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Analisis Simultan untuk Menentukan Kadar Asam Askorbat dan Niacinamide dalam Serum Wajah Menggunakan Spektrofotometer UV-Visible dengan Pendekatan Kemometrik Suri, Faradila Azzahra; Auli, Winni Nur; Nareswari, Tantri Liris
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.9023

Abstract

Ascorbic acid and niacinamide are active brightening ingredients in facial serum skin care products. These two active substances are used together in one product. This research aims to develop a method for analyzing ascorbic acid and niacinamide simultaneously using a chemometric UV-Vis spectrophotometer. The research was carried out by testing specificity using a UV-visible spectrophotometer, and development was carried out by building a Partial Least Square (PLS) model using 20 training sets, which were cross-validated through leave-one-out cross-validation to obtain 5 test sets. Next, internal and external validation was carried out on model and method validation tests focusing on linearity, precision, limit of detection (LOD), and limit of quantification (LOQ). Tests were carried out at wavelengths of 244 and 262 nm. The model and method validation tests' internal and external validation results meet USP requirements. The method for measuring ascorbic acid and niacinamide levels using a UV-Vis chemical spectrophotometer meets the appropriate method validation parameters. The results of concentration measurements in facial serum on the market showed that the sample contained 18.97% ascorbic acid and 13.74% niacinamide. Based on these results, the analysis method for determining the levels of AA and NAC using a UV-Vis spectrophotometer chemometrically has met the validity requirements according to USP.
PENAMBATAN MOLEKUL SENYAWA AKTIF CURCUMA XANTHORRHIZA ROXB KANDIDAT ANTI KANKER KOLOREKTAL TERHADAP RESEPTOR LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE Sativa, Nasywa Oryza; Putri, Adelia Ofira; Natasya, Zaskiya; Rislia, Rana Atikah; Ulfa, Lutfiyana; Karima, Miska Aulia; Balqis, Selvi; Saputro, Anjar Hermadi; Auli, Winni Nur
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.702

Abstract

Background: Temulawak (Curcuma xanthorrhiza Roxb) contains essential oils and curcuminoid compounds which have anti-cancer activity. Temulawak (Curcuma xanthorrhiza Roxb) can increase colorectal cancer chemotherapy agents against Lck receptors on colon epithelial cells. Purpose(s): The aim of this research is to identify active compounds that have the potential to act as colorectal anticancer contained in Temulawak (Curcuma xanthorrhiza Roxb) against Lck receptors through in silico studies using molecular docking methods. Methods: This study was carried out of molecular docking using software AutoDock Tools-1.5.6., Lipinski predictions with LigandScout, and visualitation using Biovia Discovery Studio 2021 Client. Results: Xanthorrizol has hydrogen bonds with the same amino acid residues as native ligand and reference compound, namely GLU317 and MET319. The results of the molecular binding energy of the native ligand are -10.12 kcal/mol. Conclusion: Based on research results, the xanthorrizol compound has the best potential to be a colorectal anticancer candidate and qualified of Lipinski's rules so it is safe to be administered orally.
Pemberdayaan Kader PKK dan Posyandu untuk Cegah Stunting di Desa Bumisari Fauziyya, Riri; Rahayyu, Annisa Maulidia; Windari, Nurul Irna; Auli, Winni Nur; Riana, Elisa Nurma
JPEMAS: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2025): JPEMAS : Jurnal Pengabdian Kepada Masyarakat
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71456/adc.v3i2.1204

Abstract

Stunting merupakan permasalahan kesehatan serius yang berdampak jangka panjang terhadap kualitas sumber daya manusia, terutama di daerah pedesaan. Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pemahaman kader PKK dan Posyandu mengenai pencegahan stunting melalui edukasi gizi seimbang dan pengolahan makanan bergizi sederhana berbahan lokal. Metode yang digunakan adalah sosialisasi interaktif. Kegiatan ini dilaksanakan pada 18 Desember 2024 di Desa Bumisari, Kecamatan Natar, Kabupaten Lampung Selatan. Hasil kegiatan menunjukkan adanya peningkatan pemahaman peserta terkait gizi seimbang dan praktik pencegahan stunting. Para kader berkomitmen untuk menyebarkan informasi ini ke masyarakat lebih luas. Pendampingan berkelanjutan diharapkan dapat menjadikan Desa Bumisari sebagai percontohan desa bebas stunting.
Antimicrobial and Antioxidant Activities of Various Freeze-Dried Yogurt Fermented with The Addition of Pineapple: An In Vitro Study Auli, Winni Nur; Fajriani, Rahmatul; Anisah, Nadya; Lianti, Lita; Rahmadi, Isnaini; Nasution, Syahrizal
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.274

