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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa VALENSI Jurnal Veteriner Jurnal MIPA Biologi Edukasi : Jurnal Ilmiah Pendidikan Biologi Jurnal Ilmu-Ilmu Peternakan (Indonesian Journal of Animal Science) Jurnal Peternakan Indonesia Proceeding International Conference on Global Resource Conservation JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Jurnal Ilmu Produksi dan Teknologi Hasil Peternakan BERITA BIOLOGI Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Bioma : Jurnal Biologi Indonesia ARSHI Veterinary Letters Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas ADPI Sains dan Teknologi Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine
A.S. Satyaningtijas
IPB University, Bogor
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Veterinary Other

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Journal : Jurnal MIPA

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Nilai Indeks Aterogenik Plasma (IAP) Dan Indeks Castelli (IC) Mencit Model yang Diinduksi Minyak Trans Supiyani, Atin; Sukmawati, Dalia; Kusumorini, Nastiti; Santoso, Koekoeh; Satyaningtijas, Aryani Sismin
Jurnal MIPA Vol 10, No 2 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jmuo.10.2.2021.34094

Abstract

dikembangkan melalui pendekatan hewan model untuk mempelajari tentang PJK. Minyak goreng yang digunakan secara berulang dapat meningkatkan kadar asam lemak bebas yang berdampak negatif bagi kesehatan terutama jantung dan pembuluh. Tujuan dari penelitian ini mengukur indeks aterogenik plasma (IAP) dan indeks Castelli (IC) dari mencit model yang diinduksi minyak trans (MT). Sebanyak 16 ekor mencit galur DDY dibagi menjadi 4 kelompok yaitu mencit yang diinduksi 20% minyak trans (MT20), 40% minyak trans (MT40) dan 60% minyak trans (MT60) dan kontrol (K). Persentase minyak trans diberikan berdasarkan dari total energi konsumsi pakan harian. Minyak trans diberikan per oral sehari sekali selama 70 hari. Darah diambil pada hari ke-70 dari vena lateral ekor tikus untuk mengukur profil lipid plasma yaitu kolesterol total, trigliserida (TG), High Density Lippoprotein (HDL) dan Low Density Lipoprotein (LDL) plasma  menggunakan alat uji cepat Lipid Pro®. Nilai Indeks Aterogenik Plasma (IAP) yaitu log (TG/HDL) dan Indeks Castelli (IC) yaitu LDL/HDL. Hasil pengkuran profil lipid plasma menunjukkan kolesterol total, trigliserida, HDL dan LDL plasma pada kelompok MT meningkat secara nyata dibandingkan kontrol (sig<0,05). Nilai IA pada mencit yang diberi minyak trans berbeda nyata dari kontrol (sig<0,05) dan memiliki risiko tinggi. Nilai IC pada mencit yang diberi minyak trans berbeda nyata dari kontrol (sig<0,05) dan memiliki risiko sedang-tinggi. Minyak trans meningkatkan nilai indeks aterosklerosis dan indeks resiko koroner mencit.Coronary Heart Disease (CHD) is a "silent killer" disease. Various studies were developed through an animal model approach to studying CHD. Cooking oil that is used repeatedly can increase levels of free fatty acids which have a negative impact on health, especially the heart and vessels. The aim of this study was to measure the plasma atherogenic index (IAP) and Castelli index (IC) of trans oil-induced model mice (MT). A total of 16 DDY mice were divided into 4 groups, namely mice induced with 20% trans oil (MT20), 40% trans oil (MT40) and 60% trans oil (MT60) and control (K). The percentage of trans oil is given based on the total energy consumption of the daily feed. Trans oil is given orally once a day for 70 days. Blood was taken on the 70th day from the lateral vein of the rat tail to measure the plasma lipid profile, namely total cholesterol, triglycerides (TG), High Density Lippoprotein (HDL) and plasma Low Density Lipoprotein (LDL) using the