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Journal : International Journal Of Science, Technology

 1 
Testing Of The Nephroprotective Effectiveness Of Sail Leaf (Syzygium Polyanthum (Wight.)Walp.) In DoxorubisinInduced Male Wistar Rat Dewi; Ali Nafiah Nasution; Ermi Girsang
International Journal of Science, Technology & Management Vol. 2 No. 6 (2021): November 2021
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v2i6.372

Abstract

Cancer is one of the leading noncommunicable diseases leading to death worldwide. Cancer treatment has progressed but has side effects including nephrotoxic effects. The toxicity of doksorubisin has been widely known which is likely to be chained by the metabolic conversion of doxorubicin to doxorubicinol. The main mechanism of doxorubicinol toxicity occurs due to its interaction with iron and the formation of ROS that damages cell macromolecules. One of the plants that are widely used by the community to deal with various diseases and prevention is bay leaves. Bay leaves contain secondary metabolites that are antioxidant in nature. Antioxidants are needed to protect the body's cells from oxidative damage, preventing various degenerative diseases such as cancer, cardiovascular disease. The study aimed to determine the content of nephroprotective EEDS chemical compounds in phytochemical screening, EEDS characterization and EEDS nephroprotective activity in doxorubicin-induced mice based on uric acid, ureum and creatine levels. The study was experimentally laboratory using mice as test animals. The treatment group consisted of CMC-Na 0.5%, Nature E, EEDS doses of 100 mg/kgBB, 300 mg/kgBB and 500 mg/kgBB followed by administration of doxorubicin. The results showed phytochemicalally EEDS contains chemical compounds that are nephroprotective namely flavonoids, steroids / triterpenoids, saponins . EEDS has a water soluble sari content value of 21.64%, total ash content of 1.79%, water content of 9.98%. Ethanol soluble juice levels were 45.38% and acid insoluble ash levels were 0.39%. EEDS doses of 100 mg/kgBB, 300 mg/kgBB and 500 mg/kgBB can lower uric acid, ureum and cretinine levels and can picture the histopathology of doxorubicin-induced mouse kidneys with an effective dose of 500 mg/kgBB. It can be concluded that ethanol extract of bay leaves has nephroprotective activity.
Co-Authors Abd. Rasyid Syamsuri Abdul Pandi Adzra Agnes Doraresta Khatarina Tokan Ahmad Muktamar B Aisyah Dhianisa Ali Nafiah Nasution Aliyas Aliyas Alwi, Muhammad Khidri Alwiyah Alamsyah Andita Andreas Anjelina Atok Syihabuddin Basrin, Fitriani Bistari Budhi Ardani Camelia Casmudi Darmawati Darmawati Delviani Dewi, Andi Dewi Dr. Setinawati, M.T Een Kurnaesih Ekatni, Triana Elis Susanti Elmi Yuliani Ermi Girsang Ernawati Fatmah Afrianty Gobel Fauzan Febrianti, Ine Firly Fuji Pratiwi Galura Muhammad Suranegara Gladys Christiani Gst. Kade Adi Widyas Pranata Hafiyyan Haq, Arinal Helda Sapira Helina Apriyani Hestia Alika K Hwa, Lee Yong I Putu Suka Arsa Ichwan Indra Heri Rukmana Indra Syahputri Irfan Nasruddin, Irfan Ismanto Ismanto Isna, Nur Isnaini Jayanti, Meivina Kamil, Abdu Rahim Kartini H, Anita Lianda, Inge Cahaya Liena Mahmudah, Amirotul MH Mardiana Ng Mochammad Imron Awalludin Muh Yasir Muhammad Muhammad Nur Hadi Mutiara Niar Astaginy Novitasari, Silvi Indri Novitasari Nur Kartika Ramadhan Nursusanti, Ayut Nurul Pangalapan Tua, Pasaribu Satria Pangestu, Mustaqiim Pransiska, Flora Purnama, Shilmy Putra, Edy Yulianto Putri , Yulia Putri, Bella Isa rachman, aris Rafli Refa Lestari Reza Resita Riani, Shofia Rika Roslyn Rosdiah Rosros Rosdiantini Ruth Elisabeth Saputri, Citra Ayu Sari Serina Serina Serina Sihombing, Christina N. Silaban, Nataria Yanti Simon, Bernandus Louis Siti Muslihah Sri Mulyaningsih Sucipto Sucipto Sudirman Sudirman Sugeng Santoso Sukmandari Sulaiman Suliyah Sumarmi Sumarmi Syifaul Fuada Syofiyanti, Dessy Tamara, Rusdiana Tasya Rahmawati Tobing , Fenny BNL Tri Revita Sari Trisnawaty TRY APRIANI ATIEKA Umi Halimatun Sa’diyah Wardah Wayan Mahardika Prasetya Wiratama Wenny Pebrianti Wirren Chang Wisnu Yuwono WULANDARI Wulansari, Novia Yong Hwa , Lee Zahra Rizkya Fillah Zainal Zariul Antosa Zefri Maulana