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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Medula Juke Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kedokteran Ibnu Nafis Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran JOURNAL OF Qualitative Health Research & Case Studies Reports Health & Medical Sciences Jurnal Ilmu Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine Essentia: Journal of Medical Practice and Research
Indri Windarti
Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medula

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The ROLE OF OBESITY IN BREAST CANCER METASTASIS Fadila Gustiani Daraz; Indri Windarti; Putu Ristyaning Ayu Sangging
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.562

Abstract

Breast cancer is the most common type of cancer in women worldwide. One of the factors that are believed to have a role in the development and growth of breast cancer is nutritional status which can be associated with the body mass index of adult patients. It is estimated that overweight and obesity are risk factors for the spread of breast cancer to distant metastases. Mechanism of spread through two ways, estrogen and leptin. Aromatase is an enzyme in estrogen biosynthesis that promotes tumor growth through its expression in breast adipose stromal cells. Meanwhile, leptin is produced by adipocytes. Adipocytes that experience hypertrophy and hyperplasia cause pathophysiological changes that affect the development of breast cancer. Various case studies show that a diet high in fat and calories is associated with breast cancer. The high risk of obesity for breast cancer metastases. This is important to be studied further because of the large number of cases of breast cancer both globally, in Indonesia and in Lampung. This review article is important to know the relationship between obesity and breast cancer metastases, as scientific information and knowledge, and can be used as material for dietary intervention in obese breast cancer patients.
Anemia pada Pasien Tuberkulosis Inna Kurniaji; Waluyo Rudiyanto; Indri Windarti
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.592

Abstract

Tuberculosis (TB) is one of the most common causes of health problems in the world. The prevalence of TB in the world is estimated at 10.6 million, and 1.6 million of them died from TB, in Indonesia the incidence of TB reached 503,712. Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, which is known to cause complex hematological disorders. The hematopoietic system is thought to be affected during TB infection, so that Hb levels tend to decrease along with bacterial increase, which eventually causes anemia. The article aims to determine the incidence of anemia in TB patients and the mechanism of anemia in TB patients. Based on the results of a literature review conducted on references found from 2012–2022, it shows that anemia is a common condition in TB. The mechanism that causes anemia in TB patients is due to its pathogenesis as a chronic inflammatory disease. Anemia is an indicator in providing clues to diagnosis, prognosis, complications and response to TB therapy. Nutritional intake and adherence to TB therapy need to be done properly to prevent the development of severe disease and improve the patient's quality of life.
Ekstrak Lidah Buaya (Aloe Vera) Menurunan Kadar Glukosa Darah Tikus Putih (Rattus Norvegicus) Yang Diinduksi Streptozotocin Marzel, Rivaldi; Darwis, Iswandi; Windarti, Indri
Medula Vol 13 No 7 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i7.857

Abstract

Diabetes mellitus (DM) is a chronic disorder in the metabolism of protein, fat and carbohydrates. Diabetes mellitus is described as an increase in blood glucose. DM cases in Indonesia rapidly increases. Diabetes mellitus  is a disease that requires anti-diabetes drugs continuously. Continuous use will have side effects that  encourages patients to look for alternative treatments that are cheaper, efficacious, without side effects, and easy to obtain such as herbal medicines. Many medicinal plants around the world contain antihyperglycemic compounds, such as Aloe vera.This is study experimental study using a randomized controlled design method with Post-test only Control Group Design. There were 24 rats consist of 4 treatment groups (K1, K2, K3, K4). (K1) = rats  were given by a standard diet. K2 = rats induced streptozotocin 40 mg/kgBW.K3 = rats were treated with metformin. K4 = rats were treated with Aloe vera extract 250 mg/kg BW. After 21st day,  blood glucose levels were measured. The research was conducted at the animal house of the Faculty of Medicine, University of Lampung. Samples were analyzed using the one way Annova test. Blood glucose levels of the 4 treatment groups were K1 = 67.16 mg/dl, K2 = 366.33 mg/ dl, K3 = 77.83 mg/dl, K4 = 127.16 mg /dl. The blood glucose level in the control and treatment groups were significantly different (p<0,05).  Aloe vera extract ameliorates blood glucose levels of streptozotocin-induced diabetes in white rats (Rattus norvegicus).
Surgical Site Infection Lubis, Aisyah; Wintoko, Risal; Ismunandar, Helmi; Windarti, Indri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.956

