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All Journal Journal of Marine Research INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Adi Widya : Jurnal Pengabdian Masyarakat Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia JFIOnline Jurnal Mandala Pharmacon Indonesia Cendekia Journal of Pharmacy Science Midwifery Budimas : Jurnal Pengabdian Masyarakat Avicenna : Journal of Health Research Jurnal Farmasi Journal of Fundamental and Applied Pharmaceutical Science Jurnal Pengabdian kepada Masyarakat Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan East Asian Journal of Multidisciplinary Research (EAJMR) Medical Sains : Jurnal Ilmiah Kefarmasian Formosa Journal of Multidisciplinary Research (FJMR) Jurnal Farmasi Sains dan Praktis Journal of Halal Science and Research Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian

Ilham Kuncahyo, Ilham

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Author-ID : 552969

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Preclinic Activity Test of Capsule of Natural Ingredients Extract Combination of Noni Fruit (Morinda citrifolia L.) and Papaya Leaf (Carica papaya L.) as Hepatoprotector Agent for Tuberculosis (TB) Treatment Ilham Kuncahyo; Supriyadi Supriyadi
Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Research has been conducted in year 1st with the manufacture capsule of noni fruit (Morinda citrifolia L.) and papaya leaf (Carica papaya L.) as the active material to cope with damage to the liver (hepatoprotective) for the treatment of tuberculosis (TB). Year 2nd pre-clinical tests have been conducted using rats as test animals given INH and rifampicin that are often used in the treatment of tuberculosis for 28 days. Test animals consisted of 30 rats were grouped into six groups. Group I (normal control) were without any treatment, rat were given only the usual food and drink. Group II (negative control) were given INH-rifampicin suspension (INH dose of 10 mg/200 g BW and rifampicin dose of 10 mg/200 g BW. Group III (positive control) were given INH-rifampicin suspension and drug antihepatotoxic methicolÂ®. Group IV were given formula capsule 1, group V were given formula capsule 2, and group VI were given formula capsule 3. Parameters of liver damage was observed by measuring the levels of serum bilirubin, ALT and AST values. The parameters were measured on day 0 (before treatment), day 14, day 21, and day 28. There were observed liver histologically by histological methods-microscopic photograph using hematoxylin eosin staining. The data obtained were statistically evaluated using ANOVA one way for percentage of liver necrosis and two-way ANOVA for ALT, AST and serum bilirubin, with a 95% confidence level. The results showed that the formula capsule 1 of extract combination of papaya leaf and noni fruit with PVP binder 1 % was able to provide reduced liver damage on rats induced isoniazidrifampicin which was better than formula capsule 2 and 3.

Optimasi Formula Tablet Lepas Lambat Mucoadhesive Nifedipin dengan Carbopol 940 dan HPMC K15M Sebagai Matriks secara Simplex Lattice Design Octavia Krisma O; T. N. Saifullah Sulaiman; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Nifedipin is a calcium chanel blocker has been used for hypertension treatment. Nifedipin has a short half-life (2-4 hours), and perfectly absorb in stomach. These characteristics indicate a good candidate for mucoadhesive formulation. This research aimed to optimize and determine the influence of the Carbopol 940 and HPMC K15M proportion on the physical properties of the tablet and the drug release. Tablets preparation using dry granulation method was carried out using difference proportion of HPMC K15M (A) and Carbopol 940 (B) for each formula i.e. 0% A: 100% B 940, 25% A: 75% B, 50% A: 50% B, 75% A: 25% B and 100% A: 0% B. The weighting of each tablet 250 mg with nifedipin 20 mg per tablet. Mucoadhesive strength was determined using rabbit gastric and the drug release using buffer chloride addition by 0.5% sodium lauryl sulfate pH 1.2 for 6 hours. Optimum formula was analyzed using simplex lattice design method. The results showed that increasing proportion of Carbopol 940 increased the tablet hardness and mucoadhesive strength and increasing the proportion of HPMC K15M reduced the drug release. Optimum formula was obtained at proportion of HPMC K15M 30,610 mg and Carbopol 940 mg 19,390 mgKeywords : Nifedipin, mucoadhesive, HPMC K15M, Carbopol 940.

