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All Journal Medula Jurnal Kreativitas PKM Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Mandala Pharmacon Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Buguh: Jurnal Pengabdian Kepada Masyarakat Jurnal Kedokteran Ibnu Nafis JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Risti Graharti
Bagian Ilmu Patologi Klinik, Fakultas Kedokteran Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Medula

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Faktor-Faktor Yang Mempengaruhi Malnutrisi Muhammad Ihsan Fariqy; Graharti, Risti
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.986

Abstract

Malnutrition in children is a serious issue that can impact both health and optimal growth. This condition arises from a nutritional imbalance, involving an excess or deficiency of calories, protein, and other essential nutrients. Risk factors include socio-economic status, maternal lack of awareness, Low Birth Weight (LBW), family food intake, infections, maternal education, breastfeeding practices, and environmental sanitation. Clinical manifestations of malnutrition encompass stunted growth, dry skin and hair, fatigue, decreased appetite, and motor development disorders. Effective preventive efforts require a holistic approach, including heightened public awareness of nutrition, changes in social and economic policies, and improvements in environmental sanitation. By understanding and addressing these factors, it is hoped that the prevalence of malnutrition can be reduced, thereby enhancing the overall quality of life for children worldwide.
Diagnosis dan Tatalaksana Kalazion Eksaserbasi Akut ODS Rahmat, Aprin Nabila; Graharti, Risti; Maulana, Muhammad
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.998

Abstract

Chalazion is a granulomatous inflammation with lipogranuloma or chronic non-infectious inflammation of the eyelid, in the form of a nodule formed due to inflammation and obstruction of the tarsal meibomian gland or zeis. This chalazion often occurs in all age groups, but the chalazion occur more commonly in the productive age. We report the case of a 20-year-old man with complaints of a lump on the upper eyelid, at the left and right eye for 4 months before entering the hospital. The lump is initially small but gets bigger over time, becomes red, feels painful and lumpy. This complaint has been repeated since 10 months ago. Currently the lump no longer feels painful, itchy or hot, but the lump is now permanent. On ophthalmological examination, it was found that the superior eyelid of the right eye had a nodule measuring ±5 mm and the superior eyelid of the left eye had a nodule measuring ±3mm. The diagnosis made was acute exacerbation of chalazion of right eye, then the patient was given non-medicamentosa therapy, medicamentosa, and operative treatment.
Hubungan Antara Konsumsi Probiotik terhadap Regulasi Emosi Maharani, Atifah Fadilah; Berawi, Khairun Nisa; Graharti, Risti
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1219

Abstract

Digestion organs and brain communicate through specific pathway that involves nervous, endocrine, and immune system onto it. Guts microbiota especially probiotics holds a crucial matter in communicating with brain, that’s why it can affect one’s mood and cognitive functions by producing neurotransmitters that are related to brain through endocrine and autonomy nervous system. The consumption of probiotics is known to be able to improve the quality of guts microbial environment, where this matter has a profound impact in increasing mood so that a person can regulate their emotion better. A good emotion regulation has a beneficial impact in order to prevent and solve stress, anxiety, and depression. Psychosocial changes can be a stressor for individual so that the ability to regulate mood and emotion is needed to help a person adapt well. The aims of this study is to know how beneficial probiotics can be in individual mood changes. The relation between probiotics consuming and mood changes have been such an interest topics to be researched in order to gain knowledge and truth how it may give an enormous impact on people’s health by consuming it regularly. It is also proved by many articles and prior literatures that show the benefits of it in physical and mental aspects yet individual quality of life, vice versa it has negative impacts if it happens in a long-term period. Daily stressors are inevitable so that by knowing what could help to at least manage it. Managing how to face stressor isn’t easy for several people, thus it also can be fatal if it isn’t treated well, such as depression or even suicide.
Uji Efektivitas Ekstrak Kulit Batang Bakau Lindur (Bruigiera gymnorrhiza) Sebagai Antibakteri Terhadap Streptococcus pyogenes Annisa Fath; Kurniawaty, Evi; Graharti, Risti; Berawi, Khairun Nisa
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1250

