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All Journal Journal of Food and Pharmaceutical Science Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Pharmascience Berkala Ilmiah Kedokteran Duta Wacana Majalah Farmaseutik Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Media Ilmu Kesehatan JFIOnline Jurnal Ilmu Kefarmasian Indonesia Generics: Journal of Research in Pharmacy Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia Journal of Food and Pharmaceutical Sciences Generics : Journal of Research in Pharmacy Jurnal Kefarmasian Indonesia Indonesian Journal of Pharmacology and Therapy
Agung Endro Nugroho
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta Indonesia 55281
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
AND DOSAGE RANGE TESTS OF TENSIGARD  AS A HYPOTENSIVE PHYTOPHARMACA Djatmiko, M.; Suhardjono, Djoko; Nugroho, Agung Endro
INDONESIAN JOURNAL OF PHARMACY Vol 12 No 1, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.382 KB) | DOI: 10.14499/indonesianjpharm0iss0pp33-43

Abstract

Tensigard is a phytofarmaca product of Agromed ( PT. Phapros Tbk., Semarang) formulated for antihypertension therapy. The product comprises celery extract (Apium graveolens) 75 % and kumis kucing extract (Orthosiphon stamineus Benth) 25 %. The aims of the research is to study whether Tensigard has an effect to decrease blood pressure in the normo and hypertensive (adrenaline induced hypertension) experimental animals. The specific aim of the study is to determine the D50 value of Tensigard to lower the blood pressure of the hypertensive experimental animals. The tests were conducted using anesthetized using anesthetized cats which were randomly divided into two groups, each of which consisted of 35 normotensive cats and the other 35 cats with hypertension (due to adrenaline treatment, in which the blood pressure was increased about 1,5 times than normal value). Furthemore, each group was devided into seven sub groups, each of which consists of 5 cats. One sub group was used as the control group, while the remaining sub groups were treated with Tensigard (6 dosage levels). The results of the studies indicated, that Tensigard has a hypotensive effect in the cats,either with normal or hypertension (adrenaline induced). The D50 value of the hypotensive effect in hypertensive cats is 16,37  1,08 mg/kg BW., in which the extrapolation of this dosage value for a 50 kg, human being is about 249,05 mg.Key Word : tensigard, antihypertension, effective dosage
Analgesic and anti-inflammatory activities of combrang (Nicolaia speciosaHoran) stem the extract Susilowati, Sri Sutji; Martono, Sudibyo; Riyanto, Sugeng; Nugroho, Agung Endro
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.077 KB) | DOI: 10.14499/indonesianjpharm0iss0pp115-119

Abstract

Long-term  goal  of  this  study  is  the  use  of  combrang  (Nicolaia  speciosa Horan)  as  an  ingredient  of  traditional  medicine  after  being  evaluated  through preclinical  testing  and  clinical  trials  both  extract  and  its  bioactive  compounds. This  study  includes  analgesic-antiinflammatory  activity  test  of  n-hexane, chloroform,  ethyl  acetate  and  methanol  extract  of combrang stem.  Analgesic test against crude extract of n-hexane, chloroform,ethyl acetate and methanol, using acetate writhing method. Antiinflammatory test using inhibition method of paw oedema by carrageenan induced on Wistar rats. Analgesic-antiinflammatory activity  compared  to  Na-diclofenac.  The  result  is  four  extracts  have  analgesic and  antiinflammatory  activity,  ethyl  acetate  extract  has  the  highest  analgesic and antiinflammatory activity.Key words: analgesics, anti-inflammatory, extract of combrang stem
INCREASING SENSITIVITY OF MCF-7/DOX CELLS TOWARDS DOXORUBICIN BY HESPERETIN THROUGH SUPPRESSION OF P-GLYCOPROTEIN EXPRESSION Sarmoko, .; Pamungkas P, Dyaningtyas Dewi; Susidarti, Ratna Asmah; Nugroho, Agung Endro; Meiyanto, Edy
Indonesian Journal of Pharmacy Vol 25 No 2, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (870.371 KB) | DOI: 10.14499/indonesianjpharm25iss2pp84

Abstract

Long-term use of doxorubicin causes cancer resistance due to overexpression of P-glycoprotein (P-gp), a protein that plays a role in cell drug efflux. The purpose of this study is to determine the action of hesperetin in increasing the cytotoxicity of doxorubicin on MCF-7 cancer cells resistant to doxorubicin (MCF-7/DOX) through suppression of P-gp expression. Cytotoxic assay of single and combinational treatment of doxorubicin and hesperetin were performed by using MTT assay. Apoptosis evidence was examined by using double staining with acridine orange and ethidium bromide dyes, while Pgp expression was determined by using immunocytochemistry. Hesperetin reduced cell viability in dose dependent manner. Both MCF-7 ori and MCF-7/DOX cells gave different responses to hesperetin with the IC50 values of >500μM and 267μM, respectively. Combining treatment of hesperetin and doxorubicin to MCF-7/DOX cells at the dose of 95μM and 230nM increased apoptosis evidence and suppressed P-gp expression. These results suggest that hesperetin enhances the anticancer effect of doxorubicin to resistance MCF-7 cells through suppression of P-gp expression.
Hypoglycemic Activity and Pancreas Protection of Combination Juice of Mengkudu (Morinda citrifolia Linn.) Juice and Temulawak (Curcuma xanthorrhiza Roxb.) Juice on Streptozotocin-Induced Diabetic Rats Santoso, Bilal Subchan Agus; Sudarsono, Sudarsono; Nugroho, Agung Endro; Murti, Yosi Bayu
Indonesian Journal of Pharmacy Vol 29 No 1, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1451.748 KB) | DOI: 10.14499/indonesianjpharm29iss1pp16