Optimasi Proporsi Polisorbat 80 dan Sorbitan 80 dalam Formulasi Krim Ekstrak Etil Asetat Daun Jengkol (Pithecollobium lobatum Benth) Sebagai Antibakteri dengan Metode Desain Faktorial Ghani Nurfiana Fadma Sari; Ilham Kuncahyo; Mamik Ponco Rahayu
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Jengkol leaves ethyl acetate extract shows to have antibacterial activity because it contains saponins, flavonoids and tannins. The use of jengkol leaves ethyl acetateextract directly assessed less well, so that it made cream preparations to make it more convenient to use. This study aimed to obtain the optimum formula of cream of jengkol leavesethyl acetate extract using additional materials polysorbate 80 and sorbitan 80 by Factorial Design method. The Jengkol leaves extract obtained by soxhletation using n-hexane solvent followed by ethyl acetate was then evaporated to obtain a viscous extract. Jengkol leaves extract ethyl asetat cream was made four made in four formulas based on factorial design method. The resulting cream conducted stability tests including organoleptic test, viscosity, adhesiveness, and dispersive power. Optimum formulation parameters based on physical properties, namely: viscosity, viscosity shift, and dispersive power, using Design EaseÂ® Software version 7.1.6. Optimum formula was determined the physical properties and the data were analyzed using t-test. Antibacterial activity was tested by diffusion method. Optimum formula cream of jengkol leaves ethyl acetate extract obtained from proportion polysorbate 80 of 0.44 g and sorbitan 80 of 1.15 g with the physical properties of the response of the optimum formula predictions and experimental result showed no significant difference. Optimum cream showed antibacterial activity presented as inhibition diameter of 14 mm after one day incubation, more potential than formulation 1 (12.8 mm), formulation A (13,8 mm), formulation B (13,2 mm), and formulation AB (13 mm) against Staphylococcus aureus bacteria.

Pengembangan Dan Optimasi Formula Self Mikroemulsi Drug Delivery System (SMEDDS) Kurkumin Untuk Meningkatkan Bioavaibilitas Ilham kuncahyo; Pudiastuti RSP
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Curcumin has been shown to have activity as an anti-tumor, anti-inflammatory, anti-viral, anti-oxidizing and anti-HIV. The use of curcumin in a long-term treatment process provides a low toxicity so it is clinically very beneficial to develop. The active ingredient of curcumin derived from curcuma longa plant extract has a very low bioavaiblity. This is due to the poor solubility of curcumin in water (11 ng / ml, pH 5.0) so that it is slightly absorbed in the gastrointestinal tract. This problem can be overcome by making the preparation of curcumin in the form of Self Microemulsion Drug Delivery System (SMEDDS). Initial studies were screened for the solubility of curcumin with carriers of various types of oils, surfactants and cosurfactants. The screening results continued with the selection of optimum formula SMEDDS kurkumin using Simpelx Lattice Design (SLD) method. Three variables will give 14 SMEDDS curcumin formulas each of which the formula is tested for its characteristics as a critical point include:% transmittance, emulsification time and drug loading. The results of each test were analyzed with Exspert version 7 and continued validation of optimum formula with T test with 95% confidence level. The results showed that the initial screening of curcumin was found to be the highest solubility in olive oil, Tween 80 surfactant and PEG 400 cosurfactant. The three types of materials were optimized with SLD giving optimum formula of SMEDDS curcumin composition with 0,026 olive oil composition; 0.0913 Tween 80 and 0.061 PEG 400.

Optimasi Proporsi Campuran Carbopol 941 dan CMC-Na dalam Pembuatan Gel Lendir Bekicot (Achatina fullica Ferr.) secara Simplex Lattice Design ELISABETH APRILIA; ILHAM KUNCAHYO; Siti Aisiyah
Jurnal Farmasi Indonesia Vol 9 No 1 (2012): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Snail (Achatina fulica Ferr) mucus efficacious as cure wounds. The use of snail mucus directly considered less practical, so that made the gel preparation. This study aims to obtain the optimum formula of snail mucus gel from carbopol 941 and CMC-Na mixtures using simplex lattice design. Snail mucus obtained by solving the top shell snail then shell reversed for inside snail mucus out. Optimum gel formula based on the simplex lattice design with 2 components, i.e: carbopol 941 (K) and CMC-Na (C) using 3 formulas, i.e: formula I (100% K: 0% C), formula II (50% K: 50% C) and formula III (0% K: 100% C). The physical properties observed were viscosity, adhesiveness and dispersive, which then is used to make the SLD equation. The equation used to make the optimum formula gel from the total response of the most large gel physical nature. Results obtained from the simplex lattice design equation compared with actual test results with t-test (T-test). The results showed an optimum gel formula of snail mucus obtained from of 30% carbopol 941 and 70% CMC-Na mixtures. From the results of t-test (T-tesf) against viscosity, adhesiveness and dispersive showed no significant difference between the predictions with actual experimental results.

