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Molecular docking analysis of flavonoid compounds from gandaria (Bouea macrophlla Griff) as potential alpha-glucosidase inhibitors Azzahrah, Qurrota A’yun; Novelina, Laras; Rosviena, Nyi Ayu Fayza; Saabirah, Ghania Parsa; Adilla, Annisa Rahma; Saeli, Pinka Mustika; Uswatunhasanah, Putri; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.75

Abstract

Diabetes mellitus represents a significant metabolic disorder with elevated global prevalence, necessitating development of effective antidiabetic therapies. This study investigates flavonoid compounds from gandaria (Bouea macrophylla Griff) as potential α-glucosidase inhibitors through molecular docking analysis. Eight flavonoid compounds were evaluated against human α-glucosidase enzyme (PDB ID: 2QMJ) using AutoDock Tools version 1.5.6. The methodology achieved validation with an RMSD value of 1.98 Å, confirming computational reliability. Lipinski's Rule of Five assessment identified four compounds meeting drug-likeness criteria for analysis. Quercetin demonstrated the strongest binding affinity among tested compounds with a binding energy of -4.72 kcal/mol, compared to the native ligand N-acetylglucosamine at -5.12 kcal/mol. Interaction analysis revealed quercetin formed significant hydrogen bonds with key active site residues including Lys389, Asn393, and Asn417, indicating potential competitive inhibition mechanisms. All flavonoid compounds exhibited consistent binding patterns with Lys389 serving as a critical interaction site. These computational findings establish quercetin as the most promising flavonoid candidate for α-glucosidase inhibition, supporting its potential as a natural antidiabetic agent.
Molecular docking of hybrid coumarin thiazole derivative as anti-breast cancer on VEGFR-2 protein Liswatini, Putri; Rahma, Sophia; Mariska, Putri; Anggraeni, Fibria; Agustin, Desti; Sari, Desi Puspita; Afrian, Mahisa Shzara; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.76

Abstract

VEGFR-2 is a tyrosine kinase receptor located on cell membranes, originally identified in endothelial cells but also expressed in tumor cells and various cancer types, including breast cancer. In breast cancer, VEGFR-2 expression is upregulated during early stages of primary tumors and invasive metastases, with elevated levels associated with lymph node metastasis and reduced survival outcomes. This computational study evaluated the potential of coumarin-thiazole derivative compounds against VEGFR-2 as anticancer agents using molecular docking analysis. Three coumarin-thiazole hybrid compounds (42a, 54a, and 54b) were assessed for their binding affinity to VEGFR-2, with sorafenib serving as the reference drug. The docking analysis utilized the three-dimensional structure of VEGFR-2 (PDB ID: 2OH4) downloaded from the RCSB Protein Data Bank. Ligand structures were prepared using molecular modeling software and converted to appropriate formats for analysis. Molecular docking was performed using AutoDockTools v.1.5.7, and protein-ligand interactions were visualized using BIOVIA Discovery Studio 2024 software.Method validation using the native GIG ligand yielded a binding energy of -10.88 kcal/mol. The binding energy values for the three test compounds were -9.81 kcal/mol for compound 42a, -12.71 kcal/mol for compound 54a, and -12.77 kcal/mol for compound 54b. Compound 54b demonstrated the strongest binding affinity to VEGFR-2, surpassing the native ligand GIG, the reference drug sorafenib, and the other test compounds. These results indicate that compound 54b represents the most promising candidate for anti-breast cancer therapy through VEGFR-2 targeting, warranting further experimental validation.
Molecular docking of several compounds in katuk (Sauropus androgynus (L.)) leaves as anti-breast cancer in AKT1 protein Sutjiningsih, Ni Nyoman Ota; Ulisya, Azzaima Ayu; Utami, Amalda; Natalia, Christine; Mumtaz, Fakhira Chairunnisa; Yulanda, Nola Rohmi Eka; Sari, Victoria Rekina; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 3 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.77