Abstract

As a fermented milk, yogurt is functional food which contains a lot of bioactive compounds beneficial for human health. Yogurt can also be made with the addition of fruit such as pineapple, where pineapple contains phytochemical compounds as antimicrobial and antioxidant. This research aims to determine the antimicrobial and antioxidant activity of freeze-dried yogurt with raw material skim milk, full cream, and soy powder with addition of pineapple juice. Antimicrobial activity was conducted using disc diffusion and macro-dilution methods. While antioxidants activity conducted using the DPPH method at a maximum wavelength of 516 nm and FTIR method. The results showed that the antimicrobial activity of freeze-dried yogurt macro-dilution method against Escherichia coli showed that most yogurt at a concentration of 1 g/mL could be determined as minimum bactericidal concentration (MBC). Antioxidant activity showed pineapple soy yogurt has the lowest IC50 namely 43.67 ± 0.21 μg/mL. Functional group analysis of samples with the highest antioxidant activity in pineapple soy yogurt showed C–H, C–C, C=O, N–H, C=C, and amide II groups. The antimicrobial and antioxidant activities of freeze-dried yogurt are influenced by the raw materials used and the addition of pineapple fruit.
Bioactive Compounds of Insulin Leaves (Smallanthus sonchifolius) as DPP4 Enzyme Inhibitors in Insulin Signaling Mechanism for the Treatment of Type 2 Diabetes Mellitus: In Silico Study Wardani, Intan Kusuma; Aulia, Winni Nur; Saputro, Anjar Hermadi; Ainiya, Aliva; Mariska, Soraya; Kamilaini, Diva Arisanti; Vega, Amelia; Maharani, Ayu Puspita; Fransisca, Ni Putu Vina
Chimica et Natura Acta Vol 13, No 1 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n1.55137

Abstract

Type 2 Diabetes Mellitus (DM) is characterized by a relative insulin deficiency caused by pancreatic cell dysfunction and insulin resistance. Herbal-based traditional medicine can be an alternative, one of which is insulin leaf (Smallanthus sonchifolius), which has antidiabetic effects and can lower blood sugar levels by inhibiting glycogenolysis and gluconeogenesis. DPP4 inhibitors are a class of antidiabetic drugs used in the treatment of type 2 DM. This study aims to analyze and predict the binding patterns of flavonoid derivatives from insulin leaf (Smallanthus sonchifolius) compounds to the DPP4 enzyme inhibitor, to determine the binding affinity of these compounds to the target protein as an antidiabetic agent. The study was conducted using an in silico method, utilizing the Research Collaboratory for Structural Bioinformatics (RCSB), Avogadro Software, AutoDockTools (version 1.5.6), and Biovia Discovery Studio 2021 for molecular docking and prediction of binding patterns and affinity for the DPP4 N7F protein. The results of this study showed that the binding energy value obtained from the natural ligand N7F was -11.0 kcal/mol. The binding energy value for 1,19-dihydroxy-2,6,10,14-phytateraen-18-oic-acid with the N7F protein was -9.8 kcal/mol. Therefore, 1,19-dihydroxy-2,6,10,14-phytateraen-18-oic-acid has a more stable binding with the DPP4 enzyme N7F target protein. Based on the results obtained from molecular docking of the flavonoid derivative compounds from insulin leaf (S. sonchifolius), the compound 1,19-dihydroxy-2,6,10,14-phytateraen-18-oic-acid  showed the most potential as a DPP4 enzyme inhibitor among the other compounds.
STUDI IN SILICO METABOLIT AKTIF GOLONGAN ALKALOID DARI Ficus fitulosa TERHADAP RESEPTOR HIV-1 RT Auli, Winni Nur; Billa, Firly Shalsha; Zusela, Titah; Aulia, Nanda; Anjani, Arfina Puteri; Sarini, Sarini; Utami, Firanti Putri; Ummi, Ummi; Utami, Widia; Saputro, Anjar Hermadi
Jurnal Sains dan Teknologi Farmasi Indonesia Vol 13, No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58327/jstfi.v13i2.245