Abstract

Surgical site infection (SSI) is a fairly common complication that can arise after surgery, both minor surgical procedures and more complex surgical procedures. This infection can occur due to the entry of pathogenic microorganisms into the surgical wound, causing an inflammatory reaction. This infection can prolong recovery time, increase mortality, require additional medical intervention, and affect the patient's quality of life. This impacts patient clinical outcomes as well as additional care costs. Factors such as surgical technique, cleanliness of the operating environment, use of implants, and the patient's health condition can influence and also contribute to increasing the risk of infection. Symptoms of surgical site infection include pain, swelling, redness, or the presence of pus in the surgical wound. When this infection occurs, immediate medical action is needed to prevent the spread of infection which can cause advanced conditions such as sepsis. Prevention of surgical site infections involves sterile measures before and during surgical procedures, the use of prophylactic antibiotics, and thorough post-operative monitoring. These efforts aim to reduce the risk of surgical site infections, ensure optimal recovery, and improve the overall results of the surgical procedure. An in-depth understanding of the risk factors and prevention of surgical site infections can help medical personnel provide quality care and ensure the success of the operation. There is also the importance of early detection and treatment of infections in patients undergoing surgery.
Anatomi dan Fisiologi Ginjal: Tinjauan Pustaka Alwiyah, Fadilah; Rudiyanto, Waluyo; Anggraini, Dwi Indria; Windarti, Indri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.977

Abstract

The kidneys are retroperitoneal organs located at the top on both sides of the III lumbar vertebra and attached directly to the abdominal or ventral wall of the M. psoas major and M. quadratus lumborum. The kidneys function to regulate the amount and concentration of ECF electrolytes and maintain nerve and muscle excitability, activating vitamin D which is important for calcium absorption in the digestive tract and producing erythropoietin which is a hormone to stimulate the bone marrow to form red blood cells. The main function of the kidneys is to filter and excrete metabolic waste products in the urine so that administration of toxic compounds or irritating compounds can cause degenerative changes such as fatty degeneration to necrosis of the kidneys. Disorders of the kidneys can disrupt kidney function. Chronic Kidney Disease (CKD) sufferers have several complications such as overhydration, hyperkalemia, metabolic acidosis, mineral and bone disorders, hypertension, anemia and dyslipidemia. The most common etiologies of CKD in adult patients are diabetes mellitus and hypertension. In children, the most common primary cause of PGTA is congenital abnormalities of the kidneys and urinary tract (such as obstructive uropathy, vesicoureteral reflux, renal dysplasia). Indonesian Nephrology Association (PERNEFRI) in 2006, which found that the prevalence of Chronic Kidney Disease (CKD) was 12.5%. Meanwhile, data according to the 2019 Health Insurance Administration (BPJS) shows that there were 1.93 million cases of kidney failure and 1.79 million cases in 2020. With this data, the author is interested in discussing the kidneys in more depth.
Pengaruh Ekstrak Bawang Putih (Allium Sativum) Terhadap Kadar Glukosa Darah Dan Gambaran Histopatologi Pankreas Pada Tikus Putih (Rattus Norvegicus) Galur Sprague-Dawley Yang Diinduksi Streptozotocin Cyntithia, L. Gita; Windarti, Indri; Soleha, Tri Umiana
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1138

