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Molecular docking of triterpene glycoside compounds (cucurbitane, charantin and momordicin) in bitter gourd (Momordica charantia L.) fruit as anti-diabetes mellitus type 2 Cristiannanda, Daniel; Hati, Dinda Mutiara; Hafid, Gina Mutia; Anggini, Joya Talitha; Setiawati, Luh Gede Elen; Putri, Mutiara; Chandra, Nabella Oktaviana; Auli, Winni Nur Auli; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 2 No. 3 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.68

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin secretion, insulin resistance, or both. Type 2 diabetes mellitus (T2DM) accounts for approximately 90% of all diabetes cases and remains a significant global health challenge. Current pharmacological treatments often have limited efficacy and adverse side effects, necessitating the exploration of safer, more effective antidiabetic agents. Momordica charantia (bitter melon) is a medicinal plant known for its hypoglycemic properties, attributed to bioactive compounds such as cucurbitane-type triterpenoid glycosides, charantin, and momordicin. This study evaluated the potential of cucurbitane, charantin, and momordicin as antidiabetic agents for T2DM using molecular docking simulations. The crystal structure of aldose reductase (PDB ID 2HV5) was obtained from the Protein Data Bank, and AutoDock Tools 1.5.7 was used for docking studies. The binding affinities and interaction patterns of the test compounds were compared with zopolrestat, a standard ligand. Cucurbitane exhibited the lowest binding free energy (-11.70 kcal/mol), indicating the strongest interaction with the 2HV5 protein. All compounds demonstrated similarities in their interactions with key amino acid residues, suggesting comparable biological activity. These findings highlight cucurbitane’s potential as a lead compound for developing more effective antidiabetic therapies for T2DM.
Molecular docking of alkaloid compounds from the pule pandak plant (Rauvolfia serpentina L.) as inhibitors of angiotensin-converting enzyme Rahma, Annisa Nur; Aghalfi, Revin Rindra Aghalfi; Panggabean, Diva Selviana; Muflihah, Hanny; Gusman, Adisti Faradilla; Aulia, Yasinta Sahma; Regita, Putu Ayu; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 2 No. 3 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.69

Abstract

Hypertension is a major global health issue requiring effective treatments with minimal side effects. The angiotensin-converting enzyme (ACE) is a key target in hypertension therapy, and plant-derived compounds are being explored as potential ACE inhibitors. The pule pandak plant (Rauvolfia serpentina L.) contains alkaloid compounds that may have antihypertensive properties. This study aimed to evaluate the potential of alkaloid compounds (ajmaline, rescinnamine, reserpine, and serpentine) from the pule pandak plant as antihypertensive agents using an in silico molecular docking approach. Molecular docking was conducted to analyze the binding affinity of the alkaloid compounds to the ACE protein (PDB ID: 1UZF). Binding free energy values were calculated using AutoDockTools software. The ajmaline-1UZF complex exhibited the lowest binding free energy (-5.89 kcal/mol), indicating the strongest binding affinity among the tested compounds. This suggests that ajmaline has the highest inhibitory potential for ACE.
Molecular docking analysis of acetogenin and procyanidin, components of soursop (Annona muricata Linn.) seed, as potential anti-cervical cancer agents Pravita, Nabila Cahya; Fazilla, Rizki Fakhri; Febrian, Tobi; Mellina, Echa Dian; Kumara, Gusti Made Bagus; Nugraha, Muhammad Aditya; Vernanda, Pramyudha; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 2 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.71