Abstract

Human Immunodeficiency Virus (HIV) atau Acquired Immune Defisiency Syndrome (AIDS) merupakan salah satu penyakit yang sulit ditangani. Hingga kini, belum ada pengobatan dalam menangani serta mencegahnya. Ficus fistulosa diketahui memiliki metabolit aktif berupa alkaloida yang memiliki aktivitas sebagai antiviral yaitu; thyloporine, phenanthroindolizidine, antofine, secoantofine, thylocrebrine, dan septicine. Penelitian ini bertujuan untuk mengetahui potensi F. fistulosa sebagai pengobatan terbaru pada terapi HIV secara in silico. Metode yang digunakan di dalam penelitian ini yaitu molekuler docking menggunakan software Autodock, Avogadro, serta BIOVIA Discovery Studio Visualizer 2021. Berdasarkan hasil penelitian, diketahui bahwa binding energy yang diperoleh pada senyawa dari golongan alkaloida pada F. fistulosa yaitu senyawa antofine memiliki nilai ikatan sebesar -9,21 kcal/mol dan nilai ikatan ligan alami sebesar -9,91.kcal/mol antofine memiliki potensi sebagai agen anti HIV. 
Studi In Silico Potensi Antikanker Kolorektal Senyawa Zerumbone dan Derivatnya terhadap Protein P38-MAPK: Study of In Silico Anticancer Colorectal Potential of Zerumbone Compounds and Their Derivatives Against on P38-MAPK Protein Al-Husni, Ihza Adzkiya Mubarak; Napitu, Ade Shinta Maria Br; Melki, Yana Putri Amelia; Azti, Zahara; Ahmad, Winda Tiara; Primasty, Ratna Dewi; Fida, Marsa Jannatul; Saputro, Anjar Hermadi; Auli, Winni Nur
Jurnal Sains dan Kesehatan Vol. 7 No. 3 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i3.2469

Abstract

Colorectal cancer (CRC) is one of the diseases with the highest incidence rate in Indonesia and the world. Cancer treatment often uses natural compounds as an alternative treatment such as zerumbone in lempuyang rhizome. P38-Mitogen-activated protein kinase (MAPK) becomes the main target because it can regulate various cellular programs. Research was conducted to analyze the interaction of zerumbone and its derivatives against P38-MAPK proteins as potential anti-colorectal cancer. The method used was in silico using the pkCSM web, ProTox-II, Pubchem, SwissADME, and software such as Avogadro, AutoDockTools, BIOVIA Discovery Studio Visualizer. In Silico results of Dibenzosuberone compound as a natural ligand with a binding energy value of -13.05 kcal/mol, while the best test ligand is Derivat 21 with a binding energy value of -10.94 kcal/mol. Derivat 21 binds to the same active side as the natural ligand, namely: LEU104, LYS53, ALA51, ILE 84. ASP168, MET109, and ASP112. So that Derivat 21 has the potential as an anti-colorectal cancer drug that is more effective and safe compared to other compounds. Keywords:          Zerumbone, Colorectal Cancer, P38-MAPK, In silico   Abstrak Kanker kolorektal (colorectal cancer, CRC), salah satu jenis penyakit dengan tingkat kejadian tertinggi di Indonesia juga di dunia. Pengobatan kanker sering menggunakan senyawa alami sebagai pengobatan alternatif seperti zerumbone pada rimpang lempuyang. P38-Protein kinase teraktivasi mitogen (MAPK) menjadi target utama karena dapat mengatur berbagai program seluler. Penelitian dilakukan untuk menganalisis interaksi zerumbone dan derivatnya terhadap protein P38-MAPK sebagai potensi anti kanker kolorektal. Metode yang digunakan secara in silico menggunakan web pkCSM, ProTox-II, Pubchem, SwissADME, dan software seperti Avogadro, AutoDockTools, BIOVIA Discovery Studio Visualizer. Hasil In Silico senyawa Dibenzosuberone sebagai ligan alami dengan nilai binding energy -13,05 kkal/mol, Sedangkan ligan uji terbaik yaitu Derivat 21 dengan nilai binding energy -10,94 kkal/mol. Derivat 21 berikatan pada sisi aktif yang sama dengan ligan alami yaitu: LEU104, LYS53, ALA51, ILE 84. ASP168, MET109, dan ASP112. Sehingga Derivat 21 memiliki potensi sebagai obat anti kanker kolorektal yang lebih efektif dan aman dibandingkan dengan senyawa lainnya. Kata Kunci:         Zerumbone, Kanker Kolorektal, P38-MAPK, In Silico
Molecular docking of several compounds in Bauhinia thonningii as alfa estrogen receptor inhibitors in breast cancer Zaqia, Lulu; Alhestha, Salsabila Zahra; Rahmadini, Celina Fadila; Kusumawati, Maiya; Dhiya, Syifa Nasywa; Andriani, Wellen Putri; Azzahra, Zeta Agustri; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.70

