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All Journal Jurnal Ilmu Pertanian Jurnal Pendidikan Matematika dan IPA bionature AL KAUNIYAH Biogenesis: Jurnal Ilmiah Biologi Teknosains: Media Informasi Sains dan Teknologi Prosiding Seminar Biologi Elkawnie Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Ilmiah Ekonomi Islam Indonesia Journal of Halal AkMen JURNAL ILMIAH AL-HAYAT: Journal of Biology and Applied Biology Biota jurnal Ilmu Pertanian (Agricultural Science) Scripta Biologica Jurnal Biotek BISEI: Jurnal Bisnis dan Ekonomi Islam Journal of Islam and Science Muttaqien; Indonesian Journal of Multidiciplinary Islamic Studies El-Iqtishady Iqtishaduna : Jurnal Ilmiah Mahasiswa Hukum Ekonomi Syariah Jurnal Studi Ekonomi dan Bisnis Islam (SEBI) International Journal Mathla'ul Anwar of Halal Issues Formosa Journal of Multidisciplinary Research (FJMR) Tadayun: Jurnal Hukum Ekonomi Syariah Robust: Research of Business and Economics Studies Al-Iqtishad : Jurnal Ekonomi Filogeni: Jurnal Mahasiswa Biologi SAUJANA : Jurnal Perbankan Syariah dan Ekonomi Syariah Southeast Asia Journal of Graduate of Islamic Business and Economics Belalek Jurnal Bisnis dan Kewirausahaan Samawa (sakinah, Mawaddah Warahmah) Tropical Genetics Journal of Innovative and Creativity SEGARA : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Ekonomi, Akuntansi dan Pajak Kalam Al Gazali: Education and Islamic Studies Journal PESHUM Berita Biologi BIOTROPIC
Cut Muthiadin
Universitas Islam Negeri Alauddin Makassar
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Journal : Elkawnie

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Black Cumin (Nigella sativa) Against Mycobacterium tuberculosis Strain H37RV And MDR-TB Mashuri Masri; Cut Muthiadin; Masita Masita; Tri Cahyanto; Lianah Lianah; Rusny Rusny; Siska Tridesianti
Elkawnie: Journal of Islamic Science and Technology Vol 7, No 1 (2021)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v7i1.9335

Abstract

Abstract: Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. 10 million people suffer from TB Every year. Although TB is a preventable and treatable disease, 1.5 million people die every year due to TB. Alternative treatments continue to be pursued, and treatment with the latest TB drugs that are continuously being encouraged. Black cumin (Nigella sativa) seed contains essential oils with active compounds such as thymohydroquinone, Oleoresins, flavonoids, alkaloids, saponins, tannins, and terpenoids that act as antibacterial drugs. This study aims to determine the sensitivity of  N. sativa seed extract in inhibiting the growth of  M. tuberculosis strain H37RV and MDR-TB (Multidrug Resistance-TB). This research using Microscopic-Observation and Drug-Susceptibility Assay (MODS) method. Extraction of N. sativa was carried out by the maceration method using 70% methanol as a solvent. The results showed that the M. tuberculosis strain H37RV and MDR-TB were sensitive to N. sativa extract at concentrations of 5 and 10% but resistant to N. sativa extract at concentrations of 1 and 3%.Abstrak: Tuberkulosis (TB) adalah penyakit menular yang disebabkan oleh Bakteri Mycobacterium tuberculosis. Penyakit ini menimbulkan dampak kematian yang cukup mengkhawatirkan.  Penyakit tersebut dapat dicegah dan diobati. Salah satu sumber pengobatannya menggunakan biji jintan hitam (Nigella sativa) yang mengandung minyak atsiri dengan senyawa aktif seperti timohidrokuinon, oleoresin, flavonoid, alkaloid, saponin, tanin, dan terpenoid yang berfungsi sebagai obat antibakteri. Penelitian ini bertujuan untuk mengetahui sensitivitas ekstrak biji N. sativa dalam menghambat pertumbuhan M. tuberculosis strain H37RV and MDR-TB (Multidrug-Resistance-TB). Penelitian ini menggunakan metode Microscopic-Observation and Drug-Susceptibility Assay (MODS). Ekstraksi N. sativa dilakukan dengan metode maserasi menggunakan pelarut metanol 70%. Hasil yang diperoleh menunjukkan bahwa bakteri M. tuberculosis strain H37RV dan TB-MDR, kedua  strain tsb sensitif terhadap ekstrak N. sativa konsentrasi 5 dan 10%,  tetapi resisten terhadap  ekstrak N. sativa konsentrasi 1 dan 3%.
Black Cumin (Nigella sativa) Against Mycobacterium tuberculosis Strain H37RV And MDR-TB Mashuri Masri; Cut Muthiadin; Masita Masita; Tri Cahyanto; Lianah Lianah; Rusny Rusny; Siska Tridesianti
Elkawnie Vol. 7 No. 1 (2021)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v7i1.9335