OPTIMASI FORMULA KRIM DAUN JENGKOL (Pithecollobium lobatum Benth) SEBAGAI ANTIBAKTERI MENGGUNAKAN DESAIN FAKTORIAL Kiki Puspitasary; Ilham Kuncahyo; Mamik Ponco Rahayu
Avicenna : Journal of Health Research Vol 3, No 1 (2020): MARET
Publisher : STIKES Mamba'ul 'Ulum Surakarta

Latar belakang : Daun jengkol (Pithecollobium lobatum Benth) merupakan bahan obat tradisional yang digunakan oleh masyarakat sebagai obat eksim, kudis, luka dan bisul, kulit buahnya untuk borok. Daun jengkol mengandung saponin, flavonoid dan tanin. Menurut Salni (2011) fraksi etil asetat daun jengkol pada konsentrasi 160 ppm mempunyai aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923. Tujuan Penelitian : Penelitian ini untuk mendapatkan formula optimum krim ekstrak daun jengkol dan mengetahui aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923. Metode : Ekstraksi diawali dari pelarut n-heksan kemudian etil asetat. Ekstrak etil asetat dipekatkan dengan evaporator kemudian digunakan sebagai zat aktif dalam pembuatan krim. Krim ekstrak daun jengkol dibuat empat formula berdasarkan metode desain faktorial. Krim yang dihasilkan diuji sifat fisiknya meliputi organoleptis, viskositas, daya sebar, daya lekat. Formula optimum berdasarkan parameter sifat fisik krim yaitu: viskositas, daya sebar, daya lekat diperoleh menggunakan software Design Ease® versi 7.1.6. Formula optimum yang diperoleh dibuat dan diuji sifat fisiknya selama 4 minggu serta aktivitas antibakterinya menggunakan metode difusi. Hasil : Formula optimum krim ekstrak daun jengkol diperoleh pada proporsi polisorbat 60 sebesar 0,41 g dan sorbitan 60 sebesar 1,19 g. Respon sifat fisik formula optimum dari hasil prediksi dan percobaan menunjukkan tidak ada beda signifikan. Aktivitas antibakteri krim optimum sebesar 15,3 mm. Simpulan : Ekstrak daun jengkol dapat dibuat krim dengan formula optimum dengan sifat fisik yang baik melalui pengujian beberapa formula menggunakan desain faktorial.

Pengaruh Perbandingan Tween 80 dan Fosfatidilkolin Pada Formulasi Transfersom Naringenin dan Kajian Permeasi Berbasis Hidrogel Ilham Kuncahyo; Juniar Kalpika Resmi; M Muchalal
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 6, No 3 (2021)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v6i3.50738

Naringenin merupakan flavonoid isolat kulit buah jeruk yang mempunyai kelarutan yang rendah. Potensi naringenin dalam terapi dermatitis atopik pada sistem penghantaran transfersom dapat meningkatkan kemampuan naringenin dalam berpenetrasi ke dalam kulit sehingga mampu mengefektifkan proses penyembuhan. Penelitian ini bertujuan untuk mengkaji pengaruh perbandingan molar fosfatidilkolin sebagai pembentuk vesikel dan Tween 80 yang berfungsi sebagai surfaktan terhadap karakteristik transfersom naringenin dan mengetahui permeasi narigenin terinkorporasi dalam trasfersom berbasis hidrogel. Formula dibuat menjadi 4 untuk diaplikasikan pada proses pembuatan transfersom naringenin dengan variasi perbandingan molar fosfatidilkolin dan Tween 80 yaitu 97,5:2,5 (FI), 90:10 (FII), 85:15 (FIII), dan 80:20 (FIV) menggunakan teknik evaporation-ultrasonication. Hasil transfersom naringenin masing-masing formula dilakukan karakterisasi terhadap ukuran partikel, indeks polidispersi, dan efisiensi penjerapan. Formula transfersom terpilih diformulasikan dalam sediaan gel dan dilakukan uji permease menggunakan membran selofan (WMCO 8 kDa). Hasil penelitian menunjukkan bahwa peningkatan jumlah surfaktan akan menurunkan ukuran partikel dan peningkatan jumlah fosfatidilkolin akan meningkatkan jumlah obat yang terjerap. Formula dengan perbandingan Phospholipon 90G: Tween 80 (85:15, F3) merupakan formula terpilih dengan ukuran dan indeks polidispersi partikel masing-masing 115,6 nm dan 0,274 serta efisiensi penjerapan sebesar 88,63 ± 0,59%. Sediaan gel naringenin transfersom memberikan nilai jumlah kumulatif dan laju penetrasi yang besar dibandingkan gel naringenin tanpa transfersom.