Abstract

Compounds contained in Bauhinia thonningii have been proven in vitro to have anti-breast cancer effects. This research was carried out to validate in silico the compounds contained in Bauhinia thonningii. The molecular docking process begins with the ER target protein alpha (PDB id: 2BJ4) downloaded from the web http://www.rcsb.org/. After that, validation was carried out on natural ligands and target proteins using AutodockTools (Autodock 4.2 and Autogrid). Continued with optimization of the compounds to be tested, namely 6,8-Di-C-methyl kaempferol 3,7-dimethyl ether; 6-C-Methylquercetin-3,4'-dimethylether; Quercetin‑3‑O‑α‑L‑rhamnopyranoside and Tamoxifen as a positive control was downloaded at https://molview.org/ then geometrically optimized using Avogadro then docked with the target protein ER-α. Obtained bond energy results between natural ligands, 3 test compounds and 1 control compound 4-HYDROXYTAMOXIFEN; 6,8-Di-C-methyl kaempferol 3,7-dimethyl ether; 6-C-Methylquercetin-3,4'-dimethylether ;Quercetin-3–O-α-L-rhamnopyranoside and tamoxifen were -11.32,-6.07, -7.26,-8.88, -10.33 kcal/mol. If we look at the smallest bond energy, it is found that the compounds that have the greatest potential when sorted are the natural ligand, positive control, Quercetin‑3‑O‑α‑L‑rhamnopyranoside, 6-C-Methylquercetin-3,4'-dimethyl ether and 6,8-Di-C-methyl kaempferol 3,7-dimethyl ether.
Molecular docking analysis of guaiacin and chalcone from nutmeg (Myristica fragrans) as novel HSP90A inhibitors for skin cancer treatment Arrafi, Muhammad Zhafran; Cahyani, Ayu Sukma; Sitohang, Nada Nikita; Ulya, Salsa Nabila Ahlika; Anggraeni, Inggrid; Amalia, Miranti; Putri, Gladys Ellnora; Rajwa, Raihan M Dhiya; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.73

Abstract

Skin cancer represents one of the most prevalent malignancies globally, with Indonesia reporting the third highest incidence among cancer types. Despite advances in treatment, there remains a critical need for novel therapeutic agents. Heat Shock Protein 90 Alpha (HSP90A) has emerged as a promising target for cancer therapy due to its critical role in stabilizing oncogenic proteins. This study aimed to evaluate the potential of guaiacin and chalcone from nutmeg (Myristica fragrans) as HSP90A inhibitors for skin cancer treatment through computational analysis. Molecular docking was performed using AutoDock Tools with the HSP90A crystal structure (PDB ID: 2VCJ). The compounds were assessed for binding affinity, molecular interactions, and drug-likeness properties according to Lipinski's Rule of Five. Redocking validation yielded an RMSD of 1.24 Å, confirming protocol reliability. Guaiacin demonstrated promising binding affinity (-7.40 kcal/mol) with key hydrogen bonds to Asp93 and Lys58, while chalcone showed moderate affinity (-5.99 kcal/mol) with a single hydrogen bond to Thr184. Both compounds exhibited favorable drug-like properties with high predicted gastrointestinal absorption. Guaiacin emerges as a promising natural HSP90A inhibitor candidate with binding energy exceeding the stability threshold (-7.00 kcal/mol) and interactions with critical residues in the ATP-binding pocket, providing a foundation for further development of nutmeg-derived compounds as potential anticancer agents.
Molecular docking of capsaicin and its derivatives as acetylcholinesterase (AChE) inhibitors in Alzheimer disease Syah, Vicky Ardian; Geralda, Rifka; Sakti, Nickyta Salsabila Ira; Febriyanti, Kharisma; Bokshow, Rency Violita Vanden; Wulandari, Valentri; Hasanah, Siti Fadhilatul; Fadillah, Muhammad Zakki; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.74