Abstract

Cervical cancer is one of the most prevalent cancers among women. This study aimed to investigate the molecular interactions of acetogenin and procyanidin, compounds found in soursop (Annona muricata Linn.) seed extract, as potential anti-cervical cancer agents using a molecular docking approach. The software tools used included Biovia Discovery Studio® 2024, Autodock Tools 1.5.6, Avogadro, pkCSM, PubChem, Notepad++, and Molview. Molecular docking analysis focused on the interaction of these compounds with the human vaccinia-related kinase 2 (VRK-2) protein (PDB ID: 5UU1). The native ligand-5UU1 protein complex exhibited two hydrogen bonds, a binding free energy of -8.84 kcal/mol, and an inhibition constant of 331.88 nM. In comparison, acetogenin formed three hydrogen bonds with 5UU1, achieving a binding free energy of -7.33 kcal/mol and an inhibition constant of 4.21 nM. Similarly, procyanidin also formed three hydrogen bonds, with a binding free energy of -2.99 kcal/mol and an inhibition constant of 6.38 nM. The results indicate that both acetogenin and procyanidin have potential as anti-cervical cancer agents, with acetogenin demonstrating stronger binding affinity and inhibition potential compared to procyanidin.
Exploring the anti-diabetic potential of stevia-derived compounds through PPAR-γ targeted molecular docking Putri, Amalia Sonita; Prawicha, Ertika Agtha; Putri, Esterike Alfatien; Wulandari, Indah; Saputri, Mutiara Anggun; Syakilla, Nadia Nur; Hidayati, Putri Aulia Nurul; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 2 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.78

Abstract

This study explores the potential of Stevia rebaudiana Bertoni-derived compounds as anti-diabetic agents by targeting the peroxisome proliferator-activated receptor gamma (PPAR-γ), a key regulator of glucose metabolism. Utilizing in silico molecular docking, we evaluated the binding affinities of four stevia-derived compounds (dulcoside A, steviol, isosteviol, steviolmonoside) and compared them to the native ligand (J35) and the well-known PPAR-γ agonist, rosiglitazone. Isosteviol exhibited the strongest binding affinity to PPAR-γ, with a binding energy of -8.89 kcal/mol, surpassing that of rosiglitazone (-8.26 kcal/mol) and closely following the native ligand (-9.01 kcal/mol). The interactions between isosteviol and PPAR-γ included multiple hydrogen bonds and hydrophobic interactions. These findings indicate that isosteviol, along with other stevia-derived compounds, has a potential as a natural anti-diabetic agent.
PELATIHAN INOVASI OLAHAN COKLAT MENJADI SELAI DAN MASKER COKLAT UNTUK MASYARAKAT DESA TARAHAN Nabila, Novrilia Atika; Tantri Liris Nareswari; Auli, Winni Nur; Rahayyu, Annisa Maulidia; Rooswita, Putri Amelia; Hidayaturahmah, Rizky
JURNAL ABDIMAS DOSMA (JAD) Vol. 3 No. 2 (2024): JUNI
Publisher : IKATAN ALUMNI DOSEN MAGANG KEMENRISTEKDIKTI TAHUN ANGKATAN 2017

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70522/jad.v3i2.22

Abstract

South Lampung Regency is the second largest cocoa bean producer in Lampung Province. This natural resource is very abundant, one of which is in Tarahan Village, South Lampung, but until now it has not been optimally processed and is only sold in the form of dry brown beans which have low selling value. This is because the villagers does not know how to process cocoa beans into cocoa products. Therefore, this service program aims to assist the target community in processing cocoa beans into ready-to-sell products (jam and mask) to improve people welfare. This activity consisted of providing material and training in making jam and chocolate masks for 1 day. After the training, the villagers were able to understand and practice making the chocolate jam and mask. This program is expected to increase chocholate selling value as local regional commodities.
Penerapan Edible Film dari Singkong Sebagai Kemasan Primer Ramah Lingkungan pada Produk UMKM Kopi 49 Syahrizal Nasution; Grace Sihombing; Winni Nur Auli; Harmiansyah Harmiansyah; Lita Lianti
KREATIF: Jurnal Pengabdian Masyarakat Sains dan Teknologi Vol 1 No 2 (2023): KREATIF
Publisher : Fakultas Teknik, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/kreatif.v1i2.10223

