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CLINICAL FEATURES IN NEPHROTIC SYNDROME PATIENTS: A CASE REPORT Maylisca Theresia Mulya Diprasta, Made; Diarnasa Zihara Safira, Lavenda; Larassanti, Levina; Amin, M. Shadiqul; Pratama Adiwinoto, Ronald
Jurnal Impresi Indonesia Vol. 3 No. 1 (2024): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v3i1.4438

Abstract

Nephrotic Syndrome is a glomerular disease characterized by edema, massive proteinuria >3.5 grams/day, hypoalbuminemia <3.5 grams/day, hypercholesterolemia, and lipiduria. Nephrotic syndrome has a variety of metabolic effects that impact the individual. Some episodes of nephrotic syndrome are self-limited, and some respond to specific therapy, while others are chronic. A 49 year old female patient complained of frequent sweats at night and chills in the morning. Then, the patient complained that his legs had been swollen since he left the hospital until now. Apart from that, edema also occurs in the lower extremities. The management given is general management such as rest, low cholesterol, low salt, fluid restriction <1500ml, and a protein diet. Treatment of edema with diuretics, treatment of proteinuria, treatment of hypertension and history of stroke, as well as causal treatment according to the etiology of nephrotic syndrome. The patient has undergone management planning and treatment therapy for nephrotic syndrome.
From silos to systems: Reimagining zoonotic neglected tropical disease management through the lens of one health Adiwinoto, Ronald Pratama; Adnyana, I Made Dwi Mertha; Soedarsono, Soedarsono; Gustam, Tasalina Yohana Parameswari
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 3 (2024): November 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i3.61

Abstract

Zoonotic neglected tropical diseases (zNTDs) pose significant global public health challenges, particularly in low-income and middle-income countries. Traditional siloed approaches to zNTD management have proven inadequate for addressing the complex interplay between human, animal, and environmental health factors. This review examined the limitations of fragmented strategies and explored the potential of integrated one-health approaches for more effective zNTD control. This narrative review covered publications from 2000 to 2023, sourced from databases including PubMed and Scopus, emphasizing studies that met inclusion criteria of peer-reviewed research focused on zNTDs through a One Health lens. A comprehensive analysis of the current literature and case studies was conducted to evaluate the multifaceted drivers of zoonotic pathogen spillover, assess the economic and health impacts of zNTDs, and identify successful implementation of the One Health strategy in endemic regions. This review highlights the inadequacies of siloed disease management approaches, which often lead to inefficient resource allocation and missed opportunities for synergistic intervention. Successful case studies have demonstrated the effectiveness of the One Health strategy in improving disease surveillance, enhancing cross-sectoral collaboration, and achieving sustainable health outcomes. The potential of emerging technologies and innovations to support integrated approaches has also been explored. Transitioning from siloed to systemic approaches in zNTD management requires overcoming institutional barriers, fostering cross-sector collaboration, and implementing multitiered frameworks that operate at the local, national, and global levels. Investing in cross-sectoral capacity development and leveraging technological innovations are crucial for building a workforce capable of addressing the complex challenges posed by zNTDs. Adopting the One Health principle offers a promising path toward more comprehensive, efficient, and sustainable strategies for zNTD prevention.
Raising the flag of vigilance on Mpox outbreak in Indonesia: are we prepared? Adnyana, I Made Dwi Mertha; Maulana, Sidik; Lutfian, Lutfian; Adiwinoto, Ronald Pratama
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 2 (2024): September 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i2.63

Abstract

In the wake of the COVID-19 pandemic, the world has become acutely aware of the devastating impact of infectious diseases on public health, economies, and societies. As we gradually recover from the aftermath of COVID-19, another potential threat looms on the horizon, mpox, formerly known as monkeypox. The recent surge in mpox cases worldwide has prompted health authorities to sound an alarm, and Indonesia, as a populous nation with a complex healthcare system, must ask itself: Are we prepared for this emerging challenge?. The question "Are we prepared?" may not have a simple yes or no answer. Instead, it should serve as a reminder of the need for vigilance, adaptation, and continuous improvement in public health systems. As we navigate this new health challenge, the true measure of Indonesia's preparedness is its ability to respond swiftly, effectively, and equitably to protect the health and well-being of all citizens.
A Rare Pediatric Case of Dengue Hemorrhagic Fever with Encephalopathy and Suspected Subdural Hemorrhage Cempakasari, Aulia; Rahmawati, Tiara; Arifin, Alief Qobidh Al Bashor; Syahputri, Dewi; Hutami, Firdha Yekti; Prameswari, Renata; Nugraheni, Pramita Anindya; Adiwinoto, Ronald Pratama; Adnyana, I Made Dwi Mertha
Asian Journal of Health Research Vol. 4 No. 3 (2025): Volume 4 No 3 (December) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i3.262