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder predominantly affecting older adults, characterized by pathological processes that include excessive acetylcholinesterase (AChE) activity leading to depleted acetylcholine levels. Although synthetic AChE inhibitors such as donepezil are used therapeutically, their clinical application is often limited by adverse effects and high costs. Capsaicin, a bioactive compound derived from chili peppers, has exhibited neuroprotective properties—including cognitive enhancement and amyloid-β reduction—suggesting its potential as a natural alternative for AD treatment. This study investigated capsaicin and six structural derivatives as potential AChE inhibitors through in silico molecular docking simulations against the human AChE crystal structure (PDB: 4EY7), using donepezil as a reference ligand. The docking protocol was validated with a root-mean-square deviation (RMSD) value of 0.71 Å, confirming reproducibility and reliability. The calculated binding affinities of the evaluated compounds ranged from –6.13 to –11.60 kcal/mol. Among them, 2-Hydroxy-3-(octyloxy)phenyl-5-(acrylamido)methylbenzophenone (Compound 2) exhibited the strongest binding affinity (–11.60 kcal/mol), slightly exceeding that of donepezil (–11.45 kcal/mol). Compound 2 formed four hydrogen bonds within the active site and shared key interactions with residues Phe338 and Trp286, consistent with the binding mode of donepezil. These results suggest that Compound 2 may serve as a potent natural AChE inhibitor and warrant further investigation as a candidate for Alzheimer’s disease therapy.
Co-Authors Adilla, Annisa Rahma Afada, M. Mufti Afrian, Mahisa Shzara Aghalfi, Revin Rindra Aghalfi Agustin, Desti Agustin, Lanita Ahmad, Winda Tiara Ainiya, Aliva Ainun, Hadhistia Nur Al Iman, Arif Al-Husni, Ihza Adzkiya Mubarak Alhestha, Salsabila Zahra Alika Putriyana Boru Tumanggor Alsadila, Kalista Alya Pinahayu Sakanthi Amalia, Miranti Andriani, Wellen Putri Anggini, Joya Talitha Anggraeni, Fibria Anggraeni, Inggrid Anisah, Nadya Anjani, Arfina Puteri Anjar Hermadi Saputro Arif Al Iman arif ashari Arif Ashari Arrafi, Muhammad Zhafran Aulia, Nanda Aulia, Yasinta Sahma Azizah, Nadya Nur Azti, Zahara Azzahra, Zeta Agustri Azzahrah, Qurrota A’yun Balqis, Selvi Billa, Firly Shalsha Bokshow, Rency Violita Vanden Bulan Rosita Sari Cahyani, Ayu Sukma Cahyani, Nabila Chandra, Nabella Oktaviana Choiriah, Ika Putri Christine Natalia Citra Andini Cristiannanda, Daniel Damayanti Abdul Karim, Dewi Derina Paramitasari Dewi, Intan Azkya Dhea Anggun Ferlinda Dhiya, Syifa Nasywa Dina Putri Agustina Dinda Naila Dhiya Salsabila Dirga Dirga Dwi Wijayanti Dzaki Arrafif Erniningsih, Ni Ketut Evanggeulista, Arnanda Fadhila, Safira Cahya Fadhilla Asara Fadillah, Muhammad Zakki Fahmi, Achmad Gus Fajar Fauzi, Muh Fajriani, Rahmatul Fatonah Fatonah Fauziyya, Riri Fazila, Safia Fazilla, Rizki Fakhri Febrian, Tobi Febriyanti, Kharisma Fida, Marsa Jannatul Fira Anggraini Firgianti, Sinta Rani Firmansyah, Arya Kurnia Fransisca, Ni Putu Vina Gabriela Kasih Mawarni Gacatorina, Alfiraza