Abstract

Diabetes mellitus (DM) is one of the highest causes of death in the world whose prevalence increases every year, DM is characterized by elevated blood glucose levels and damage of the pancreas. Streptozotocin is a drug used to induce diabetes mellitus in experimental animals, single high dose administration can cause type 1 DM. Garlic has various component that have the potential as antidiabetic, anti-inflammatory and antioxidant. This study aim to determine the effect of garlic extract (Allium sativum) on blood glucose levels and pancreas histopathological images in white rats (Rattus norvegicus) Sprague-Dawley strain induced by streptozotocin. This research is an experimental study with a post test only control group design. This study used 24 rats and divided into 4 group, K- (normal group), K+ (STZ 60 mg/kgBB), P1 (STZ + garlic extract 500 mg/kgbb), P2 (STZ + garlic extract 750mg/kgBB). Blood glucose levels were assessed with a glucometer and the histopathological images of the pancreas was assessed by counting the number and size of the langerhans islet. The mean blood glucose levels for each group were K- = 73.3mg/dL, K+ = 400 mg/dL, P1=203.8 mg/dL, and P2=132.3 mg/dL. One Way ANOVA test obtained p value = 0.000. The mean number of langerhans islet in 10 fields of view obtained K- = 26.1; K+ = 4.6; P1= 7.8; P2=15.1. One Way ANOVA test obtained p = 0.000. The mean area of ​​the langerhans islet in each group obtained K- = 19092.4 µm2; K+ = 4759.3 µm2; P1=8561,4 µm2; P2=9621.8 µm2. Kruskal-Wallis test obtained p = 0.000 (p <0.05). There is an effect of garlic extract (Allium sativum) on blood glucose levels and pancreas histopathological images in white rats (Rattus norvegicus) Sprague-Dawley strain induced by streptozotocin.
PENGARUH EKSTRAK BAWANG PUTIH (Alium sativum) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR PADA TIKUS PUTIH (Rattus norvegicus) GALUR Sprague- dawley YANG DIINDUKSI STREPTOZOTOCIN Fadly, Ahmad Aulia; Windarti, Indri; Hanriko, Rizki
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1154

Abstract

Diabetes Mellitus (DM) is a chronic disease characterized by blood sugar levels that exceed normal limits. Chronic DM can cause liver complications in the form of inflammation. Streptozotocin can induce mice to become a DM model and can also directly damage the liver. Garlic (Allium sativum) is a tuber that is often found in Indonesia. The various compounds contained in it have anti-diabetic and antioxidant effects which have the potential to prevent inflammation in the liver. This research was conducted to determine the effect of garlic extract (Allium sativum) on histopathological features in the form of lymphocyte cell infiltration in the portal and lobular tracts of the liver in white rats (Rattus norvegicus) of the Sprague-dawley strain induced by streptozotocin. The method used was a randomized controlled design with a pre-clinical Post-test Only Control Group Design pattern. This study used 24 mice divided into 4 groups with 6 mice in each group. The appearance of lymphocyte cell infiltration will be assessed based on the Omenetti scoring. The mean scores for lymphocyte cell infiltration in the portal tract obtained were KN=0.22, K+=2.10, P1=0.60, and P2=0.56. From the analysis using the One-Way ANOVA test followed by the Post Hoc Benferroni test, the results showed a significant difference in scores between K+ and P1 and P2. Meanwhile, the mean scores for lymphocyte cell infiltration in the lobular area obtained were KN=0.50, K+=1.16, P1=0.50, and P2=0.33. From the analysis using the Kruskal-Wallis test, no significant differences in scores were found between all groups. There was an effect of garlic extract (Allium sativum) on the infiltration of lymphocyte cells in the portal tract and no effect was found on the lobular area of ​​the liver in white rats (Rattus norvegicus) of the Sprague-dawley strain which were induced by streptozotocin.
Characteristics of Thyroid Carcinoma Patients at Dr. H. Abdul Moeloek Hospital for the Period of January 2023 – August 2024 Qurani, Istiqomatul; Septiani, Linda; Kurniati, Intanri; Windarti, Indri
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1333

