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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Science Midwifery Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Abdimas Kartika Wijayakusuma Medical Sains : Jurnal Ilmiah Kefarmasian Public Health and Safety International Journal (PHASIJ) Sciences of Pharmacy Jurnal Farmasi Indonesia Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Ardhi: Jurnal Pengabdian dalam Negri Jurnal Kesehatan Bakti Tunas Husada Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Ekspresi: Publikasi Kegiatan Pengabdian Indonesia International Journal of Health and Medicine Jurnal Farmasi Galenika Indonesian Journal of Jamu Sasambo: Jurnal Abdimas (Journal of Community Service)
Jajang Japar Sodik
Faculty Of Pharmacy, Universitas Bhakti Kencana
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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UJI IN-SILICO SENYAWA TURUNAN KURKUMINOID SEBAGAI INHIBITOR BRUTON TYROSINE KINASE PADA LEUKIMIA LIMFOSITIK KRONIS Mulki Irpani, Abdul; Ilham Bintang, Muhamad; Putriyanti, Al-fira; Adinda, Deistha; Japar Sodik, Jajang
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 25 No 1 (2025)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v25i1.1496

Abstract

Leukemia is a blood cancer that occurs due to abnormal blood cell growth, especially white blood cells in the bone marrow. Research shows that curcumin is proven to be effective in inhibiting the activity of the NF-κB transcription factor which is often involved in the proliferation of cancer cells. This study aims to determine the potential of natural curcuminoid compounds against specific blood cancers, namely chronic lymphocytic leukemia. Through in-silico testing of curcuminoid derivative compounds against the Bruton Tyrosine Kinase protein target which plays a role in the pathophysiological process of chronic lymphocytic leukemia. The results of docking the test ligand molecule on the Tyrosine-protein kinase BTK enzyme, the native ligand has the lowest binding energy value (ΔG) of -12.04 kcal/mol with an inhibition constant (KI) of 1.49 nM. As a comparison drug, imatinib showed ΔG -11.05 kcal/mol with a KI of 7.88 nM. Test ligands s02, s05, and s08. Ligand s02 showed a ΔG of -9.43 kcal/mol with a KI of 123.19 nM, while s05 had a ΔG of -9.09 kcal/mol with a KI of 218.10 nM. Meanwhile, s08 recorded a ΔG of -9.33 kcal/mol and a KI of 143.83 nM. Although the affinity values of the three test ligands were lower than those of the natural ligands, they had the potential to bind to the target enzyme. Based on the interaction analysis, it was seen that s05 had the potential for competitive inhibition, while s02 and s08 showed lower interaction stability compared to imatinib. This indicates that s05 has the greatest potential as a potential inhibitor of the BTK enzyme compared to other test ligands.
PENINGKATAN SIFAT FISIKOKIMIA KELARUTAN DAN DISOLUSI RAMIPRIL DENGAN KRISTAL MULTIKOMPONEN MENGGUNAKAN KOFORMER GOLONGAN ASAM KARBOKSILAT Muhamad Reza, Pahlevi; M. Ramadhan, Saputro; Jajang Japar, Sodik; Reza, Pratama
Pharmacoscript Vol. 8 No. 1 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i1.2040

