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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Ilmiah Farmasi Statistika Jurnal Kedokteran Brawijaya Jurnal Teknosains Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Indonesian Journal of Biotechnology Journal of Agromedicine and Medical Sciences Pharmacon Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY JURNAL BIOLOGI INDONESIA Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry Jurnal Kimia Terapan Indonesia JFIOnline YARSI Medical Journal Majalah Kesehatan Pharmamedika Pharmaceutical Sciences and Research (PSR)
Edy Meiyanto
Faculty Of Pharmacy, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Chemopreventive effect of ethanolic extract of Gynura procumbens (Lour), Merr on the carcinogenesis of Rat breast cancer development Meiyanto, Edy; Susilowati, Sri; Tasminatun, Sri; Murwanti, Retno; ., Sugiyanto
INDONESIAN JOURNAL OF PHARMACY Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.982 KB) | DOI: 10.14499/indonesianjpharm0iss0pp154-161

Abstract

Gynura procumbens (Lour) Merr., empirically, used to prevent cancer development and has been proven to be able to suppress lung cancer development. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBA-induced breast cancer development. Sprague Dawly Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 3 levels of doses, namely 250, 500, and 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, 500, and 750 mg/kgBW reduced tumor incidence by 60%, 30 %, and 20 % respectively. The doses of 500 and 750 mg/kgBW exhibited strong suppression of tumor multiplicity, where as the dose of 250 performed less potential suppression. In conclusion, ethanolic extract of G. procumbens performs chemopreventive effect to suppress breast cancer development at the dose of 250 mg/kgBW.Key words : chemopreventive, Gynura procumbens (Lour) Merr, breast cancer.
Ethanolic extract of Areca catechu seeds inhibit proliferation and induce apoptosis on MCF-7 cells Meiyanto, Edy; Susidarti, Ratna Asmah; Handayani, Sri; Rahmi, Fitria
INDONESIAN JOURNAL OF PHARMACY Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.642 KB) | DOI: 10.14499/indonesianjpharm0iss0pp12-19

Abstract

Areca catechu seed contains antioxydant substances, supposed to have anticancer property. This research therefore addressed to examine the inhibitory effect of Areca catechu seed ethanolic extract (EP) on proliferating breast cancer cells, MCF-7. Areca catechu seed ethanolic extract (EP) standardization was done according to the standard of BPOM. Areca catechu seed powder extraction was done using ethanol 96%. Cytotoxic assay – to get the value of IC50 and to prevent the cell proliferation (using doubling time assay) – was carried out by using MTT assay. Apoptosis observation was done by acrydine orange- etidium bromide staining method (double staining). The result showed that treatment with Areca catechu seed ethanolic extract (25-100 µg/m) for 48 h caused 13-84% growth inhibition (IC 5077 µg/mL) of the cells, while arecoline (ARE) treatment (10-500 µg/mL) showed 8-73% inhibition (IC50 180 µg/mL). The extract also inhibited cell proliferation and induced apoptosis. These results conclude that Areca catechu seed ethanolic extract (EP) possesses antiproliferative effect through growth inhibition and apoptosis induction.Key words:MCF-7, Areca catechu, antiproliferative 
In Vitro Study of the Combination of Doxorubicin, Curcuma xanthorrhiza, Brucea javanica, and Ficus septica as a Potential Novel Therapy for Metastatic Breast Cancer Sutejo, Ika Rahmawati; Putri, Herwandhani; Handayani, Sri; Jenie, Riris Istighfari; Meiyanto, Edy
Indonesian Journal of Pharmacy Vol 30 No 1, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1629.862 KB) | DOI: 10.14499/indonesianjpharm30iss1pp15

