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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan JURNAL PROMOSI KESEHATAN INDONESIA Medical Journal of Indonesia Biomedical Journal of Indonesia JURNAL KESEHATAN LINGKUNGAN: Jurnal dan Aplikasi Teknik Kesehatan Lingkungan Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Gizi Klinik Indonesia Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Hearty : Jurnal Kesehatan Masyarakat JPP Jurnal Kesehatan Poltekkes Palembang Health Information : Jurnal Penelitian Jurnal 'Aisyiyah Medika Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal PREPOTIF : Jurnal Kesehatan Masyarakat Science Midwifery Indonesian Journal of Global Health research Journal of Sport Coaching and Physical Education Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Sains Kesehatan Jurnal Health Sains Journal SAGO Gizi dan Kesehatan Mitra Raflesia (Journal of Health Science) Jurnal Kesehatan Tambusai Prima Abdika: Jurnal Pengabdian Masyarakat KESANS : International Journal of Health and Science Jurnal Ilmu Kesehatan Masyarakat Electronic Journal Scientific of Environmental Health And Diseases Eduvest - Journal of Universal Studies Jurnal Keperawatan Riset Informasi Kesehatan Ranah Research : Journal of Multidisciplinary Research and Development JUKEJ: Jurnal Kesehatan Jompa Jurnal Kesehatan Metro Sai Wawai JPK : Jurnal Penelitian Kesehatan Indonesian Journal of Sport Science and Coaching Malahayati International Journal of Nursing and Health Science Poltekita: Jurnal Pengabdian Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rostika Flora
Faculty of Medicine Sriwijaya University
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Journal : Medical Journal of Indonesia

 1 
Correlation of hypoxia inducible factor-1α and vascular endothelium growth factor in rat myocardium during aerobic and anaerobic exercise Flora, Rostika; Freisleben, Hans-Joachim; Ferdinal, Frans; Wanandi, Septelia I.; Sadikin, Mohamad
Medical Journal of Indonesia Vol 21, No 3 (2012): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (837.72 KB) | DOI: 10.13181/mji.v21i3.493

Abstract

Background: Exercise increases the need for oxygen to generate ATP through oxidative phosphorylation. If the high energy demand during exercise is not balanced by sufficient oxygen supply, hypoxia occurs in skeletal muscle tissue leading to upregulation of hypoxia inducible factor-1α (HIF-1α). The activity of HIF-1α increases the expression of various genes in order to reduce the metabolic dependence on oxygen and to increase oxygen supply to the tissue, e.g., VEGF which plays a role in angiogenesis. In myocardium, it is unclear whether exercise leads to hypoxia and whether HIF-1α and VEGF play a role in the mechanism of hypoxic adaptation. This study aimed to investigate the correlation of HIF-1α and VEGF in heart muscle tissue of rats during aerobic and anaerobic exercise.Methods: A rat treadmill was used with a specific exercise program for 1, 3, 7 and 10 days. The concentrations of HIF-1α and VEGF were measured the myocardium.Results: Both, HIF-1α protein and VEGF were increased (p < 0.05) in the groups with aerobic and anaerobic exercise. Concentrations of HIF-1α were highest on the first day of activity, being higher in the anaerobic than in the aerobic group (156.8 ± 33.1 vs. 116.03 ± 5.66). Likewise, the highest concentration of VEGF in the group with anaerobic exercise occurred on the first day (36.37 ± 2:35), while in the aerobic group, VEGF concentration was highest on day 3 (40.66 ± 1.73). The correlation between the myocardial tissue consentrations of HIF-1α and VEGF is moderate (r = 0.59) in the aerobic group and strong in the anaerobic group (r = 0.69).Conclusion: Aerobic and anaerobic exercise increase HIF-1α and VEGF concentrations in rat myocardium in specific patterns. The anaerobic condition triggers vascularization stronger and obviously earlier than aerobic exercise. (Med J Indones. 2012;21:133-40)Keywords: Exercise, HIF-1α, myocardium, VEGF
Erratum: Chronic physical exercise increases a neurogenesis marker within hippocampus Zulkarnain, Mohammad; Flora, Rostika; Andrianti, Septi
Medical Journal of Indonesia Vol 27, No 3 (2018): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.864 KB) | DOI: 10.13181/mji.v27i3.3172

Abstract

[This corrects the article DOI: 10.13181/mji.v27i2.1685]
Myocardial damage after continuous aerobic and anaerobic exercise in rats Flora, Rostika; Ferdinal, Frans; Hernowo, Bethy S.; Wanandi, Septelia I.; Sadikin, Mohamad; Freisleben, Hans-Joachim
Medical Journal of Indonesia Vol 22, No 4 (2013): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (813.04 KB) | DOI: 10.13181/mji.v22i4.601

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Background: Regular physical activity is highly recommended in preventive, curative, and rehabilitative programs in order to promote health, especially cardiovascular health. However, physical activity can also cause sudden death. In athletes, sudden death may occur during sport competitions, with myocardial infarction as the most common etiology. It is suspected that continuous training without any rest-day play a role in cardiac muscle damage and sudden death during competition. Our study was aimed to learn about cardiac muscle adaptation on continuous aerobic and anaerobic physical activity without any rest-day. Methods: The specimens in our study were cardiac muscle tissue obtained from rats that had performed aerobic and anaerobic physical activity on treadmill for 1, 3, 7, and 10 days without any rest-day. Blood gas analysis and hematological assessment were used as parameters of systemic adaptation to hypoxia during physical activity. Moreover, histopathology of cardiac muscle tissue was performed as parameter for cardiac muscle damage.Results: The results showed that aerobic and anaerobic physical activity caused a systemic hypoxic condition and triggered adaptation responses. Cardiac muscle damage occurred on the 10th day in both treatment groups, with more severe damage observed in the group with anaerobic physical activity. The tissue protein level in the anaerobic group increased progressively on the 10th day.Conclusion: Physical activity may result in hypoxia and systemic adaptation. Aerobic and anaerobic physical activities performed for 10 days without any rest-day may cause cardiac muscle damage. (Med J Indones. 2013;22:209-14. doi: 10.13181/mji.v22i4.601)Keywords: Cardiac muscle, cardiac muscle damage, histopathology, physical activity
Chronic physical exercise increases a neurogenesis marker within hippocampus Zulkarnain, Mohammad; Flora, Rostika; Andrianti, Septi
Medical Journal of Indonesia Vol 27, No 2 (2018): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.964 KB) | DOI: 10.13181/mji.v27i2.1685