Abstract

Salah satu tantangan utama pengembangan obat saat ini adalah kelarutan yang buruk, karena diperkirakan 40% dari semua obat yang baru dikembangkan memiliki kelarutan dan permeabilitas yang buruk. Akibatnya, kandidat baru yang memasuki jalur pengembangan obat gagal karena sifat biofarmasi yang tidak optimal. Ramipril termasuk ke dalam BCS kelas II dengan nilai pKa 5,2 dan memiliki kelarutan air yang buruk dengan nilai bioavailabilitas yang rendah yaitu 28%. Absorbsi ramipril setelah pemberian oral yaitu 50%-60%. Keterbatasan sifat fisikokimia yang dimiliki ramipril dapat diatasi dengan modifikasi kristal salah satunya dengan pembentukkan kristal multikomponen menggunakan teknik kokristalisasi. Pendekatan dalam memperbaiki sifat fisikokimia ramipril dengan konteks kelarutan dan disolusi masih jarang dilakukan, sehingga dengan teknik kokristalisasi dalam modifikasi kristal ramipril menjadi suatu novelty dalam penelitian ini. Pendekatan dengan kristal multikomponen bertujuan untuk meningkatkan sifat fisikokimia ramipril seperti kelarutan dan disolusi. Metode yang digunakan dalam preparasi kristal multikomponen dengan teknik kokristalisasi yaitu liquid assisted grinding menggunakan koformer golongan asam karboksilat seperti asam tartrat dengan perbandingan 1:1. Hasil penelitian menunjukkan bahwa kelarutan kristal multikomponen ramipril 4,35 mg/10 mL dan ramipril murni 1,69 mg/10 mL dalam aquadest. Kristal multikomponen ramipril terdisolusi 73,27% dan ramipril murni 51,74% selama 60 menit menggunakan media aquadest. Modifikasi kristal ramipril menggunakan teknik kristal multikomponen menggunakan metode liquid assisted grinding memberikan dampak perubahan sifat fisikokimia dalam meningkatkan kelarutan dan laju disolusi.
Transformasi Jagung Manis menjadi Produk Bernilai Tambah: Pemberdayaan Ibu Posyandu melalui Inovasi Nugget Jagung Astira Kosmawati; Helen Fitri Novianti; Ratu Fania Aprilyanti; Destia Tresna Prima; Ajeng Pramesti; Jajang Japar Sodik; Entris Sutrisno; Mia Nisrina A; Fenti Fatmawati; Wempi Budiana
ARDHI : Jurnal Pengabdian Dalam Negri Vol. 3 No. 4 (2025): ARDHI : Jurnal Pengabdian Dalam Negri
Publisher : Asosiasi Riset Pendidikan Agama dan Filsafat Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ardhi.v3i4.1420

Abstract

Corn (Zea mays L.) is an important commodity in Indonesia, but in Citaman Village, Nagreg District, its utilization is still limited to fresh sales with low added value. To address this issue, a community service program was implemented that focused on empowering village women through training in processing corn into corn nuggets as an innovative product with economic value. The activity was designed with a community-based participatory approach that included coordination with village officials, extension sessions, processing demonstrations, hands-on practice, and evaluation through pre- and post-training questionnaires. The results of the activity showed that more than 85% of participants were very satisfied and more than 80% expressed a high interest in developing corn nuggets as a small-scale business opportunity. These findings indicate a significant increase in participants' knowledge, skills, and entrepreneurial motivation. The corn nugget innovation is not only a means of optimizing the use of local commodities, but is also relevant to the global trend of plant-based foods and supports the achievement of the Sustainable Development Goals (SDGs), specifically Zero Hunger, Decent Work and Economic Growth, and Responsible Consumption and Production. Overall, this program proves that local food-based innovation can be used as a model for replicating community empowerment that contributes to strengthening economic resilience while encouraging sustainable development in rural areas.
Uji Aktivitas Antioksidan Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) Yang Diformulasikan Kedalam Sediaan Masker Gel Zaelani, Diki; Pratama, Reza; Japar Sodik, Jajang; Hilda Restu, Afria
JURNAL FARMASI GALENIKA Vol 11 No 1 (2024): Jurnal Farmasi Galenika Vol 11 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i1.330