OPTIMASI FORMULASI TABLET SUSTAINED-RELEASE NIFEDIPIN KOMBINASI NATRIUM ALGINAT DAN HPMC K15M SEBAGAI MATRIKS MUKOADHESIF SECARA SIMPLEX LATTICE DESIGN Rizqi Fitria Yanuar; T.N. Saifullah Sulaiman; Ilham Kuncahyo
Majalah Farmaseutik Vol 11, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Nifedipin digunakan untuk obat angina dan hipertensi dengan waktu paruh yang singkat (2-4 jam) dan terabsorbsi baik di lambung sehingga cocok dibuat sediaan tertahan di lambung dengan sistem mukoadhesif. Penelitian ini bertujuan untuk mengetahui pengaruh dan interaksi Na alginat dan HPMC K15 M terhadap sifat fisik dan pelepasan obat serta menentukan proporsi optimum kombinasi Na alginat dan HPMC K15M sebagai polimer bioadhesif. Pembuatan tablet menggunakan metode granulasi kering dengan perbandingan berbagai perbandingan Na alginat (A) dan HPMC K15M (B) dengan model simplex lattice design. F1 (100% A), F2 (75% A : 25% B), F3 (50% A : 50% B), F4 (25% A : 75% B), dan F5 (100% B). Setiap tablet mengandung 20 mg nifedipin dengan bobot total 250 mg dan dilakukan uji sifat fisik granul dan tablet serta uji disolusi. Waktu alir, kekerasan, daya mukoadhesif, dan DE360 sebagai parameter formula optimum yang diolah dengan software Design Expert versi 8.0. Hasil penelitian untuk waktu alir dari interaksi antara Na alginat dan HPMC K15M dapat meningkatkan waktu alir, menurunkan kekerasan, meningkatkan daya mukoadhesif, dan peningkatan pelepasan obat. Proporsi formula optimum diperoleh pada Na alginate 10,00 – 33,75 mg dan HPMC K15M 36,25 – 60,00 mg. Hasil disolusi menunjukkan bahwa kombinasi dari Na alginat dan HPMC K15M dapat meningkatkan obat terlepas. kinetika pelepasan obat mengikuti orde nol dengan model pelepasan higuchi. Verifikasi formula optimum didapat pada daerah 21 mg Na alginat dan 49 mg HPMC K15M menunjukkan tidak ada perbedaan bermakna antara data prediksi dengan percobaan pada parameter optimum yang digunakan.

Formulation and Optimization of Furosemide Snedds With Variation Concentration of Tween 80 and PEG 400 Sesilia Putri Nandita; Ilham Kuncahyo; Reslely Harjanti
Journal of Fundamental and Applied Pharmaceutical Science Vol 2, No 1 (2021): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v2i1.12180

Furosemide is a potent diuretic drug that has low bioavailability. Furosemide can be formulated into nanoemulsion preparations using the SNEDDS method to increase its bioavailability as SNEDDS can form stable nanoemulsions with droplet sizes is less than 200 nm. This study aims to identify the optimum formula for variations in the concentration of surfactant Tween 80 and cosurfactant PEG 400 based on the characterization tests of emulsification time, percent transmittance, and drug loading. The independent variables used in this study were Tween 80 and PEG 400. Seven furosemide SNEDDS formulas from the Simplex Lattice Design (SLD) method were tested for characterization in the form of emulsification time, percent transmittance, and drug loading. The characterization results were optimized using Simplex Lattice Design. The optimum formula was re-characterized, including emulsification time, percent transmittance, drug loading, particle size, zeta potential, and in vitro dissolution. The results were then compared with theoretical values and analyzed using the One-Sample T-test method. Optimization results showed Tween of 61.4922% and PEG 400 of 18.5078% with the characterization of emulsification time 15.25 seconds, percentage transmittance 94.20%, drug loading 50 100.2 ppm, particle size 12.18 nm. Furthermore, the zeta potential was -17.6 mV, and the in vitro dissolution rate reached 106.71% within 15 minutes.