Geralda, Rifka Grace Sihombing Gusman, Adisti Faradilla Hafid, Gina Mutia Handayani, Kiki Yuli Hanifa, Milla Harmiansyah Hasanah, Siti Fadhilatul Hasnaussalim, Hamidah Hati, Dinda Mutiara Hidayati, Putri Aulia Nurul Hidayaturahmah, Rizky Hutabarat, Stefanny Herlin Natalya Ihza Adzkiya Mubarak Al-Husni Ilham Marvie Ilma Nugrahani Indah Puspita Sari Indah Wulandari intan kusuma wardani Isna Mulyani Jannah, Aryn Fatkhul Kaerani Tri Lestari Kamilaini, Diva Arisanti Karima, Miska Aulia Kartika Sari Ramadhani, Untia Keisya Aurora Natasha Chairunisa Kiki Yuli Handayani Koeswara, Thobias Tantra Kumara, Gusti Made Bagus Kusumawati, Maiya Lianti, Lita Liswatini, Putri Lita Lianti Lulu Zaqia Maharani, Ayu Puspita Maharani, Gita Putri Mariska, Putri Mariska, Soraya Maulidia Rahayyu, Annisa Melki, Yana Putri Amelia Mellina, Echa Dian Mendrofa, Alexander Yoel Harazachi Muflihah, Hanny Muhammad Aditya Nugraha Muhammad Rizky Ramanda Mumtaz, Fakhira Chairunnisa Musa Musa Mutia Adfi Pratiwi Mutiara Putri, Mutiara Nabila Ahlika Ulya Nabila, Novrilia Atika Nadapdap, Ezra Gabriella Oktaviany Nadia Nur Syakilla Nadya Miranda Atiek Nainggolan, Yolanda Petra Napitu, Ade Shinta Maria Br Natalia, Dela Natasya Armelia Putri Natasya, Zaskiya Naura Nurnahari Nisa Yulianti Suprahman Novelina, Laras Nurnahari, Naura Okta Dinata Saputri Okta Nama Putra Pane, Esteria Christina Pangestu, Maryo Adjie Panggabean, Diva Selviana Pasaribu, Romualdo Pramudya, Siti Alifia Prasetyoningrum, Pinasti Pravita, Nabila Cahya Prawicha, Ertika Agtha Primasty, Ratna Dewi Putri Liswatini Putri, Adelia Ofira Putri, Amalia Sonita Putri, Esterike Alfatien Putri, Gladys Ellnora Putri, Tikarahayu Qurrota A`yun Azzahrah Raden Mohamad Herdian Bhakti Rahayyu, Annisa Maulidia Rahma, Annisa Nur Rahma, Sophia Rahmadi, Isnaini Rahmadi, Muhammad Zaki Ammar Rahmadini, Celina Fadila Rajwa, Raihan M Dhiya Ramadhani, Syanindita Lulu Refsya Azanti Putri Regita, Putu Ayu Riana, Elisa Nurma Riani, Nadia Nanda Riri Fauziyya Rislia, Rana Atikah Rizkyka, Fitria Romualdo Pasaribu Rooswita, Putri Amelia Rosviena, Nyi Ayu Fayza Saabirah, Ghania Parsa Saeli, Pinka Mustika Safia Fazila Sakti, Nickyta Salsabila Ira Salsa Nabila Ahlika Ulya Salsabila Fauziah Salsabila, Fathul Aini Saputra, Chandra Prayoga Saputri, Mutiara Anggun Saputri, Syabina Sofa Sari, Desi Puspita Sari, Victoria Rekina Sarini, Sarini Sarmoko Sarmoko Sarmoko Sativa, Nasywa Oryza Sekarsari Yusuf, Mubarika Setiawati, Luh Gede Elen Sigalingging, Yonathan Adi Nugroho Simorangkir, Nanda Lenny Yuniaty br Sitohang, Nada Nikita Sukrasno Sukrasno Sukrasno Suri, Faradila Azzahra Suryaneta Sutjiningsih, Ni Nyoman Ota Syah, Vicky Ardian Syahrizal Nasution Syaikhul Aziz Syakilla, Nadia Nur Tantri Liris Nareswari Tursino, Tursino Ulfa, Lutfiyana Ulisya, Azzaima Ayu Ulya, Salsa Nabila Ahlika Ummi, Ummi Uswatunhasanah, Putri Utami, Amalda Utami, Firanti Putri Utami, Widia Vega, Amelia Vernanda, Pramyudha Vita Julia Saputri Windari, Nurul Irna Wulandari, Valentri Yulanda, Nola Rohmi Eka Yuliana , Rita Yunita, Nadia Rahma Zada Agna Talitha Zada Agna Talitha Zahra, Miralda Zaqia, Lulu Zusela, Titah