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Optimasi Sifat Fisik Krim dengan Variasi Asam Stearat dan Trietanolamin dalam Pembuatan Basis Krim Amelia, Fazila; Amelia, Fitri
Periodic Vol 14, No 2 (2025): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v14i2.132857

Abstract

Cosmetics in cream form are more suitable. Stearic acid and triethanolamine are used as emulsifiers in making creams. The purpose of this study was to see the variation of stearic acid with triethanolamine that produces a stable cream against the physical properties of the cream preparation. The cream made was a cream with an oil-in-water (w/o) type with variations of stearic acid 5, 10, 15, 20%, and triethanolamine 2, 2.5, 3, 3.5, 4%. The heating temperature used was 400C. The cream preparation formed was evaluated through physical property testing including pH testing and Homogeneity testing and organoleptic testing. The results showed that the higher the concentration of stearic acid used, the pH of the cream decreased, but was still within the requirements of a good cream for the skin, as well as homogeneity, the higher the concentration of stearic acid, the more homogeneous the cream produced. Panelist organoleptic testing liked the color, odor and homogeneity of the 20% stearic acid variation, which was preferred by panelists. Based on the results obtained, it can be concluded that the concentration of the cream preparation with variations of stearic acid: triethanolamine 20%: 3.5% is the best preparation based on testing of physical and organoleptic properties.
Uji Antidiabetes pada Ekstrak Buah Alpukat (Persea americana) Menghambat α-Amylase secara in silico Sari, Lisa Permata; Amelia, Fitri
Periodic Vol 14, No 2 (2025): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v14i2.133024

Abstract

DM is a metabolic disorder characterized by chronic high blood glucose levels that can cause death. Long-term hyperglycemia can slowly cause retinopathy, heart and blood vessel disease, and neuropathy. Avocado is known to be used as an anti-diabetic because it contains saponin, alkaloid, steroid, phenol, tannin dan glikoside that are effective in lowering blood glucose levels. This study aims to test the potential for inhibition of the α-amylase enzyme using the molecular docking method. The study was conducted by utilizing a protein that has PDB ID 2QV4 to interact with active compounds in the ethanol extract of Avocado fruit. The results obtained were that the compounds procyanidin, vitexin, dan isoharment rhamnoside have good binding ability to α-amylase. Thus, these compounds have the potential as antidiabetics.
Uji Aktivitas Antikolesterol Chromolaena Odorata Secara In Silico dengan Sisi Penghambat HMG-CoA Reduktase Irma, Tri Wahyuni; Amelia, Fitri; Rahmayani, Sherly
Periodic Vol 14, No 2 (2025): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v14i2.132836

Abstract

Cholesterol is a disease caused by an unhealthy lifestyle. Cholesterol occurs because fat accumulates in blood vessels so that plaques form which causes blood vessels to narrow. With this problem in mind, this research was conducted to predict drug compounds capable of treating cholesterol disease by comparing them with simvastatin. Chromolaena odorata can be used as a medicinal plant that can treat cholesterol disease because this plant contains active compounds of flavonoids. This research tries to see the active interaction with HMG-CoA reductase inhibition in an improved way using Moe 2009.10 software. Based on the results of research that has been done based on the comparison of ∆G, compound O-Geranylvanillin, Avenestergenin B2, 5-O-Methylembelin, Kaempferol 3-[2’’-(6’’’-coumaroylglucosyl)- rhamnoside] 7-glucoside, ( ± )-Taxifolin, Hesperetin, ( ± )-Naringenin, Luteolin, 3′ ,4′ -Methylenedioxy epicatechin 5,7-dimethyl ether has the potential to be used as a candidate for anti-cholesterol drugs to replace simvastatin through the HMG-CoA reductase inhibition mechanism.
Studi In Silico pada Ekstrak Buah Andaliman (Zanthoxylum acanthopodium DC.) Menghambat α-Amylase sebagai Antidiabetes Rani, Rada; Amelia, Fitri; Rahmayani, Sherly
Periodic Vol 14, No 2 (2025): PERIODIC
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/periodic.v14i2.132859

