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Journal : Pharmascience

Lumbricus Rubellus Earthworm Extract Hydrogel for Treatment of Diabetic Ulcer Wounds Diana Tri Lestari; Muhamad Jauhar; Eko Retnowati
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.22880

Abstract

A diabetic ulcer is a complication that requires serious treatment because it is the highest cause of amputation. This condition has an impact on the morbidity, mortality, and socioeconomics of people with diabetes. Therefore, accuracy is needed in managing diabetic ulcers, one of which is natural ingredients that have potential as topical ulcer medicines, namely the Lumbricus rubellus earthworm. This study aims to find out the most effective formula for the treatment of diabetic ulcer wounds. The formula for this drug candidate is made using the hydrogel preparation formulation using an HPMC 940 base with variations in the active ingredient of lumbricus worm extract of 20%, 50%, and 80% to obtain the desired hydrogel preparation. The candidate drug will be tested, namely physical tests including organoleptic tests, homogeneity tests, pH tests, viscosity tests, spreadability tests, and adhesive tests. After that in vivo trial using Wistar rat experiments. The results of the organoleptic test showed that the three formulas were in gel form with a distinctive extract odor, but the three preparations showed different colors, namely brownish yellow, dark brown, and blackish brown. The three formulations appear homogeneous, having a pH between 4.36 and 4.44 and a viscosity between 5,376 cp and 5,894 cp. The spreading power in formulas 2 and 3 is good, and formula 2 has good adhesion. The results of this study demonstrate that the group treated with 50% Lumbricus rubellus topical extract experienced the most significant and rapid wound healing among all intervention groups. Lumbricus extract can be used as a topical gel preparation for wound care, with the best formulation at a concentration of 50%.
Co-Authors A Nur Anna AS Aeni, Linda Nur Agustiani, widya Ahmad Suriyadi Muslim Alfiatur Rochma Amarilla Melati Anggara Dwi Sulistiyanto Anny Fauziyah Anny Rosiana Masithoh Anny Rosiana Masithoh Anny Rosisana Masithoh Ardiansyah, Diki Arina Novitasari Ariyanto, Andhika Arwani Arwani Ashri Maulida Rahmawati Astuti Yuni Nursasi Astuti, Verra Widhi Aulia Chusna, Arda Auliya, Arida Balqis Fashila Catur Ririn Indarsih Choiruna, Hasby Pri Ckancer Bela Romantis D. Eka Harsanto Darmawati, Laesa Desak Parwati Dewi Hartinah Dewi Murti Sari Diah Irawati Diah Widowati Diana Tri Lestari Dina Indrati Dwi Astuti Dwi Mei Anggraini Edi Wibowo Suwandi Edita Pusparatri Eko Retnowati Elisa Elisa Ema Saputri Kusuma Wardani Endang Triyanto Endang Triyanto Erni Setiyowati Eswanti, Noor Etikasari, Ria Eva Luthfiati Putri Fajar Surachmi Fajar Surachmi Fajar Surahmi, Fajar Fania Nurul Khoirunnisa Faridha Alfiatur Rohmaniah Fatihatul Husna Fery Nanik Handayani Fitriana Kartikasari Futkhatin Nasikhah Gunardi Pome Gunardi Pome Heny Siswanti I Gusti Ayu Putu Desy Rohana Ifa Nailatul Iza Iffah Hanifah Iis Sriningsih Iis Sriningsih Ike Puspitaningrum Ike Puspitaningrum Ilham Syarochman Putra Ilyana Sari Inayah Alviorizka Pujanti Indah Risnawati Indanah Intan Endyka Kurniasaria Intan Idiasari Ismail, Wan Ismahanisa Iswatun Qasanah Jelita, Monica Artha Kanan, Thanalechumy Kurniati Puji Lestari Kurniati Puji Lestari kusumawardani, lita heni Lasmini Lasmini Lasmini Lasmini Lasmini Lasmini, Lasmini Lestari, Rizka Puji Lita Heni Kusumawardani Lita Heni Kusumawardani Lita Heni Kusumawardani Lita Heni Kusumawardani Maksuk Marendra, Irvan Maulana Masayu Hartina Ulfa Maulana, Bonnix Hedy Mauludina, Ibtasama Misga, Nesdania Mohamad Khafidh Rio Irwansyah Mohammad Sholahudin Mugi Hartoyo Muhammad Hasan Burhanudin Muhammad Niko Bagus Saputro Muhammad Purnomo Nadya Tiara Sabila Nana Umi Farida Nanda Arum Widya Warapsari Nasriyah Nasriyah Nerlita Yogi Rizki Rulloh Nikmah, Mauliana Nurlaila Nisa Herlina Puspitasari Noor Eswanti Noor Hidayah Noor Hidayah Novi Tiara Novy Kumalasari Nur Ulisetiani Okta Yosiana Dewi Padad, A. Tenri Pingki Agit Setyasih Putra, Ilham Syarochman Putra, M. Adib Jaharii Dwi Rachmawati, Utami Rahmasari, Lutfir Fitri Rasdiyanah, Rasdiyanah Ririn Navita Sari Ririn Widyasari Risah Wati Dewi Riza Yanti Rizka Himawan Rohana, I Gusti Ayu Putu Desy Roisul Fahmi Ilyas rusnoto rusnoto Rusnoto Rusnoto Salma Adilanisa Sari, Etik Nila Sekar Ayuningtyas Septyani, Ima Aulia Sheva Jusuf Az Zahra Shobirun Shobirun Shobirun Shobirun Sholikhah, Shafa Artamevia Siti Rukhaniyah Siti Wahyuni Sofiana Nur Mardhiyah Sri Karyati Sri Widiyati Sugih Wijayati Sugih Wijayati Sugih Wijayati, Sugih Sukarmin Sukarmin Sukarmin Sukesih Sukesih Sukesih Sukesih Sukesih Sukesih, Sukesih Sukoharjanti, Bintari Tri Susanti, Sofy Norma Taftazani Ghazi Pratama Tassya Yanurifsa Ameilia Theresia Avila Kurnia Tiara, Novi Trianita Siwi Utami Umi Faridah Umi Faridah Unsa, Annisa Laila Usamah Jundullah Verra Widhi Astuti Widara, Jihan Zinnia widya Agustiani Widyatuti Wisdom Rudiyana Wiwik Dewi Mulyani Wiwin Wiarsih Yasinta Anugrah Heni Yasmina Izzat Yayuk Mundriyastutik Yuliastuti, Fitri Zaenal Fanani