Abstract

The bacterium Streptococcus pyogenes is a gram-positive bacterium that causes various diseases in humans. Pharyngitis is the most common infection caused by Streptococcus pyogenes, occurring in 15-30% of children and 5-10% of adults. The extract of mangrove bark contains bioactive compounds that can serve as an antibacterial alternative.  This research is an experimental study. The mangrove bark was extracted using 96% ethanol solvent through the maceration method and subjected to phytochemical testing. The treatment consists of 96% ethanol extract preparations with concentrations of 25%; 50%; 70%; 90%; and 100%, as well as a negative control using aquades and a positive control using amoxicillin. Each treatment was repeated 4 times. Antibacterial activity testing was conducted using the well method on Muller Hinton Agar. The results of the phytochemical test showed that the 96% ethanol extract positively contained flavonoid, phenol, alkaloid, tannin, saponin, steroid, and triterpenoid compounds. The results of the antibacterial activity study from 25%, 50%, 70%, 90%, and 100% concentrations of 96% ethanol extract produced zone diameters of 4.33 mm; 5.68 mm; 6.61 mm; 7.72 mm; and 9.02 mm. These results indicate that the 96% ethanol extract of the mangrove bark has an inhibitory effect on the growth of Streptococcus pyogenes. Data analysis of the 96% ethanol extract of the mangrove bark using the One-Way ANOVA test showed p< 0.05.
Differences in Obesity Status on Blood Pressure at Panjang Health Center Bandar Lampung City Putri, Syalika Dianisa; Carolia, Novita; Graharti, Risti; Oktarlina, Rasmi Zakiah; Wahyuni, Ari
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1282

Abstract

Obesity continues to be a major health problem worldwide and has become an epidemic that has worsened over the past 50 years. Obesity has a prevalence that continues to increase every year due to unhealthy lifestyles and energy intake that is greater than energy expenditure. Obesity is closely related to the habit of consuming high-fat foods, which can increase the risk of increased blood pressure. Several studies have found that a 15% increase in body weight can cause an 18% increase in blood pressure. The results of the 2018 Indonesian Basic Health Research showed that the prevalence of obesity in the Indonesian population aged 18 years and over reached 21.8%. The purpose of this study was to determine the difference in obesity status on blood pressure at the Panjang Health Center, Bandar Lampung City. This study used an observational analytical method with a cross-sectional approach. The population in this study were obese patients registered at the Panjang Health Center, Bandar Lampung City in the period August 2023 to August 2024. The total number of research subjects who met the inclusion and exclusion criteria was 113 research subjects obtained from medical records of obese patients at the Panjang Health Center, Bandar Lampung City in the period August 2023-August 2024. Data are presented in a distribution table and analyzed using the Mann-Whitney test. The results showed a P value of 0.001 which indicated that there was a difference in the effect of obesity status on blood pressure status at the Panjang Health Center, Bandar Lampung City.
Literature Review: Hubungan Kepuasan Pasien Hipertensi Rawat Jalan Terkait Kepatuhan Minum Obat Hipertensi Disaputera, Alfafa Tsalaatsa; Oktarlina, Rasmi Zakiah; Graharti, Risti; Larasati, TA
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1628

Abstract

Patient satisfaction is a key indicator in assessing healthcare quality, especially in hospital pharmacy services which play a vital role in treatment effectiveness. Hypertension is a major chronic illness requiring strict medication adherence to prevent complications such as heart disease, stroke, and kidney failure. This review examines the relationship between outpatient hypertension patients' satisfaction with pharmacy services and their medication adherence. Findings highlight that satisfaction dimensions such as reliability, empathy, responsiveness, tangibles, and assurance significantly shape patient perceptions. Higher satisfaction correlates with increased adherence. Continuous education, empathetic interaction, efficient service systems, and clear pharmacist communication are essential. Quality pharmacy services not only improve patient outcomes but also support long-term hypertension control.
Case Report: Dermatitis Kontak Iritan Pada Wanita 54 Tahun Setiawan, Putri Ayundari; Graharti, Risti; Fatmasari, Dina
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1668