Abstract

Breast cancer represents a leading cause of cancer-related mortality among women worldwide. Katuk leaves (Sauropus androgynus L.) demonstrate potential as anticancer agents through their ability to inhibit metastatic processes. The AKT1 protein plays a critical role in preventing apoptosis in breast cancer cells, making it an important therapeutic target. This study employed molecular docking analysis to evaluate the binding affinity of bioactive compounds from katuk leaves to the AKT1 protein. The docking methodology involved protein preparation using structures obtained from the Protein Data Bank (PDB ID 3O96), followed by ligand preparation and validation using AutoDockTools version 1.5.6. Chemical interaction analysis was performed using BIOVIA Discovery Studio 2021 software. The binding energy analysis encompassed one native ligand, one reference drug (afuresertib), and five katuk-derived compounds: kaempferol, catechin, coumarin, squalene, and phytol. The respective binding energies were determined as -12.59, -8.70, -5.92, -6.44, -5.05, -8.11, and -6.70 kcal/mol. Among the tested compounds, squalene exhibited the strongest binding affinity (-8.11 kcal/mol), demonstrating superior interaction with the AKT1 protein compared to other katuk-derived bioactive compounds. The in silico screening results indicate that bioactive constituents in katuk leaves possess favorable binding characteristics for breast cancer protein targets, with squalene showing particular promise as a natural AKT1 inhibitor.
Molecular docking of piperine, limonene, and eugenol in black pepper (Piper nigrum L.) as anti-stroke Azzahra, Fauzia; Nadapdap, Ezra Gabriella Oktaviany; Cahyani, Nabila; Salsabila, Fathul Aini; Afada, M. Mufti; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 3 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.79

Abstract

Stroke remains a leading cause of death and disability worldwide, necessitating the development of effective therapeutic agents. This study explores the potential of bioactive compounds from Piper nigrum L. (black pepper) as anti-stroke candidates targeting the cGMP-specific phosphodiesterase 5A (PDE5A) receptor (PDB ID: 3BJC). The evaluation employed molecular docking and drug-likeness assessment methodologies. Piperine, limonene, and eugenol were assessed using Lipinski's Rule of Five (RO5) to predict oral bioavailability. All compounds met the RO5 criteria, indicating favorable drug-likeness characteristics. Molecular docking was validated through re-docking of the native ligand WAN, yielding an RMSD ≤ 2 Å, confirming the accuracy of the docking protocol. Following validation, molecular docking analysis revealed that piperine demonstrated the lowest binding energy (-7.71 kcal/mol), followed by limonene (-5.28 kcal/mol) and eugenol (-4.86 kcal/mol). Visualization results revealed that piperine shared key interaction motifs and amino acid residues with the native ligand, including hydrogen bonding and hydrophobic interactions, indicating strong receptor affinity and molecular stability. Additionally, the ligand-receptor interaction distance of piperine (2.21 Å) closely resembled the native ligand (2.15 Å), further supporting its structural and functional similarity. These findings highlighted piperine as the most promising anti-stroke candidate among the tested compounds. Further in vitro and in vivo studies are recommended to validate its pharmacological efficacy and safety.
Edukasi dan Pelatihan Pembuatan Minuman Fungsional Anti Anemia di SMA 2 Muhammadiyah Bandar Lampung Nurnahari, Naura; Aziz, Syaikhul; Fauziyya, Riri; Nur Auli, Winni; Maulidia Rahayyu, Annisa; Kartika Sari Ramadhani, Untia; Azanti Putri, Refsya; Fajar Fauzi, Muh; Sekarsari Yusuf, Mubarika; Mulyani, Isna
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 5 No. 1 (2025): Agustus 2025
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v5i1.236

