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All Journal HAYATI Journal of Biosciences Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Natural Science: Journal of Science and Technology Journal Pharmaceutical Science and Application (JPSA) e-Journal Pustaka Kesehatan Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Khazanah: Jurnal Mahasiswa Malacca Pharmaceutics Indonesian Journal of Pharmacology and Therapy
Triana Hertiani
Faculty Of Pharmacy, Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulation and Stability Test of HPMC and Carbomer 940 based-Gel Formulation Containing Plantago major L. hydroalcoholic extract Khafi, Muhammad; Hertiani, Triana; Murwanti, Retno; Bayu Irawan, Muhamad; Marzuki, Ahmad; Dwi Salim, Rozin
Majalah Farmaseutik Vol 21, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i2.95893

Abstract

The P. major plant has long been utilized in traditional herbal medicine and is widely accessible in Indonesia and globally. Extensive research has demonstrated its efficacy in wound healing through both clinical and preclinical studies. Gel formulations are recognized for establishing a conducive moist environment essential for wound healing, thus rendering them suitable for topical wound treatment. This study assesses the stability of HPMC gel base, carbomer 940, and their combination as carriers for the ethanol extract of P. major leaves. Stability testing involved a freeze-thaw cycle test at temperatures of 4°C and 40°C for three cycles. The findings indicate no significant alteration in the organoleptic properties and pH of the gel formulations before and after stability testing. However, t-test analysis reveals a noteworthy decrease in viscosity for carbomer and its combination, albeit not for HPMC alone. In conclusion, HPMC exhibits superior stability as a gel base compared to Carbomer 940 and their combination.
Correlating Color and The Chemical Profiles of Sterculia quadrifida Barks for Herbal Raw Materials Quality Hertiani, Triana; Siswandi, Siswandi; Pratiwi, Agrita Eka; Pamungkas, Aryaningtyas Widya; Rumondang, Amanda; Rodiata, Tsania Andaya; Pratiwi, Sekar Ayu; Lay, Caterina Siskadewi; Agustina, Ikra
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.95624

Abstract

The traditional use of faloak (Sterculia quadrifida R. Br.) stem bark as an effective treatment for various diseases has led to its widespread cultivation and collection. Therefore, this study aims to determine the correlation between the intensity and color variation of faloak stem bark with its antioxidant activity and phytochemical content using chemometrics analysis. The study procedures were carried out by collecting samples from different locations in East Nusa Tenggara, Indonesia. Stem bark intensity and color variations were then associated with chemical profiles of extract produced. Chemical profiles analyzed were Total Phenolic Content (TPC), Total Flavonoid Content (TFC), and antioxidant activity as measured using the DPPH, b-carotene bleaching, and CUPRAC methods. Subsequently, the data were subjected to multivariate statistical analyses utilizing Principal Component Analysis (PCA) and Cluster Analysis (CA). The results showed that color variations on faloak stem bark had no significant impact on cluster formation. CA and PCA showed grouping according to gray value representing color intensity. Meanwhile, PCA revealed significant correlations between gray value of faloak stem bark extract and TPC, antioxidant activity, and extract yield, with TFC having no association. Based on these results, color detection system could be developed to facilitate S. quadrafida bark collection as herbal medicine raw materials in the field.
Aktivitas Penghambatan enzim Dipeptidyl Peptidase 4 (DPP-4) dari ekstrak dan seskuiterpen lakton yang Diisolasi dari Daun Yacon (Smallanthus sonchifolius) Tamhid, Hady Anshory; Hertiani, Triana; Murti, Yosi Bayu; Murwanti, Retno
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 6, ISSUE 2, October 2025
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol6.iss2.art2

