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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Natural Science: Journal of Science and Technology e-Journal Pustaka Kesehatan Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Jurnal Ilmu Kefarmasian Indonesia JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Nursing Care and Health Technology Journal (NCHAT) Khazanah: Jurnal Mahasiswa Malacca Pharmaceutics Indonesian Journal of Pharmacology and Therapy
Triana Hertiani
Faculty Of Pharmacy, Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Characterization and Effect of Chitosan Concentration Variations on the Nanosuspension Formula of Ethanol Extracts from Plantago major L. Leaves Using the Ionic Gelation Method Irawan, Muhamad Bayu; Hertiani, Triana; Martien, Ronny
Majalah Farmaseutik Vol 21, No 4 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i4.107330

Abstract

The ethanol extract of Plantago major L. leaves contains secondary metabolites, including phenolics and iridoid glycosides, which exhibit anti-inflammatory and wound-healing properties. Nanoparticle technology, in the form of nanosuspensions, is a method that can enhance the ability of active compounds to pass through cell membranes at the nanoscale. This study aimed to characterize and investigate the effects of varying chitosan concentrations on the nanosuspension formulation of Plantago major L. ethanol leaf extract using the ionic gelation method. The ethanol extract was formulated into nanosuspensions with five different concentrations of chitosan polymer: 0.25% (F1), 0.5% (F2), 0.75% (F3), 1% (F4), and 1.25% (F5). Testing parameters included particle size, polydispersity index (PDI), and zeta potential, measured using the Malvern Zetasizer Nano ZS instrument. The characterization results for all formulations showed an average particle size ranging from 445.7 to 811.5 nm, a PDI ranging from 0.385 to 0.518, and a zeta potential between 23.9 and 31.0 mV. These results indicate that all formulations fall within the nanoparticle size range (10–1,000 nm), exhibit relatively homogeneous polydispersity indices, and display stable zeta potentials. Variations in chitosan concentration in each nanosuspension formula of ethanol extract of Plantago major L. influenced the characterization, with increasing chitosan concentration resulting in larger particle sizes and higher zeta potentials, thereby enhancing the potential for these nanosuspensions to be formulated into drug delivery systems.
Uji Kadar Kurkumin Pada Temulawak dan Kuersetin Pada Sambung Nyawa dengan Metode Kromatografi Lapis Tipis Kinerja Tinggi Endang Setyowati; Zullies Ikawati; Triana Hertiani; Elza Fadia Irzani
Nursing Care and Health Technology Journal (NCHAT) Vol. 6 No. 1 (2026): Nursing and Health Care Technology-January to June Period
Publisher : Progres Ilmiah Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56742/nchat.v6i1.261