Abstract

Anemia adalah suatu kondisi di mana jumlah sel darah merah atau konsentrasi Hemoglobin di dalam darah lebih rendah dari normal. Berdasarkan Survei Kesehatan Nasional Indonesia 2023, prevalensi anemia pada kelompok  usia 15-24 tahun sebesar 15,5%. Anemia bisa dicegah dengan nutrisi yang tepat. Tujuan pengabdian masyarakat ini adalah mengedukasi para remaja mengenai pemanfaatan bahan alam untuk mencegah anemia serta pelatihan pembuatan minuman fungsional untuk mencegah anemia. Kegiatan ini berlangsung di SMA 2 Muhammadiyah Bandar Lampung dan melibatkan 39 siswa-siswi. Metode yang diterapkan dalam kegiatan ini meliputi ceramah dan demonstrasi. Penilaian peningkatan pengetahuan dilakukan melalui pre-test dan post-test. Evaluasi dilakukan menggunakan instrumen pre-test dan post-test yang terdiri dari 10 butir pertanyaan. Uji normalitas Shapiro-Wilk menunjukkan bahwa data berdistribusi normal (pre-test p = 0,7485; post-test p = 0,2501), sehingga dilanjutkan dengan uji paired sample t-test. Hasil analisis menunjukkan peningkatan yang signifikan secara statistik (p = 0,0008), dengan rata-rata skor meningkat dari 59,3% menjadi 80,5%.
Studi In Silico Molecular Docking Senyawa Turunan Fenolik dan Terpenoid Kunyit Putih (Curcuma zedoaria) terhadap Protein 5MMN (pdb_00005mmn) sebagai Inhibitor DNA Gyrase Subunit B Escherichia coli Penyebab Diare Prasetyoningrum, Pinasti; Nainggolan, Yolanda Petra; Dewi, Intan Azkya; Hanifa, Milla; Pramudya, Siti Alifia; Nurnahari, Naura; Auli, Winni Nur
Jurnal Penelitian Sains Vol 27, No 2 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i2.1217

Abstract

Penelitian ini bertujuan mengevaluasi potensi senyawa turunan fenolik dan terpenoid dari kunyit putih (Curcuma zedoaria) sebagai inhibitor protein DNA gyrase subunit B (5MMN) dari bakteri Escherichia coli penyebab diare dengan metode in silico molecular docking. Tujuh senyawa bioaktif, yaitu bisdesmethoxycurcumin, curcumadiol, curcumin, curdione, curzerenone, demethoxycurcumin, dan epicurzerenone, dipilih berdasarkan pemenuhan kriteria Lipinski’s Rule of Five yang menunjukkan potensi sebagai calon obat oral. Preparasi target protein dan ligan dilakukan dengan perangkat lunak AutoDockTools, Avogadro, dan BIOVIA Discovery Studio Visualizer, dan validasi metode docking diperoleh nilai RMSD 1,98 Å menunjukkan validitas metode yang digunakan. Akan tetapi, hasil docking menunjukkan bahwa bisdesmethoxycurcumin memiliki afinitas pengikatan terendah terhadap target protein (-6,80 kkal/mol), diikuti curcumadiol, demethoxycurcumin, dan curcumin. Dominan interaksi antara ligan dan protein melibatkan residu asam amino Asn46, Asp73, Glu50, dan Thr165 melalui ikatan hidrogen dan van der Waals, yang berperan utama dalam menstabilkan kompleks ligan-protein. Penelitian ini menunjukkan bahwa senyawa fenolik dan terpenoid dari Curcuma zedoaria berpotensi sebagai inhibitor DNA gyrase subunit B E. coli dan bisa dikembangkan kedepannya menjadi kandidat obat antidiare berbasis bahan alam.
Analisis Formalin dan Asam Salisilat pada Ikan Asin yang dijual di Beberapa Pasar di Bandar Lampung Auli, Winni Nur; Al Iman, Arif; Fadhila, Safira Cahya; Firmansyah, Arya Kurnia; Gacatorina, Alfiraza; Saputra, Chandra Prayoga; Wijayanti, Dwi
Communication in Food Science and Technology Vol. 2 No. 1 (2023): Communication in Food Science and Technology, April Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Institut Teknologi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/cfst.v2i1.1271