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is a severe arboviral infection that rarely leads to neurological complications. Dengue encephalopathy, often secondary to metabolic disturbances or shock, presents a significant diagnostic and management challenge in the pediatric population. Case Presentation: We report the case of a 4-year-3-month-old obese girl presenting with fever, gastrointestinal symptoms, and progressively decreasing consciousness (apathetic). Diagnosis of DHF was confirmed by a positive NS1 antigen test, severe thrombocytopenia (nadir 14,000/µL), and hemoconcentration with pleural effusion. Hepatic involvement was noted (SGOT 117.81 U/L). Neurological involvement was characterized by clinical encephalopathy, and a head CT scan revealed hyperdense lesions suspecting subdural hemorrhage (SDH). The patient required multidisciplinary management in the Intensive Care Unit (ICU) for supportive fluid therapy, inotropic support (Dobutamine), and platelet transfusion. The patient showed marked clinical improvement and was discharged on day nine. At a two-week post-discharge follow-up, she demonstrated full cognitive and motor recovery with no neurological sequelae Conclusion: This case highlights the critical need for clinical vigilance for rare, simultaneous neurological complications (encephalopathy and suspected SDH) in pediatric DHF. It underscores that early diagnosis and aggressive, multidisciplinary supportive care can lead to complete recovery even in severe presentations.
Clinical Improvement in Autism Spectrum Disorder Symptoms Following Hyperbaric Oxygen as Adjuvant Therapy in a 12-Year-Old Boy Untari, Ni Komang Sri Dewi; Nugraheni, Pramita Anindya; Agustin, Renny; Oktavia, Reza Mardiana Ayu; Rantika, Rheina Hasna; Hadi, Rifqi Athaya Vinanta; Utami, Rina Mega; Adiwinoto, Ronald Pratama
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.70643

