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All Journal Medula Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Journal of Biomedicine and Translational Research Biology, Medicine, & Natural Product Chemistry JPSriwijaya Sari Pediatri Biomedical Journal of Indonesia Molecular and Cellular Biomedical Sciences (MCBS) Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics & Gynecology Science Pharmacology and Clinical Pharmacy Research Indonesian Journal for Health Sciences (IJHS) Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Plastik Rekonstruksi Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientia Psychiatrica Indonesian Journal of Anesthesiology and Reanimation (IJAR) Sriwijaya Journal of Surgery Jurnal Integrasi Kesehatan dan Sains JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai Jurnal Pengabdian Masyarakat: Humanity and Medicine Natural Sciences Engineering and Technology Journal Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Wal'afiat Hospital Journal International Journal of Islamic and Complementary Medicine Journal of Anesthesiology and Clinical Research Jurnal Riset Kedokteran Conferences of Medical Sciences Dies Natalis WAL'AFIAT HOSPITAL JOURNAL
Ziske Maritska
Department Of Biology Medicine, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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The Effect of Activated Growth Factor (AGF) from Platelets on Alpha-SMA Levels in Osteoarthritis: Invivo Study Ziske Maritska; Hidayat, Rachmat; Septi Purnamasari; Muhammad Rizky Hidayatullah; Sarah; Najla Khairunnisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.980

Abstract

Background: The most prevalent joint condition and leading contributor to disability is osteoarthritis (OA), resulting in a significant socio-economic impact. It occurs due to an imbalance of pro-inflammatory and anti-inflammatory mediators, influencing anabolic and catabolic activities. This study aims to determine the effect of activated growth factor (AGF) on alpha-SMA levels. Methods: This research is an in vivo post-test-only control group experimental study conducted at the Eureka Research Laboratory. Thirty male Wistar rats were divided into five treatment groups: normal control group, negative control group, AGF I group (TGF-β 100 pg/mL), AGF II group (TGF-β 1000 pg/mL), and AGF III group (TGF-β 10,000 pg/mL). AGF was obtained from rat blood intravenously and centrifuged at a predetermined speed. Growth factor activation was performed by adding 10% CaCl2, and then TGF-β levels were measured. All groups of rats were acclimatized for 7 days. After that, osteoarthritis was induced with intra-articular injection of monoiodoacetate (MIA) 4.8 mg/60μL in all groups of rats except the normal control group. Next, rats were given treatment according to the group for 21 days. On the 21st day, rats were euthanized, and alpha-SMA levels were measured using the sandwich method ELISA kit. Results: Sequentially, the mean Alpha-SMA levels for each group in pg/mL were: 91.495 ± 2.36; 10.682 ± 1.09; 30.502 ± 2.00; 52.892 ± 1.29; and 76.180 ± 2.65. In the AGF group, there was an increase in alpha-SMA levels directly proportional to the dose of TGF-β injected. Conclusion: AGF has an effect on increasing alpha-SMA levels in the joints of rats with a model of osteoarthritis.
Comparison of Morphometric Variation of Ramus Length and Mandibular Corpus Length in Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, Based on Gender Muzakkie, Mufida; Muhammad Febriandi Djunaidi; S.N.A Ratna Sari Devi; Ziske Maritska
Sriwijaya Journal of Surgery Vol. 6 No. 2 (2023): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v6i2.87

Abstract

Introduction: Planned mandibular reconstruction with the help of morphometry allows plastic surgeons to perform operations with greater precision. They can plan bone shifts and cuts more accurately, minimize damage to surrounding tissue, and achieve cosmetically and functionally better results. This study aimed to compare the morphometric variation of ramus length and mandibular corpus length in patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, based on gender. Methods: This study was a cross-sectional analytic observational study. A total of 96 research subjects participated in this study, where the length of the ramus and corpus of the mandibular was obtained by assessing the 3D CT scan of the mandibular. Data analysis was carried out using SPSS in a bivariate. Results: The length of the mandibular ramus dextra and sinistra shows that the male gender is longer than the female gender, where the p-values are 0.000 and 0.001, respectively (p<0.05). The length of the mandibular corpus dextra and sinistra did not show a statistical difference in length, where the p-value was > 0.05. Conclusion: There is a difference in the length of the mandibular ramus between men and women, but there is no significant difference between the length of the corpus mandibular between men and women.
The Role of Pattern Recognition Receptor (PRR) in the Body's Defense System: A Narrative Literature Review Ziske Maritska; Hidayat, Rachmat
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 2 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i2.300