Abstract

Irritant contact dermatitis (ICD) is a non-immunologic inflammatory skin disorder resulting from direct damage to the epidermal barrier by chemical, physical, or biological agents. ICD is more common than allergic contact dermatitis since most individuals are at risk of repeated exposure to irritants in daily activities, such as detergents. We report the case of a 54-year-old woman presenting with peeling, erythema, pruritus, and stinging pain on both hands after washing clothes with powdered detergent without protective gloves. Dermatologic examination revealed erythematous plaques with thick scales, diffuse borders, and fissures on the dorsal and palmar regions bilaterally. The diagnosis of ICD was established based on a clear exposure history, characteristic clinical features, and the absence of allergic manifestations. Management included ceramide-based moisturizer to restore skin barrier function, high-potency topical corticosteroid (clobetasol propionate 0.05%) to reduce inflammation, and oral antihistamine (cetirizine) to relieve pruritus. Patient education emphasized adherence to therapy, skin hygiene, and strict avoidance of repeated detergent exposure. Marked clinical improvement was achieved within a short period following combination therapy. This case highlights detergent exposure as an important cause of ICD among housewives and underscores the significance of preventive strategies, including the use of personal protective equipment, safer cleaning alternatives, and continuous patient education. Early recognition and comprehensive management are essential to reduce recurrence and improve patient quality of life.
Episode Depresi Berat Dengan Gejala Psikotik Pada Wanita Berusia 17 Tahun: Sebuah Laporan Kasus rizki_novtarina21; Boy K.H, High; Graharti, Risti
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1674

Abstract

Major depressive episodes with psychotic symptoms are a form of major depressive disorder characterized by severe affective symptoms accompanied by delusions or hallucinations. This condition is relatively rare, but is associated with a poorer prognosis, a high risk of recurrence, and an increased suicide rate compared to depression without psychotic symptoms. This case report aims to describe the clinical manifestations, diagnostic process, and management strategies in patients with major depressive episodes accompanied by psychotic symptoms. The patient presented with feelings of depression, sadness, and lack of enthusiasm in performing daily activities for 1 year, which had worsened for 4 months prior to admission to the hospital, since the death of the patient's mother. The diagnosis was established based on a psychiatric interview, mental status examination, and diagnostic criteria from the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Management consisted of a combination of antidepressants and antipsychotics, as well as intensive psychosocial support. This report emphasizes the importance of early detection, accurate diagnosis, and comprehensive management to reduce the risk of complications, improve the patient's quality of life, and reduce the recurrence rate. Thus, this case study is expected to serve as an additional reference in the clinical management of major depressive disorder with psychotic symptoms.
Update on Hypertension Guidelines: A Literature Review Andika, Gede Agus; Graharti, Risti
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1682

Abstract

Hypertension is one of the major worldwide health problems, with its prevalence continuing to increase year by year. This condition is known as the “silent killer” because it often does not cause specific symptoms, but is closely related to increased morbidity and mortality due to cardiovascular and non-cardiovascular complications. Various epidemiological studies show that hypertension contributes to high rates of coronary heart disease, stroke, kidney failure, and premature death. Recent literature also confirms that risk factors for hypertension include unhealthy lifestyles, high-salt diets, obesity, stress, and genetic predisposition. The diagnosis of hypertension requires accurate blood pressure measurement using standard protocols, either through examinations at healthcare facilities or self-monitoring at home. Various international guidelines, such as ACC/AHA, ESC/ESH, and national guidelines such as PERKI, emphasize the importance of early detection and blood pressure control with specific targets. Hypertension management strategies include non-pharmacological approach such as lifestyle modifications, as well as pharmacological approach using evidence-based antihypertension medications, such as diuretics, ACE inhibitors, ARBs, CCBs, and beta blockers. This literature concludes that hypertension management must be comprehensive, integrated, and sustained to prevent complications. These efforts does not only depend on medical interventions, but also involve patient education, routine monitoring, and health system support to reduce the burden of hypertension in the future.
Hubungan Daerah Tempat Tinggal dengan Kejadian Dermatitis Atopik Izdihar, Adinda Fairuz; Sibero, Hendra Tarigan; Graharti, Risti; Carolia, Novita
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1311