Optimasi HPMC K15M, Karbopol 940, dan Propilen Glikol pada Formula Nanoemulgel Naringenin Metode D-Optimal Mixture Design Rakhmi Hidayati; Opstaria Saptarini; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1460

Naringenin is a flavanone from citrus fruit which has antioxidant activity which has low bioavailability in water. The way to increase the bioavailability of naringenin is to create a SNEDDS delivery system. Nanoemulsion preparations are considered to be comfortless to use due to low viscosity, dispersibility and stability. To solve this problem, SNEDDS is combined into a gel base known as nanoemulgel. The nanoemulgel formed is optimized using D-Optimal Mixture Design method. The aim of this study are determining the combination of HPMC K15M, carbopol 940 and propylene glycol in the optimal nanoemulgel naringenin formula. Naringenin is made into SNEDDS formulation, determined by the hydrogel base formula design: HPMC K15M, carbopol 940, and propylene glycol and obtained 16 formulas. The formed naringenin SNEDDS is dispersed in hydrogel and optimization of viscosity, dispersion, adhesion, cumulative percent of naringenin using franz diffusion cells and stability test are carried out. The data is analyzed on the D-Optimal Mixture Design method using Software Design Expert Version 12. The optimum proportions on a hydrogel base are HPMC K15M of 2%, carbopol 940 of 0.50%, and propylene glycol of 2.50% can have an effect on the critical parameters of viscosity of 3996 cp, dispersion of 5.80 cm, adhesion of 63.39 seconds, and the cumulative percent of naringenin penetration test of 26,54%.

Co-Authors Adam Ferdian Sigit Pratama Alfiana, Ina Ana Indrayati Anisa Devi Kharisma Wibowo Ayuk Armadani , Valentina Chaesti Setyo Hastuti Chatarina Umbul Wahyuni Dewi, Fitri Jaya Santi Utami Dian Marlina Dian Puspitasari Efrilia, Erin ELISABETH APRILIA Endang Diyah Ikasari Endang Dyah Ikasari Ghani Nurfiana Fadma Sari Gunawan, Lucia Sincu Hafizah, Dila Auli Hutami, Shabrina Nindya Ibnu Pratikto Ismi Rahmawati Iswandi Iswandi Kartikasari, Ayu Lifia Nur Kiki Puspitasary Kusumawati, Mulyaningtyas Ayu M Muchalal M. Andi Chandra M. Andi Chandra M. Henityo Agung As'adi Mahayana, Argoto Mamik Ponco Rahayu Mardiyono Mardiyono, . Mointi, Sella Septiyani Muhammad Dzakwan Noval Noval Nur Hidayati Nuraini Harmastuti Octavia Krisma O Opstaria saptarini Prasasti, Anin Pudiastuti RSP Putri, Hana Maylinda Putri, Sukma Oktafiani Rakhmi Hidayati Reslely Harjanti Resmi, Juniar Kalpika Rini Prastiwi Rizqi Fitria Yanuar Roosma Hatmayana Rudhi Pribadi Saifullah, T.N Septiawan Adi Nugroho Sesilia Putri Nandita Setyaningrum, Dewi Anggraheni setyawan, Ferdinta D Siti Aisiyah Siti Aisiyah Soebiyanto, Soebiyanto Sugiyarmasto Sugiyarmasto, Sugiyarmasto Suhartinah Suhartinah, Suhartinah Sukarno Sumardiyono Sumardiyono Sunardi Sunardi Supriyadi Supriyadi Supriyadi Supriyadi Syafira Nabillah Syaiful Choiri T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman Taena, Adriani Teuku Nanda Saifullah Sulaiman Titik Sunarni Titik Sunarni TN Saifullah Sulaiman, TN Saifullah Turdiyanto, Totok Valentina Ayuk Armadani Vivin Nopiyanti Waluyo Budi Atmoko, Waluyo Budi Wijayanti, Ifa Rizki Wiwin Herdwiani Wulandari, RR Sri Yudanti, Gendis Purno Yudi Rinanto Yuliana, Sinta Zahra, Iklila

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