Abstract

This study utilizes the Phaleria macrocarpa fruit (Phaleria macrocarpa (Scheff.) as an active ingredient in gel mask formulation due to its widespread use as a medicinal plant and its antioxidant properties that can inhibit free radicals. The research began with the collection of the fruit from the experimental garden in Lembang-Bandung, identified as Phaleria macrocarpa (Scheff.) Boerl. Extraction was conducted using the maceration method with 96% ethanol for 3x24 hours. Phytochemical screening results indicated the presence of alkaloids, flavonoids, tannins, triterpenoids, and steroids. Antioxidant activity of the gel masks was tested using the DPPH immersion method, resulting in IC50 values of 60.18 ppm, 57.18 ppm, and 54.82 ppm for three different formulations. The pure extract had an IC50 of 45.11 ppm. The gel masks remained stable despite changes in pH and viscosity, with formulation 2 being the most preferred according to the hedonic test. In conclusion, the Phaleria macrocarpa gel mask exhibits effective antioxidant activity and good stability.
Tingkat Kepuasan Pasien terhadap Kualitas Pelayanan Obat di Apotek Rio Mamay Maulana Sobandi; Akhamad Priyadi; Jajang Japar Sodik
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.647

Abstract

Patient satisfaction with pharmacy services is a crucial indicator in assessing the quality of healthcare services provided. Patient satisfaction is influenced by the comparison between perceived performance and expectations. If service performance exceeds expectations, patients will be highly satisfied. This study aims to measure the level of patient satisfaction with the quality of drug services at Rio Pharmacy. This descriptive study uses primary data obtained through questionnaires completed by respondents. The results show that all five dimensions of service quality received positive ratings. The Responsiveness dimension has the most significant influence with a score of 56, followed by Reliability, Assurance, and Empathy, each with a score of 52, and Tangible with a score of 47. Overall, patients are satisfied with the quality of drug services at Rio Pharmacy.
Tingkat Kepuasan Pasien Terhadap Pelayanan Farmasi Di Salah Satu Apotek Bandung Timur Mamay Maulana Sobandi; Jajang Japar Sodik; Elvira Najwa Zain Nabawi
Public Health and Safety International Journal Vol. 5 No. 02 (2025): Public Health and Safety International Journal (PHASIJ)
Publisher : YCMM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55642/phasij.v5i02.1173

Abstract

Pelayanan kefarmasian yang bermutu di apotek berperan penting dalam memenuhi harapan pasien, yang pada gilirannya mempengaruhi tingkat kepuasan konsumen. Seiring dengan perubahan orientasi pelayanan dari drug-oriented menjadi patient-oriented, pelayanan kefarmasian kini berfokus pada peningkatan kualitas hidup pasien melalui pendekatan pharmaceutical care. Perubahan ini menuntut apoteker untuk meningkatkan pengetahuan, keterampilan, dan perilaku dalam berinteraksi langsung dengan pasien. Penelitian ini bertujuan untuk mengukur tingkat kepuasan pasien terhadap pelayanan informasi obat di salah satu apotek di Kabupaten Bandung, dengan menggunakan metode deskriptif. Penelitian ini mengumpulkan data primer melalui kuesioner, yang mengukur kepuasan pasien berdasarkan lima dimensi: Tangible (fasilitas dan tampilan apotek), Empathy (perhatian terhadap pasien), Reliability (keandalan pelayanan), Responsiveness (kecepatan pelayanan), dan Assurance (jaminan pelayanan). Hasil penelitian ini diharapkan dapat memberikan gambaran objektif tentang kualitas pelayanan kefarmasian di apotek dan memperlihatkan area yang perlu ditingkatkan untuk mencapai kepuasan pasien yang lebih baik.
The role of honey, curcuma, and black cumin supplements in overcoming stunting on the adaptive immune system Sabarudin, Cecep; Hasimun, Patonah; Kusriani, Herni; Zuniarto, Ahmad Azrul; Pandanwangi, Siti; Fatmawati, Eva; Afief, Arief R.; Sodik, Jajang Japar
Science Midwifery Vol 13 No 5 (2025): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2185