Abstract

DM is a metabolic disorder characterized by chronic high blood glucose levels that can cause death. Long-term hyperglycemia can slowly cause retinopathy, heart and blood vessel disease, and neuropathy. Andaliman is known to be used as an anti-diabetic because it contains flavonoids, terpenes, and essential oils that are effective in lowering blood glucose levels. This study aims to test the potential for inhibition of the α-amylase enzyme using the molecular docking method. The study was conducted by utilizing a protein that has PDB ID 2QV4 to interact with active compounds in the ethanol extract of andaliman fruit. The results obtained were that the compounds astragalin, cyclocerine, coribulbine, Kaempferol-3-glucuronide, morin, mururin A, oroxin B, rhamnetin, and pyrocyanidin B7 have good binding ability to α-amylase. Thus, these compounds have the potential as antidiabetics.
Studi In Silico pada Ekstrak Daun Sirsak (Annona muricata Linn.) Menghambat α-Amylase dan α-Glukosidase sebagai Antidiabetes Ramadhani, Andini Novita; Amelia, Fitri; Rahmayani, Sherly
Jambura Journal of Chemistry Vol 7, No 2 (2025): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v7i2.24224

Abstract

Diabetes melitus (DM) merupakan kelainan metabolisme glukosa yang ditandai dengan gangguan sekresi dan resistensi insulin. Diabetes melitus tipe 2 (DMT2) dan komplikasinya merupakan penyakit tidak menular dengan angka kematian yang tinggi. Daun A. muricata dapat digunakan sebagai antidiabetes tipe 2. Daun sirsak mengandung senyawa aktif berupa senyawa alkaloid, karbohidrat, saponin, protein dan asam amino, fitosteroid, kumarin, quinon, minyak dan lemak, serta fenolik dan flavonoid yang dapat menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk menghambat α-Amylase dan α-Glukosidase. Untuk mengetahui aktivitas penghambatannya, dilakukan molekuler docking menggunakan protein dengan PDB ID : 3BAJ dan PDB ID : 5NN5 yang akan diinteraksikan dengan senyawa aktif yang terkandung dalam ekstrak metanol daun sirsak. Senyawa Octadecanoic acid dan Eicosanoic acid mempunyai afinitas pengikatan yang baik terhadap α-amilase. Sedangkan pada α-Glukosidase senyawa yang mempunyai afinitas pengikatan paling baik adalah n-Hexadecanoic acid. Senyawa asam n-Hexadecanoic acid berpotensi untuk dikembangkan sebagai antidiabetes.
Formulasi Dan Optimasi Basis Gel Karbopol 940 Dengan Variasi Lidah Buaya dan Trietanolamin (Tea) Ardita, Negi; Amelia, Fitri
Jurnal Pendidikan Tambusai Vol. 9 No. 2 (2025): Agustus
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i2.31232

Abstract

Zaman sekarang kosmetik lebih dari sekedar kebutuhan tambahan. Salah satu bentuk kosmetik yang paling umum digunakan adalah bentuk sediaan gel. Gel adalah sistem semipadat yang terdiri dari partikel anorganik kecil atau molekul organik besar yang terendam dalam cairan. Tujuan penelitian ini adalah untuk mengetahui formulasi gel yang stabil secara fisik. Penelitian ini diawali dengan optimasi basis gel karbopol 940 dengan variasi konsentrasi lidah buaya 1, 2, 3, 4 dan 5% dan trietanolamin (TEA) dengan konsentrasi 0.1, 0.2, 0.25, 0.5, 0.75 dan 1%. Selanjutnya evaluasi terhadap basis gel meliputi pengujian pH, uji daya sebar, uji daya lekat dan uji homogenitas. Hasil penelitian menunjukkan bahwa semua formulasi pada pengujian pH menunjukkan semakin tinggi TEA yang digunakan maka pH nya semakin tinggi. Pada Pengujian Sifat Fisik Gel meliputi daya sebar, daya lekat dan homogenitas pada konsentrasi TEA 0.1 dan 0.2% didapatkan sediaan gel yang memenuhi syarat sediian gel yang baik. Berdasarkan hasil penelitian dapat disimpulkan bahwa semua formulasi homogen, sifat kimia dan fisik gel yang terbaik adalah pada basis gel dengan variasi lidah buaya 4% dan TEA 0.1%.
Strategi Penetapan Harga Kebutuhan Pokok Toko Arafah Cirebon Dalam Konsep Ibnu Taimiyah Lubaba, Abu; amelia, fitri
Ecopreneur : Jurnal Ekonomi dan Bisnis Islam Vol. 4 No. 01 (2023): Ecopreneur : Jurnal Ekonomi dan Bisnis Islam
Publisher : Institute of Research and Community Service at Islamic University of Bunga Bangsa Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penetapan harga atau harga jual adalah sejumlah biaya yang dikerluarkan perusahaan untuk memproduksi suatu barang atau jasa ditambah dengan presentase laba yang diinginkan perusahaan. Harga yang tepat ialah harga yang sesuai dengan kualitas produk/barang dan harga tersebut dapat memberikan kepuasan kepada konsumen. Metode yang dipakai dalam penelitian ini adalah metode kualitatif, dengan desain penelitian studi kasus agar lebih mempermudah dalam pengambilan kesimpulan pada hasil penelitian. Penelitian ini menggunakan teknik wawancara dengan sumber data berasal dari hasil wawancara narasumber kepala Toko dan bagian keuangan. Penetapan harga Kebutuhan Pokok di Toko Arafah Cirebon, telah sesuai dengan konsep ekonomi Islam. Hal ini dikarenakan konsep penetapan harga telah dijalankan dengan baik, dimana dalam konsep Ekonomi Islam tidak ada pembatasan untuk meraih keuntungan , selagi tidak memberatkan pembeli dan dengan keadaan suka sama suka diantara keduanya. Kata Kunci : Penetapan Harga, Ekonomi Islam Abstract Pricing or selling price is a number of costs incurred by the company to produce a product or service plus the percentage of profit that the company wants. The right price is a price that is in accordance with the quality of the product/goods and that price can provide satisfaction to consumers. The method used in this research is a qualitative method, with a case study research design to make it easier to draw conclusions on the research results. This study uses interview techniques with data sources derived from interviews with the head of the store and the finance department. The pricing of basic necessities at the Arafah Store, Cirebon, is in accordance with the concept of Islamic economics. This is because the concept of pricing has been carried out well, where in the Islamic concept there are no restrictions on making profits, as long as it does not burden the buyer and is consensual between the two. Keywords : Pricing or selling, Islamic Economy
Analisis SiLPA Sebagai Alat Ukur Pengelolaan APBD pada Dinas Perindustrian dan Perdagangan Kabupaten Blitar Amelia, Fitri; Khoiriawati, Novi
Al-Muhasib: Journal of Islamic Accounting and Finance Vol. 2 No. 1 (2022)
Publisher : Department of Islamic Accounting, The Faculty of Islamic Economics and Business, State Islamic Institute of Kediri [IAIN Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30762/almuhasib.v2i1.141

