p-Index From 2020 - 2025
9.992
P-Index
This Author published in this journals
All Journal International Journal of Evaluation and Research in Education (IJERE) HAYATI Journal of Biosciences Jurnal Pangan dan Gizi Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences SAINSMAT Jurnal Nalar Pendidikan Jurnal Pendidikan Sains Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Pendidikan Indonesia Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Journal of Education and Learning (EduLearn) Pharmaciana: Jurnal Kefarmasian Biogenesis: Jurnal Ilmiah Biologi Jurnal Online Mahasiswa (JOM) Bidang Ilmu Ekonomi Jurnal Online Mahasiswa (JOM) Bidang Ilmu Keperawatan Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Biotropika Biomedical Engineering AGRIVITA, Journal of Agricultural Science Jurnal Pendidikan Biologi Indonesia Mutiara Medika: Jurnal Kedokteran dan Kesehatan Bioeksperimen: Jurnal Penelitian Biologi Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Majalah Lontar Jurnal Pendidikan Biologi Science and Technology Indonesia International Journal of Applied Biology Universa Medicina Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Akademika Kimia BIOEDUKASI Biosaintifika: Journal of Biology & Biology Education Berdikari: Jurnal Pengabdian Masyarakat Indonesia Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Lectura : Jurnal Pendidikan Amerta Nutrition AL-HAYAT: Journal of Biology and Applied Biology JPBIO (Jurnal Pendidikan Biologi) Scripta Biologica Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Jurnal Karinov El-Umdah Maternal Child Health Care Journal JURNAL GIZI DAN KESEHATAN JPP (Jurnal Pendidikan dan Pembelajaran) Journal of Community Service and Empowerment Window of Public Health Journal Bioscientist : Jurnal Ilmiah Biologi JIPB (Jurnal Inovasi Pembelajaran Biologi) Jurnal Studi Islam Lintas Negara (Journal of Cross-Border Islamic Studies) Proceeding Biology Education Conference Berkala Penelitian Hayati Jurnal Pijar MIPA Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Al-Hijr: Journal of Adulearn World Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Journal of Accounting and Finance Management (JAFM) SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam ALSYS : Jurnal Keislaman dan Ilmu Pendidikan Acta Pedagogia Asiana Jurnal Kedokteran Hewan Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) Molekul: Jurnal Ilmiah Kimia Berkala Ilmiah Biologi Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Jurnal Ilmu Hayat Madrasah Ibtidaiyah Research Journal Jurnal Pemikiran dan Pengembangan Pembelajaran Prosiding Dedikasi: Pengabdian Mahasiswa Kepada Masyarakat Jurnal Info Kesehatan
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Science and Technology Indonesia

Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells Dewi Sekar Miasih; Yuslinda Annisa; Sri Rahayu Lestari; Hendra Susanto; Sunaryono
Science and Technology Indonesia Vol. 7 No. 4 (2022): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1699.595 KB) | DOI: 10.26554/sti.2022.7.4.417-426