Abstract

The use of prohibited food additives in the community is a concern due to insufficient education and supervision. Some of them are formalin and salicylic acid in salted fish which is used to extend shelf life. The prohibition on them is due to their damage effects on health. The market in Bandar Lampung is one of the routine selling places for salted fish where it is necessary to study the use of formalin and salicylic acid. The analysis was carried out by random sampling using 5 different salted fish from 5 different markets in Bandar Lampung including Rajabasa, Way Halim, Way Kandis, Korpri, and Gintung market. The analytical method was carried out based on the formation of a redox reaction with KMnO4 for formalin and a complexation reaction of salicylic acid with FeCl3. The results of the analysis showed that one of the WK code samples contained formalin and one of the WH code samples contained salicylic acid. These results indicate that the use of prohibited food additives is still being used by salted fish producers in Bandar Lampung. Supervision and education from various parties, especially in the field of regulation, are very urgent to do.
Bioinformatic and Molecular Docking Study of Zerumbone and Its Derivates against Colorectal Cancer Fauziyya, Riri; Auli, Winni Nur; Suprahman, Nisa Yulianti; Sarmoko, Sarmoko; Ashari, Arif; Alsadila, Kalista; Agustin, Lanita; Fazila, Safia; Zahra, Miralda; Pane, Esteria Christina; Sukrasno, Sukrasno
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp39-48

Abstract

The prevalence of colorectal cancer (CRC) is ranked third among all cancer types in both men and women, highlighting the urgency for drug exploration. Zerumbone and its derivatives have gained attention for their ability to inhibit angiogenesis, invasion, and metastasis and have been tested for their efficacy against various cancer cells. This study aimed to investigate the potential targets and mechanism of action of zerumbone derivatives in colon cancer invasion and migration. Bioinformatic analysis was conducted using STITCH and STRING to identify potential target genes, and molecular docking was used to search for anticancer candidates from 20 zerumbone derivatives. The results revealed that six proteins were targeted by zerumbone derivatives, including XIAPBIR3 (1TFT), AKT1 (3O96), JAK2 (6VGL), HASP90AA (2XJX), MDM2 (4MDN), and XIAPBIR2 (4KJU). Compound 4 was found to have a lower binding energy than zerumbone as well as AZD5363 (pan-Akt inhibitor) when interacting with the protein target AKT1. This makes it the most promising candidate among the zerumbone derivatives for treating colorectal cancer. Further development, such as the addition of an amine functional group, is expected to improve the potency of this molecule through the formation of hydrogen bonds and other interactions with lower bond energy.Keywords: Bioinformatic, molecular docking, zerumbone derivatives, colorectal cancer.
In Silico Study: Andrographolide Compounds and Their Derivatives as Antimalarials Targeted at PfENR Auli , Winni Nur; Ramadhani, Syanindita Lulu; Firgianti, Sinta Rani; Sigalingging, Yonathan Adi Nugroho; Hasnaussalim, Hamidah; Yuliana , Rita; Saputri, Syabina Sofa
Indonesian Journal of Chemical Science Vol. 14 No. 1 (2025): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v14i1.6313

Abstract

Malaria is an infectious disease that poses a significant danger due to its potential to cause severe anemia. The malaria parasite comes from the genus Plasmodium, which can attack erythrocytes. In recent years, good target proteins have been discovered as antimalarials. The target protein is taken from the type II fatty acid biosynthesis pathway, the fatty acid specific to Plasmodium falciparum is Enoyl Acyl Carrier Protein Reductase (PfENR). This study aims to evaluate the antimalarial activity of the Andrographolide compound which targets PfENR using in silico as an alternative for developing new drugs. Evaluation of the Andrographolide compound was carried out in silico with Autodock Tools and Biovia Discovery Studio Visualizer, then compared between the native ligand and the target compound, and the compound with the best interaction was determined so that it could provide a maximum therapeutic effect on the target compound. This research shows that the Andrographiside compound has a lower binding affinity, compared to native ligan is  -5.94 kkal/mol and other compounds, namely -8.21 kkal/mol, so it has better bonding affinity, and the bond is reversible, making it suitable for developing new drugs. However, the Andrographiside compound still requires further molecular modifications to comply with Lipinski's rules.
PELATIHAN INOVASI OLAHAN COKLAT MENJADI SELAI DAN MASKER COKLAT UNTUK MASYARAKAT DESA TARAHAN Nabila, Novrilia Atika; Tantri Liris Nareswari; Auli, Winni Nur; Rahayyu, Annisa Maulidia; Rooswita, Putri Amelia; Hidayaturahmah, Rizky
JURNAL ABDIMAS DOSMA (JAD) Vol. 3 No. 2 (2024): JUNI
Publisher : IKATAN ALUMNI DOSEN MAGANG KEMENRISTEKDIKTI TAHUN ANGKATAN 2017