Abstract

Background:Aerobic and anaerobic physical exercises conducted in both acute and chronic are really essential in keeping the body especially brain healthy. Physical exercise plays an important role in molecular system and is beneficial for the brain by enhancing neurogenesis which is mediated by the increase of BDNF level. This study aimed to evaluate the effect of physical exercise to the BDNF level of hippocampus tissues in Wistar rats.Methods: Thirty male rats were divided into five groups i.e. control group, acute aerobic physical exercise group, acute anaerobic physical exercise group, chronic aerobic physical exercise group, and chronic anaerobic physical exercise group. Physical exercises were conducted on animal treadmill. The level of hippocampus BDNF was determined using ELISA. The data were analyzed using independent t-test.Results: BDNF average levels of chronic aerobic and anaerobic physical exercises were higher than those of acute ones (152.86±1.62 pg/ml and 122.22±1.53 pg/ml vs 59.38±6.10 pg/ml and 54.05±3.35 pg/ml). There were significant differences in the BDNF average levels of hippocampus tissues between aerobic and anaerobic groups, in both acute and chronic exercise.Conclusion: The chronic physical exercises, both aerobic or anaerobic, are increasing higher the level of BDNF in brain tissue.
Co-Authors : Samwilson Slamet, : Samwilson Adela, Novita adelina irmayani lubis Aguscik, Aguscik Aini, Putri Citra Qurrothu Alam Fajar, Nur Amalia, Risa Nur Amrina Rosyada Ananingsih, Esti Sri Andrianti, Septi Anggriani, Bayu Anita Rahmiwati Annisa Rahmawaty Antasari, Dwi Appulembang, Yeni Anna Apriliani, Ferenadia Ariana, Rika Aurora, Wahyu Indah D. Ayu Wulan Sari Bethy S. Hernowo Bina Melvia Bina Melvia Girsang Bingsih, Windi Indah Fajar Chairil Anwar Dwi Apriani Dwi Inda Sari, Dwi Inda Dwifitri, Uthu Eichi Septiani Elvi Sunarsih Elyantari, Gresi Fatmalina Febry Fitri Fitri Fitria Fitria Fitria, Fitra Fitriani, Novi Fitriawati, Fitriawati Fontani, Bernardin Dwi Frans Ferdinal Fretty, Heni Haerawati Idris, Haerawati Hakim, Dwi Ratnawaty Hamzah Hasyim HANS-JOACHIM FREISLEBEN Hardhono Susanto Harto, Toto Hayati, Thursina Vera Hervilanti, Putri Ikhsan Ikhsan Indah Yuliana Indahsari, Siti Rachmi Irawan, Purna Iyakrus Januar Sitorus, Rico Jasmine, Annisah Biancika Jayanti, Jahia Juniarti, Elda Kiki Sulaningsi Kurniati, Halisa Kusuma Aerosta, Danny Lasepha, Ani Lubis, Fatma Juwita M. Zulkarnain M. Zulkarnain, M. Zulkarnain Mariana Mariana Marissa, Febi Marissa Meirizal Usra, Meirizal misnaniari, Misnaniarti Misnaniarti Misnaniarti Mohamad Sadikin Moriskha, Moriskha Mukni Mukni, Mukni Nabilah, Defa Nuzul Nadia Purnama Sari Najmah, Najmah Ngudiantoro . Ningsih, Windi Indah Fajar Nirmalasari, Melisa Yuni Novitrie, Ayu Novrika, Novrika Novrikasari Novrikasari Novrikasari, Novrikasari Novrinda, Hilza Nur Alam Fajar Nurmalia Ermi Nursalim, Alfina Putri Ocktariana, Ocktariana Ocktariyana, Ocktariyana Octariyana, Octariyana Permana Putra, Dicky Pradisa, Dea Purnama, Yetti Puspita, Tari Rahima Rahima Rahmi Fitri J Ramdika, Sari Bema Rico Januar Sitorus Riris Diana Rachmayanti Rismiati, Meti Risnawati Tanjung Rizma Adlia Syakurah Rosaria, Rini Rosaria Samwilson, Samwilson Sari, Novrika Sari, Yuanita Windu Septelia I. Wanandi Shaputra, Roni Zakaria Sigit Purwanto Sitorus, Rico J Suhendra, Ahmad Adi SUKENDRO SUKENDRO, SUKENDRO Sukirno Sukirno Sulung, Neshy Sunarsi, Elvi Suryadi Tjekyan Susanti Susanti Syamsuryadi Tan Malaka Theodorus Theodorus Udin Bahrudin, Udin Wahyu Indra Bayu Wijaya, Bagas Rindra Wulanda, Ayu Febri Yuanita Windusari Yuliantari, Devy Yuliastuti, Maria Eka Zulkarnain Zulkarnain Zulkarnain, HM Zulkarnain, M. Zulkarnain Zulkarnain, Mohammad