Abstract

Penggunaan kemasan plastik masih menjadi permasalahan limbah di Indonesia. Plastik memiliki kelemahan sulit terurai sehingga tidak ramah lingkungan dan dapat mencemari lingkungan. Pemanfaatan edible film merupakan salah satu solusi yang dapat mengatasi masalah tersebut, yaitu kemasan yang dapat terurai dan dapat dimakan. Edible film dapat dibuat dari bahan utama pati singkong mengingat kandungan pati dalam singkong. Pengabdian ini bertujuan untuk menerapkan edible film dari pati singkong sebagai kemasan pada kopi instan yang dijual oleh UMKM Kopi 49. Pengabdian dimulai dari tahap perencanaan untuk mendiskusikan kriteria kemasan yang diharapkan, formulasi edible film, pelatihan pembuatan edible film dan proses pengemasannya untuk produk kopi, serta evaluasi. Pada pelatihan diberikan materi mengenai edible film mulai dari definisi, fungsi dan manfaat serta demo praktik cara pembuatan edible film bersama mitra pengabdian UMKM Kopi 49. Pelatihan telah dapat meningkatkan pemahaman mitra untuk membuat edible film dan pemanfaatannya sebagai kemasan kopi. Hasil evaluasi kuesioner kegiatan pengabdian yang dilaksanakan tepat sasaran, sesuai kebutuhan, dan merupakan solusi dari masalah di masyarakat khususnya UMKM Kopi 49.
Studi In Silico Potensi Antikanker Leukemia Limfositik Senyawa Alkaloid Indol terhadap Protein BCL-2: Study of In Silico Anticancer Action Potentials of Lymphocytic Leukemia Indole Alkaloid Compounds Against on BCL-2 Protein Bulan Rosita Sari; Winni Nur Auli; Vita Julia Saputri; Okta Dinata Saputri; Alika Putriyana Boru Tumanggor; Dhea Anggun Ferlinda; Fira Anggraini; Fatonah Fatonah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1880

Abstract

BCL-2 is an anti-apoptotic protein that can inhibit cell death, prolong cell survival time, and turn cells into malignant ones, which is one of the pathways targeted in the development of leukemia therapy by binding and inactivating the BH3 domain pro-apoptotic protein. Indole alkaloids have pharmacological activities and contribute to the development of new drug leads. This study aims to analyze the potential of insilico alkaloids against Bcl-2 in silico. The docking process initiated from preparing the ligand taken from the Pubchem website. The three-dimensional macromolecular structure of the protein used was BCL-2 retrieved from the RCSB Protein Data Bank (www.rcsb.org) with PDB ID number 6O0K. The validation and docking process was carried out using the AutodockTools software program from MGLTools 1.5.6. Chemical bond interaction analysis was carried out using BIOVIA Discovery Studio 2021 Client. The binding energy results from validating the native ligand venetoclax as existing drug is -14.46 kcal/mol. The results obtained from the three ligands, namely aspidodasycarpine, tetrahydroalstonine, and kopsamine have binding energies of -6.76, -7.92, -7.57 kcal/mol respectively. When compared with tetrahydroalstonine which has the smallest value among the three other ligands, it can be concluded that venetoclax is still smaller so that it becomes more potent than tetrahydroalstonine. Keywords:          Indole alkaloids, Cancer, Bcl-2, Docking   Abstrak BCL-2 adalah protein anti-apoptosis yang dapat menghambat kematian sel, memperpanjang waktu hidup sel, dan mengubah sel menjadi ganas, yang merupakan salah satu jalur yang ditargetkan dalam perkembangan terapi penyakit leukemia dengan mengikat serta menonaktifkan protein pro-apoptosis domain BH3. Alkaloid indol memiliki aktivitas farmakologi dan berkontribusi untuk pengembangan lead obat baru, dimana salah satu senyawa yang paling aktif memiliki berbagai aktivitas farmakologi, yaitu antikanker. Penelitian ini bertujuan untuk menganalisis potensi alkaloid indol terhadap Bcl-2 in silico. Proses docking dimulai dari penyiapan ligan yang diambil dari situs web Pubchem. Struktur makromolekul tiga dimensi protein yang digunakan dalam studi docking ini adalah BCL-2 yang diunduh dari RCSB Protein Data Bank (www.rcsb.org) dengan nomor ID PDB 6O0K. Proses validasi dan docking dilakukan menggunakan perangkat lunak program AutodockTools dari MGLTools 1.5.6. Analisis interaksi ikatan kimia dilakukan menggunakan BIOVIA Discovery Studio 2021 Client. Hasil energi ikatan dari validasi ligan bawaan venetoclax sebagai obat yang telah dikembangkan yaitu -14.46 kkal/mol. Diperoleh hasil dari analisis data energi ikatan dari tiga ligan, yaitu aspidodasycarpine, tetrahydroalstonine, dan kopsamine berurutan sebesar -6,76, -7,92, -7,57 kkal/mol. Apabila dibandingkan dengan tetrahydroalstonine yang memiliki nilai paling kecil diantara ketiga ligan lain maka dapat disimpulkan bahwa venetoclax masih lebih kecil sehingga menjadi lebih poten dibandingkan dengan tetrahydroalstonine. Kata Kunci:         Alkaloid indol, Kanker, BCL-2, Docking
Molecular Docking Analysis of Zerumbone Derivatives as XIAP-BIR3 Inhibitor for Anticancer Agent Winni Nur Auli; Nisa Yulianti Suprahman; Riri Fauziyya; Sarmoko; Arif Ashari; Safia Fazila; Qurrota A`yun Azzahrah; Romualdo Pasaribu; Putri Liswatini; Ihza Adzkiya Mubarak Al-Husni; Dinda Naila Dhiya Salsabila
Nusantara Science and Technology Proceedings Multi-Conference Proceeding Series F
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4602