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70522/jad.v3i2.22

Abstract

South Lampung Regency is the second largest cocoa bean producer in Lampung Province. This natural resource is very abundant, one of which is in Tarahan Village, South Lampung, but until now it has not been optimally processed and is only sold in the form of dry brown beans which have low selling value. This is because the villagers does not know how to process cocoa beans into cocoa products. Therefore, this service program aims to assist the target community in processing cocoa beans into ready-to-sell products (jam and mask) to improve people welfare. This activity consisted of providing material and training in making jam and chocolate masks for 1 day. After the training, the villagers were able to understand and practice making the chocolate jam and mask. This program is expected to increase chocholate selling value as local regional commodities.
Co-Authors Adilla, Annisa Rahma Afada, M. Mufti Afrian, Mahisa Shzara Aghalfi, Revin Rindra Aghalfi Agustin, Desti Agustin, Lanita Ahmad, Winda Tiara Ainiya, Aliva Ainun, Hadhistia Nur Al Iman, Arif Al-Husni, Ihza Adzkiya Mubarak Alhestha, Salsabila Zahra Alika Putriyana Boru Tumanggor Alsadila, Kalista Alya Pinahayu Sakanthi Amalia, Miranti Andriani, Wellen Putri Anggini, Joya Talitha Anggraeni, Fibria Anggraeni, Inggrid Anisah, Nadya Anjani, Arfina Puteri Anjar Hermadi Saputro Arif Al Iman Arif Ashari arif ashari Arrafi, Muhammad Zhafran Aulia, Nanda Aulia, Yasinta Sahma Azizah, Nadya Nur Azti, Zahara Azzahra, Zeta Agustri Azzahrah, Qurrota A’yun Balqis, Selvi Billa, Firly Shalsha Bokshow, Rency Violita Vanden Bulan Rosita Sari Cahyani, Ayu Sukma Cahyani, Nabila Chandra, Nabella Oktaviana Choiriah, Ika Putri Christine Natalia Citra Andini Cristiannanda, Daniel Damayanti Abdul Karim, Dewi Derina Paramitasari Dewi, Intan Azkya Dhea Anggun Ferlinda Dhiya, Syifa Nasywa Dina Putri Agustina Dinda Naila Dhiya Salsabila Dirga Dirga Dwi Wijayanti Dzaki Arrafif Erniningsih, Ni Ketut Evanggeulista, Arnanda Fadhila, Safira Cahya Fadhilla Asara Fadillah, Muhammad Zakki Fahmi, Achmad Gus Fajar Fauzi, Muh Fajriani, Rahmatul Fatonah Fatonah Fauziyya, Riri Fazila, Safia Fazilla, Rizki Fakhri Febrian, Tobi Febriyanti, Kharisma Fida, Marsa Jannatul Fira Anggraini Firgianti, Sinta Rani Firmansyah, Arya Kurnia Fransisca, Ni Putu Vina Gabriela Kasih Mawarni Gacatorina, Alfiraza Geralda, Rifka Grace Sihombing Gusman, Adisti Faradilla Hafid, Gina Mutia Handayani, Kiki Yuli Hanifa, Milla Harmiansyah Hasanah, Siti Fadhilatul Hasnaussalim, Hamidah Hati, Dinda Mutiara Hidayati, Putri Aulia Nurul Hidayaturahmah, Rizky Hutabarat, Stefanny Herlin Natalya Ihza Adzkiya Mubarak Al-Husni Ilham Marvie Ilma Nugrahani Indah Puspita Sari