Abstract

Thyroid carcinoma is the most common cancer found in the endocrine system that arises from thyroid parenchymal cells.  Its prevalence has increased over the past few decades with a mortality rate of 0.5% per 100,000 cases. The incidence of thyroid carcinoma in 2020 ranks 7th in the world as the 9th most frequent incidence occurs from all types of cancer. Objective: This study aims to determine the characteristics of thyroid carcinoma patients at Dr. H. Abdul Moeloek Regional General Hospital for the period of January 2023 – August 2024. Method: This study used a descriptive observational design and Total Sampling technique with a data source in the form of secondary data on medical records from 82 thyroid carcinoma patients at the Dr. H. Abdul Moeloek Regional General Hospital for the period January 2023 to August 2024.  Results: In this study, thyroid carcinoma patients were mostly female, with an age group in the range of 41-60 years. The most common type of thyroid carcinoma is papillary carcinoma and the least common type is anaplastic carcinoma. Conclusion: In this study, the characteristics of thyroid carcinoma patients were obtained based on gender, age group, and type of histopathological diagnosis.
Profile of Melanoma and Non-Melanoma Skin Cancer based on Histopathology Results Zulfa, Fathimah; Windarti, Indri; Sutarto; Carolia, Novita
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1342

Abstract

Skin cancer is an abnormal condition in the structure of the skin that arises because the skin loses the ability to regenerate periodically. Skin cancer is high risk in people who live in tropical countries such as Indonesia. All provinces in Indonesia receive evenly distributed sunlight including Lampung province. Lampung Province is an agricultural province with the dominance of the population working in agriculture and marine sectors. Agriculture and marine sectors workers get continuous and long-term exposure to UV rays so that they are at high risk of skin disorders, one of them is skin cancer. This study was conducted in August-December 2024 in the medical record from Dr. H. Abdul Moeloek Hospital Bandar Lampung. This study was observational and was conducted by collecting data and univariate analysis on medical record data of skin cancer patients including the type of skin cancer, age, gender ], and location of tumor growth of skin cancer patients. The results showed that the most common type of skin cancer diagnosed at Dr. H. Abdul Moeloek Bandar Lampung Hospital in the 2019-2024 period was non-melanoma skin cancer (squamous cell carcinoma followed by basal cell carcinoma). The most common age of skin cancer patients is ≥40 years old, female and the location of tumor growth is mostly in the head and neck area.
Article Review: Risk of Lung Cancer in Patients with History of Pulmonary Tuberculosis and Chronic Obstructive Pulmonary Disease (COPD) Wahdah, Annisa Shohifatul; Windarti, Indri; Setyaningrum, Endah; Sukohar, Asep
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1344