Abstract

Abstract: Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. 10 million people suffer from TB Every year. Although TB is a preventable and treatable disease, 1.5 million people die every year due to TB. Alternative treatments continue to be pursued, and treatment with the latest TB drugs that are continuously being encouraged. Black cumin (Nigella sativa) seed contains essential oils with active compounds such as thymohydroquinone, Oleoresins, flavonoids, alkaloids, saponins, tannins, and terpenoids that act as antibacterial drugs. This study aims to determine the sensitivity of  N. sativa seed extract in inhibiting the growth of  M. tuberculosis strain H37RV and MDR-TB (Multidrug Resistance-TB). This research using Microscopic-Observation and Drug-Susceptibility Assay (MODS) method. Extraction of N. sativa was carried out by the maceration method using 70% methanol as a solvent. The results showed that the M. tuberculosis strain H37RV and MDR-TB were sensitive to N. sativa extract at concentrations of 5 and 10% but resistant to N. sativa extract at concentrations of 1 and 3%.Abstrak: Tuberkulosis (TB) adalah penyakit menular yang disebabkan oleh Bakteri Mycobacterium tuberculosis. Penyakit ini menimbulkan dampak kematian yang cukup mengkhawatirkan.  Penyakit tersebut dapat dicegah dan diobati. Salah satu sumber pengobatannya menggunakan biji jintan hitam (Nigella sativa) yang mengandung minyak atsiri dengan senyawa aktif seperti timohidrokuinon, oleoresin, flavonoid, alkaloid, saponin, tanin, dan terpenoid yang berfungsi sebagai obat antibakteri. Penelitian ini bertujuan untuk mengetahui sensitivitas ekstrak biji N. sativa dalam menghambat pertumbuhan M. tuberculosis strain H37RV and MDR-TB (Multidrug-Resistance-TB). Penelitian ini menggunakan metode Microscopic-Observation and Drug-Susceptibility Assay (MODS). Ekstraksi N. sativa dilakukan dengan metode maserasi menggunakan pelarut metanol 70%. Hasil yang diperoleh menunjukkan bahwa bakteri M. tuberculosis strain H37RV dan TB-MDR, kedua  strain tsb sensitif terhadap ekstrak N. sativa konsentrasi 5 dan 10%,  tetapi resisten terhadap  ekstrak N. sativa konsentrasi 1 dan 3%.
Co-Authors Abd Rauf Muhammad Amin Abdul Rauf Muhammad Amin, Abdul Rauf Muhammad Adin Ayu Andriyani AGUS AGUS Ahyar Ahmad Alir, Rahmat Fajrin Amalia, Andi Dewi Reski Amir, Andi Muhammad Nur Atma Amnah, Alifah Zul Amril Andi Nabila Nurfitrah Annisa Zakiyah Darojat Ar. Syarif Hidayat Asbar Hamzah Ashari Ananda, Iva Asmuddin Nasir Asmuddin Natsir Auriga, Fitriani Ayu Andi Indra, Ayu Baiq Farhatul Wahidah Bakri Zakia, Bakri Basmiati, Basmiati Burhan, Eliazar Dedi Mardianto Dedi Susanto Dewi Ratnasari Dirhamzah, Dirhamzah Erniawati, Erniawati Fachrurrazy, Muhammad Fatmawati Nur Fatmawati, Fatmawati Febriani, Ayu Ferial, Ferial Firdayana Firdayana Firmansyah, Yuman Fuadi, Ni'ma Ainul Gafur, Muslimah Fitrah Abd Gazali, Megawati Hadidarma, Nasyrah Hafid, Abd Hafsan, Hafsan Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah, Hajrah Halik, Abdul Chadjib Harja, Husnul Sri Mulyani Hartono Helmy Syamsuri, Helmy Hermawan, Isna Ainun Hidayat, Kusnadi S Hidayat, Muhammad Tasri Hidayati, Ulfa Idris Parakkasi Indradewa, Rhian Isna Rasdianah Aziz Isna Rasdianah Aziz Isna Rasdianah Aziz Isna Rasdianah Aziz Isna Rasdianah Aziz Isna Rasdianah Aziz Isna Rasdianah Aziz Isna Rasdianah Aziz Isna Rasdianah Aziz Japar, Rahayu Jusni, Jusni K., M. Yusuf Karmila, Yusri Kartika Kasfina, Ina Khatimah, Khusnul Kholid Albar Khudaer , Faten Kumala, Nur Hakiki Dewi Laily Agustina Lasinrang Aditia Lianah Lianah, Lianah Mahfut Marcia Bunga Pabendon Mashuri Masri Mashuri Masri Mashuri Masri Masita Masita Masita, Masita Masriany, Masriany Maulana Maulana Maulana Maulana, Maulana Mudyawati Kamaruddin Muh. Khalifah Mustami Muhammad Amin, Abd Rauf Muhammad Amin, Abdul Rauf Muhammad Khalifah Mustami Mukhtar Galib Nur Alfi Hidayati Nur, AbdurRahman Shakhr Nurhaedah ., Nurhaedah Nurhikmah Nurhikmah Nurisyah, Nurisyah Nurjannah Nurjannah Nurmayanti, Nurmayanti Nurul Muhlisyah Nurul Muhlisyah Paraikkasi, Idris Parakkasi, Idris Permatasari, Artha Rezki Pujarena Putri Idris Rahadian Pratama Rahmat Fajrin Alir Ramlah Ramlah Ramlah Rasnawati Risdayanti Adi Purba Rosalina, Hamna Rukmana, Rusmadi Rum, Magfirah Rahimah Rusny Rusny Rustam, Aswar Sahin, Andini Sapa, Nasrullah Bin Sapinah Sapsuha, Mubasysyyratul Ummah Sembiring, Christine Sijid, St Aisyah Sitti Saenab, Sitti Sri Wahyuni St. Aisyah Sijid St. Aisyah Sijid Sudarmi Sudarmi Sukmawaty, Eka Sumarlin, Abdul Suryafly, Fanny Dhea Syam, Agus Syaripuddin Syaripuddin Tri Cahyanto Triananinsi, Nurhidayat Tridesianti, Siska Tuti Supatminingsih Tuty Arisuryanti, Tuty Umar, Rahmawati Upreti, Brij Mohan Wahab, Andi Rizki Berliana Zahra Wamaulana, Farlinda Yuniar Harviyanti Zahra, Najmatul Zamzam, Miftahul Khairiyah Zulkarnain Zulkarnain