Abstract

Single bulb garlic (SBG) has the potential as an immunomodulator; however, it has low solubility and bioavailability. A lipid-based delivery system, that is, the self-nanoemulsifying drug delivery system (SNEDDS), offers a novel opportunity in drug delivery. SBG can be a suitable candidate for SNEDDS development. This research aims to describe the physical stability, toxicity test of the SNEDDS, and SNEDDS SBG potential as antiinflammation in 3T3-L1 cells. The SNEDDS is made with various ratios of concentrations of carrier oil, surfactants, and cosurfactants, namely, 0.50: 3.45: 0.96, and added with SBG extract (SBGE) of 20 mg/mL. The results of the response test of SNEDDS SBGE formulation indicate an average and standard deviation of emulsification time of 16.38±3.01 (second), pH 7.21±0.08, and transmittance of 98.40±0.23(%). The average nanoemulsion size is 14.333±0.416 nm, polydispersion index of 0.213±0.056, and zeta potential of -14.67±0.72 mV. The results of the physical stability test indicate no segregation, deposition, cracking, or creaming in all nanoemulsion samples and SNEDDS SBG. The MTT test in a dose of 62.5, 125, 250, 500, 100, 2000, and 4000 µg/mL suggests that the highest viability of the 3T3-L1 cells is at a dose of 2000 µg/mL, which is 97.83%±1.55%. Therefore, SNEDDS SBGE can be a potential candidate for oral preparation by increasing bioavailability and reducing toxicity in the 3T3-L1 cells. An antiinflammatory test on the TNF-???? and IL-1???? expressions influences the 3T3-L1 cells. the SNEDDS of SBGE has the potential to reduce the expression of TNF-???? and IL-1???? and increase IL-10 expression in the methylglyoxal-induced 3T3-L1 cells.
Co-Authors A. Irma Suryani Abdul Ghofur Abdul Ghofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Ade Wahyu Pratama Agnesa, Oki Sandra Agung Witjoro Agus Dharmawan Agus Muliadi Agustina Gubali Agustini, Ferina Ahmad Rudijanto Aisyah, Dahniar Nur Ajeng Daniarsih Ajeng Radhita Putri Azella Al Azhar A Alif Rofiqotun Nurul Alimah Alif Rosyidah El Baroroh Alwan Mahsul Amalia Nur Rahma Amy Tenzer Andi Esse Jumriani Andi Nurlinda Andi Rahmat Saleh Anggraini, Atika Anggraini, Lilik Anisah Mahmudah Anisya Purnamasari Annisa, Yuslinda Arindra Nirbaya Atho'illah, Mochammad Fitri Athoillah, M. Fitri Atik Kurniawati Atik Kurniawati, Atik Atika - Anggraini Atika Anggraini Atika Anggraini Aulia, Azra Azmi, Shafly Badriyatur Rahma Fidiya Bagus Priambodo Baroroh, Alif Rosyidah El Betty Lukiati Chasanah, Isfatun Chasanah, Isfatun Dahniar Nur Aisyah Daradjatul Aulia Deny Setiawan Dev Anand, Dev Dewi Murni Dewi Murni Dewi Sekar Miasih Dewi Sekar Miasih Dewi, Putri Elok Septiana Dianatur Raviqah Dimas Nur Ramadhani Dina Maulina Dina Maulina Dini Wijayanti Dio Rizki Nadar Putra Dita Purwinda Anggrella Djoa, Dominikus Djago Dyah Ayu Eka Fitriana Eka Pratama Putri Eka Pratama Putri Eko Sri Sulasmi El Baroroh, Alif Rosyidah Endang Suarsini Eri Wiharni Eva Kristinawati Putri Farid, Ulfa Maulida fatchiyah . Fatchiyah Fatchiyah Fatchur Rohman Fatchur Rohman Fatmah Afrianty Gobel Febriani, Candra Putri Fikri, Ahmadani Darul Fine Reffiane Finga Fitri Amanda Finga Fitri Amanda* Firdaus, Laras Firnindia Putri Frida Kunti Setiowati Ghaziah Kusumawati Chusjairi Hadi Suwono Halisma Amili Helsa Rahmatika Hendra Susanto Herawati Susilo Herdini ' Hisyam Baidlowi Hunaepi Hunaepi Ibrohim Ida Wulandari Ika Nurani Dewi Ilda Sartifa Sari Ilmawati, Riza Rahayu Indriani, Wiwik Indriati, Ganis Istaufa, Inna Milki Amnun Ita Nur Eka Pujiastuti Izzalqurny, Tomy Rizky Jekti Prihatin Jevi Milda Rahmawati Jimatul Arrobi Joko Waluyo Joko Waluyo Kartikasari, Nur'aini Laras Firdaus Laras Firdaus Laras Firdaus Laras Firdaus Laras Firdaus Lelitawati, Mardiana Lianto Lianto Lutfiyanti Fanani M. Fitri Athoillah Mahmudah, Anisah Mahmudah, Anisah Maria Angelina Genere Koban Markus Diantoro Masiah Masiah Masiah Masiah Masiah Masiah Masiah, Masiah Maulina, Dina Mellinda Setiani Nusa Diennata Miasih, Dewi Sekar Miftahul Mufinadiroh Mimien Henie Irawati Moch Sasmito Djati Mochammad Fitri Atho'illah Mochammad Yordan Adi Pratama Moh. Hafidhuddin Karim Mohamad Amin Mohamad Amin Mohammad Amin Mohammed, Najib Muchtar Muchtar Mufidah, Ikfi Nihayatul Muhammad Amin Muhammad Andry Prio Utomo Muhammad Athoillah Muhammad Aziz Murni Sapta Sari Mustika Ayu Wulansari Nasikh Nenes Prastita Nesya Adiva Nurhasanah Nik Malek, Nik Ahmad Nizam Ningrum, Sansan Hastuti Novita Kartika Indah Nuning Wulandari Nur Fitriana Nur Fitriana Nursasi Handayani Oki Sandra Agnesa Paidi Paidi Prastita, Nenes Pujiyanto, Eko Putri Diyah Anggraini Putri Elok Septiana Dewi Qadariah, Nosi Qomaria, Durrotul Rachmawati , Hidajah Rahayu, Andriana Rahma, Amalia Nur Rahmawati, Jevi Milda Rahmi Masita Resty Noflidaputri Ria Nelly Sari Rifqi, Nadiya Dini Rinu Bhakti Dewantara Rissa Rizky Rahmawati, Maria Rizky Nurdiansyah Rochmatul Ummah Rohayati, Yulista Trias Rony Irawanto Roza Linda Rudianto, Rony SATRIYAS ILYAS Siti Imroatul Maslikah Siti Imrotul Maslikah Siti Nur Arifah Siti Nur Arifah Siti Nur Arifah Siti Nur Arifah, Siti Nur Siti Nurjanah Siti Rahma Lestaluhu Siti Zubaidah Siti Zubaidah Sitoresmi Prabaningtyas Sitti Saenab Sitti Saenab Sitti Saenab, Sitti Soeyati Poejiani Soeyati Poejiani Sri Endah Indriwati Sri Nopita Primawati Suharti Sunaryono Sunaryono Sunaryono, Sunaryono Supiani, Endang Susriati Mahanal Susriyati Mahanal Sutiman B Sumitro Sutiman B. Sumitro Sutiman Bambang Sumitro Syahru Ramadan, Syahru Umie Lestari Utami Sri Hastuti Vivi Novianti W. Wisanti Wahyuni, Dilla Santhia Wisanti Wisanti Wisanti Wisanti Wulandari, Ida Yesi Hasneli N Yeti S. Hasan Yunita Rakhmawati Yuslinda Anisa Yuslinda Annisa Yuslinda Annisa Yuslinda Annisa Zaenul Mujahidin Zahra Anggita Pratiwi Zulkifli, Muhammad Mauludi