Abstract

Cancer is the second most common cause of death worldwide. Common therapies used to treat cancer include radiation, chemotherapy, and surgery. However, resistance to treatment often gives a challenging problem, and new alternative therapies derived from natural compounds are needed. Zerumbone is terpenoid compound with various biological activities, including anti-tumor and anti-cancer. This study aims to investigate the activity of Zerumbone and its derivatives against the XIAP-BIR3 protein. The target protein used PDB ID: 4KMP as inhibitor of XIAP-BIR3. There are 21 zerumbon derivatives retrieved from published article. Docking of zerumbone derivatives was performed using Autodock 1.5.6. Molecular docking result showed derivative 6 of Zerumbone has potential as an anti-cancer agent with a binding energy of -7.84 kcal/mol; meanwhile, the reference inhibitor has a binding energy of -5.21 kcal/mol. These results of the study indicate that the development of inhibitor XIAP-BIR3 may be a potential strategy in cancer treatment and zerumbone derivatives are predicted to be potential candidates that can be analyzed further.
In silico analysis of quercetin and its derivatives as potential TRPC6-targeted treatments for diabetic neuropathy Pangestu, Maryo Adjie; Auli, Winni Nur; Saputro, Anjar Hermadi; Pasaribu, Romualdo; Maharani, Gita Putri; Yunita, Nadia Rahma; Choiriah, Ika Putri; Ainun, Hadhistia Nur; Erniningsih, Ni Ketut; Andini, Citra
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.12119

Abstract

Background: Diabetic neuropathy is a condition that arises as a complication of diabetes mellitus and often causes pain in patient. Quercetin and its derivatives have antinociceptive activity, making them potential agents for relieving the pain associated with diabetic neuropathy. Objective: This study aims to analyze the interactions between quercetin and its eight derivatives with canonical transient receptor potential channels 6 (TRPC6) as protein target. Method: The TRPC6 structure (PDB ID: 6UZ8) was prepared and validated with redocked to native ligand R0D using Autodock 4.2.6, with the established grid box and grid center settings. The test compounds were then optimized and docked using the same grid box and grid center settings as in the validation process, followed by visualization and analysis of the docking results. Results: The compound with the best affinity for TRPC6 was tamarixetin, with a binding energy value of -3.27 kcal/mol, close to the binding energy value of the native ligand, which was -4.22 kcal/mol. The amino acid residues interacting with tamarixetin at the active site were 702-Asn, 705-Tyr, 706-Val, and 709-Gly. This indicates that tamarixetin and the native ligand bind to the same active site amino acids, resulting in a similar affinity to the native ligand in inhibiting TRPC6. Conclusion: A total of eight quercetin derivatives were predicted to have TRPC6 antagonistic activity against diabetic neuropathy, with tamarixetin exhibiting the highest affinity compared to the other quercetin derivatives.
Analysis of Lead (Pb) Contamination in Lipstick and Eye Shadow Powder in the King Street Market in Bandar Lampung Using UV-Visible Spectrophotometer Method Alya Pinahayu Sakanthi; Syaikhul Aziz; Salsa Nabila Ahlika Ulya; Auli, Winni
Indonesian Journal of Chemical Science Vol. 13 No. 3 (2024): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v13i3.11465