Abstract

Kanker paru merupakan salah satu penyebab utama kematian akibat kanker di dunia, dengan angka kejadian yang sangat tinggi. Di Indonesia, kanker paru menduduki peringkat kedua setelah kanker payudara dengan jumlah kasus mencapai 38.904 pada tahun 2022. Penyakit ini lebih sering terjadi pada laki-laki dibandingkan perempuan. Berbagai faktor risiko berkontribusi terhadap kejadian kanker paru, termasuk kebiasaan merokok, paparan polusi udara, paparan radon, faktor genetik, serta riwayat penyakit paru seperti tuberculosis (TB) paru dan penyakit paru obstruktif kronik (PPOK). Tuberculosis paru adalah penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis dan masih menjadi masalah kesehatan utama di Indonesia, dengan lebih dari satu juta kasus pada tahun 2023. Infeksi TB dapat menyebabkan inflamasi kronik yang mengarah pada fibrosis jaringan paru, yang dapat meningkatkan risiko kanker paru. Inflamasi kronik ini juga memicu peningkatan Reactive Oxygen Species (ROS) dan sitokin proinflamasi, yang dapat menyebabkan kerusakan DNA serta memicu mutasi genetik yang berkontribusi terhadap karsinogenesis. PPOK, di sisi lain, merupakan penyakit tidak menular yang umumnya dikaitkan dengan paparan asap rokok dalam jangka panjang. PPOK ditandai dengan inflamasi kronik pada saluran napas yang menyebabkan penyempitan dan kerusakan alveoli secara ireversibel. Proses inflamasi ini melibatkan pelepasan berbagai mediator inflamasi seperti TNF-α, IL-6, dan IL-8, yang dapat memicu stress oksidatif dan mempercepat proses epithelial-mesenchymal transition (EMT), suatu mekanisme penting dalam perkembangan kanker paru. Hubungan erat antara TB paru, PPOK, dan kanker paru menunjukkan bahwa kedua penyakit paru ini bukan hanya sekadar faktor risiko, tetapi juga berkontribusi secara langsung dalam proses karsinogenesis melalui mekanisme inflamasi, fibrosis, dan mutasi genetik. Oleh karena itu, deteksi dini dan penanganan yang tepat terhadap TB paru dan PPOK dapat menjadi strategi penting dalam pencegahan kanker paru.
Co-Authors - Muhartono Agustyas Tjiptaningrum Aisyah Lubis, Aisyah Ajipurnomo, Adhari Alwiyah, Fadilah Amalia, Salsabila Ambarwati, Yuli ananti, anggini tasyakurillah Andreas Infianto Apri Lyanda Asep Sukohar Ayu Tiara FItri Bayu Putra Danan Jaya, Bayu Putra Danan Bayu Putra DJ Cyntithia, L. Gita Danan Jaya, Bayu Putra Devya Aulia Dewi Nur Fiana Diah Septia Liantari, Diah Septia Dwi Indria Anggraini Ekawati, Diyan Endah Setyaningrum, Endah Endang SR Hardjolukito Ety Apriliana Exsa Hadibrata Fadila Gustiani Daraz Fadly, Ahmad Aulia Fala, Arzety Rifda Firdaus, Elman Dani Fitria Saftarina Gatot Sudiro Hendarto, Gatot Sudiro Hadibrata, Exsa Haikal Shiddiq Ham, Maria Francisca Hana Muthi'a Putri Hanna Mutiara, Hanna Helmi Ismunandar Hendri Busman Hendri Tarigan S I Gede Eka Widayana Infianto, Andreas Inna Kurniaji Intanri Kurniati Iswandi Darwis Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Joni, Agnesia Priskila Khairun Nisa Kusumajati, Pusparini Kusumaningtyas, Aditya Laisa Azka Liana Sidharti M. Aqmal Hidayah Marzel, Rivaldi Mayasari, Diana Mubarak, Raka Anzil Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Muhartono Sudarmo Kasban Novita Carolia Nur Irawati Nurmayeni Nurmayeni Nurmayeni Nurul Islamy Oktadoni Saputra Qurani, Istiqomatul rahmawati, selvi Rajagukguk, Nanda Frisila Ramadhana Komala Rasmi Zakiah Oktarlina Ratna, Maya Ganda Reni Zuraida Resti Arania Rian Hendriyana Dwi Imanta Rika Lisiswati Risal Wintoko Risti Graharti Rizki Hanriko Rodiani, Rodiani Rosbhaiti Chodijah Rudiyanto, Waluyo Sangging, Putu Ristyaning Ayu Septiani, Linda Setiorini, Anggi Sezia Marina Sinaga, Fransisca T.Y. Siregar, Bintang Abadi Soemarwoto, Retno Ariza S Suryadi Islami Susianti Susianti Susianti Susianti, Susianti Sutarto Sutarto Sutarto Sutarto SYAIFUL BAHRI Syazili Mustofa Talin, Jinan Naura Tri Umiana Soleha Tubagus Djumhana Atmakusuma Wahdah, Annisa Shohifatul Waluyo Rudiyanto Wardani, Nanda Fitri Wulan, Anggraini Janar Wulyo Rajabto Yolanda Fratiwi Yunianto, Andi Eka Zulfa, Fathimah