Abstract

Mengkudu fruit contains scopoletin and temulawak rhizome contains curcumin have been observed because they have strong antioxidant activity and they were used traditionally as antidiabetic. This research aimed to evaluate effect of antihyperglycemic and pancreas protection of juice combination of mengkudu fruit juice (MFJ) and temulawak rhizome juice (TRJ) on diabetes rats which were inducted with streptozotocin (STZ). Rats were grouped into 7 groups, each of group consisting 5 rats. Each of group was treated accordingly for 28 days except for a normal group of rats. Rats taken blood from the plexus retroorbitalis for examination of blood glucose levels every week. On the last day, rats blood was examined for malondialdehyde (MDA) levels. After that the rats were turned off for examination of pancreatic morphological conditions. The results showed that diabetic rats given MFJ-TRJ combination juice experienced a significant decrease in blood glucose levels, a significant decrease in MDA levels and improvement pancreas morphology when compared with the negative control group. The conclusion of this research was giving combination juice of MFJ-TRJ juice can decreased blood glucose level, decreased MDA level and can improved pancreas morphology condition.
Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System Astuti, Ika Yuni; Marchaban, Marchaban; Martien, Ronny; Nugroho, Agung Endro
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1392.999 KB) | DOI: 10.14499/indonesianjpharm29iss2pp60

Abstract

The recent work focuses on the physical characterization and dissolution study of PGV-0 loaded self-nanoemulsifying drug delivery system (SNEDDS). The PGV-0 SNEDDS was prepared by spontaneous emulsification method using oleic acid, tween 20:labrasol (1:1) and polyethylene  glycol  400. The zeta potential of the PGV-0 SNEDDS was   -34.4 ± 7.66 mv. The nanoemulsion of PGV-0 SNEDDS was thermodynamically stable with forming droplet oil containing PGV-0 in it and spherical. The dissolution result showed that the PGV-0 SNEDDS was able to increase the dissolution significantly (p <0.05) compared with PGV-0 powder of 44.13% in AGF medium and 30.37% in AIF medium. It is concluded that SNEDDS PGV-0 was able to increase the PGV-0 aqueous solubility.
Co-Authors . Anindyajati Abd. Rasyid Syamsuri Abdul Rohman Agung Giri Samudra Alexxander Alexxander, Alexxander Amalia, Retno Amir Husni Amprih Martha, Amprih Andita Pra Darma Arief Nurrochmad Arief Rahman Hakim Atharini, Yanita Harliana Awidarta, Kevin Ciptasari, Debora Purwasista Dani Dwi Agistia, Dani Dwi Dewi Wulandari Dirga Dirga Dita Brenna Septhea Djoko Suhardjono, Djoko Doddy Aditya Purnomo Dyaningtyas Dewi Putri Pamungkas Ediati Sasmito Eka Prasasti Nur Rachmani Eka Siswanto Syamsul Endang Lukitaningsih Farisa Luthfiana Fita Rahmawati Fredie Irijanto Gunawan Pamudji Widodo HARI PURNOMO HARI PURNOMO Harno Dwi Pranowo I Dewa Gde Mayun Permana I Dewa Putu Pramantara Ignatius Ryan Adriawan, Ignatius Ryan Ika Nurzijah Ika Puspitasari Ika Yuni Astuti Illian, Didi Nurhadi Isnaini, Puti JOKO TRI WIBOWO Kasih, Nirvane Zefanya Kazutaka maeyama KAZUTAKA MAEYAMA Khoerul Anwar Kiki Damayanti, Kiki Kustanto, Satya Prima Lina Widiyastuti Lini Veriony, Lini M. Djatmiko Marbun, Prajona Marchaban, Marchaban Martien, Ronny Maulana Tegar AdityaNugraha Maulita Cut Nuria Meiyanto, Edy Mohamad Andrie MOHAMAD ASPOLLAH SUKARI Mohamad Aspollah Sukari, Mohamad Aspollah Nanang Fakhrudin, Nanang Ningsih, Diana Rachma Novena Yety Lindawati, Novena Yety Novianti, Feby Galuh Nugroho, Nidhar Ainu Faza Nurul Maziyyah Pamungkas P, Dyaningtyas Dewi Pradana, Theophani Bagas Pramantara, Dewa Putu Presticasari, Hardiyani Priyasana, I Putu Probosuseno Probosuseno, Probosuseno PUGU NOVI ARSITO Puji Astuti Pulungan, Yulianasari Purwantiningsih, Purwantiningsih Putri, Cyndi Yulanda Raditya, Rakta Ratna Asmah Susidarti Ratnawati, Galuh Retno Murwanti Rina Susilowati risha fillah fithria Riyanto, Ratna Dewi Setiarini Riyanto, Sugeng Rizaldy Pinzon Rommy Ronny Martien Santoso, Bilal Subchan Agus Saputra, Yuli Edy Sardjiman . Sari, Juwita Permata Sarmoko Sarmoko Saroh, Muya Siswanto, Soni Sitarina Widyarini Siti Sendari Soraya, Fenthy Soraya, Fenthy Subagus Wahyuono Sudarsono, Sudarsono Sudibyo Martono Sugeng Riyanto SUGENG RIYANTO Sukmarini, Zhafira Supardjan A. Margono Susilowati, Sri Sutji Suwidjiyo Pramono SUWIJIYO PRAMONO Tivanie, Riza Ayu Tri Murti Andayani Umar Anggara Jenie Untari, Meta Kartika Wahyono Wahyono Widyati, Widyati Yance Anas Yose V. Sagala, Yose Yosi Bayu Murti Zamzani, Irfan