Abstract

  Lipsticks and eye shadows are cosmetics frequently used by women every day. Some cosmetic products contain heavy metals like lead. This study aims to validate the UV-Visible Spectrophotometer method for analyzing lead in cosmetics and determine the lead content in lipsticks and eye shadows. Sample preparation was conducted using closed wet digestion with reflux. The samples consisted of 5 lipsticks and eye shadows from the King Street Market in Bandar Lampung. Lead content was determined using a UV-Visible spectrophotometer after method validation. Validation parameters included selectivity, linearity (correlation coefficient = 0.998), accuracy (% recovery = 99-100%), precision (%RSD = < 2% for all experiments), detection limit 0.044 µg/mL, and quantitation limit 0.148 µg/mL, all of which met validity criteria. Lead levels in lipsticks ranged from ±6,000 to 11,000 µg/gram, while in eye shadows, they ranged from ±5,000 to 10,000 µg/gram. The results indicate that lead levels in lipsticks and eye shadows exceed the BPOM RI limit of 20 µg/gram.
Co-Authors Adilla, Annisa Rahma Afada, M. Mufti Afrian, Mahisa Shzara Aghalfi, Revin Rindra Aghalfi Agustin, Desti Agustin, Lanita Ahmad, Winda Tiara Ainiya, Aliva Ainun, Hadhistia Nur Al Iman, Arif Al-Husni, Ihza Adzkiya Mubarak Alhestha, Salsabila Zahra Alika Putriyana Boru Tumanggor Alsadila, Kalista Alya Pinahayu Sakanthi Amalia, Miranti Andriani, Wellen Putri Anggini, Joya Talitha Anggraeni, Fibria Anggraeni, Inggrid Anisah, Nadya Anjar Hermadi Saputro Arif Al Iman arif ashari Arif Ashari Arrafi, Muhammad Zhafran Aulia, Yasinta Sahma Azizah, Nadya Nur Azti, Zahara Azzahra, Zeta Agustri Azzahrah, Qurrota A’yun Balqis, Selvi Bokshow, Rency Violita Vanden Bulan Rosita Sari Cahyani, Ayu Sukma Cahyani, Nabila Chandra, Nabella Oktaviana Choiriah, Ika Putri Christine Natalia Citra Andini Cristiannanda, Daniel Damayanti Abdul Karim, Dewi Derina Paramitasari Dewi, Intan Azkya Dhea Anggun Ferlinda Dhiya, Syifa Nasywa Dina Putri Agustina Dinda Naila Dhiya Salsabila Dirga Dirga Dwi Wijayanti Dzaki Arrafif Erniningsih, Ni Ketut Evanggeulista, Arnanda Fadhila, Safira Cahya Fadhilla Asara Fadillah, Muhammad Zakki Fahmi, Achmad Gus Fajar Fauzi, Muh Fajriani, Rahmatul Fatonah Fatonah Fauziyya, Riri Fazila, Safia Fazilla, Rizki Fakhri Febrian, Tobi Febriyanti, Kharisma Fida, Marsa Jannatul Fira Anggraini Firmansyah, Arya Kurnia Fransisca, Ni Putu Vina Gabriela Kasih Mawarni Gacatorina, Alfiraza Geralda, Rifka Grace Sihombing Gusman, Adisti Faradilla Hafid, Gina Mutia Handayani, Kiki Yuli Hanifa, Milla Harmiansyah Hasanah, Siti Fadhilatul Hati, Dinda Mutiara Hidayati, Putri Aulia Nurul Hidayaturahmah, Rizky Hutabarat, Stefanny