Abstract

Stunting is strongly associated with impaired immune function, as chronically malnourished children tend to have weaker immunity and are more vulnerable to infection. This study aimed to examine the effect of temulawak–black cumin herbal honey on the adaptive immune system in stunted children. A quasi-experimental one-group pre-test and post-test design was used. The findings showed that the intervention significantly increased height-for-age (TB/U) in the treatment group compared to the control group (p = 0.014). Weight-for-age (BB/U) also rose significantly within the treatment group (p = 0.013), but no significant difference was found relative to the control group (p = 0.192). The supplement significantly elevated IgM levels in the treatment group (p = 0.001), though again without a significant difference from the control (p = 0.546). CD4 concentration decreased in the treatment group (p = 0.003), but the change was not significantly different from the control (p = 0.682). In conclusion, temulawak–black cumin herbal honey can improve nutritional status and enhance adaptive immunity by increasing IgM levels, although it does not raise CD4 levels and instead slows CD4 decline. However, its effectiveness in increasing IgM and CD4 concentrations compared to controls is not significant.
The role of honey, curcuma, and black cumin supplements in overcoming stunting on the adaptive immune system Sabarudin, Cecep; Hasimun, Patonah; Kusriani, Herni; Zuniarto, Ahmad Azrul; Pandanwangi, Siti; Fatmawati, Eva; Afief, Arief R.; Sodik, Jajang Japar
Science Midwifery Vol 13 No 5 (2025): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2185

Abstract

Stunting is strongly associated with impaired immune function, as chronically malnourished children tend to have weaker immunity and are more vulnerable to infection. This study aimed to examine the effect of temulawak–black cumin herbal honey on the adaptive immune system in stunted children. A quasi-experimental one-group pre-test and post-test design was used. The findings showed that the intervention significantly increased height-for-age (TB/U) in the treatment group compared to the control group (p = 0.014). Weight-for-age (BB/U) also rose significantly within the treatment group (p = 0.013), but no significant difference was found relative to the control group (p = 0.192). The supplement significantly elevated IgM levels in the treatment group (p = 0.001), though again without a significant difference from the control (p = 0.546). CD4 concentration decreased in the treatment group (p = 0.003), but the change was not significantly different from the control (p = 0.682). In conclusion, temulawak–black cumin herbal honey can improve nutritional status and enhance adaptive immunity by increasing IgM levels, although it does not raise CD4 levels and instead slows CD4 decline. However, its effectiveness in increasing IgM and CD4 concentrations compared to controls is not significant.
Evaluation of antipsychotic utilization among outpatient schizoprenia patients at the mental health facility in West Java Sutrisno, Entris; Selifiana, Nita; Sodik, Jajang Japar; Fajarrini, Uvika Nurul
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1632

Abstract

Rational use of drugs aims to give therapy according to patient’s clinical needs. Based on Ni komang's research (2021) there are still inaccuracies in the use of antipsychotic drugs. The purpose of this study was to determine the evaluation of the use of Antipsychotics based on the parameters of right indications, drugs, dosage, and frequency in outpatient schizophrenia patients at the West Java Provincial Mental Hospital. The study used a method with descriptive presentation of data and retrospective data collection. Data obtained period October-December 2022 from 130 patients, this study evaluated the use of Antipsychotics with the parameters of right indications, drugs, dosage, and frequency then the data will be analyzed based on the criteria for drug use from Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS. The results of the study on the use of Antipsychotics in schizophrenic patients at the Java Provincial Mental Hospital based on Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS obtained the right indications as much as (100%), the right drugs (100%), the right dose (98%), and the right frequency (98%).
Comparative Glycemic Effectiveness of Long- and Rapid-Acting Insulin in Patients with Type 2 Diabetes Mellitus Sutrisno, Entris; Kaniawati, Marita; Maharani, Ilmi Intan; Sodik, Jajang Japar
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404502