Lipid Pro® rapid test kit. The Plasma Atherogenic Index (IAP) values are log (TG / HDL) and the Castelli Index (IC) is LDL / HDL. The results of measuring the plasma lipid profile showed that plasma total cholesterol, triglycerides, HDL and LDL in the MT group increased significantly compared to the control (sig<0,05). The IA value in mice treated with trans oil was significantly different from the control (sig<0.05) and had a high risk. The IC value in mice treated with trans oil was significantly different from the control (sig<0.05) and had a medium-high risk. Trans oil increased the atherosclerosis index and coronary risk index of mice.
Co-Authors . andriyanto A. Suprayogi A. Wijaya Abadi Sutisna Abadi Sutisna Achmad Dinoto Achmad Dinoto Adam Kustiadi Nugraha Adi Winarto Adisti Dwijayanti Adkhilni Utami Adrien Jems Akiles Unitly Adrien Jems Akiles Unitly, Adrien Afnan, R. Agik Suprayogi Agus Wijaya Ahmad Tjahja Nugraha, Ahmad Tjahja Ainul Khadija Saleema Alif Iman Fitrianto Alvina Gitacahyani Ardiana Amani, Aqila Zata Andayani, Prawita Lintang Andhika Yudha Prawira Andhika Yudha Prawira Andriyanto Andriyanto Andriyanto Andriyanto Anisa Rahma, Anisa Ardiansyah Nurdin Arief Boediono Arif Darmawan Armando Ramadhoni Athirah Rerana Fitrianthy Aulia Andri Mustika Baehaqi Bambang Kiranadi Bambang Kiranadi Bambang Kiranadi D. R. Ekastuti Dalia Sukmawati Damhuri Damhuri Damiana Rita Ekastuti Danang Dwi Cahyadi David Anwar Dede Sukandar Desrayni Hanadhita Desrayni Hanadhita Desrayni Hanadhita Desrayni Hanadhita Desrayni Hanadhita Dewi Prabuwati Dewi Ratih Agungpriyono Dewi, Fitriana Dirwan Rahman Divo Jondriatno Divo Jondriatno Dwi Nurhidayah Zubaidah Elok Budi Retnani Epi Taufik Eva Harlina Evalina E Evalina E, Evalina F. B. Harlimawan Fitriana Dewi Frans Dhyanagiri Suyatna Gandasari, Ira Agustina Dewi Gilang Kala Maulana, Gilang Kala Hadiyanti, Cresensia Rara Hanadhita, Desrayni HERA MAHESHWARI Hernomoadi Huminto Heru Setijanto Huda Salahuddin Darusman Huda Shalahudin Darusman I wayan Teguh Wibawan IETJE WIENTARSIH Ika Amalia, Ika Indra Bachtiar Irfan Nurhidayat, Irfan Irwan Oktoni Isdoni Bustaman Jefri Naldi Joko Pamungkas Julianto . Jumadin, La Kelvin Yaprianto Ketut Adnyane Mudite Khoirun Nisa koekoeh santoso Kusdiantoro Mohamad La Jumadin La Jumadin La Ode Sumarlin Lili Darlian Lili Darlian Lina Novianti Sutardi Madyastuti, Rini Maharani Salsabila Mahendra, Arindina Maheshwari2, Hera Maneewong, Sattabongkoch Maryce Agusthinus Walukou Mawali, Maharja Meta Levi Kurnia Moh. Mursyid Fachrudin Mokhamad Fakhrul Ulum, Mokhamad MUHAMMAD ADIB MUSTOFA Muhammad Ardiansyah Nurdin Muhammad Zhaahir MULYATI EFFENDI N. Kusumorini Nadelia, Nurul Nastiti Kusumorini NASTITI KUSUMORINI Nastiti Kusumorini NASTITI KUSUMORINI Natalia, Ratna Delima Niken Ulupi Nugroho, Radhitya Aryo Nur Isnaini Ulfa Nurul Masyita, Nurul Ong Huey, Lynette P. Achmadi Parwati, E. D. Pudji Achmadi Purnomo . Putri, Fatimatus Sa’diyah Putri, Maritrana R. Tarigan Raden Yufiandri Rahma Anisa Rahma, Kinanti Dwi Rahmadhani, Elsi Rahminiwati, Min Ramadhoni, Armando Ratna Delima Natalia Regina Wulandari Resti Rahma Dianti Rita Dwi Rahayu Rita Dwi Rahayu Ronald Tarigan Rudi Afnan Sandra Hapsari Sandra Hapsari Santa Nova A Siburi Santoso, Hera Satriawan, Ivan Satvika, Fadhila Savitri Novelina Sa’diah, Siti Sri Estuningsih Srihadi Agungpriyono Suci, Yulia Sulistyana, Yanti Supiyani, Atin Supratikno . Sus Derthi Widhyari Sus Dherti Widhyari Tarigan, Ronald Thol’at Hamdi Trioso Purnawarman Ulupi, N. Umi Cahyaningsih Vinda Mulyetti Darwin W. Manalu Wahono Esthi Prasetyaningtyas Warysatul Ummah Wasmen Manalu Widhyari, Sus Dherti Wining Astini Wisnugroho Agung Pribadi Wisnugroho Agung Pribadi YENI KEZIA BEKALANI Yulia Suci Yulia Suci Rahmadani Yulvian Sani Zora, Nelda Fliza Zulvia Maika