Abstract

Atopic dermatitis is a frequently occurring skin inflammation characterized by pruritus and lesions in specific areas such as the face and extremities. The majority of cases manifest during the first year of life, with a high prevalence among children under five years of age. In Europe, 118 million cases were recorded in 2023, whereas in Indonesia, the prevalence reached 10-20% among children and 1-3% among adults. This condition involves an interplay of exogenous and endogenous factors, including environmental exposure, genetic predisposition, immunological mechanisms, and colonization by Staphylococcus aureus. Environmental factors contributing to the incidence of atopic dermatitis include exposure to pollutants such as carbon monoxide, nitrogen dioxide, PM2.5, PM10, and volatile organic compounds (formaldehyde). Such exposure is a significant risk factor for atopic dermatitis in urban areas. This study aimed to analyze the correlation between residential areas and the incidence of atopic dermatitis at RSUD Dr. H. Abdul Moeloek during the period of January 2022 to July 2024. Data were collected from medical records, encompassing a total sample size of 82 patients. The chi-square test revealed a statistically significant relationship between residential area and the occurrence of atopic dermatitis, with individuals residing in urban areas being 0.23 times more likely to develop atopic dermatitis compared to those living in non-urban areas (p=0.02; OR=0.23)
Co-Authors A.P, Gadila Ade Yonata, Ade Adrifianie, Femmy aflika happy, terza Agatha Catherine Agustyas Tjiptaningrum Airlangga Damara Akbar, Fareel Wahyu Al Ghifari, Ghaza Ahmad Ali, Nur Fitriana Muhammad Andika, Gede Agus Andrifianie, Femmy Angga Wijaya, Angga Anggraeni, Ranesya Eka Annisa Fath Ari Wahyuni Arif Yudho Prabowo Arnida Rahman Asep Sukohar Assirri, Agung Aulia Berliana Avisa Jinan Azura Ayu, Putu Ristyaning Bayu Anggileo Pramesona Benny Syahputra Gumay betta kurniawan Betta Kurniawan, Betta Boy K.H, High Cintawan, Ni Made Karenina Rini Dwi Daffa, Meysha Nur Devya Aulia Dewi Nur Fiana Diaru Fauzan Farizy Disaputera, Alfafa Tsalaatsa Djausal, Anisa Nuraisa Dorisman, Hari Dwiki WIjaya Rahman Endah Setyaningrum, Endah Evi Kurniawati Fardiansyah, Ahmad Irzal Farhah, Putri Dzahabiyyah Farid Rakhman Fatmasari, Dina Fitria Saftarina George Pestalozi Gigaramadan Sema Hadibrata, Exsa Hafizh, Ahmad Fauzan Happy, Terza Aflika Helmi Ismunandar Hendra Tarigan Sibero Idris, Mohamad Indri Windarti Indriyani, Reni Intan Kusumaningtyas Intanri Kurniati Iswandi Darwis Izdihar, Adinda Fairuz Jati, Pandu Kumaya Khairun Nisa Khairunnisa, Aulia Kurniawaty, Evi Kusumaningrum, Desy Liana Sidharti, Liana Maharani, Atifah Fadilah Mallarangeng, Andi Nafisah Tendri Adjeng Maulida, Syakira Zahra Mayasari, Diana Muhammad Ihsan Fariqy Muhammad Maulana Muhammad Ricky Ramadhian Ningrum, Kurnia Nisa, Lutfi Khoirun Novita Carolia Nuraini, Bianti Nurul Utami Oktoba, Zulpakor Prameswari, Putu Arya Indira Pratiwi, Aulia Sari Prayogi, Norbertus Marcell Purnama Sari, Faraztya Putri, Syalika Dianisa Putu Ristyaning Ayu Rachman Aziz Rahmadani, Tiara Sekar Rahmat, Aprin Nabila Rahmayani, Fidha Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Reni Indriyani Retno Mareintika Ricky Rivalino Sitepu, Ricky Rivalino Rika Lisiswanti Rina Hayati Risal Wintoko rizki_novtarina21 Rodiani Roro Rukmi Windi Roro Rukmi Windi Perdani, Roro Rukmi Rudianto, Waluyo Ruslani, Nada Oktista Sangging, Putu Ristyaning Ayu Sany Setiawan Sema Gigaramadan Septa, Tendry Septiani, Linda Setiawan, Putri Ayundari Setiorini, Anggi Sheira Indah Anjani Soemarwoto, Retno Ariza Soeprihatini Sofyan Musyabiq Wijaya Suharmanto Sulthan Alam Yasyfa Susianti, Susianti Sutarto Sutarto Sutarto Sutarto Syahrul Hamidi Nasution Syazili Mustofa TA Larasati Tri Umiana Soleha Wardhani, Dyah Wulan Sumekar Rengganis Wardhani, Oktiva Risma Widjaja, Jovan Winda Trijayanthi Utama, Winda Trijayanthi