Herlin Natalya Ihza Adzkiya Mubarak Al-Husni Ilham Marvie Ilma Nugrahani Indah Puspita Sari Indah Wulandari intan kusuma wardani Isna Mulyani Jannah, Aryn Fatkhul Kaerani Tri Lestari Kamilaini, Diva Arisanti Karima, Miska Aulia Kartika Sari Ramadhani, Untia Keisya Aurora Natasha Chairunisa Kiki Yuli Handayani Koeswara, Thobias Tantra Kumara, Gusti Made Bagus Kusumawati, Maiya Lianti, Lita Liswatini, Putri Lita Lianti Lulu Zaqia Maharani, Ayu Puspita Maharani, Gita Putri Mariska, Putri Mariska, Soraya Maulidia Rahayyu, Annisa Melki, Yana Putri Amelia Mellina, Echa Dian Mendrofa, Alexander Yoel Harazachi Muflihah, Hanny Muhammad Aditya Nugraha Muhammad Rizky Ramanda Mumtaz, Fakhira Chairunnisa Musa Musa Mutia Adfi Pratiwi Mutiara Putri, Mutiara Nabila Ahlika Ulya Nabila, Novrilia Atika Nadapdap, Ezra Gabriella Oktaviany Nadia Nur Syakilla Nadya Miranda Atiek Nainggolan, Yolanda Petra Napitu, Ade Shinta Maria Br Natalia, Dela Natasya Armelia Putri Natasya, Zaskiya Naura Nurnahari Nisa Yulianti Suprahman Novelina, Laras Nurnahari, Naura Okta Dinata Saputri Okta Nama Putra Pane, Esteria Christina Pangestu, Maryo Adjie Panggabean, Diva Selviana Pasaribu, Romualdo Pramudya, Siti Alifia Prasetyoningrum, Pinasti Pravita, Nabila Cahya Prawicha, Ertika Agtha Primasty, Ratna Dewi Putri Liswatini Putri, Adelia Ofira Putri, Amalia Sonita Putri, Esterike Alfatien Putri, Gladys Ellnora Putri, Tikarahayu Qurrota A`yun Azzahrah Raden Mohamad Herdian Bhakti Rahayyu, Annisa Maulidia Rahma, Annisa Nur Rahma, Sophia Rahmadi, Isnaini Rahmadi, Muhammad Zaki Ammar Rahmadini, Celina Fadila Rajwa, Raihan M Dhiya Refsya Azanti Putri Regita, Putu Ayu Riana, Elisa Nurma Riani, Nadia Nanda Riri Fauziyya Rislia, Rana Atikah Rizkyka, Fitria Romualdo Pasaribu Rooswita, Putri Amelia Rosviena, Nyi Ayu Fayza Saabirah, Ghania Parsa Saeli, Pinka Mustika Safia Fazila Sakti, Nickyta Salsabila Ira Salsa Nabila Ahlika Ulya Salsabila Fauziah Salsabila, Fathul Aini Saputra, Chandra Prayoga Saputri, Mutiara Anggun Sari, Desi Puspita Sari, Victoria Rekina Sarmoko Sarmoko Sarmoko Sativa, Nasywa Oryza Sekarsari Yusuf, Mubarika Setiawati, Luh Gede Elen Simorangkir, Nanda Lenny Yuniaty br Sitohang, Nada Nikita Sukrasno Sukrasno Sukrasno Suri, Faradila Azzahra Suryaneta Sutjiningsih, Ni Nyoman Ota Syah, Vicky Ardian Syahrizal Nasution Syaikhul Aziz Syakilla, Nadia Nur Tantri Liris Nareswari Tursino, Tursino Ulfa, Lutfiyana Ulisya, Azzaima Ayu Ulya, Salsa Nabila Ahlika Uswatunhasanah, Putri Utami, Amalda Vega, Amelia Vernanda, Pramyudha Vita Julia Saputri Windari, Nurul Irna Wulandari, Valentri Yulanda, Nola Rohmi Eka Yunita, Nadia Rahma Zada Agna Talitha Zada Agna Talitha Zahra, Miralda Zaqia, Lulu