Abstract

Each cell has receptors on the cell surface that specifically bind to solutes (ligands) produced during tissue damage or infection. This review aimed to describe the role of PRR in the human body's defense system. The binding of the ligand to its receptor results in the activation of intracellular signaling pathways and cell activation. The B and T lymphocytes of the adaptive immune system have developed surface receptors (that is, the T-cell receptor, or TCR, and the B-cell receptor, or BCR) that bind a broad spectrum of antigens. The cells involved in innate resistance have developed a distinct set of receptors that recognize a much more limited array of specific molecules. These are called pattern recognition receptor (PRR), and they recognize the molecular patterns in infectious agents or their products (pathogen-associated molecular patterns, or PAMP) or products of cellular damage (necrosis or apoptosis; molecular pattern-associated damage, or DAMPs). In conclusion, the pattern recognition receptor (PRR) is a receptor complex that interacts with various molecules, such as PAMP and DAMPs. PRR bonds with these various molecules and play a role in various actions of innate immunity and adaptive immunity.
The Effect of Activated Growth Factor (AGF) from Platelets on Alpha-SMA Levels in Osteoarthritis: Invivo Study Ziske Maritska; Hidayat, Rachmat; Septi Purnamasari; Muhammad Rizky Hidayatullah; Sarah; Najla Khairunnisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.980

Abstract

Background: The most prevalent joint condition and leading contributor to disability is osteoarthritis (OA), resulting in a significant socio-economic impact. It occurs due to an imbalance of pro-inflammatory and anti-inflammatory mediators, influencing anabolic and catabolic activities. This study aims to determine the effect of activated growth factor (AGF) on alpha-SMA levels. Methods: This research is an in vivo post-test-only control group experimental study conducted at the Eureka Research Laboratory. Thirty male Wistar rats were divided into five treatment groups: normal control group, negative control group, AGF I group (TGF-β 100 pg/mL), AGF II group (TGF-β 1000 pg/mL), and AGF III group (TGF-β 10,000 pg/mL). AGF was obtained from rat blood intravenously and centrifuged at a predetermined speed. Growth factor activation was performed by adding 10% CaCl2, and then TGF-β levels were measured. All groups of rats were acclimatized for 7 days. After that, osteoarthritis was induced with intra-articular injection of monoiodoacetate (MIA) 4.8 mg/60μL in all groups of rats except the normal control group. Next, rats were given treatment according to the group for 21 days. On the 21st day, rats were euthanized, and alpha-SMA levels were measured using the sandwich method ELISA kit. Results: Sequentially, the mean Alpha-SMA levels for each group in pg/mL were: 91.495 ± 2.36; 10.682 ± 1.09; 30.502 ± 2.00; 52.892 ± 1.29; and 76.180 ± 2.65. In the AGF group, there was an increase in alpha-SMA levels directly proportional to the dose of TGF-β injected. Conclusion: AGF has an effect on increasing alpha-SMA levels in the joints of rats with a model of osteoarthritis.
Effect of Vitamin D Supplementation on Recurrence Risk in Graves’ Disease Measured By The GREAT Score at Dr. Mohammad Hoesin General Hospital Palembang Ali Rabbani, Muhammad Iqbal; Anggraini, Ratna Maila Dewi; Kusnadi, Yulianto; Maritska, Ziske
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.370

Abstract

Graves’ disease is the most common cause of primary hyperthyroidism with a prevalence of approximately 0.5%, predominantly affecting women (female-to- male ratio 6–7:1) aged 35–40 years. Predictors of treatment outcomes and recurrence risk have been studied, among them the GREAT Score, which combines age, goiter size, FT4, and TRAb levels. The aim of this study was to analyze changes in the GREAT Score after the addition of vitamin D supplementation in Graves' disease patients at Dr. Mohammad Hoesin General Hospital, Palembang, within 3 months. This was a double-blind randomized clinical trial involving 30 patients with Graves’ disease, both inpatients and outpatients, who met the inclusion criteria. Patients were randomly assigned into two groups: the intervention group received10,000 IU of vitamin D, while the control group received placebo. Recurrence risk was assessed using the GREAT Score at the first and third months, and data were analyzed with SPSS v.25. Analysis using the Wilcoxon test showed no significant change in the GREAT Score for the vitamin D group (p=0.102). At the first month, the distribution was 53.3% class I, 40.0% class II, and 5.7% class III, while at the third month it was 40.0% class I, 40.0% class II, and 20.0% class III. In the placebo group, results were also not significant (p=0.480), with the first-month distribution of 33.3% class I, 40.0% class II, and 26.7% class III, and the third month 40.0% class I, 33.3% class II, and 13.3% class III. In summary, Vitamin D supplementation has no significant effect in reducing the recurrence of Graves' disease compared to placebo.
MOLECULAR DOCKING ANALYSIS OF THE BIOACTIVE COMPOUND EMODIN WITH VEGFR2 IN CERVICAL CANCER Innayah Rania Farzana; Rara Inggarsih; Ziske Maritska; Ayeshah Augusta Rosdah; Soilia Fertilita
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 2 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/z96yxv93