Abstract

The Sesquiterpene lactones, enhydrin and uvedalin, are the chemotype and subtype compounds of the yacon leaf. They are known to have anti-diabetic activity, but their mechanisms are not clear. One of the mechanisms of anti-diabetic agents is to inhibit the activity of the dipeptidyl peptidase 4 enzyme (DPP-4). The research aimed to determine the inhibition of the extract, enhydrin, and uvedalin isolated from the yacon leaf against the DPP-4 enzyme activity. Yakon leaves were extracted using 70% ethanol by the maceration method. Enhydrin and uvedalin were obtained from previous research. The inhibitory activity of the DPP-4 enzyme was then determined by the fluorescence assay method using a multi-well plate reader. Sitagliptin was used as standard inhibitor of DPP-4 enzyme. The ethanol extract of yacon leaves inhibits the DPP-4 enzyme with an IC50 of 856.9 ppm. The percentage inhibition of the DPP-4 enzyme by the enhydrin and uvedalin at a concentration of 250 ppm was 2.37 and 35.16%, respectively. The inhibitory potency of the pure isolated compounds was not substantially greater than that of the crude extract itself. This led us to the conclusion that the overall contribution of enhydrin and uvedalin to the extract's DPP-4 inhibitory activity is actually modest, suggesting the presence of other active compounds within the extract. However, it may provide a new approach to the treatment of type 2 diabetes.
Antiplasmodial activity and cytotoxicity of kapur (Harmsiopanax aculeatus) leaf extracts traditionally used for the treatment of malaria in Maluku Turalely, Rachel; Mustofa; Mahardika Agus Wijayanti; Triana Hertiani
Indonesian Journal of Pharmacology and Therapy Vol 1 No 1 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.512

Abstract

Harmsiopanax aculeatus leaf, locally name kapur, has been use traditionally to treat malaria in Maluku, Indonesia. However, the scientific evidences that support its use are still limited. This study aimed to investigate antiplasmodial activity of H. aculeatus leaf extract and its cytotoxicity on cancer cells line. Three extracts i.e. methanolic, n-hexanic and ethyl acetate extracts were evaluated for their in vitro activity against Plasmodium falciparum FCR3 strain using microscopic method. Cytotoxicity of the extracts on T47D, HeLa and Vero cells lines were determined using MTT assay method. The inhibitory concentration 50% (IC50) against P. falciparum or the cells lines growth was determined using probit analysis. Furthermore, their selectivity index (SI) were determined. The results showed that the methanolic extract was the most active extract with an IC50value of 13.82 μg/mL and the most selective with a SI value of 172.84. The three extracts tested exhibited weak or no cytotoxicity against the cells lines used with IC50 values ranged 101-2388.69 μg/mL. Further study will be conducted to isolate active antiplasmodial compounds from the methanol extract.
Characterization and Effect of Chitosan Concentration Variations on the Nanosuspension Formula of Ethanol Extracts from Plantago major L. Leaves Using the Ionic Gelation Method Irawan, Muhamad Bayu; Hertiani, Triana; Martien, Ronny
Majalah Farmaseutik Vol 21, No 4 (2025): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i4.107330