Abstract

Temulawak (Curcuma xanthorrhiza Roxb.) dan sambung nyawa (Gynura procumbens) merupakan tanaman obat yang mengandung senyawa bioaktif penting, yaitu kurkumin dan kuersetin. Variasi proses pengolahan dan bentuk sediaan dapat memengaruhi kadar kedua senyawa tersebut sehingga diperlukan standarisasi. Penelitian ini bertujuan untuk menentukan kadar kurkumin pada temulawak dan kadar kuersetin pada sambung nyawa dalam bentuk infusa, serbuk, dan produk herbal menggunakan metode Kromatografi Lapis Tipis Kinerja Tinggi (KLTKT). Analisis dilakukan dengan menotolkan larutan standar dan sampel pada plate silika gel F254, kemudian elusi dan pembacaan densitometri dilakukan untuk mendapatkan luas area puncak yang selanjutnya dimasukkan ke dalam persamaan regresi kurva baku. Hasil penelitian menunjukkan bahwa ekstrak infusa memberikan kadar tertinggi baik untuk kurkumin (0.28 ± 0.008%) maupun kuersetin (1.50 ± 0.13%). Kesimpulannya, bentuk sediaan dan metode ekstraksi berpengaruh terhadap kadar senyawa aktif, dan metode KLTKT dapat digunakan sebagai metode evaluasi mutu herbal.
Co-Authors ., Sudarsono ACHMAD FUDHOLI Afandi, Karima Agustina, Ikra Agustinus Yuswanto Ahmad Marzuki Ainaini, Rizkia Aini Febriana Aini Febriana  Akhmad Khumaidi Ali Djamhuri Amalia, Latifa Ardani, Marisya Atikana, Akhirta Bawon Triatmoko Bayu Irawan, Muhamad Budi Pranoto Christin Marganingsih Santosa Dellyna Feronica Manik Dewi Setyaningsih Dian Adityaningrum Dwi Salim, Rozin Ediati Sasmito EDIATI SASMITO Edrada, Ru Angelie Eka Prasasti Nur Rachmani Elza Fadia Irzani Endang Setyowati Erma Yunita Erna Prawita Setyowati Erna Prawita Setyowati Fadilah Qonitah FERRY RAHMA PUSPITA Fitri Apriliany, Fitri Fransiska Leviana Galih Pratiwi Galih Pratiwi, Galih Gemini Alam Gemini Alam Hady Anshory Hady Anshory Hady Anshory Hamzah, Hasyrul Hanif Nasiatul Baroroh Harjanti, Kestri Indah Purwantini Irami Duma Kencana Irianto Iramie Duma Kencana Irianto Irawan, Muhamad Bayu Kartika, Senda Kestri Harjanti Khafi, Muhammad Khairan Khairan Kharismatul Khasanah Lay, Caterina Siskadewi LINDA SUKMARINI LISA SOEGIANTO Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Marchaban Marchaban Marchaban Marchaban, Marchaban Maria Ulfah Maulidia, Faiqoh Nur Michael Kubbutat Mistriyani, Mistriyani mufrod mufrod Mufrod Mufrod Muller, Werner E.G. Musthofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Narastika, Longina Ni Luh Putu Vidya Paramita Novi Febrianti NURI IRIYANI Nurul Jannah Oktavia Tri Wahyuni Pamungkas, Aryaningtyas Widya peter Proksch Peter Proksch Peter Proksch, Peter Pratama, Nofran Putra Pratiwi, Agrita Eka Pratiwi, Sekar Ayu Pratiwi, Sylvia Prayoga, Muhammad Bagas Proksch, Peter Puji Astuti Puji Astuti Purnomo, Kurnia Rahayu PUSPITA LISDIYANTI Puspita, Nanda Ayu Putri Indah Sayakti Putri, Faradhyta Maharani Rachel Turalely Rachel Turalely Rachel Turalely Rachel Turalely Rahmayani, Almira Rasydi, Ahmad Retno Murwanti Rica Rica Rica Rica, Rica Rima Munawaroh Rinaldi Idroes Rizkia Ainaini rob W.M. van Soest Rob W.M. Van Soest, Rob W.M. ROCHMAT MUDJAHID Rodiata, Tsania Andaya Ronny Martien Ru Angelie Edrada-Ebel RuAngelie Edrada RuAngelie Edrada, RuAngelie Rumondang, Amanda Sanan, Antonius Oenunu Sari R Sari R, Sari Sasmito, Ediati SEPTI WULANDARI Setiawan, Vania SHANTI RATNAKOMALA Silvia Utami Tanjung Pratiwi SINTAYU PUTRI WANDAN SARI Siswadi Siswadi Siswandi Siswandi, Siswandi Sobri Iskandar Sofia Mubarika Haryana Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sudarsono . SUDIBYO MARTONO Sukarti Moeljopawiro Sumarni Sumarni Sumarni Sumarni Suryawati Suryawati SUWIJIYO PRAMONO Syamsu Nur, Syamsu Sylvia Pratiwi Sylvia Utami Tanjung Pratiwi Sylvia Utami Tunjung Pratiwi Tamhid, Hady Anshory Tantri Liris Nareswari Tho’atun Ma'rufah Titik Nuryastuti Ulfa Afrinurfadhilah Darojati Untari, Febriana Van Soest, Rob W.M. Werner E.G. Muller Wiwin Herdwiani WOUTER L.J. HINRICHS Yolanda Yolanda Yolanda Yolanda, Yolanda YOSI BAYU MURTI Yosi Bayu Murti Yuli Nurullaili Efendi Yuli Nurullaili Efendi, Yuli Nurullaili Zahra Zahra Zahra Zahra Zulbayu, L.M. Andi Zullies Ikawati