Abstract

Less optimized therapeutic effects constrain the use of doxorubicin as the main agent of chemotherapy for metastatic breast cancer, resistance and side effects. Therefore we need a combination of more than one chemopreventive agent which has different molecular targets to solve that problem. The aims of this study is to prove the inhibitory effect of ethanolic extract of rhizome of Curcuma xanthorrhiza (ECx), fruit of Brucea javanica (EBj), leave of Ficus septica (EFs) and doxorubicin (Dox) alone and its combination on migration and invasion of a highly metastatic 4T1 breast cancer cell line. Cytotoxic activity of single and combination treatment was evaluated by MTT assay, followed by an experiment of apoptosis induction by using flow cytometry. The inhibitory effect on migration was observed by the scratch wound-healing assay. Furthermore, the observation of the activity of matrix metalloproteinase-9 (MMP-9) was analyzed by gelatin zymography. The results showed that ECx, EBj, EFs, and Dox has cytotoxic activity on 4T1 cells with the value of IC50 respectively 49.7±1.53mg/mL, 59.9±1.79mg/mL, 15.2±2.12mg/mL and 1.2±0.23mM. Furthermore, combination of ECx-EBj-Dox and ECx-EBj-EFs revealed synergistic effect on 4T1 cells and decrease cell viability through the induction of apoptosis and necrosis. Based on wound healing assay, 24 hours incubation of this combination inhibited 4T1 cells migration compared to single treatment. Gelatin zymography analysis showed that this combination also inhibited the activity of MMP-9 greater than a single use. Curcuma xanthorrhiza, Brucea javanica, and Ficus septica may have potential to be developed as a combination with or without doxorubicin for metastatic breast cancer treatment.
SELAGINELLA ACTIVE FRACTIONS INDUCE APOPTOSIS ON T47D BREAST CANCER CELL Handayani, Sri; Risdian, Chandra; Meiyanto, Edy; Udin, Zalinar; Andriyani, Rina; Angelina, Marissa
Indonesian Journal of Pharmacy Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.839 KB) | DOI: 10.14499/indonesianjpharm23iss1pp48-53

Abstract

Apoptosis  is  an  important  target  on  anticancer  mechanism. The  purpose  of  this  research  is  to  investigate  apoptosis  induction of Selaginella plana Hieron active fractions on T47D cells. Absolute ethanol  was  used  to  extract Selaginella  plana powders.  Ethanolic extract  was  dilluted  by  methanol:water  (4:1)  and  then fractionated  by  hexane  (S_Hex),  methylene  chloride  (S_MTC), ethyl acetate (S_EA), and buthanol (S_BuOH). The proliferation of T47D  cell  line  was  detected  by  SRB  (Sulforhodamine  B) assay which  was  measured  at  a  wavelength  of  515nm.  Flowcytometry analysis  to  determine  apoptosis  was  examined  by  Propidium Iodide  (PI)  and  Annexin  V  assay  using  T47D  breast  cancer  cell line.  The  result  showed  that  the  IC50 value  of  S_Hex,  S_MTC, S_EA,  and  S_BuOH  on  T47D  cells  were  107  µg/mL,  4  µg/mL,  6 µg/mL,  and  17  µg/mL  respectively.  The  active  fractions  (S_MTC and  S_EA)  at  its  IC50 concentration  significantly  (P<0.05) increased  the  total  number  of  early  apoptotic  cells  in  the  T47D cells  3.39%  and  4.1%  respectively  compared  to  that  of  control (1.95%).  Based  on  the  result,  methylene  chloride  and  ethyl acetate  fraction  of Selaginella  plana induced  apoptosis  on  T47D cell.Keywords: apoptosis, breast cancer, Selaginella
SYNTHESIS AND CYTOTOXIC ACTIVITY OF 2,5-BIS(4-BORONIC ACID)BENZYLIDINE CYCLOPENTANONE ON HER2 OVEREXPRESSED-CANCER CELLS Rohmad Yudi Utomo; Herwandhani Putri; Pudjono Pudjono; Ratna Asmah Susidarti; Riris Istighfari Jenie; Edy Meiyanto
Indonesian Journal of Pharmacy Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (949.546 KB) | DOI: 10.14499/indonesianjpharm28iss2pp74