Abstract

The ethanol extract of Plantago major L. leaves contains secondary metabolites, including phenolics and iridoid glycosides, which exhibit anti-inflammatory and wound-healing properties. Nanoparticle technology, in the form of nanosuspensions, is a method that can enhance the ability of active compounds to pass through cell membranes at the nanoscale. This study aimed to characterize and investigate the effects of varying chitosan concentrations on the nanosuspension formulation of Plantago major L. ethanol leaf extract using the ionic gelation method. The ethanol extract was formulated into nanosuspensions with five different concentrations of chitosan polymer: 0.25% (F1), 0.5% (F2), 0.75% (F3), 1% (F4), and 1.25% (F5). Testing parameters included particle size, polydispersity index (PDI), and zeta potential, measured using the Malvern Zetasizer Nano ZS instrument. The characterization results for all formulations showed an average particle size ranging from 445.7 to 811.5 nm, a PDI ranging from 0.385 to 0.518, and a zeta potential between 23.9 and 31.0 mV. These results indicate that all formulations fall within the nanoparticle size range (10–1,000 nm), exhibit relatively homogeneous polydispersity indices, and display stable zeta potentials. Variations in chitosan concentration in each nanosuspension formula of ethanol extract of Plantago major L. influenced the characterization, with increasing chitosan concentration resulting in larger particle sizes and higher zeta potentials, thereby enhancing the potential for these nanosuspensions to be formulated into drug delivery systems.
Co-Authors ., Sudarsono ACHMAD FUDHOLI Afandi, Karima Agustina, Ikra Agustinus Yuswanto Ahmad Marzuki Ainaini, Rizkia Aini Febriana Aini Febriana  Akhmad Khumaidi Ali Djamhuri Amalia, Latifa Ardani, Marisya Atikana, Akhirta Bawon Triatmoko Bayu Irawan, Muhamad Budi Pranoto Christin Marganingsih Santosa Dellyna Feronica Manik Dewi Setyaningsih Dian Adityaningrum Dwi Salim, Rozin EDIATI SASMITO Ediati Sasmito Edrada, Ru Angelie Eka Prasasti Nur Rachmani Erma Yunita Erna Prawita Setyowati Erna Prawita Setyowati Fadilah Qonitah FERRY RAHMA PUSPITA Fitri Apriliany, Fitri Fransiska Leviana Galih Pratiwi Galih Pratiwi, Galih Gemini Alam Gemini Alam Hady Anshory Hady Anshory Hady Anshory Hamzah, Hasyrul Hanif Nasiatul Baroroh Harjanti, Kestri Indah Purwantini Irami Duma Kencana Irianto Iramie Duma Kencana Irianto Irawan, Muhamad Bayu Kartika, Senda Kestri Harjanti Khafi, Muhammad Khairan Khairan Kharismatul Khasanah Lay, Caterina Siskadewi LINDA SUKMARINI LISA SOEGIANTO Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Marchaban Marchaban Marchaban Marchaban, Marchaban Maria Ulfah Maulidia, Faiqoh Nur Michael Kubbutat Mistriyani, Mistriyani mufrod mufrod Mufrod Mufrod Muller, Werner E.G. Musthofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Narastika, Longina Ni Luh Putu Vidya Paramita Novi Febrianti NURI IRIYANI Nurul Jannah Oktavia Tri Wahyuni Pamungkas, Aryaningtyas Widya peter Proksch Peter Proksch Peter Proksch, Peter Pratama, Nofran Putra Pratiwi, Agrita Eka Pratiwi, Sekar Ayu Pratiwi, Sylvia Prayoga, Muhammad Bagas Proksch, Peter Puji Astuti Puji Astuti Purnomo, Kurnia Rahayu PUSPITA LISDIYANTI Puspita, Nanda Ayu Putri Indah Sayakti Putri, Faradhyta Maharani Rachel Turalely Rachel Turalely Rachel Turalely Rachel Turalely Rahmayani, Almira Rasydi, Ahmad Retno Murwanti Rica Rica Rica Rica, Rica Rima Munawaroh Rinaldi Idroes Rizkia Ainaini rob W.M. van Soest Rob W.M. Van Soest, Rob W.M. ROCHMAT MUDJAHID Rodiata, Tsania Andaya Ronny Martien Ru Angelie Edrada-Ebel RuAngelie Edrada RuAngelie Edrada, RuAngelie Rumondang, Amanda Sanan, Antonius Oenunu Sari R Sari R, Sari Sasmito, Ediati SEPTI WULANDARI Setiawan, Vania SHANTI RATNAKOMALA Silvia Utami Tanjung Pratiwi SINTAYU PUTRI WANDAN SARI Siswadi Siswadi Siswandi Siswandi, Siswandi Sobri Iskandar Sofia Mubarika Haryana Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sudarsono . SUDIBYO MARTONO Sukarti Moeljopawiro Sumarni Sumarni Sumarni Sumarni Suryawati Suryawati SUWIJIYO PRAMONO Syamsu Nur, Syamsu Sylvia Pratiwi Sylvia Utami Tanjung Pratiwi Sylvia Utami Tunjung Pratiwi Tamhid, Hady Anshory Tantri Liris Nareswari Tho’atun Ma'rufah Titik Nuryastuti Ulfa Afrinurfadhilah Darojati Untari, Febriana Van Soest, Rob W.M. Werner E.G. Muller Wiwin Herdwiani WOUTER L.J. HINRICHS Yolanda Yolanda Yolanda Yolanda, Yolanda YOSI BAYU MURTI Yosi Bayu Murti Yuli Nurullaili Efendi Yuli Nurullaili Efendi, Yuli Nurullaili Zahra Zahra Zahra Zahra Zulbayu, L.M. Andi Zullies Ikawati