Abstract

Cervical cancer remains a leading cause of cancer-related mortality among women and represents the third most common cancer globally. Elevated VEGF expression in cervical cancer is associated with poor prognosis, highlighting the relevance of anti-VEGF therapeutic strategies. Several studies have shown that emodin, a natural anthraquinone derivative mainly isolated from Rheum palmatum, inhibits VEGF-stimulated proliferation, migration, and formation of endothelial cells. This study aims to characterize the interaction between emodin and the VEGF receptor in cervical cancer through in silico molecular docking. The workflow included preparation of the compound structure, preparation of the target protein structure, docking protocol validation, and docking of the compound to the receptor. Lower binding energy reflects a stronger and more stable interaction. The docking analysis showed that the emodin–VEGFR2 complex exhibits a binding energy of −7.78 kcal/mol, forming three hydrogen bonds with GLU915, CYS917, and LEU838, as well as three van der Waals interactions with PHE916, GLY920, and VAL846. These findings demonstrate a stable interaction between emodin and VEGFR2 and suggest its potential as a lead compound for further development of VEGFR2-targeted inhibitors, underscoring the need for subsequent in vitro and in vivo validation.
Mortality Predictors in Spontaneous Intracerebral Hemorrhage: External Validation of the ICH Score in the Indonesian Surgical Population Grady Christian; Trijoso Permono; Ziske Maritska
Sriwijaya Journal of Surgery Vol. 9 No. 1 (2026): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v9i1.143