Abstract

Development of chemotherapeutic agent and boron carrying pharmaceutical based on HER2 specific targeted is important due to its role in enhancing cancer progression. The purpose of this study is to synthesize curcumin analogue, namely Pentagamaboron-0 (PGB-0) or 2,5-bis(4-boronic acid)benzylidine cyclopentanone, and to explore the cytotoxic activity on HER2 overexpressed-cancer cells. MCF-7/HER2 was used as a model of HER2 overexpressed-cancer cells and NIH3T3 as normal cells. PGB-0 bound to ATP binding site of HER2 and EGFR based on molecular docking study. PGB-0 was synthesized resulting in 33% yield and was confirmed by IR, 1HNMR, 13CNMR and Mass spectroscopy. Based on MTT assay PGB-0 decreased cells viability on MCF-7/HER2 cells with IC50 value of 270 µM but performed no effect on NIH3T3 cells. Cell cycle analysis revealed that PGB-0 increased sub-G1 accumulation. PGB-0 decreased HER2 expression in a dose-dependent manner. We conclude that the new compound PGB-0 inhibits cell growth through cell death induction and decreased HER2 expression. Thus, PGB-0 is potential to be developed as a chemotherapeutic agent and boron carrying pharmaceutical targeted on the HER2 receptor.
CYP1A1 and GSTm expression of hepatocytes induced by 7,12-dimethylbenz(a)anthracene and the influence of ethanolic extract of Gynura procumbens Iwan Sahrial Hamid; Sugiyanto .; Edy Meiyanto; Sitarina Widyarini
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.093 KB) | DOI: 10.14499/indonesianjpharm0iss0pp198-206

Abstract

The cytochrome P-450 (CYP) and glutathione S-transferase (GST) enzyme systems may influence the biological effects of carcinogens. As such, these enzymes may predict the developmental risk of breast cancer, as well as be potential targets for chemoprevention. The purpose of this study was to compare the expression of CYP1A1 and GST* between treatment groups. Expression of CYP1A1 and GST* was quantified in liver tissue from 18 female Sprague Dawley rats aged 40 days, which randomly divided into six treatment groups. Those are base line group (without DMBA and ethanolic extract treatment), DMBA induced cancer group, the other two groups was administrated by DMBA after treated by ethanolic extract in two different doses, 300 mg /kg BW and 750 mg/kg BW. The last two groups were given two doses of extract ethanolic only, without initiated of DMBA. The ingestion of the extract was carried for three weeks and the ingestion of DMBA was performed twice in the third week. The expression CYP1A1 and GST was quantified by immunohistochemistry. CYP1A1 expression was significantly higher (P < 0.05) in cancer group (DMBA) as compared with other groups. On the other hand, GST expression was lower in cancer group (P < 0.05). Result of this study demonstrated that ethanolic extract leaves of G. procumbens in 300 mg/kg BW dose could inhibit CYP1A1 stronger than are other and induced GST* level. Has effect on ethanolic extract leaves of G. procumbens has ability in played role of as blocking agent in preventing initiation stage of carsinogenesis, therefore it should be taken into account for chemopreventing agent in mammary carsinogenesis.Key words : Gynura procumbens, breast cancer, Chemopreventive, CYP1A1, GSTμ
The anticarcinogenic activity of plants compounds Sugiyanto .; B. Sudarto; Edy Meiyanto; Agung Endro Nugroho; Umar A. Jenie
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (759.227 KB) | DOI: 10.14499/indonesianjpharm0iss0pp216-225

Abstract

The study was conducted to observe the effect of extracts of ngokilo (Gynura procumbens), beluntas (Pluchea indica), murbei (Morus alba) dan tapak doro (Vinca alba) leaves. Showed anticarcinogenic activity on lung tumor growth of mice. In the nex step, compounds having anticarcinogenic effect was isolated and identified, and evaluated on the cultures of meilomaand Vero cells. The results showed that non-polar fraction of ethanol extract of ngokilo leaves did not have anticarcinogenic activity, whereas the polar fraction show anticarcinogenic activity. At least there were three flavonoids (flavon or flavonol groups) in this polar fraction. It was only two of these flavonoids inhibit the growth of myeloma and Vero cells.Key words : ngokilo, Gynura procumbens, anticarcinogenic, flavonoid.
Geometric Isomers and Cytotoxic Effect On T47D Cells of Curcumin Analogues PGV-0 and PGV-1 Edy Meiyanto; Muhammad Da&#039;i; Supardjan A. M.; Umar Anggara Jenie
Indonesian Journal of Pharmacy Vol 18 No 1, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.101 KB) | DOI: 10.14499/indonesianjpharm0iss0pp40-47

