Chatarina Umbul Wahyuni Dewi, Fitri Jaya Santi Utami Dian Marlina Dian Puspitasari Efrilia, Erin ELISABETH APRILIA Endang Diyah Ikasari Endang Dyah Ikasari Ghani Nurfiana Fadma Sari Gunawan, Lucia Sincu Hafizah, Dila Auli Hutami, Shabrina Nindya Ibnu Pratikto Ismi Rahmawati Iswandi Iswandi Kartikasari, Ayu Lifia Nur Kiki Puspitasary Kusumawati, Mulyaningtyas Ayu M Muchalal M. Andi Chandra M. Andi Chandra M. Henityo Agung As'adi Mahayana, Argoto Mamik Ponco Rahayu Mardiyono Mardiyono, . Mointi, Sella Septiyani Muhammad Dzakwan Noval Noval Nur Hidayati Nuraini Harmastuti Octavia Krisma O Opstaria saptarini Prasasti, Anin Pudiastuti RSP Putri, Hana Maylinda Putri, Sukma Oktafiani Rakhmi Hidayati Reslely Harjanti Resmi, Juniar Kalpika Rini Prastiwi Rizqi Fitria Yanuar Roosma Hatmayana Rudhi Pribadi Saifullah, T.N Septiawan Adi Nugroho Sesilia Putri Nandita Setyaningrum, Dewi Anggraheni setyawan, Ferdinta D Siti Aisiyah Siti Aisiyah Soebiyanto, Soebiyanto Sugiyarmasto Sugiyarmasto, Sugiyarmasto Suhartinah Suhartinah, Suhartinah Sukarno Sumardiyono Sumardiyono Sunardi Sunardi Supriyadi Supriyadi Supriyadi Supriyadi Syafira Nabillah Syaiful Choiri T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman Taena, Adriani Teuku Nanda Saifullah Sulaiman Titik Sunarni Titik Sunarni TN Saifullah Sulaiman, TN Saifullah Turdiyanto, Totok Valentina Ayuk Armadani Vivin Nopiyanti Waluyo Budi Atmoko, Waluyo Budi Wijayanti, Ifa Rizki Wiwin Herdwiani Wulandari, RR Sri Yudanti, Gendis Purno Yudi Rinanto Yuliana, Sinta Zahra, Iklila