Indah Wulandari intan kusuma wardani Isna Mulyani Jannah, Aryn Fatkhul Kaerani Tri Lestari Kamilaini, Diva Arisanti Karima, Miska Aulia Kartika Sari Ramadhani, Untia Keisya Aurora Natasha Chairunisa Kiki Yuli Handayani Koeswara, Thobias Tantra Kumara, Gusti Made Bagus Kusumawati, Maiya Lianti, Lita Liswatini, Putri Lita Lianti Lulu Zaqia Maharani, Ayu Puspita Maharani, Gita Putri Mariska, Putri Mariska, Soraya Maulidia Rahayyu, Annisa Melki, Yana Putri Amelia Mellina, Echa Dian Mendrofa, Alexander Yoel Harazachi Muflihah, Hanny Muhammad Aditya Nugraha Muhammad Rizky Ramanda Mumtaz, Fakhira Chairunnisa Musa Musa Mutia Adfi Pratiwi Mutiara Putri, Mutiara Nabila Ahlika Ulya Nabila, Novrilia Atika Nadapdap, Ezra Gabriella Oktaviany Nadia Nur Syakilla Nadya Miranda Atiek Nainggolan, Yolanda Petra Napitu, Ade Shinta Maria Br Natalia, Dela Natasya Armelia Putri Natasya, Zaskiya Naura Nurnahari Nisa Yulianti Suprahman Novelina, Laras Nurnahari, Naura Okta Dinata Saputri Okta Nama Putra Pane, Esteria Christina Pangestu, Maryo Adjie Panggabean, Diva Selviana Pasaribu, Romualdo Pramudya, Siti Alifia Prasetyoningrum, Pinasti Pravita, Nabila Cahya Prawicha, Ertika Agtha Primasty, Ratna Dewi Putri Liswatini Putri, Adelia Ofira Putri, Amalia Sonita Putri, Esterike Alfatien Putri, Gladys Ellnora Putri, Tikarahayu Qurrota A`yun Azzahrah Raden Mohamad Herdian Bhakti Rahayyu, Annisa Maulidia Rahma, Annisa Nur Rahma, Sophia Rahmadi, Isnaini Rahmadi, Muhammad Zaki Ammar Rahmadini, Celina Fadila Rajwa, Raihan M Dhiya Ramadhani, Syanindita Lulu Refsya Azanti Putri Regita, Putu Ayu Riana, Elisa Nurma Riani, Nadia Nanda Riri Fauziyya Rislia, Rana Atikah Rizkyka, Fitria Romualdo Pasaribu Rooswita, Putri Amelia Rosviena, Nyi Ayu Fayza Saabirah, Ghania Parsa Saeli, Pinka Mustika Safia Fazila Sakti, Nickyta Salsabila Ira Salsa Nabila Ahlika Ulya Salsabila Fauziah Salsabila, Fathul Aini Saputra, Chandra Prayoga Saputri, Mutiara Anggun Saputri, Syabina Sofa Sari, Desi Puspita Sari, Victoria Rekina Sarini, Sarini Sarmoko Sarmoko Sarmoko Sativa, Nasywa Oryza Sekarsari Yusuf, Mubarika Setiawati, Luh Gede Elen Sigalingging, Yonathan Adi Nugroho Simorangkir, Nanda Lenny Yuniaty br Sitohang, Nada Nikita Sukrasno Sukrasno Sukrasno Suri, Faradila Azzahra Suryaneta Sutjiningsih, Ni Nyoman Ota Syah, Vicky Ardian Syahrizal Nasution Syaikhul Aziz Syakilla, Nadia Nur Tantri Liris Nareswari Tursino, Tursino Ulfa, Lutfiyana Ulisya, Azzaima Ayu Ulya, Salsa Nabila Ahlika Ummi, Ummi Uswatunhasanah, Putri Utami, Amalda Utami, Firanti Putri Utami, Widia Vega, Amelia Vernanda, Pramyudha Vita Julia Saputri Windari, Nurul Irna Wulandari, Valentri Yulanda, Nola Rohmi Eka Yuliana , Rita Yunita, Nadia Rahma Zada Agna Talitha Zada Agna Talitha Zahra, Miralda Zaqia, Lulu Zusela, Titah