Abstract

Curcumin analogues 2,5-bis-(4’-hidroxy-3’-methoxy)-benzilidinecylopentanone (PGV-0) and 2,5-bis-(4’hidroxy-3’,5’-dimethyl)-benzilidinecylopentanone (PGV-1) have a potency to be developed as cytotoxic agent. The aims of this research are to elucidate the geometric isomer and to study the cytotoxic effect on T47D cells of both compounds. To establish the geometric isomer these compounds, they were elucidated by LC-MS, 1H-NMR, 13C-NMR, HMBC, HMQC, NOESY. Their cytotoxic effect were evaluated by MTT assay method on T47D cells. The results concluded that the geometric isomer of PGV-1 is zusammen-zusammen (Z-Z) and PGV-0 is entgegen-entgegen (EE). The IC50 of both compounds are 1.74 and 9.39 μM respectively.Key words: PGV-0, PGV-1, Cytotoxicity
Antiangiogenic effect of sambung nyawa leaves (Gynura procumbens (Lour.) Merr.) etanolic extract on chick embryo chorioallantoic membrane (CAM) Riris Istighfari Jenie; Edy Meiyanto; Retno Murwanti
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.767 KB) | DOI: 10.14499/indonesianjpharm0iss0pp50-55

Abstract

Antiangiogenesis (inhibition of new blood vessels formation) has become a strategy to inhibit cancer development lack of nutrition and oxygen supply. The aim of the present research is to investigate antiangiogenesis effect of ethanolic extract of Gynura procumbens (Lour.) Merr. Leaves in situ using chick embryo chorioallantoic membrane (CAM). Eight to 9 days old fertilized chicken eggs were treated with b-FGF (angiogenesis inductor) and extracts. Eggs were then incubated for 3 days in order to observe its angiogenesis response (new blood vessels converged toward the implant).The results showed that the ethanolic extract of G.procumbens could inhibit angiogenesis in a dose-dependent manner. Doses 10, 20, 40, 80 ug gave angiogenesis response of (in percent) 82.32 ± 6.33; 68.38 ± 6.24; 56.48 ± 11.61; 41.43 ± 7.46 (p<0.05), respectively. These results indicate a potential antiangiogenic effect of the extract.Key words: antiangiogenic, CAM, G.procumbens.
Co-Authors . Anindyajati . Larasati . Sugiyanto Adam Hermawan Adam Hermawan Adisusilo, Midori Rahmadhany Putri Aditya Fitriasari Aditya Fitriasari Agung Endro Nugroho Agusta Fauzi, Ilham Agustina Setiawati Ainun Wulandari Alexxander, . Alexxander, . Ameilinda Monikawati Ameilinda Monikawati Andita Pra Darma Andita Pra Darma Andriyani, Rina Angelina, Marissa Angraini, Sonia Meta Anif Nur Artanti, Anif Nur Ardriyanto, Maria Indra Arief Nurrochmad Arief Rahman Hakim Asih Triastuti Astrid Ayu Maruti Aulia Katarina Aulia Rahman, Faaza Ayu Maruti, Astrid B. Sudarto Banun Kusumawardani Chio Oka, Chio D., Andita Pra D., Andita Pra Da'i, Muhammad Da’i, Muhammad Dewi Arum Sekti, Dewi Arum Dewi Pamungkas Putri, Dyaningtyas Dewi Pratiwi Dini Maharani Djaswadi Dasuki Dwi Ana Nawangsari Dwi Ana Nawangsari, Dwi Ana Dwi Merry Christmarini Robin Dwi Nurahmanto Dyaningtyas D. P. Putri Dyaningtyas Dewi Putri Pamungkas Effendi, Fatiha Citra Endah Puji Septisetyani, Endah Puji Endah Puspitasari Endang Lukitaningsih Endang Purwaningsih