Abstract

Funds and Budget Calculation Excess Remaining (SiLPA) is the difference in funding from the realization of the revenues and expenditures for one period. The existence of SILPA in a period indicates the excess remaining financing in that period. The objective of this research was to analyze the performance of APBD management and found out the causes of SILPA in the period 2016 – 2020. This research was carried out at the Department of Industry and Trade of Blitar Regency using descriptive qualitative methods. Data collection techniques were carried out by observation, interviews, and documentation. The results showed that the performance of APBD management was good and efficient. Meanwhile, the existence of SILPA was due to the efficiency of spending and exceeding income. Keywords : APBD, SiLPA
Enhancing Students’ Communication Skills through Project Based Learning in Chemistry Instruction at MAN 2 Bengkalis Aprilia Susilo, Resti; Amelia, Fitri; Yerimadesi, Yerimadesi; Noliea
The Future of Education Journal Vol 4 No 8 (2025)
Publisher : Lembaga Penerbitan dan Publikasi Ilmiah Yayasan Pendidikan Tumpuan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61445/tofedu.v4i8.1039

Abstract

This research aimed to enhance students’ communication skills in chemistry through the application of Project Based Learning (PjBL) at MAN 2 Bengkalis. The study utilized a Classroom Action Research (CAR) design following the Kemmis and McTaggart framework, which includes the stages of planning, acting, observing, and reflecting across three cycles. The participants were 24 eleventh-grade students in the 2024/2025 academic year. Data were gathered using observation sheets to evaluate communication abilities and post-tests to measure learning achievement. The findings demonstrated a steady increase in students’ communication performance, improving from 73% in Cycle I to 81% in Cycle II and reaching 86% in Cycle III. Progress was evident in four key areas: accuracy of responses, participation in group discussions, presentation quality, and teamwork. Additionally, students’ learning outcomes showed notable gains, with mastery levels increasing from 54% in the first cycle to 88% in the final cycle. These results suggest that implementing PjBL effectively fosters active engagement, improves collaboration, and strengthens students’ conceptual understanding of chemistry concepts. In general, the use of this model contributes to a more dynamic and meaningful classroom experience, supporting the cultivation of essential 21st-century competencies.
Peran Guru Penggerak dalam Meningkatkan Pemerataan Kualitas Kinerja Guru Lubis, Rahmat Rifai; Amelia, Fitri; Alvionita, Elvira; Nasution, Ismail Effendi; Lubis, Yulia Haliza
Jurnal At-Tadbir : Media Hukum dan Pendidikan Vol. 33 No. 1 (2023): Jurnal At-Tadbir: Media Hukum dan Pendidikan Volume 33 Nomor 1 Tahun 2023
Publisher : Institut KH Ahmad Sanusi (INKHAS) Sukabumi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52030/attadbir.v33i1.170

