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Journal : Al-Kimia

Docking Molecular dari Kompleks Zn(II)Amina (Prolin)dithiokarbamat terhadap Reseptor Estrogen-α Rizal Irfandi; Ruslang Ruslang; Indah Raya; Ahmad Yani; Muhammad Nasir; Nurcaya Nurcaya; Sulistiani Jarre
Al-Kimia Vol 9 No 2 (2021): DESEMBER
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v9i2.23949

Abstract

Estrogen-α (ER-α) is a major target in cancer therapy. Targeting the ER-α target protein is known to slow the proliferation of breast cancer cells. The purpose of this study was to determine the interaction of the complex compound Zn(II)Prolinedithiocarbamate against the Estrogen-α Receptor. The Zn(II)Prolinedithiocarbamate complex was predicted canonical SMILE by Cheminfo online application (O=C(O)C1CCCN1C2S[Zn]S2) and modeled with online corina to obtain a three-dimensional structure. The structure of the complex compound Zn(II)Prolinedithiocarbamate interacted with Estrogen receptor alpha protein to test its potential anticancer activity. Molecular docking results show the interaction of the Zn(II)Prolinedithiocarbamate complex with the Estrogen- receptor on the amino acid residues ARG394, LEU387, GLU353, LEU346, LEU349, and PHE404. The Zn(II)Prolinedithiocarbamate complex interacts directly with ER-α in the estrogen region which causes the failure of the interaction between estrogen and the estrogen receptor, so it can be predicted that the Zn complex has activity as an ER-α inhibitor and has the potential to be developed in the treatment of breast cancer.
Co-Authors Abd. Raziq Abdul Ba'iz Mus'ing Abdul Ba’iz Mus’ing Abdullah Haddade Abdullah, Ashari Ade Sucitra Putri Adhan, Muh. Agus Kurniawan B Agustin, Ananda Putri Ahmad Riadi Ahmad Yani Ahmad Yani Ailinnia, Tia Akbar, Zaidil Albiruni, Muh.Farhan Alfiyani, Lina Ambo Aming Ambo Upe Amir Imbaruddin Amir Imbaruddin, Amir Ananda Putri Agustin Andi Akbar Amin Andi St Nurazizah Akbar Andi Syahril Gunawan Angga Andriana Anggreni, Nuranisa Anugerah Anugerah Yanuar Azis Anugerah Yanuar Azis Anugerah Yanuar Azis Anugerah Yanuar Azis Aprilia Amir, Mirdah Aprilia, Andi Hafidha AR, Arni Arafah , Eka Hardianti Arni AR Arni AR AYU LESTARI Azis, Anugerah Yanuar Azizah, A. Nur B, Khaeriah B, Salmawati Barangkau Barangkau, Barangkau Darwis Darwis, Nirmawati Devy Febrianti Dollah, Aris Sakkar Eka Hardianti Eka Hardianti Arafah Eri Wardanengsih Erwing Erwing Ery Wardanengsih Ery Wardanengsih Farman Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Firda Sintia Fitriani Fitrianti Fitrianti, Fitrianti Haerunnisa Haerunnisa, Haerunnisa Halim Halim Halim, Halim Hasan, Masrah Hasdiani Nur, Fauziah Hasnidar Hasnidar Hasriani Hasriani, Hasriani Hasriyanti Hermawin Hermawin Holyness Nurdin Singadimedja Husni Nasir Ikdafila Ikdafila Ikdafila, Ikdafila Indah Raya Irfandi, Rizal Irmayani Irmayani Irsani Damayanti Islamia, Islamia Jayawarsa, A.A. Ketut Jumrah , Jumrah Junar, Wirdawati Khaeria Khaeriah B Khaeriah B Khaeriyah Adri Lili Suryani Lisna Lisna Lisna Lisna Mardhatillah Mariani, Syarifah Masrah Hasan Mien Burhanuddin Mikhrunnisai, Andi Monicha, Andi Muh. Hasbi Muh. Ilham Muhammad Arafah Muhammad Syarif, Muhammad Muliani Musdalifah Mustafa, Idarwati Mu’sing, Abdul Baiz Nia Febrianti Nirmawati Darwis Nirmawati Darwis Nirmawati Darwis Nirmawati Darwis Nirmawati Darwis Nirmawati Darwis Nirmawati Darwis Nirmawati Darwis Nirmawati Darwis Nirmawati Hamka Nismayanti Nur Aulia Hazzah Nur Azizah, A Nurcaya Nurcaya Nurcaya Nurcaya Nurdiana Nurdiana Nurfadilah Maulana S. Nurhaeda, Nurhaeda Nurhaedah Nurhaedah Nurhalisa, Nurhalisa Nurhikmah Paddiyatu, Nurhikah Puspita, Haswinda Putri Handayani Putri, Widya Kaharani Rahmah, Anindita Hasniati Rahwana, Rahwana Ramlan, Pratiwi Ratu Sulung, Andi Zhalzabila Regitha Cahya Putri W Renaldi Resti Oktavia Rifai, Triaman Riki Rusanda Riki Rusanda Rizky Rahayu Amas Rizky Rahayu Amas Rosdiana Rosdiana Samramadana, Muh Akram Santoso, Efrans Budi Selpiana Sintia, Firda Siti Hardianti Sri Hardianti Rosadi St. Nurjannah Rizkia Wahyuni Putri St. Rahma Sulistiani Jarre Sumini Sumini, Sumini Sunandar Said Suriani Suriani Surianti, Tetti Syah, Uswah Trywulan Syahruddin, A. Syahriyunita Syamsu Rijal Syamsuddin Tetti Surianti Tetti Surianti Tetti Surianti Tetti Surianti Tetti Surianti Tikirik, Wita Oileri Trywulan Syah, Uswah Uzizulloh, Muhammad Rafi Wardanengsih, Ery widya astuti Wijaya, Nurhikmah Winarti Winarti Wulansari, Eka Yakob, Asmirati Yammar Yammar, Yammar Yanuar Azis, Anugerah Yudi Rafial Hadi Zulkarnain Sulaiman