Abstract

Highlight: The potential role of hyperbaric oxygen therapy (HBO) as an adjunctive treatment for autism spectrum disorder (ASD), demonstrating significant improvements in clinical symptoms. By exploring the plausible mechanisms of HBO, the manuscript underscores the importance of further research and clinical trials to validate its efficacy and safety in the ASD population. This study adds to the literature advocating for innovative therapeutic strategies that address the complex interplay of oxidative stress, neuroinflammation, and mitochondrial dysfunction, inviting a personalized treatment approach.   ABSTRACT Introduction:  Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental condition influenced by both genetic predispositions and environmental factors. Its underlying pathophysiology commonly involves oxidative stress, impaired cerebral perfusion, neuroinflammation, immune dysregulation, and mitochondrial dysfunction. Although conventional interventions, such as applied behavior analysis (ABA), are commonly employed, they may yield limited progress for some individuals. Consequently, emerging interventions, such as hyperbaric oxygen therapy (HBO), show promise for enhancing neurological outcomes and warrant further exploration. HBO, a well-established treatment for decompression sickness, is currently being investigated for its potential benefits in various neurological disorders, including ASD. Case: We present a case of ASD in a 12-year-old boy characterized by minimal eye contact, limited expressive language, and restricted, repetitive behaviors. On neurological examination, the patient was alert and capable of spontaneous eye opening, vocalizing incomprehensible words, and, at times, responding to simple commands. Despite undergoing ABA therapy, the patient exhibited limited developmental progress. The patient was subsequently undergoing hyperbaric oxygen therapy (HBO) at 1.3 ATA for 60 minutes for 10 days. Following the completion of HBO therapy, there was a decline in the CARS score from 41.5 (severe) to 29 (mild), the ATEC score from 115 to 68, the platelet count (51,000 / μL), and interleukin-1β levels (181.4 pg/mL). Conclusion: This case highlights the potential of HBO therapy as an adjunctive treatment modality for ASD, offering significant symptomatic improvements in a patient for whom traditional therapies were insufficient. The presumed mechanisms underlying these effects include anti-inflammatory effects and enhanced cerebral oxygen delivery, which may facilitate neuronal recovery and function. Given these findings, further research and clinical trials are warranted to confirm the therapeutic efficacy, long-term benefits, and safety profile of HBO therapy.
Co-Authors Abdul Azis, Bima ADAM, OLIVIA MAHARDANI Adisyahputra, Vega Adnyana , I Made Dwi Mertha Agung Dwi Wahyu Widodo Agung Pranoto Agustin, Renny Al Hasan, Hafidz Ramadhan Alpha Fardah Athiyyah Amin, M. Shadiqul Angelica Kresnamurti Ariewibawa, Fariz Atiqi Arifin, Alief Qobidh Al Bashor Artha Budi Susila Duarsa Astrid Kusuma Avelline, Kendraadine Dheayu Baita, Etina Noor Biutifasari, Verna Brilliandinda Ichsasqia Sidqi Auliayahya Brilliant , Fahridho Ramadhana Cahya Yudha Laksmana Putra Cempakasari, Aulia da Cruz , Zito Viegas Devanda, Kasilda Pasha Dewi, I Gusti Ayu Ajeng Widia Kencana Dewindra Candra Puspita, Amalia Diah Utami, Prawesty Diana, Adawiyah Putri Diarnasa Zihara Safira, Lavenda Dinda Umardy, Fairuziah Distyvanya, Shakira Azzahra Dwinka Syafira Eljatin Dwitama Adiwinoto, Robert E.J.T, SIHNING Effendi, Muchiddin Andri Setyo Eka Fitriani Hafel Erina Yatmasari Ersanda Nurma Fathir Fadhilah, Yahdiyan Febri Endra Budi Setyawan Florentina Sustini Graciela, Anne Maria Hadi, Janto Poernomo Hadi, Rifqi Athaya Vinanta Hamdy, Irza Hasanal Hardiono Hardiono, Hardiono Hardjono, Ellen Angelique Haris, Ivana Angelica Hayati, Khofifah Bela Rachmanu Helda Dwiana Sari HENDRATA ERRY ANDISARI2 Herdiyantini, Mita Heru Nurdianto Hibatullah, Faiz Nur Hidajat, Boerhan Hutami, Firdha Yekti Izzah Al Nabilah Jongky Hendro Prajitno Kalada, Elisabeth Chelsea Uma Ketut Edy Sudiarta Kharizmatika Kurnia Cahya, Sekar Larassanti, Levina Lauwis, Keziah Queency Liliawanti Liza Yudistira Yusan Lutfian, Lutfian Made Ayu Mira Cyntia Dewi Made Peni Juliana Maliku Nurrochman Widandi Manata Wijaya Sasmita Martono, Alicia Stevina Maulana Muchammad Aunun Najib Maulana, Sidik Maylisca Theresia Mulya Diprasta, Made Medina, Nadra Odifa Meiriyanti Dhita Mentari Nata Kusuma Michael Bramantya Michelle Madeline Maydavania Miranda, Stefani MOCHAMAD ALVIRIO NEDYA RIZKA Muhammad Kalaznykov MUHAMMAD RIZAL Nadya Aisyah Sasqia Putri Nahdah, Jaudah NANDA ABIGAIL Nelya Rindayu, Dinnara Ni Luh Gede Sudaryati Norholila Nugraheni, Pramita Anindya Oki Nugraha Putra Oktavia, Reza Mardiana Ayu Peppy Nawangsasi Peter Gunawan Tandean Pikir, Rizqi Rokhmadhoni Poerwanto, Eka Pramita Anindya Nugraheni Pramudita Riwanti Prasasti, Vincentia Prasetya, Hanung Prasetyadi , Frans O.H. Prima Arundani Purmata, Andrew Theo William Chris Putra, Fabianus Yvan Marino Cahaya Putra, Oki Nugraha Putri, Fernita Naomi Putri, Ida Ayu Govinda Lazenobia De Sanjaya Putri, Jeanaya Hedya Alfara Putri, Jenniefer Clarissa Raharja, Febrila Tarisa Rahmadita, Annisa Putri Rahmawati, Tiara Rantika, Rheina Hasna Rasyida, Annisa Ullya Raza, Syed Meesam Renata Prameswari Retno Budiarti Retno Budiarti Riami Ristanti, Safira Roanna Gabrielle, Vania Robert Dwitama Adiwinoto Rokhmadhoni Pikir, Rizqi Rr. MUTIARA DEVANIA SAMARA QALBA Rusli, Christina S. Soedarsono Sadya Wendra SAES, JOVITASARI ELVIANA PUTRI Safira, Vita Sandy, Emy Noviana Santoso, Clara Cindy Ateng Saptono Putro Setyawan, Yuswanto Sianipar, Habel Ryan Annerico Soedarsono Soedarsono Soelistijo, Soebagijo Adi Sri Umijati STEFANUS DJONI HUSODO Sudiarta, Ketut Edy Sulistiawati Sulistiawati Sulistiawati Sulistiawati Sulistio, Timothy Sunur, Vincentius William Syahputri, Dewi Sylvia Rizki Tamam Jauhar Tasalina Yohana Parameswari Gustam Titong Sugihartono Ubaid, Angling Febriani Ariqoh Ulwani, Qulistan Balqis UNTARI, NI KOMANG SRI DEWI Usman Hadi Utami , Prawesty Diah Utami, Rina Mega Vivien Earlyanti, Callista Wahyu Prasasti Mutiadesi Wahyu Prasasti Mutiadesi Widati Fatmaningrum Widjajanto , Hendra Wijaya, Jennifer Wijaya, Rike Andy Wijayaningrum, Lena Zeeva, Evane Jovanie Zenjaya, Kellyn Trycia Zunnahri, Salsabila Qurrotul Aini