Abstract

Penelitian ini bertujuan untuk menganalisis peran guru penggerak dalam meningkatkan pemerataan kualitas kinerja guru di Sekolah Dasar Negeri 104267 Pegajahan. Fokus kajian pada penelitian ini yaitu pada peran guru penggerak di sekolah, faktor-faktor pendudukung guru penggerak di sekolah serta yang menjadi hambatan dalam peran guru penggerak di sekolah. Penelitian ini menganalisis upaya-upaya yang dilakukan oleh guru penggerak dalam meningkatkan pemerataan kualitas kinerja guru di Sekolah Negeri 104267 Pegajahan. Metode penelitian yang digunakan yaitu metode kualitatif dekskriptif. Teknik pengumpulan data yang dilakukan ialah observasi, wawancara dan sumber lain yang dianggap mampu mengembangkan penelitian. Data yang diperoleh kemudian diambil kesimpulan dari reduksi dan penampilan data. Hasil penelitian ini memaparkan bahwa usaha yang dilakukan guru penggerak dalam pemerataan kualitas kinerja guru di Sekolah Dasar Negeri 104267 Pegajahan bahwasanya peran aktif guru penggerak dalam pemerataan kinerja guru telah aktif dilaksanakan pada sekolah ini dan telah dilaksanakan dalam proses pembelajaran daring maupun luring. Dalam pelaksanaan ini guru harus berperan aktif dan wajib memiliki keahlian dalam ilmu teknologi (IT), adapun kendala yang dilami yaitu pada waktu yang terbatas sehingga menjadikan peran guru penggerak terbatas dan tidak leluasa melaksanakan perannya sebagai guru penggerak.
Co-Authors Abdul Aziz Hunaifi Adzam, Muhammad Afreni Hamidah Aini, Syamsi Al-latifatuzzahra, Siti Safira Alamsyah, Indra Fajar Allya Roosallyn Assyoffa Alvionita, Elvira Amelia, Fazila Aprilia Susilo, Resti Ardian Ayu Fitriana, Ardian Ayu Ardita, Negi Asrizal, A Bahrun, Muhammad Farhan Bakri Muhammad Bakhiet Cyntia Citra Maharani Desy Kurniawati Devi, Diana Dewi Chamidah Edi Nasra Era Nopera Rauzi Erna Irawan, Erna Eva Sulastri Sagita Fahmi Tsani Irsyadi, Fahmi Tsani Fikriyah, Khusnul Friyatmi Friyatmi Hary Sanjaya Heditama, Muhammad Raffi Hidayat, Basultan Honni Honni, Honni Ifan Rivaldo Irma, Tri Wahyuni Iryani Iryani Iryani UNP Iswendi iswendi Kiki Amelia, Kiki Latifah Latifah Latunreng, Wahyuddin Lubaba, Abu Lubis, Yulia Haliza Maida, Margarita Claudya Mairizwan, M Meri Maryati Mustakim Sagita Muswita Muswita Nahrin, Sari Nuralita Nanny Harmani Nasution, Ismail Effendi Ningsih, Lutfiyah Nizar, Umar Kalmar Noliea Novi Khoiriawati Nugroho, Rama Puji Nurzakiah, Hana Okatiranti O Parbuntari, Hesty Permana, Hara Permatasari, Dian Anggraheni Pernadi, Niza Lian Putra, Ananda Qomari, Nur Qurata’aini, Faizah Rahmasari, Alfina Ika Rahmayani, Sherly Ramadhani, Alya Ramadhani, Andini Novita Rani, Rada Ranny Rachmawati Rd. Dian Herdiana Utama, Rd. Dian Herdiana Rifai Lubis, Rahmat Rinata, Taufik Maulana Rizki, Suci Yulia Rosidah, Rina Saiman Saiman Sari, Lisa Permata Sheanny Ocmi Sakti Shofil Fikri Sidiq, Aqil Marsya Siti Fatimah Soemadi, Rr Anggraini Subarkah, Imam Sulistianingsih Suryani, Fajar Suryani, Okta Syafari, Nofiana Tiana Pustaka, Tiana Wulandari, elysa Yerimadesi Yohandri, Y Yuliana Seputraningrum, Yuliana Yulistari, Riska Yusmaita, Eka Zulfarazi Zunaidah, Farida Nurlaila