Abstract

Introduction: Spontaneous intracerebral hemorrhage (ICH) is a major contributor to stroke-related mortality and long-term disability, particularly in Indonesia, which faces the highest age-standardized stroke mortality rate in Southeast Asia. This study evaluates the predictive accuracy of the ICH Score for 30-day mortality among patients undergoing surgical intervention at a primary referral center in South Sumatra. Methods: This analytical observational study utilized a retrospective cohort design, analyzing 81 patients with spontaneous ICH who underwent surgical evacuation at Dr. Mohammad Hoesin Central General Hospital Palembang between July 2024 and June 2025. Demographic, clinical, and radiological parameters were evaluated. Accuracy was determined using Receiver Operating Characteristic (ROC) curve analysis to establish the Area Under the Curve (AUC), sensitivity, and specificity. Results: The cohort was predominantly male (56.8 percent) and aged under 80 years (86.4 percent). Significant predictors of 30-day mortality included age 80 years or older (p < 0.001, OR 26.84), lower Glasgow Coma Scale (GCS) scores (p = 0.012), and the presence of intraventricular hemorrhage (IVH) (p < 0.001, OR 15.24). ROC analysis demonstrated an AUC of 0.958 (95 percent CI 0.910–1.000). An optimal ICH Score cut-off of 3 or higher yielded a sensitivity of 86.2 percent and a specificity of 100 percent. Conclusion: The ICH Score serves as an exceptionally accurate prognostic tool in the Indonesian surgical population. An admission score of 3 or higher is a definitive predictor of mortality, facilitating risk stratification and informed clinical decision-making.
Co-Authors Abdullah Sahab Achmad Zulfa Juniarto Adam Triyoga Aditya Rafrenda Agustina Septi Hijir Aisyah Izzatinisa Al Farisi Sutrisno, Muhammad Ali Rabbani, Muhammad Iqbal Alya Rahmadani Amalia Salsabilla Amirah Adillah Amirah Dhia Nabila Sinum Andhika Diaz Maulana Anggraini, Friska Anggraini, Ratna Maila Dewi Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardy Oktaviandi Ardy Santosa Ardy Santosa Arroyantri Prananjaya, Bintang Arroyantri, Bintang Arroyantri, Bintang Atikah M. Ihsan Awang Budi Saksono Ayeshah A Rosdah Azalia Talitha Zahra Azizah Hanun Yasmin Baharudin Baharudin Balqis Wulandari Basir, Salni Beauty Novianty Benny Issakh Benny Issakh Bintang Arroyantri Bintang Arroyantri P Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bintang Arroyantri Prananjaya Bunga Anggreini Sari Carissa Delania Cendy Legowo Ching Leng Kee Chris Alberto Amin Citra Wulandari Citra Wulandari Clinton F.M Sitanggang Corinna Faustina Dastamuar, Shalita Defa Pratama Diah Andini Dian Puspita Sari Dian Puspita Sari Dian Widia Lestari Didit Pramudhito Dipta Anggara Diyaz Syauki Ikhsan Diyaz Syauki Ikhsan Eka Febri Zulissetiana Eka Febri Zulissetiana Eka I Fitriana Eka I Fitriana Eka Kurniawan Perangin-Angin Ella Amalia, Ella Emelda Emelda Endah Rahmadani Endi Taris Pasaribu Endi Teris Pasaribu Ernes Putra Gunawan Fachmi Idris Fakhri Abdurrahman Fakhri Abdurrahman Febryana Ramadhani Machyar Ferdy Rahadiyan Fiona Widyasari Firmansyah Basir Fitri Az-Zahrah Fitri Mareta Elzandri Friska Anggraini Ganda Purba Tasti Grady Christian Hartati Hartati Hawari Martanusa Husada, Abdillah Ignatius Aldo Winardi Ina Rahmawati Inggarsih, Rara Innayah Rania Farzana Irfan Ferdinand Tambunan Irga, Muhammad Irsan Saleh issakh, Benny Jayawarsa, A.A. Ketut Jessica Putri Salim Jessica William Joko Marwoto Joko Marwoto Julius Anzar Karina, Mathius Kemas Yusuf Effendi Khairunnisa, Tyas Citra Khumaisiyah Khumaisiyah Lathifah Nudhar Lawrencia Toline Layal, Kamalia Leonardo Satria Lovina Lovina Lusia Hayati Lusia` Hayati M. Khairul Kahfi Pasaribu MA Husnil Farouk Mahayu Dewi Ariani Manurung, Maya Rina Santara Masagus Irsan Saleh Hasani Mayasari Mayasari Mgs Irsan Saleh Mgs. A. Rifqi Murtadho Mgs. Irsan Saleh, Mgs. Irsan Mohammad Hilal Atthariq Ramadhan Mufida Muzakkie Mufida Muzakkie Muhammad Adib Dwitamma Muhammad Adib Dwitamma Putra Muhammad Barkah Muhammad Fakhri Altyan Muhammad Febriandi Djunaidi Muhammad Fikri Aulia Muhammad Hilal Atthariq Ramadhan Muhammad Irsan Saleh Muhammad J. Aldwin Muhammad Rizky Hidayatullah Muhammad Yusuf Wijahaska Muzakkie, Mufida Nabila Rizki Sakinah Nabila, Safa Putri Najla Khairunnisa Nita Parisa Novita Angkirani Novita Sari Noviyanti Eliska, Noviyanti Nudhar, Lathifah Nur Rakhman Pratama Pasaribu, Endi Taris Pasaribu, M. Khairul Kahfi Peby Maulina Lestari, Peby Maulina Perawati Perawati Prananjaya, Bintang Arroyantri Puji Rizki Suryani Puji Rizki Suryani Puji Rizki Suryani Purnamasari, Septi Puspa Zulaika Putra, Marco Manza Quardetta, Rovania Yantinez RACHMAT HIDAYAT Rachmat Taufan Raden Ayu Mulya Liansari rahman, Khaidir Yusuf Rahmat Afif Rahmi Isman Rani Iswara Rara Inggarsih Rara Inggarsih Ratna Sari Devi, Ratna Sari Ricky Fajar Adiputra Rini Nindela Rini Nindela Rini Nindela, Rini Riri Juliantika Rizka Fathia Robby Pardiansyah Rosalie Dorothea Rovania Yantinez Quardetta Rovania Yantinez Quardetta S.N.A Ratna Sari Devi S.N.A. Ratna Sari Devi Safa Nabila Putri Safa Nabila Putri Salim, Jesica Putri Salni Salni Salni Salni Sanely Saphira Nada Khalishah Saputra, Andre Sarah Sari H. S., Maharani Puspita Sarmoko Sarmoko Sativandi Riza Savero Evan Abisha Evan Abisha Sendy Aditya Nugraha Septi Purnamasari Setiadi Winata Shalita Dastamuar Siti Rahma Anissya Kinanti SNA Ratna Sari Devi Soilia Fertilita Sri Nita Sri Nita Stevanny, Bella Sultana MH Faradz Suryani, Puji Rizki Sutandar, Vivi Hendra Syarif Husin Syarifah Aini Syarifah Aini Syarinta Adenina Syauki Ikhsan, Diyaz Syifa Syifa Alkaf Syifa Syifa Syulthoni, Zain Budi Tan Yue Ming Theofilus Aswadi Tiara Fatrin Tinton Ardiyan Tinton Ardiyan Toline, Lawrencia Tri U. Pratiwi Trijoso Permono Triwani Triwani Triwani Triwani Triwani Triwani Trizky Nataza Putra Try Merdeka Puri Tryvanie R Putra Uswati Uswati Venny Patricia Veny Larasati Victor Pulpa Seda Vienna Dwinda Putri Villicia Angellika Yulianto kusnadi Yundari, Yundari Yuni Dwi Marantika Yusuf, Khaidir Yusuf Yuwono Zabila Adwie Prilishia Zabrina Zerlinda Zen Hafy Zulkifli