Erlina Rivanti Erna Prawita Setyowati Esti, Yuni Fajar Fany Mutia Cahyani Farmasyanti, Cendrawasih Andusyana Feby Handoko, Fransiscus Fikri Amalia Fina Aryani Goenadi Fina Aryani Goenadi, Fina Aryani Fitria Rahmi Fiveri, Anis Fiveri, Anis Fortunella Tjondro Handayani, Sri Handayani, Sri Hanifa, Mila Hapsari, Novia Permata Hargiani, Fransisca Xaveria Harsan, Hayfa Salsabila Hastuti, Hanaan Emilia Adi Hendra Kurniawan Maury Hendri Wasito Heni Susilowati Herwandhani Putri Herwandhani Putri Ibrahim Arifin Ida Ayu Putu Sri Widnyani Ika Nurzijah Ika Rahmawati Sutejo Ikawati, Muthi' Ilham Agusta Fauzi Ilham Agusta Fauzi Imono Argo Donatus, Imono Argo Indrasetiawan, Puguh Indri Kusharyanti Inna Armandani, Inna Inna Armandari Iwan Sahrial Hamid JAKA WIDADA Jauhari, Fahmi Ihsanuddin Jenie, Riris Istighfari Jenie, Riris Istighfari Juni Ekowati Kadarsih Soejono, Sri Kadarsih Soejono, Sri Kartika Dyah Palupi Kartika Dyah Palupi Kato, Jun-Ya Kawai, Taro Kholid Alfan Nur Kholid Alfan Nur Komang Alit Paramitasari Kuijpers-Jagtman, Anne Marie Kumara, Dennaya Laras Widawaty Putri Lestari, Dinda Luthfia Indriyani M, Kawaichi M, Kawaichi Mae Sri Hartati Wahyuningsih Maran, Gergorius Gena Marcellino Rudyanto Maria Dwi Supriyati Maria Dwi Supriyati, Maria Dwi Masashi Kawaichi Masashi Kawaichi, Masashi Muflikhasari, Haruma Anggraini Muhammad Da&#039;i Muhammad Fithrul Mubarok, Muhammad Fithrul Muthi Ikawati N., Perdana Adhi N., Perdana Adhi Nabila, Klarissa Nanda Resa Pratama Niken Nur W, Niken Novi Hastuti, Novi Novianti, Metta Novitasari, Dhania Nugraheni, Nadzifa Nunuk Aries Nurulita Nunuk Purwanti Nurma Sabila Nurrachma, Marsya Yonna P.K.W., Diah Ayu P.K.W., Diah Ayu Perdana Adhi Nugroho Perdana Adhi Nugroho Prasetyaningrum, Pekik Wiji Pudjono Pudjono Putri, Amaliya Permata Putri, Herwandhani Putri, Nindya Budiana R A Susidarti Raditya Prima Istiaji Rahmah, Inggita Hasi Rahman, Faaza Aulia Rahmawati, Desty Restia Rahmi Khamsita Ramadani, Ratna Dwi Ratih Hardika Pratama Ratna Asmah Susidarti Ratna Asmah Susidarti Retno Ardhani Retno Murwanti Rifai, Fauziah Novita Putri Riris I Jenie Riris I Jenie, Riris I Riris Istighfari Jenie Riris Istighfari Jenie Riris Istighfari Jenie Risdian, Chandra Rita Riata Rohmad Yudi Utomo Rohmad Yudi Utomo Rosa Adelina Rosana Anna Ashari Rosana Anna Ashari, Rosana Anna Rosye H.R. Tanjung Rul Afiyah Syarif Rumiyati, Rumiyati Salsabila, Irfani Aura Santoso, Christopher Filando Sari Haryanti Sari Haryanti Sarmoko Sarmoko Sendy Junedi Sendy Junedy, Sendy Shigeru Sasaki Sismindari . Sitarina Widyarini Sofa Farida Sri . Handayani Sri Handayani Sri Kadarsih Soejono Sri Kasianningsih Sri Susilowati Sri Tasminatun Sugeng Riyanto Sugiyanto . Sugiyanto . Sukardiman Supardjan A. M. Supardjan A.M., Supardjan Supardjan AM Supardjan AM, Supardjan Susi Ari Kristina Tutuk Budiati Udin, Zalinar Umar A. Jenie Umar Anggara Jenie Umar Anggara Jenie Umar Anggara Jenie Widayanti, Wasita Rachma Yundari, Yundari Yurista Gilang Yurista Gilang Ikhtiarsyah Yuyun Farida Yuyun Farida, Yuyun Zufairo, Shofa Khamdanatuz Zulfin, Ummi Maryam