Abstract

Insulin therapy is essential for managing type 2 diabetes mellitus (T2DM), particularly in patients who fail to achieve glycemic targets with oral antidiabetic agents. Long-acting insulin is primarily used to control basal glucose levels, while rapid-acting insulin targets postprandial hyperglycemia. However, comparative real-world evidence regarding their effectiveness on glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) remains limited. This study aimed to evaluate and compare the effectiveness of long-acting and rapid-acting insulin in improving HbA1c and FBG levels among patients with T2DM. A retrospective before–and–after observational study was conducted involving 122 T2DM patients treated at the outpatient unit of Majalaya Regional General Hospital between January and December 2024. Patients received either long-acting insulin (e.g., insulin glargine) or rapid-acting insulin (e.g., insulin lispro and insulin aspart) as monotherapy. Changes in HbA1c and FBG before and after therapy were analyzed using paired t-tests or Wilcoxon signed-rank tests. Clinical effectiveness was defined according to American Diabetes Association criteria as a reduction of ≥1% in HbA1c or ≥30 mg/dL in FBG. Insulin therapy significantly reduced HbA1c (−7.77 ± 3.09, p < 0.001) and FBG levels (Z = −5.53, p < 0.001). Based on ADA criteria, 90.3% of patients achieved an effective reduction in HbA1c, while 43.5% achieved an effective reduction in FBG. Insulin lispro and insulin glargine showed the highest HbA1c-based effectiveness (100%), whereas FBG-based effectiveness varied across formulations. Insulin therapy significantly improves long-term and short-term glycemic control in T2DM patients, with insulin lispro and insulin glargine demonstrating the most consistent effectiveness.
Co-Authors Adinda, Deistha Afief, Arief R. Afria Hilda Restu Agustin, Ia Nurfauziah Ajeng Pramesti Akhamad Priyadi Anbar Fatin, Mia Nisrina Ani Anggriani, Ani Aqila Fadia, Andira Arif Rubianto Aris Suhardiman Asep Kamal Sahroni Astira Kosmawati Budiana, Wempi Dadang Juanda Deden Indra Dinata Deni Iskandar Destia Tresna Prima Elvira Najwa Zain Nabawi Fajarrini, Uvika Nurul Fatmawati, Eva Fatmawati, Fenti Fenti Fatmawati Fenti Fatmawati Garnadi Jafar, Garnadi Hasimun, Patonah Helen Fitri Novianti Hilda Restu, Afria Hilman Mulyana, Hilman Ida Lisni Ika Kurnia Sukmawati Ilham Bintang, Muhamad Irfani, Abdul Mulki Isviyanti Isviyanti Lia Marliani M. Ramadhan, Saputro Maharani, Ilmi Intan Mamay M Sobandi Mamay Maulana Sobandi Marita Kaniawati Maulana Sobandi, Mamay Mia Nisrina A Mia Nisrina Anbar Fatin Muhamad Reza Pahlevi Muhamad Reza, Pahlevi Mulki Irpani, Abdul Muzaki, Yoga Adi Restu Nita Selifiana Patonah, Patonah Pratama, Reza Priyadi, Akhmad Purwaniati, Purwaniati Putriyanti, Al-fira Ratu Fania Aprilyanti Reza Pratama Reza, Pratama Riyadi, Imam Roganda Situmorang Roni, Asep Rusi Rismawanti Ruswanti, Seffi Sabarudin, Cecep Saidah Mutmainah, Siti Sanggo, Merylance Stefany Selifiana , Nita Selifiana, Nita Siti Nurfitria, Rizki Siti Pandanwangi TW Sukmawati, ika kurnia Sumbara Sumbara Sutrisno, Entris Wahyudi, Fikri Mourly Wahyudin Wempi Budiana Wempi Budiana Widhya Aligita Yakobus Lau De Yung Sinaga Yani Mulyani Yuli Astuti Zaelani, Diki Zaelani, Diki Ziska, Rahma Zuniarto, Ahmad Azrul